Receptors neural crest. Medical search. Frequent questions

In the zebrafish Danio rerio, neural crest-derived pigment cells generate different pigment patterns during different phases of the life cycle. (bath.ac.uk)
We also found that SRC-3 depletion in cultured HESCs results in a significant attenuation in the induction of a wide-range of established biomarkers of decidualization, despite exposure of these cells to a deciduogenic stimulus and normal progesterone receptor expression. (frontiersin.org)
It is now established that melanocytic nevus precursor cells are derived from neural crest tissue and migrate to and populate the developing epidermis of the embryo. (medscape.com)
The EDNRB gene provides instructions for making a protein called endothelin receptor type B. This protein is located on the surface of cells and functions as a signaling mechanism, transmitting information from outside the cell to inside the cell. (medlineplus.gov)
Endothelin 3 (produced from the EDN3 gene) is one of the proteins that interacts with endothelin receptor type B. During early development before birth (embryonic development), endothelin 3 and endothelin receptor type B together play an important role in neural crest cells. (medlineplus.gov)
In particular, endothelin 3 and endothelin receptor type B are essential for the formation of nerves in the intestine (enteric nerves) and for the production of specialized cells called melanocytes. (medlineplus.gov)
Human neuroblastoma cells express alpha and beta platelet-derived growth factor receptors coupling with neurotrophic and chemotactic signaling. (jci.org)
In this study, the anticancer properties of VPA on neural crest-derived human tumor cell lines G361 melanoma, U87MG glioblastoma and SKNMC Askin tumor cells were investigated. (iiarjournals.org)
The effectiveness of HDAC inhibitors, expecially VPA, in neuroblastoma cells, prompted us to investigate the anticancer activity of VPA in other neural crest-derived malignancies, such as glioblastoma, melanoma and Askin tumor. (iiarjournals.org)
Of course, one of the most important vertebrate features is a population of cells called the Neural Crest Cells (NCCs). (biologists.com)
In cephalochordates, the other major chordate subphylum, cells along the lateral borders of the neural plate give rise to melanocytes associated with a series of light-sensing organs in the neural tube, known as Dorsal Ocelli 2 . (biologists.com)
Although the peripheral nervous systems of tunicate larvae have several sensory neuron subtypes 9 , none of them have been decisively linked to NCCs, either because they do not arise from the neural plate borders or because they more closely resemble non-NCC-derived sensory cells in vertebrates. (biologists.com)
Its receptor tyrosine kinase, c-Met , is expressed in the cochlear epithelium and melanocyte-derived intermediate cells in the stria vascularis. (jneurosci.org)
The neural crest (NC) is comprised of specialized cells that arise from the lateral border of the neural plate and migrate into specific locations during vertebrate embryonic development. (jneurosci.org)
The excessive activation of AhR resulted in neural differentiation of Neuro2a cells. (biomedcentral.com)
WSS is caused by abnormal migration or differentiation of neural crest cells during embryonic development. (orpha.net)
The TMEM127 gene encodes a transmembrane protein of poorly known function that is mutated in pheochromocytomas, neural crest-derived tumors of adrenomedullary cells. (stanford.edu)
Here, we report that, at single-nucleus resolution, TMEM127-mutant tumors share precursor cells and transcription regulatory elements with pheochromocytomas carrying mutations of the tyrosine kinase receptor RET. (stanford.edu)
Internalization from the cell membrane and endosomal trafficking of receptor tyrosine kinases (RTK) are important regulators of signaling in normal cells that can frequently be disrupted in cancer. (stanford.edu)
Among their discoveries, the scientists found that neural crest cells - cells that are critical building blocks for the heart, face and jaw - contain temperature-sensitive properties. (neurosciencenews.com)
The researchers engineered a noninvasive magnet-based technology to create fever-like conditions in two specific temperature-sensitive ion channels called TRPV1 and TRPV4 in the neural crest cells involved in developing the heart and face. (neurosciencenews.com)
When those neural crest cells were subjected to conditions mimicking a transient fever, the embryos developed craniofacial irregularities and heart defects, including double outlet right ventricle, Tetralogy of Fallot and other outflow obstructions. (neurosciencenews.com)
In cells derived from neural crest, such as neuroblastoma cells, retinoic acid initiates differentiation into neurons. (viamedica.pl)
The majority of the enteric nervous system is formed by vagal neural crest cells which enter the foregut and migrate rostrocaudally to colonise the entire length of the gastrointestinal tract. (crick.ac.uk)
By lineage tracing neural crest cells in mice homozygous for a knock-in allele of Ret (Ret51/51), we demonstrate that normal activity of this receptor is required in vivo for the migration of enteric nervous system progenitors throughout the gut. (crick.ac.uk)
The identification of neural crest specification genes expressed in the neural plate of basal chordates, in addition to the discovery of pigmented migratory cells in ascidians, has challenged this hypothesis. (biomedcentral.com)
Resting on this archetypal chordate body plan, unique populations of cells, the neural crest and the ectodermal placodes, evolved in craniates (referred to here as 'vertebrates' for simplicity). (biomedcentral.com)
The neural crest is a transient population of embryonic cells that originate at the boundary between neural plate and dorsal ectoderm. (biomedcentral.com)
Shortly after their dorsal specification, neural crest cells undergo an epithelial-to-mesenchymal transition, migrate, and finally, upon arrival at their destination, they give rise to a variety of cell types. (biomedcentral.com)
discovered that the integration of ACE2-expressing pericyte-like cells (generated in vitro from human pluripotent stem cell-derived neural crest stem cells) into cortical brain organoids at the corticogenesis stage (60-74 days of in vitro culture) promoted astrocytic maturation, increased basement membrane component production, and supported ongoing neurogenesis in the absence of viral infection, Importantly, these features are typically attributed to human brain pericytes in vivo. (stemcellsportal.com)
Jia L, Cheng L, Raper J. Slit/Robo signaling is necessary to confine early neural crest cells to the ventral migratory pathway in the trunk. (arizona.edu)
Autologous as well as allogeneic CD8 + T cells transduced with tumor antigen specific T cell receptors (TCR) may cause significant tumor lysis upon adoptive transfer. (oncotarget.com)
Beta-3-adrenergic receptor (ADRB3) as well as chondromodulin-1 (CHM1) are over-expressed in Ewing Sarcoma (ES) but not on T cells. (oncotarget.com)
Platelet-derived growth factors (PDGFs) acting via their tyrosine kinase receptors are major mitogens for many cell types of mesenchymal origin, including fibroblasts and vascular smooth muscle cells (VSMCs)[ 1 - 4 ]. (biomedcentral.com)
In a subset of peri-vascularly located immature neural crest-like neuroblastoma cells, aggressiveness and growth promoting charasteristics have been reported to be instigated by HIF-2α, a key element of the oxygen-sensing machinery. (lu.se)

Because the receptor is necessary for the formation of enteric nerves and melanocytes, these cell types do not form normally during embryonic development. (medlineplus.gov)
During mouse embryonic development, a subpopulation of neural crest cell-derived melanocytes migrates and incorporates into a subregion of the cochlear epithelium, forming the intermediate cell layer of the stria vascularis. (jneurosci.org)
Toll-like receptors (TLRs) are the mammalian ortholog of Drosophila melanogaster protein Toll, originally identified for its involvement in embryonic development. (acbjournal.org)
As there is redundancy in signalling between the five PDGF ligand isoforms and three PDGF receptor isoforms, and deletion of either of the receptors in vivo produces an embryonic lethal phenotype, it is not know which ligand and receptor combinations mediate specific cellular functions. (biomedcentral.com)

Both genes are expressed in the nascent mesoderm and neurectoderm , and morpholino knockdown of either causes defects in differentiation and morphogenesis of the mesoderm and neural plate . (xenbase.org)
Retinoic acid is a regulator of gene expression which, by binding to its nuclear receptor, determines the degree of differentiation in multiple cancer cell types. (viamedica.pl)
Environmental cues found throughout neural crest migratory routes play a fundamental role not only in instructing the precursor's differentiation into particular phenotypes, but also in controlling their proliferation and survival [ 7 ]. (biomedcentral.com)

Following binding of an ephrin ligand to the extracellular globular domain of an Eph receptor, tyrosine and serine residues in the juxtamembrane region of the Eph become phosphorylated allowing the intracellular tyrosine kinase to convert into its active form and subsequently activate or repress downstream signaling cascades. (wikipedia.org)
This mechanism is underpinned by an unusual architecture of the receptor-ligand complex. (nature.com)
In addition, inactivation of either the ligand or receptor developmentally resulted in a profound hearing loss at young adult stages. (jneurosci.org)
Furthermore, PQBP1 knockdown changes the alternative splicing of FGF receptor-2 ( FGFR2 ) transcripts, altering the incorporation of cassette exons that generate receptor variants ( FGFR2 IIIb or IIIc) with different ligand specificities. (xenbase.org)
This syndrome is genetically heterogeneous, composed of three etiological subtypes: WS4-A, WS4-B and WS4-C, caused by mutations in the EDNRB (13q22.3, coding for the endothelin-B receptor), EDN3 (20q13.32, coding for an endothelin receptor ligand) and SOX10 (22q13.1, coding for the SOX10 transcription factor) genes, respectively. (orpha.net)
Here, we show that loss of TMEM127 causes wildtype RET protein accumulation on the cell surface, where increased receptor density facilitates constitutive ligand-independent activity and downstream signaling, driving cell proliferation. (stanford.edu)
Arrows show proven in vitro ligand-receptor interactions. (biomedcentral.com)

We show that rose corresponds to endothelin receptor hi (ednrb1), an orthologue of amniote Ednrb genes that have long been studied for their roles in neural crest and pigment cell development. (bath.ac.uk)
As murine Ednrb is essential for the development of all neural crest derived melanocytes, and D. rerio ednrb1 is required only by a subset of adult melanocytes and iridophores, these analyses also reveal variation among vertebrates in the cellular requirements for Ednrb signaling, and suggest alternative models for the cellular and genetic bases of pigment pattern metamorphosis in D. rerio. (bath.ac.uk)
Changes in the EDNRB gene disrupt the normal function of endothelin receptor type B, preventing it from playing its usual role in the development of enteric nerves. (medlineplus.gov)
Variants in the EDNRB gene disrupt the normal function of endothelin receptor type B or lead to the production of an abnormally small, nonfunctional version of the protein. (medlineplus.gov)
Barlow A, de Graaff E, Pachnis V. Enteric nervous system progenitors are coordinately controlled by the G protein-coupled receptor EDNRB and the receptor tyrosine kinase RET. (medlineplus.gov)
Endothelin 3 (EDN 3) and the endothelin receptor B (EDNRB) are involved in the development of neural crest and particularly of the melanocytes and the enteric nervous system. (elsevierpure.com)
We reported previously that the avian EDNRB gene is expressed in the neural fold before crest cell migration and later on in all the neural crest derivatives except, at any developmental stage, in the melanocytic lineage. (elsevierpure.com)
Our pharmacological studies showed that EDNRB2 binds with similar affinity to EDN 1, EDN 2, and EDN 3, further confirming that this receptor belongs to the B type, although it displays a low affinity for sarafotoxin-c, a known EDNRB- selective agonist. (elsevierpure.com)
Waardenburg syndrome type IV is autosomal recessive with variable penetrance and is due to SOX10 or endothelin-B receptor ( EDNRB ) gene mutations, which appear to correlate with the intestinal and/or neurological symptoms manifested in patients. (medscape.com)

Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma. (nature.com)
The adrenal tumour pheochromocytoma (PCC) can be caused by activating mutations of the RET receptor tyrosine kinase, or inactivation of TMEM127, a transmembrane tumour suppressor implicated in trafficking of endosomal cargos. (stanford.edu)
Mutations in the receptor tyrosine kinase RET have been identified in approximately 50% of familial cases of Hirschsprung disease but the cellular processes misregulated in this condition remain unclear. (crick.ac.uk)

Among the components of this signaling pathway, we show that natriuretic peptide receptor 3 (Npr3) plays a pivotal role by differentially regulating two developmental programs through its dual function as clearance and signaling receptor. (gene-tools.com)
Using a combination of MO-based knockdowns, pharmacological inhibitors and rescue assays we demonstrate that Npr3 cooperate with guanylate cyclase natriuretic peptide receptor 1 (Npr1) and natriuretic peptides (Nppa/Nppc) to regulate NC and CP formation, pointing at a broad requirement of this signaling pathway in early embryogenesis. (gene-tools.com)

In tunicates, similar dorsal melanocytes arise from the lateral borders of the neural plate and become associated with a light-sensing ocellus and a gravity-sensing otolith 4 . (biologists.com)
Therefore, the latest models of NCC evolution propose that the neural plate borders of the pre-vertebrate ancestor already gave rise to one NCC derivative: melanocytes. (biologists.com)

In the present studies, we examined the expression of two PDGF receptor genes in human tumor cell lines derived from neural crest. (jci.org)
pqbp1 and wbp11 genes are similarly expressed in mesoderm and neural tissues during Xenopus development. (xenbase.org)
To determine the origin of neural crest genes, we analyzed Phenotype Ontology annotations to select genes that control the development of this tissue. (biomedcentral.com)
Of neural crest genes, 9% are vertebrate innovations. (biomedcentral.com)
A remarkable proportion of the new neural crest genes encode soluble ligands that control neural crest precursor specification into each cell lineage, including pigmented, neural, glial, and skeletal derivatives. (biomedcentral.com)
We propose that the evolution of the neural crest is linked not only to the recruitment of ancestral regulatory genes but also to the emergence of signaling peptides that control the increasingly complex lineage diversification of this plastic cell population. (biomedcentral.com)

The splicing factor PQBP1 regulates mesodermal and neural development through FGF signaling. (xenbase.org)

Ephs form the largest known subfamily of receptor tyrosine kinases (RTKs). (wikipedia.org)

Taken together, our results, besides providing further evidence that VPA may represent a promising therapeutic strategy in cancer treatment, may help in the design of new protocols geared at the treatment of neural crest-derived tumors. (iiarjournals.org)
MIBG can be labeled with 131 I, which has a long half-time (8 d) and a maximal electron range of about 2.4 mm and is established in the treatment of tumors derived from the neural crest, such as GEP tumors ( 11 ). (snmjournals.org)

Required for neural tube morphogenesis and neural crest cell migration. (thermofisher.com)

In all chordates, the central nervous system derives from a dorsal neural plate, which rolls into a dorsal hollow neural tube. (biologists.com)

Both Eph receptors and their corresponding ephrin ligands are membrane-bound proteins that require direct cell-cell interactions for Eph receptor activation. (wikipedia.org)
Similar studies conducted in zebrafish have shown similar segmenting processes within the somites containing a striped expression pattern of Eph receptors and their ligands, which is vital to proper segmentation - the disruption of expression resulting in misplaced or even absent boundaries. (wikipedia.org)
Neutralising antibodies against PDGFRs were shown to block signalling through PDGFRα and PDGFRβ receptors, reduce human PDGF-AA and PDGF-BB-induced collagen gel remodelling in dermal fibroblasts, and reduce migration stimulated by all PDGF ligands in human dermal and lung fibroblasts. (biomedcentral.com)

sox10 is necessary for development of neural and pigment cell derivatives of the neural crest (NC). (silverchair.com)

Development of the vertebrate head depends on the multipotency and migratory behavior of neural crest derivatives. (biomedcentral.com)

Pannexin 1 (PANX1) is expressed in many tissue types including tissues of neural origin. (jcancer.org)
Panx1 in rodents), which forms homo-heptameric single membrane channels permeable to ion and metabolite [ 7 , 8 ], is expressed in many tissue types including tissues of neural origin [ 9 ]. (jcancer.org)
Our comparative analyses show that, among different tissues, the neural crest exhibits a particularly high rate of gene emergence during vertebrate evolution. (biomedcentral.com)
Secreted from neighboring tissues, signaling molecules of the Wnt, Fgf, and Bmp families cooperate to activate a distinct combination of transcription factors at the neural plate border. (biomedcentral.com)
Waardenburg syndrome is a rare disease characterized by deafness in association with pigmentary anomalies and defects of neural crest-derived tissues. (medscape.com)
Morbidity is related to deafness and to defects of neural crest-derived tissues, including mental retardation, seizures, psychiatric disorders, skeletal anomalies, and eye disorders (including cataracts). (medscape.com)

Here we describe a completely novel role for natriuretic peptide signaling in the control of neural crest (NC) and cranial placode (CP) progenitors formation. (gene-tools.com)

It is widely accepted that the cell origin for NB arises from the sympathoadrenal lineage of the neural crest during development [ 3 ]. (jcancer.org)

The expression of alpha and/or beta PDGF receptors was detected in a wide variety of neural crest-derived human tumor cell lines such as neuroblastoma, primitive neuroectodermal tumor, and Ewing's sarcoma by RNA blot analysis, and confirmed by immunoblot analysis. (jci.org)
We have also demonstrated that PDGF receptors on the human neuroblastoma cell lines were biologically functional. (jci.org)
Each PDGF receptor has five extracellular immunoglobulin-like domains and two intracellular tyrosine kinase domains. (biomedcentral.com)

The effects of psychedelics on neurotrophic signaling, plasticity and antidepressant-like behavior in mice depend on TrkB binding and promotion of endogenous BDNF signaling but are independent of serotonin 2A receptor (5-HT2A) activation, whereas LSD-induced head twitching is dependent on 5-HT2A and independent of TrkB binding. (bvsalud.org)

Epithelial to mesenchymal transition during mammalian neural crest cell delamination. (stowers.org)

In vivo time-lapse imaging reveals extensive neural crest and endothelial cell interactions during neural crest migration and formation of the dorsal root and sympathetic ganglia Dev Biol. (usc.edu)
We show in the chick that the nascent dorsal root ganglia (DRG) lie dorsal to the longitudinal anastomosis, adjacent to the developing neural tube at the level of the sulcus limitans. (ox.ac.uk)

POLR1A variants underlie phenotypic heterogeneity in craniofacial, neural, and cardiac anomalies. (stowers.org)

E) Expression of pqbp1 and ncam mRNA in the neural plate of early neurula embryos. (xenbase.org)

We propose that Npr3 acts as a clearance receptor to regulate local concentrations of natriuretic peptides for optimal cGMP production through Npr1 activation, and as a signaling receptor to control cAMP levels through inhibition of adenylyl cyclase. (gene-tools.com)
The receptor interacts with proteins called endothelins to regulate several critical biological processes, including the development and function of blood vessels, the production of certain hormones, and the stimulation of cell growth and division (proliferation). (medlineplus.gov)

The neural crest is present during embryogenesis and gives rise to diverse cell types including enteric neurons and glia, as well as peripheral neurons [ 3 ]. (jcancer.org)

Various Eph receptors and ephrins are expressed in these regions, and, through functional analysis, it has been determined that Eph signaling is crucial for the proper development and maintenance of these segment boundaries. (wikipedia.org)
A human three-dimensional neural-perivascular 'assembloid' promotes astrocytic development and enables modeling of SARS-CoV-2 neuropathology. (stemcellsportal.com)
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19 normal healthy in- receptor protein (CD117) that is structurally dividuals were recruited as a control group. (who.int)

related to other transmembrane receptors. (who.int)

Four EN variants with alternating break points have since been detected in a wide range of human cancers. (bvsalud.org)
We identify in total 237 high-confidence interactors, which link EN fusions to several key signaling pathways, including ERBB, insulin and JAK/STAT. We then assessed the effects of EN variants on these pathways, and showed that the pan NTRK inhibitor Selitrectinib (LOXO-195) inhibits the oncogenic activity of EN2, the most common variant. (bvsalud.org)

In vertebrates, NCCs are specified all along the lateral borders of the neural plate, which meet at the dorsal midline upon neural tube closure. (biologists.com)

This cell population is considered a vertebrate innovation and, accordingly, chordate ancestors lacked neural crest counterparts. (biomedcentral.com)

Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. (thermofisher.com)

The oncogenic ETV6-NTRK3 (EN) gene fusion joins the sterile alpha domain of the ETV6 transcription factor with the tyrosine kinase domain of the neurotrophin-3 receptor NTRK3. (bvsalud.org)
We establish that IGF-II-induced HIF2A/EPAS1 expression during hypoxia is due to de novo transcription and further present the estrogen-related receptor alpha (ERRα) transcription factor as a positive regulator of HIF2A. (lu.se)

In this study, we used PDGFR-specific neutralising antibodies to dissect out receptor-specific signalling events in fibroblasts in vitro , to further understand key cellular processes involved in wound healing and tissue repair. (biomedcentral.com)
Although stimulation of PDGFRα and PDGFRβ evokes similar signal transduction cascades, in vitro studies suggest distinct requirements for specific pathways to initiate particular receptor-mediated functions. (biomedcentral.com)

Eph receptors (Ephs, after erythropoietin-producing human hepatocellular receptors) are a group of receptors that are activated in response to binding with Eph receptor-interacting proteins (Ephrins). (wikipedia.org)
Hallberg, B. & Palmer, R. H. Mechanistic insight into ALK receptor tyrosine kinase in human cancer biology. (nature.com)

The deficient neural crest theory, suggesting a developmental abnormality of the neural crest as a cause of the disease: The association of Waardenburg syndrome and congenital aganglionic megacolon supports this hypothesis. (medscape.com)

Pericyte-specific vascular expression of SARS-CoV-2 receptor ACE2 - implications for microvascular inflammation and hypercoagulopathy in COVID-19. (stemcellsportal.com)

in addition to acting as an effector organ, the skin is also a producer of humoral and neural signals that act both locally and centrally. (psychiatrictimes.com)

Unlike most other RTKs, Ephs have a unique capacity to initiate an intercellular signal in both the receptor-bearing cell ("forward" signaling) and the opposing ephrin-bearing cell ("reverse" signaling) following cell-cell contact, which is known as bi-directional signaling. (wikipedia.org)

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