• gamma-amin
  • The GABA receptors are a class of receptors that respond to the neurotransmitter gamma-aminobutyric acid (GABA), the chief inhibitory compound in the mature vertebrate central nervous system. (wikipedia.org)
  • Enrichment analyses revealed that GABA (gamma-aminobutyric acid) SNPs were over-represented among SNPs associated at po0.05 in both the discovery (Z = 3.64, p = 0.0003) and combined cohorts (Z = 2.07, p = 0.0388). (epfl.ch)
  • There are three receptors of the gamma-aminobutyric acid. (wikipedia.org)
  • Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. (abcam.com)
  • One theory is that it acts as a non-competitive channel blocker for GABAA receptor chloride channels, specifically the gamma-aminobutyric acid-activated chloride ionophore. (wikipedia.org)
  • Memory impairment due to alcohol has been linked to disruption of hippocampal function-in particular affecting gamma-Aminobutyric acid (GABA) and N-methyl-D-aspartate (NMDA) neurotransmission which negatively impacts long-term potentiation (LTP). (wikipedia.org)
  • Gamma-aminobutyric acid receptor subunit rho-2 is a protein that in humans is encoded by the GABRR2 gene. (wikipedia.org)
  • antibody
  • GABA-modulin (GM), a basic polypeptide purified from rat brain synaptosomes, which is an allosteric inhibitor of GABA recognition sites, has been detected in primary cultures of cerebellar interneurons enriched in granule cells by immunohistochemistry, using a specific antibody raised in rabbit injected with GM purified from rat brain synaptosomes. (jneurosci.org)
  • 15 ug of antibody were used to IP 24% of all GABA-A receptors in dodecylsulfate extracts of rat forebrains (150 ul). (abcam.com)
  • 1995
  • 1995). GABA receptors are also located post-synaptically and when activated hyperpolarize the neuron thus decreasing the effectiveness of excitatory input (Malcangio and Bowery, 1996). (chiro.org)
  • pharmacology
  • An insect ionotropic Drosophila melanogaster GABAR subunit, RDL (Resistant to Dieldrin), can be heterologously expressed to form functional homo-oligomeric receptors, the pharmacology of which closely resembles that of the majority of native insect GABARs and so has proved to be of value in investigating GABAR physiology and pharmacology. (aspetjournals.org)
  • Glutamate and GABA Receptors and Transporters: Structure, Function and Pharmacology. (wikipedia.org)
  • barbiturates
  • Because it inhibits channels activated by GABA, GABA-enhancing drugs like barbiturates and benzodiazepines can be used as an antidote. (wikipedia.org)
  • Muscimol binds to the same site on the GABAA receptor complex as GABA itself, as opposed to other GABAergic drugs such as barbiturates and benzodiazepines which bind to separate regulatory sites. (wikipedia.org)
  • mediate
  • Presynaptic GABA Receptors Mediate Temporal Contrast Enhancement in Drosophila Olfactory Sensory Neurons and Modulate Odor-Driven Behavioral Kinetics. (nih.gov)
  • The purpose of the current study was to determine which spinal neurotransmitter receptors mediate manipulation-induced antihyperalgesia. (chiro.org)
  • Alpha-helical parts of the C-terminal intracellular region mediate heterodimeric interaction with GABA-B receptor 2. (abcam.com)
  • inhibit
  • The GABAreceptor belongs to the class of G-Protein coupled receptors that inhibit adenylyl cyclase, therefore leading to decreased cyclic adenosine monophosphate (cAMP). (wikipedia.org)
  • The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. (abcam.com)
  • excitatory
  • There have been numerous reports of excitatory GABAA receptors. (wikipedia.org)
  • According to the excitatory GABA theory, this phenomenon is due to increased intracellular concentration of Cl¯ ions either during development of the nervous system or in certain cell populations. (wikipedia.org)
  • Subsequent studies from originators and proponents of the excitatory GABA theory have questioned these results, but the truth remained elusive until the real effects of GABA could be reliably elucidated in intact living brain. (wikipedia.org)
  • sensitivity
  • Furthermore, acute alcohol intake promotes GABAergic neurotransmission via presynaptic release of GABA, dephosphorylation of GABAA receptors (increasing GABA sensitivity), and elevation of endogenous GABAergic neuroactive steroids. (wikipedia.org)
  • Furthermore
  • Furthermore, we show how these GABA receptors modulate the time course of innate behavioral responses after odor pulse termination, demonstrating an important role for temporal contrast enhancement in odor-guided navigation. (nih.gov)
  • NMDA
  • HQA has also been found to label a novel, yet uncharacterized binding site, which can be distinguished from the NMDA receptor with the use of 2-carboxy-3-carboxymethylquinoline (CCMQ), a selective ligand of the uncharacterized site. (wikipedia.org)
  • Traumatic brain injury, hypoxia, stroke, anti-NMDA receptor encephalitis (although further associations are being explored), injury of the spinal cord, and many other forms of brain injury can cause onset of PSH. (wikipedia.org)
  • functional
  • Interest in RDL as a model ligandgated anion channel has been enhanced by the recent discovery of pre-mRNA A-to-I editing, which, together with alternative splicing, adds to the functional diversity of this GABA receptor subunit. (aspetjournals.org)
  • Isoform 1E function may be to regulate the availability of functional GABA-B-R1A/GABA-B-R2 heterodimers by competing for GABA-B-R2 dimerization. (abcam.com)
  • neurotransmitter release
  • In studies focused on the control of neurotransmitter release, it was noted that a GABA receptor was responsible for modulating evoked release in a variety of isolated tissue preparations. (wikipedia.org)
  • Presynaptic inhibition can occur through activation of spinal γ-aminobutyric acid (GABA) receptors on primary afferent fibers, which depolarize the terminal thus inhibiting neurotransmitter release from primary afferents and the consequent incoming afferent activity (see Eccles et al. (chiro.org)
  • Whereas
  • Whereas sodium-independent GABA binding appears to represent attachment to the electrophysiologically relevant recognition site for this substance, the binding detected in the presence of sodium has the characteristics of a transport rather than a recognition site. (springer.com)
  • recognition
  • Moreover, with yet another type of tissue preparation a calcium- dependent GABA recognition site has been detected. (springer.com)
  • It likely acts within the ion channels themselves, rather than at GABA recognition sites. (wikipedia.org)