Receptors proteins. Medical search. Frequent questions

The GPCRdb database is the main repository of curated data for G protein-coupled receptors (GPCRs). (wikipedia.org)
Recent cancer genome deep sequencing efforts have revealed an unanticipated high frequency of mutations in G proteins and G-protein-coupled receptors (GPCRs) in most tumour types. (nature.com)
The most frequently mutated GPCRs include thyroid-stimulating hormone receptor (TSHR), Smoothened (SMO), glutamate metabotropic receptors (GRMs), members of the adhesion family of GPCRs and receptors for bioactive lipid mediators such as lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) that accumulate in the tumour microenvironment. (nature.com)
Aberrant expression, overexpression or signal reprogramming of GPCRs and G proteins in tumour cells can contribute to cancer development and progression. (nature.com)
G proteins, GPCRs and their linked signalling circuitry represent novel therapeutic targets for cancer prevention and treatment. (nature.com)
Aberrant expression and activity of G proteins and G-protein-coupled receptors (GPCRs) are frequently associated with tumorigenesis. (nature.com)
These studies indicate that G proteins, GPCRs and their linked signalling circuitry represent novel therapeutic targets for cancer prevention and treatment. (nature.com)
Arrestins and G proteins both dock with the GPCRs, however, researchers had previously only examined a bonded G protein. (stanford.edu)
Many of the available drugs that activate or deactivate GPCRs block both G proteins and arrestins from docking. (stanford.edu)
G-protein-coupled receptors (GPCRs) modulate many physiological processes by transducing a variety of extracellular cues into intracellular responses. (nih.gov)
Background G-protein-coupled receptors (GPCRs) play an essential role in lots of natural processes and represent a significant class of drug targets. (exposed-skin-care.net)
Furthermore, pre-exposure of GPCR transgenic pets to its ligand prospects to receptor desensitisation and behavioural version to following ligand publicity, providing further proof integration from the mammalian GPCRs in to the em C. elegans /em sensory signalling equipment. (exposed-skin-care.net)
As with mammalian systems, GPCRs play a significant part in the recognition of sensory 1062368-24-4 supplier indicators, and these indicators are relayed in the cell by heterotrimeric G protein. (exposed-skin-care.net)
Therefore, we attempt to check whether we'd elicit ligand-dependent behavioural reactions in em C. elegans /em by expressing mammalian GPCRs in the ASH and ADL gustatory neurons, because they are straight exposed to the surroundings allowing gain access to of proteins and peptide ligands towards the heterologous receptors. (exposed-skin-care.net)

Genetic drift and selective forces have shaped the individual structure of a given receptor gene but also of the species-specific receptor repertoire - a process that is still ongoing. (springer.com)
The protein encoded by this gene is an orphan G protein-coupled receptor whose ligand is unknown. (nih.gov)
These alterations may arise from cancer-specific changes in gene copy number, as well as from other genetic, epigenetic and post-translational changes resulting in higher protein expression, thereby enhancing tumour progression and metastasis. (nature.com)
Endothelial protein C receptor (EPCR) also known as activated protein C receptor (APC receptor) is a protein that in humans is encoded by the PROCR gene . (wikidoc.org)
The protein encoded by this gene is a receptor for protein C that enhances its activation. (wikidoc.org)
The protein encoded by P2RY8 gene is composed of 359-amino acids and belongs to the P2Y family of G-protein coupled receptors that are preferentially activated by adenosine and uridine nucleotides. (atlasgeneticsoncology.org)
Seibold A, Brabet P, Rosenthal W, Birnbaumer M: Structure and chromosomal localization of the human antidiuretic hormone receptor gene. (hmdb.ca)
The transcription factor TATA-box binding protein (TBP) modulates gene expression in nuclei. (sinica.edu.tw)
Gene expression is regulated by proteins known as transcription factors. (ku.edu)
The ability of NRs to drive gene activation is directed by specific interacting proteins called cofactors. (ku.edu)
This review will highlight new discoveries regarding the mechanistic role of NRs and their associated protein cofactors in regulating gene activation and in the progression of cancer, diabetes, and obesity. (ku.edu)
The ADGRE2 gene provides instructions for making a protein found in several types of immune system cells, including mast cells. (medlineplus.gov)
The ADGRE2 gene mutation that causes vibratory urticaria, written as Cys492Tyr or C492Y, replaces the protein building block (amino acid) cysteine with the amino acid tyrosine at position 492 of the protein sequence. (medlineplus.gov)
Polymorphisms in the natural killer cell receptor G2D (NKG2D) gene have been shown to increase risk of CC transformation in patients with Primary Sclerosing Cholangitis (PSC). (bvsalud.org)
SUMMARY A direct correlation between HIV infection and mutation in the chemokine receptor ( CCR5 ) gene has been established. (who.int)
HIV-1 is influenced by a mutation in the 1 infection with a typical delay of 2-4 years chemokine receptor ( CCR5 ) gene [ 3,4 ]. (who.int)

Receptors transduce these signals to alter intracellular metabolism and cellular responsiveness through heterotrimeric G protein/second messenger pathways or through small GTP-binding protein/protein kinase cascades. (duke.edu)
Oomycetes possess a family of novel proteins called GPCR-PIPKs (GKs) that are composed of a seven-transmembrane spanning (7-TM) domain fused to a phosphatidylinositol phosphate kinase (PIPK) domain. (wur.nl)
Protease inhibitors and antioxidants suppressed protein kinase C and NF-kappaB activation and induction of IL-8 promoter activity in cells exposed to dust extract. (cdc.gov)

Type I receptors consist of BMPR1B (ALK6) and BMPR1A (also called ALK3), while type II receptors comprise BMPR2 and ActRII (Activin receptor type II) subtypes. (news-medical.net)
The protein is also involved in Plasmodium falciparum malaria as subtypes of the Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family use EPCR of the host as a receptor. (wikidoc.org)
These receptor subtypes had marked differences in regional and cellular localization as shown by immunocytochemistry. (jneurosci.org)
North WG, Fay MJ, Longo KA, Du J: Expression of all known vasopressin receptor subtypes by small cell tumors implies a multifaceted role for this neuropeptide. (hmdb.ca)

The GPCRdb browsing system is structured on most relevant categories which are: GPCRdb Receptors G Proteins B-Arrestins Biased Signaling Ligands Drugs Structure Constructs Tutorials, workshops and documentation of use. (wikipedia.org)
Violin JD, Lefkowitz RJ (2007) Beta-arrestin-biased ligands at seven-transmembrane receptors. (springer.com)
Such receptors exhibit unique ligand-binding specificities and mediate distinct signaling cascades, even though they could cross-interact with other TGF-β family ligands. (news-medical.net)
Assessing the binding of 17 ligands of varying efficacy to the β2AR in the absence and presence of Nb60 or Nb80 reveals large ligand-specific effects that can only be explained using an allosteric model which assumes equilibrium amongst at least three receptor states. (nih.gov)
These data demonstrate that ligands can initiate a wide range of cellular responses by differentially stabilizing multiple receptor states. (nih.gov)
Allosteric ligands modulate receptor function by binding to a site distinct from the recognition site for the endogenous agonist. (aspetjournals.org)
This finding suggests that this receptor may have the ability to detect ligands from a broader spectrum of pathogens, not limited to fungal origins. (lu.se)

Abcam: antibodies, proteins, kits. (abcam.com)
To approach this critical issue, antibodies were generated against two peptides, one derived from olfactory receptor mOR256-17, one derived from the "mOR37" subfamily. (jneurosci.org)
By means of immunohistochemistry and double-labeling studies using transgenic mouse lines as well as Western blot analyses, it was demonstrated that the newly generated antibodies specifically recognized the receptor proteins. (jneurosci.org)
To scrutinize the hypothesis that olfactory receptor proteins may also be present in the axonal processes and the nerve terminals, serial sections through the olfactory bulb were probed with the antibodies. (jneurosci.org)
In this study, antibodies were generated against unique epitopes of distinct OR types and used in immunohistochemical experiments to visualize the receptor proteins in whole-mount preparations and tissue sections of the olfactory system. (jneurosci.org)
To characterize the family of proteins, a panel of subtype-selective antibodies was generated against recombinant muscarinic receptor proteins and shown to bind specifically to each of the cloned receptors. (jneurosci.org)
Autoantibodies (AAB) against nuclear and membrane structures as well as neurotransmitter receptors including muscarinic cholinergic receptor M3/M4-antibodies (M3-mAChR/M4-mAChR) and beta-1 and -2-adrenergic receptor (beta1-AR/beta2-AR) have been described in patients with ME/CFS ( 3 , 6 - 8 ). (frontiersin.org)
These antibodies belong to a network of natural antibodies against adrenergic, cholinergic and other G-protein coupled receptors (GPCR) which were shown to be dysregulated and dysfunctional in various autoimmune diseases ( 9 ). (frontiersin.org)
EF-Tu From Non-typeable Haemophilus influenzae Is an Immunogenic Surface-Exposed Protein Targeted by Bactericidal Antibodies. (lu.se)

A series of tools made available in the homepage for the GPCRdb can be run in the web browser to analyze structures, sequence similarities, receptor relationships, homology models, drug trends, genetic variants and ligand target profiles. (wikipedia.org)
GPRs are cell surface receptors that activate guanine-nucleotide binding proteins upon the binding of a ligand. (nih.gov)
BMPR family of proteins is a valuable tool for studying ligand-receptor interactions, downstream signaling events, and determining therapeutic targets. (news-medical.net)
Ligand binding to an extracellular orthosteric pocket propagates conformational change to the receptor cytosolic region to promote binding and activation of downstream signalling effectors such as G proteins and β-arrestins. (nih.gov)
Using em C. elegans /em to review em in vivo /em GPCR-ligand connections is an benefit because functional appearance of heterologous olfactory receptors in the AWA and AWB olfactory neurons provides previously been proven (Milani em et al /em ) [5] and our unpublished observations. (exposed-skin-care.net)
The nociceptive neurons, ASH and ADL, travel repulsive reactions, [6] therefore receptor activation is usually reflected within an avoidance response on ligand publicity, which may be analysed using strong behavioural assays [7,8]. (exposed-skin-care.net)
When this decoy receptor is engaged by a ligand to the displayed protein/peptide, the receptor expressing cell is rescued from apoptosis. (lu.se)
The nicotinic receptors are cylindrically-shaped proteins imbedded in synaptic walls that act as chemically-controlled sodium channels (also called ligand-gated sodium channels) that penetrate through the cell walls of post-synaptic nerves and myocytes at the skeletal neuromuscular junctions. (cdc.gov)

It integrates various web tools and diagrams for GPCR analysis and stores manual annotations of all GPCR crystal structures made available through the PDB (Protein Data Bank), has the largest collections of receptor mutants and reference sequence alignments. (wikipedia.org)
It crosslinks to the GuideToPharmacology database and has adopted the official NC-IUPHAR receptor naming nomenclature, has exchange with GPCR servers, and has also recently become part of the GPCR Consortium set out to generate an unprecedented number of crystal structures. (wikipedia.org)
The valuable source of large-scale genomic information initiated attempts to identify the origin(s) of G protein-coupled receptors (GPCR), count and categorize those genes, and follow their evolutionary history. (springer.com)
The chapter summarizes evolutionary processes working on GPCR genes and sheds light on their consequences at the levels of receptor structure and function. (springer.com)
The discovery provides new insight into the functioning of a common cell receptor called a G protein-coupled receptor or GPCR . (stanford.edu)
Specifically, the researchers were able to illuminate the structure of the GPCR bonded with a signaling protein called arrestin . (stanford.edu)
Furthermore, the ASH and ADL neurons communicate a large selection of G subunits [3], raising the probability of GPCR-G proteins conversation. (exposed-skin-care.net)

CCR5 is usually a chemokine receptor that binds MIP-1 (CCL3), MIP-1 (CCL4) and RANTES, and directs chemotactic reactions in leucocytes. (exposed-skin-care.net)

Mutational analysis and chimeric constructs have revealed that allosteric modulators of the calcium-sensing, metabotropic glutamate and GABA B receptors bind to the seven transmembrane domain, through which they modify signal transduction after receptor activation. (aspetjournals.org)

IL1R2 binds IL1A, IL1B and IL1RN preventing them from binding to their regular receptors and thus inhibiting the transduction of their signaling. (prospecbio.com)
It is well established now that the receptor-binding domain (RBD) of the spike protein binds to the human angiotensin-converting enzyme 2 (ACE2) as its first step of entry. (biorxiv.org)
The CR1 receptor preferentially binds C3b that is covalently attached to immune complexes, and it has a weaker affinity for bound C4b and iC3b. (medscape.com)

was subsequently clearly documented by means of genetically manipulated mice that generated a bicistronic mRNA encoding the OR as well as a marker protein. (jneurosci.org)
Fay MJ, Du J, Yu X, North WG: Evidence for expression of vasopressin V2 receptor mRNA in human lung. (hmdb.ca)
Much more study is likely needed to determine whether or not this applies to people who took the mRNA injections (Pfizer-BioNTech and Moderna), as these shots program human cells to continue producing spike proteins constantly. (naturalnews.com)

However, how agonists with varying efficacy modulate these receptor states to initiate cellular responses is not well understood. (nih.gov)
Agonists generally exert efficacy by stabilizing the active Nb80-stabilized receptor state (R80). (nih.gov)
In contrast, for a number of partial agonists, both stabilization of R80 and destabilization of the inactive, Nb60-bound state (R60) contribute to their ability to modulate receptor activation. (nih.gov)
The expression of MRGPRX2 by skin mast cells and the levels of the MRGPRX2 agonists (eg, substance P, major basic protein, eosinophil peroxidase) are upregulated in the serum and/or skin of patients with inflammatory and pruritic skin diseases, such as chronic spontaneous urticaria or atopic dermatitis. (iasp-pain.org)

Kim JY, Haastert PV, Devreotes PN (1996) Social senses: G-protein-coupled receptor signaling pathways in Dictyostelium discoideum . (springer.com)
Here I present an overview of some of the main interacting proteins, and describe what we know about how these may fit into cellular pathways that control AMPA receptor targeting, trafficking and functional expression. (portlandpress.com)

EPCR protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. [3] It belongs to the MHC class I / CD1 family of proteins, that is characterized by having a deep groove, that in other proteins in the family (but not in EPCR) is usually used for antigen binding. (wikidoc.org)

Chronic inflammation following prolonged signaling of cytokine receptors is a critical process in the pathogenesis of many inflammatory disorders, including autoimmunity, obesity, psoriasis, type 1 diabetes, endometriosis, preeclampsia and Alzheimer's disease. (lu.se)

Results: Dust extracts contained trypsin and elastase activities, and activated protease activated receptor (PAR)-1 and -2. (cdc.gov)

The m1-protein was present in cortex and striatum and was localized to cell bodies and neurites, consistent with its role as a major postsynaptic muscarinic receptor. (jneurosci.org)

Recent studies have identified the mitochondrial outer membrane proteins MOM19, MOM72, MOM38 (approximately ISP42) and p32 which have a role in initial steps of protein import. (nih.gov)
The first three components are present in a multi-subunit complex that catalyses recognition and membrane insertion of precursor proteins. (nih.gov)
Cytosolic SRP and its receptor in the ER membrane facilitate the cotranslational targeting of most ribosome-nascent precursor polypeptide chain (RNC) complexes together with the respective mRNAs to the Sec61 complex in the ER membrane. (amrita.edu)
The ADGRE2 protein consists of two parts (subunits) that interact with each other: an alpha subunit that lies on the outside surface of the cell and a beta subunit that crosses the cell membrane and extends into the cell. (medlineplus.gov)
We have demonstrated proof of concept by creating a general plasma membrane bound decoy receptor, by displaying a protein or a peptide genetically fused to a trunctated version of the CD40 molecule. (lu.se)
Type I membrane protein. (lu.se)

Fujisawa Y, Kato H, Iwasaki Y (2001) Structure and function of heterotrimeric G proteins in plants. (springer.com)
They share a common structure and signal through HETEROTRIMERIC G-PROTEINS. (harvard.edu)

Human epicardial adipose tissue expresses glucose-dependent insulinotropic polypeptide, glucagon, and glucagon-like peptide-1 receptors as potential targets of pleiotropic therapies. (harvard.edu)
One specific peptide-displaying cell could be identified and amplified, based on a specific receptor engagement, in a background of 12 500 wild-type cells after four selections. (lu.se)

Critical physiological events throughout the body are controlled by extracellular signals from neurotransmitters and hormones acting on cell surface receptors. (duke.edu)
They often have no effect on their own and therefore act only in conjunction with physiological receptor activation. (aspetjournals.org)
Identify the key physiological effects that result from stimulation of nicotinic receptors by excessive amounts of acetylcholine. (cdc.gov)

This concept implies that olfactory receptor proteins are located in sensory cilia and in the axons. (jneurosci.org)
These data indicate that olfactory receptor (OR) proteins are indeed present in the axonal processes and nerve terminals of olfactory sensory neurons, thus supporting the notion that ORs may participate in the molecular processes underlying the fasciculation and targeting of olfactory axons. (jneurosci.org)

False positive non-synonymous polymorphisms of G-protein coupled receptor genes. (nih.gov)

Cloning and characterization of a novel orphan G-protein-coupled receptor localized to human chromosome 2p16. (nih.gov)

The largest family of cell surface receptors involved in SIGNAL TRANSDUCTION. (harvard.edu)

There are eight mammalian P2Y receptors known to date ( P2Y1 , P2Y2 , P2Y4 , P2Y6 , P2Y11 , P2Y12 , P2Y13 and P2Y14 ) and they are found in most human tissues. (atlasgeneticsoncology.org)

Recombinant human protein Gal-3, EGFR, BMPR1A, and BMPR2 were obtained from Sino Biological. (news-medical.net)

Here, we present and compare the cryo-electron microscopy structures of M1R in complex with G 11 and M2R in complex with G oA The M1R-G 11 complex exhibits distinct features, including an extended transmembrane helix 5 and carboxyl-terminal receptor tail that interacts with G protein. (rcsb.org)
On serial sections through the olfactory bulb of mOR37-transgenic mouse lines, double-labeling experiments demonstrated that distinct immunoreactive glomeruli corresponded to glomeruli that were targeted by neurons expressing a particular member of the mOR37 receptor subfamily. (jneurosci.org)
mRNAs encoding five genetically distinct muscarinic ACh receptors are present in the CNS. (jneurosci.org)
Four distinct complement receptors, CR1, CR2, CR3, and CR4, have been described for the surface-bound complement fraction C3 and its cleavage fragments. (medscape.com)

A paper published in the journal Annals of Pharmacology and Pharmaceutics explains how MMS blocks the spike proteins associated with SARS-CoV-2 that are said to bind with human receptors such as Angiotensin-Converting Enzyme 2 (ACE2), allowing disease to form. (naturalnews.com)

The question whether OR proteins are indeed present in the axons and nerve terminals of OSNs is thus of fundamental importance toward an understanding of the functional wiring in the olfactory system. (jneurosci.org)
also known as the thymic stromal lymphopoietin receptor), which together with IL7 receptor alpha forms a heterodimeric complex that acts at the functional receptor for thymic stromal lymphopoietin (reviewed in Roll and Reuther, 2010). (atlasgeneticsoncology.org)
Functional maturation of steroid hormone receptors requires ordered assembly into a large multichaperone complex consisting of receptor monomer, an Hsp90 dimer, the p23 cochaperone, and an FK506-binding protein (FKBP) family member or alternate peptidylprolyl isomerase-related cochaperone. (unboundmedicine.com)
Thus the mechanisms that control the developmental and activity-dependent changes in the functional synaptic expression of AMPA receptors are of fundamental importance. (portlandpress.com)
The functional high affinity IL-12 receptor is composed of at least IL12rb1 and IL12rb2. (lu.se)

Interleukin-1 receptor accessory protein (IL-1RAcP) is a member of the immunoglobulin superfamily proteins consisting of soluble and membranous isoforms. (lu.se)

Allosteric receptor modulation is an attractive concept in drug targeting because it offers important potential advantages over conventional orthosteric agonism or antagonism. (aspetjournals.org)
This article reviews the current status of allosteric modulation at family C G-protein coupled receptors in the light of their specific structural features on the one hand and current concepts in receptor theory on the other hand. (aspetjournals.org)
The positive allosteric calcium sensing receptor modulator cinacalcet is the first drug of this type to enter the market and therefore provides proof of principle in humans. (aspetjournals.org)

The specific targeting of precursor proteins synthesized in the cytosol to various cell organelles is a central aspect of intracellular protein traffic. (nih.gov)

Detailed analysis of these structures provides a framework for understanding the molecular determinants of G-protein coupling selectivity. (rcsb.org)
Olfactory receptors are supposed to act not only as molecular sensors for odorants but also as cell recognition molecules guiding the axons of olfactory neurons to their appropriate glomerulus in the olfactory bulb. (jneurosci.org)
Their research, published April 20, 2022, in the journal Molecular Cell , identifies unique features of the receptor that distinguish it from other hormone receptors and provide clues to how androgen signaling goes awry in prostate cancer . (mskcc.org)
The team led by Dr. Kuo-Chiang Hsia (Institute of Molecular Biology, Academia Sinica) and Dr. Wei-Yi Chen (Institute of Biochemistry and Molecular Biology, College of Life Sciences, National Yang Ming Chiao Tung University) presents a cryo-EM structure of Kap114p, one of the Kap-βs, in complex with TATA box binding protein and reveals a non-canonical function beyond nuclear transport that modulates TBP-dependent transcription. (sinica.edu.tw)
In the last few years dramatic advances have been achieved towards elucidating some of the molecular events involved, and a previously unsuspected complexity of proteins that selectively interact directly or indirectly with individual AMPA receptor subunits have been identified. (portlandpress.com)
An attractive approach is to develop systems that allow for clonal selection of interacting protein pairs from large molecular libraries. (lu.se)
For those interested in learning about the molecular physiology of nicotinic receptors, the subject is discussed as optional reading below. (cdc.gov)

Protein C is an anti-coagulant serine protease activated by the blood coagulation pathway. (wikidoc.org)
The new paradigm in drug discovery is that you want to find this selective pathway - how to activate either the arrestin pathway or the G-protein pathway but not both - for a better effect," said Eric Xu , PhD, a scientist at the Van Andel Research Institute in Michigan who led the experiment. (stanford.edu)

Furthermore, increasing biophysical evidence, primarily using the β2-adrenergic receptor (β2AR) as a model system, supports the existence of multiple active and inactive conformational states. (nih.gov)
In patients with infection-triggered onset, the associations of low sCD26 with elevated autoantibodies (AAB) against alpha1 adrenergic (AR) and M3 muscarinic acetylcholine receptors (mAChR) point to a pathomechanism of infection-triggered autoimmune-mediated vascular and immunological dysregulation. (frontiersin.org)

Several lines of evidence suggest that the OR proteins may be directly or indirectly involved in convergent axon projection and glomerulus formation. (jneurosci.org)

The study is a critical first step and provides key insight into the structural interactions in these protein complexes. (stanford.edu)
This demonstrates that the approach may serve as a tool in post-genomic research for identifying protein-protein interactions, without prior knowledge of either component. (lu.se)

Several hundred different proteins are imported from the cytosol into the mitochondria. (nih.gov)
Fusion proteins are compounds that are produced in the laboratory and combine or "fuse" two different proteins with desirable immune-modifying and disease-fighting traits to form a single drug. (msdmanuals.com)

Somatostatin receptors bind two isoforms of the tetradecapeptide, SST-14 and -28 [9,10]. (exposed-skin-care.net)

As well mediating most synaptic transmission in the mammalian central nervous system, α-amino-3-hydroxy-5-methylisoxazolepropionate (AMPA) receptors are involved in the processes of synapse formation, stabilization and plasticity. (portlandpress.com)

The structural basis of G-protein-coupled receptor function and dysfunction in human diseases. (nih.gov)
Given the BMPR family's considerable involvement in several diseases, targeting these receptors presents a hopeful avenue for therapeutic interventions. (news-medical.net)
Defects in the expression of complement or complement receptors may result in loss of tolerance to self-proteins and the development of immune complex-mediated autoimmune diseases such as systemic lupus erythematosus (SLE). (medscape.com)
When given to a person, the artificial cytokine or cytokine receptor can be used to modify the person's natural immune response and treat many diseases. (msdmanuals.com)

The Bone Morphogenetic Protein Receptor ( BMPR ) family includes transmembrane receptors that play vital roles in tissue development and cellular signaling. (news-medical.net)
Previous cellular studies demonstrated that FKBP52 can potentiate receptor function. (unboundmedicine.com)
Pathogenesis and sporulation are complex processes that are governed by cellular signalling networks including G-protein and phospholipid signalling. (wur.nl)
The complement system, interacting with its regulatory molecules and cellular receptors, plays a central role in the induction and regulation of immunity. (medscape.com)
They are single-chain molecules present on host cellular membranes and belong to the complement control protein family. (medscape.com)

Muscarinic acetylcholine receptors are G protein-coupled receptors that respond to acetylcholine and play important signaling roles in the nervous system. (rcsb.org)
These results clarify the roles of these genetically defined receptor proteins in cholinergic transmission in brain. (jneurosci.org)

The substitution alters the protein structure and leads to a less stable interaction between the two subunits. (medlineplus.gov)

When the neurotransmitter, acetylcholine, attaches to the portion of the nicotinic receptor outside of the cell wall, it induces a conformational change that selectively opens up the channel to sodium ions. (cdc.gov)

protein tyrosine phosphatase, non-receptor. (wikigenes.org)
A subclass of receptor-like protein tryosine phosphatases that contain a single cytosolic protein tyrosine phosphate domain and multiple extracellular fibronectin III-like domains. (online-medical-dictionary.org)
Among these negative regulators, protein tyrosine phosphatases (PTPs) are likely to play a pivotal role in IR signaling. (bioone.org)

Polymorphisms in Natural Killer Cell Receptor Protein 2D (NKG2D) as a Risk Factor for Cholangiocarcinoma. (bvsalud.org)

This is in contrast to taste-enhancing molecules, which bind to different parts of sweet and umami receptors. (aspetjournals.org)

Points plotted indicate hour at which full loss of hemagglutination was achieved for each concentration of receptor-destroying enzyme. (cdc.gov)
The channel opening in the nicotinic receptor normally lasts less than a millisecond because the enzyme, cholinesterase, rapidly breaks down acetylcholine. (cdc.gov)

These processes have left footprints in the genomic sequence that can be detected by bioinformatic methods and may help to interpret receptor function in the light of a given species in its environment. (springer.com)
Sequence comparison does not support an evolutionary link between halobacterial retinal proteins including bacteriorhodopsin and eukaryotic G-protein-coupled receptors. (springer.com)

IL1R2 is a cytokine receptor which is a part of the interleukin-1 receptor family. (prospecbio.com)
Also, Interleukin-4 antagonizes the activity of interleukin-1 by inducing the expression and release of this protein. (prospecbio.com)

20-HETE Signals Through G-Protein-Coupled Receptor GPR75 (G(q)) to Affect Vascular Function and Trigger Hypertension. (nih.gov)
The m4-receptor was enriched in neostriatum, olfactory tubercle, and islands of Calleja, indicating an important role in extrapyramidal function. (jneurosci.org)
The specfic function of the P2RY8 receptor remains uncharacterised. (atlasgeneticsoncology.org)
Describe the key function of nicotinic receptors. (cdc.gov)
In X-linked SCID, loss of IL-2 receptor (IL-2R) function leads to the loss of a lymphocyte proliferation signal. (medscape.com)

Cytokines transmit their message by attaching to specific molecules called receptors on the surface of another cell. (msdmanuals.com)

This process requires the involvement of nuclear transport receptors, collectively termed karyopherin-ß (Kap-ß) in yeast, and various regulatory factors. (sinica.edu.tw)
One of the largest transcription factor families is the nuclear receptor (NR) superfamily. (ku.edu)

Anatomy18

Organisms14

Diseases1

Chemicals and Drugs139

Analytical, Diagnostic and Therapeutic Techniques and Equipment26

Phenomena and Processes54

Disciplines and Occupations2

Information Science3

Health Care1

GPCRs14

Gene16

Kinase3

Subtypes4

Ligands7

Antibodies9

Ligand8

GPCR7

Chemokine receptor that binds1

Seven-transmembrane1

Binds3

MRNA3

Agonists4

Pathways2

Family of proteins1

Cytokine receptors1

Protease-activate1

Muscarinic receptor1

Membrane6

Heterotrimeric2

Peptide2

Physiological3

Olfactory receptor2

Genes1

Orphan G protein-1

SIGNAL TRANSDUCTION1

P2Y121

Recombinant1

Distinct4

Pharmacology1

Functional5

Soluble1

Allosteric3

Intracellular1

Molecular7

Pathway2

Adrenergic2

Directly or indirectly1

Interactions2

Different proteins2

Isoforms1

Mammalian1

Diseases4

Cellular5

Roles2

Subunits1

Neurotransmitter1

Tyrosine3

Polymorphisms1

Bind1

Enzyme2

Sequence2

Interleukin2

Function5

Molecules1

Nuclear2