• gamma-amin
  • The GABA receptors are a class of receptors that respond to the neurotransmitter gamma-aminobutyric acid (GABA), the chief inhibitory compound in the mature vertebrate central nervous system. (wikipedia.org)
  • There are three receptors of the gamma-aminobutyric acid. (wikipedia.org)
  • Vigabatrin is an antiepileptic drug that inhibits the breakdown of gamma-aminobutyric acid (GABA) by acting as a suicide inhibitor of GABA transaminase (GABA-T). (adooq.com)
  • Tiagabine is a selective gamma-aminobutyric acid (GABA) reuptake inhibitor. (adooq.com)
  • Enrichment analyses revealed that GABA (gamma-aminobutyric acid) SNPs were over-represented among SNPs associated at po0.05 in both the discovery (Z = 3.64, p = 0.0003) and combined cohorts (Z = 2.07, p = 0.0388). (epfl.ch)
  • Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. (abcam.com)
  • One theory is that it acts as a non-competitive channel blocker for GABAA receptor chloride channels, specifically the gamma-aminobutyric acid-activated chloride ionophore. (wikipedia.org)
  • Memory impairment due to alcohol has been linked to disruption of hippocampal function-in particular affecting gamma-Aminobutyric acid (GABA) and N-methyl-D-aspartate (NMDA) neurotransmission which negatively impacts long-term potentiation (LTP). (wikipedia.org)
  • Gamma-aminobutyric acid receptor subunit rho-2 is a protein that in humans is encoded by the GABRR2 gene. (wikipedia.org)
  • antibody
  • GABA-modulin (GM), a basic polypeptide purified from rat brain synaptosomes, which is an allosteric inhibitor of GABA recognition sites, has been detected in primary cultures of cerebellar interneurons enriched in granule cells by immunohistochemistry, using a specific antibody raised in rabbit injected with GM purified from rat brain synaptosomes. (jneurosci.org)
  • 15 ug of antibody were used to IP 24% of all GABA-A receptors in dodecylsulfate extracts of rat forebrains (150 ul). (abcam.com)
  • 1995
  • 1995). GABA receptors are also located post-synaptically and when activated hyperpolarize the neuron thus decreasing the effectiveness of excitatory input (Malcangio and Bowery, 1996). (chiro.org)
  • GABAergic
  • Polygonatum sibiricum rhizome promotes sleep by regulating non-rapid eye movement and GABAergic/serotonergic receptors in rodent models. (abcam.com)
  • Furthermore, acute alcohol intake promotes GABAergic neurotransmission via presynaptic release of GABA, dephosphorylation of GABAA receptors (increasing GABA sensitivity), and elevation of endogenous GABAergic neuroactive steroids. (wikipedia.org)
  • inhibit adenylyl cyclase
  • The GABAreceptor belongs to the class of G-Protein coupled receptors that inhibit adenylyl cyclase, therefore leading to decreased cyclic adenosine monophosphate (cAMP). (wikipedia.org)
  • The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. (abcam.com)
  • excitatory
  • There have been numerous reports of excitatory GABAA receptors. (wikipedia.org)
  • According to the excitatory GABA theory, this phenomenon is due to increased intracellular concentration of Cl¯ ions either during development of the nervous system or in certain cell populations. (wikipedia.org)
  • Subsequent studies from originators and proponents of the excitatory GABA theory have questioned these results, but the truth remained elusive until the real effects of GABA could be reliably elucidated in intact living brain. (wikipedia.org)
  • responses
  • Further openings via GABA binding to the receptor then produce inhibitory responses. (wikipedia.org)
  • A similar enhancement was also observed for the GABA C receptor-mediated responses (256 pA vs 171 pA for diabetic and control bipolar cells, respectively). (arvojournals.org)
  • In addition, the GABA C receptor-mediated responses on diabetic cells exhibit slower kinetics with GABA inactivation time constants of 1.77 seconds vs 1.57 seconds for control. (arvojournals.org)
  • Furthermore, we show how these GABA receptors modulate the time course of innate behavioral responses after odor pulse termination, demonstrating an important role for temporal contrast enhancement in odor-guided navigation. (nih.gov)
  • Functions also as histamine receptor and mediates cellular responses to histamine. (abcam.com)
  • rho1
  • While the levels of GABA rho1 subunit expression were comparable in diabetic and normal retinas, there was a significant enhancement in the ratio of rho1/rho2 subunit expression in the diabetic animals. (arvojournals.org)
  • currents
  • GABA elicited larger currents on rod-bipolar cells isolated from diabetic retina (319 ± 9 pA) than those from age-matched controls (217 ± 8 pA). (arvojournals.org)
  • Acetylcholine
  • For example, in utero exposure to nicotine has been linked to adverse effects such as severe physical and cognitive deficits as a result of impeding the normal activation of acetylcholine receptors. (wikipedia.org)
  • NMDA
  • It is approximately equipotent to NMDA and about five times more potent than quinolinic acid as an agonist of the NMDA receptor. (wikipedia.org)
  • HQA has also been found to label a novel, yet uncharacterized binding site, which can be distinguished from the NMDA receptor with the use of 2-carboxy-3-carboxymethylquinoline (CCMQ), a selective ligand of the uncharacterized site. (wikipedia.org)
  • Traumatic brain injury, hypoxia, stroke, anti-NMDA receptor encephalitis (although further associations are being explored), injury of the spinal cord, and many other forms of brain injury can cause onset of PSH. (wikipedia.org)
  • functional
  • Interest in RDL as a model ligandgated anion channel has been enhanced by the recent discovery of pre-mRNA A-to-I editing, which, together with alternative splicing, adds to the functional diversity of this GABA receptor subunit. (aspetjournals.org)
  • Isoform 1E function may be to regulate the availability of functional GABA-B-R1A/GABA-B-R2 heterodimers by competing for GABA-B-R2 dimerization. (abcam.com)
  • inhibits
  • aminobutyric acid (GABA) that irreversibly inhibits the catabolism of GABA by GABA transaminase. (adooq.com)
  • Guvacine hydrochloride inhibits GABA uptake (IC50 values are 14, 58, 119 and 1870 uM for hGABA T-1, rGABA T-2, hGABA T-3 and hBGT-1 respectively). (adooq.com)
  • neurotransmitter release
  • In studies focused on the control of neurotransmitter release, it was noted that a GABA receptor was responsible for modulating evoked release in a variety of isolated tissue preparations. (wikipedia.org)
  • Presynaptic inhibition can occur through activation of spinal γ-aminobutyric acid (GABA) receptors on primary afferent fibers, which depolarize the terminal thus inhibiting neurotransmitter release from primary afferents and the consequent incoming afferent activity (see Eccles et al. (chiro.org)
  • brain
  • Since then, using technology such as in-vivo electrophysiology/imaging and optogenetics, two in-vivo studies have reported the effect of GABA on neonatal brain, and both have shown that GABA is indeed overall inhibitory, with its activation in the developing rodent brain not resulting in network activation, and instead leading to a decrease of activity. (wikipedia.org)
  • For example, by modifying the incubation conditions it has been possible to identify several pharmacologically and kinetically distinct binding sites for y-aminobutyric acid (GABA) in brain tissue. (springer.com)
  • The regional distribution of this binding in rat brain and the effects of freezing, sodium and Triton X-100 are similar to those previously reported for [3H]GABA binding to the the synaptic GABA receptor site. (semanticscholar.org)
  • It was first described as peripheral benzodiazepine receptor (PBR), a secondary binding site for diazepam, but subsequent research has found the receptor to be expressed throughout the body and brain. (wikipedia.org)
  • The effect of iomazenil of reducing levels of GABA in the brain was used by researchers to exacerbate symptoms in patients with schizophrenia in a laboratory study, supporting the theory that a GABA deficiency underlies that disease. (wikipedia.org)
  • Researcher Deepak D'Souza and colleagues at Yale University and Veterans Affairs Connecticut Healthcare System are testing iomazenil as a potential treatment for drunkenness due to its ability to bind alcohol receptors in the brain. (wikipedia.org)
  • whereas
  • Whereas sodium-independent GABA binding appears to represent attachment to the electrophysiologically relevant recognition site for this substance, the binding detected in the presence of sodium has the characteristics of a transport rather than a recognition site. (springer.com)