• permeability
  • In contrast, administration of another angiotensin II type 1 receptor blocker, losartan, was less effective compared with telmisartan in terms of preventing BBB permeability and astroglial end-foot swelling, and coadministration of GW9662 did not affect the effects of losartan. (ahajournals.org)
  • With the extension of the duration of hyperlipidemia, high levels of cerebral TC and LDL-C were shown to aggravate the deposition of Aβ, induce the secretion of VEGF, reduce the expression of tight junction protein Claudin-5 and change the permeability of blood-brain barriers to factors that could damage cerebral vessels and neurons. (biomedcentral.com)
  • One way in which intestinal permeability is modulated is via CXCR3 receptors in cells in the intestinal epithelium, which respond to zonulin. (wikipedia.org)
  • specific receptors
  • Angiotensin receptors are expressed in a wide variety of cell types and regulate important physiological activities such as blood pressure, electrolyte balance, hormone secretion, tissue growth and neuronal activity by interacting with specific receptors on target organs. (aspetjournals.org)
  • ligand
  • We further characterized by ligand binding assays using membrane fractions, and K i values of imetit (agonist) and proxyfan (partial agonist) against the MT6 receptors were lower compared with those observed in WT H3 receptors. (aspetjournals.org)
  • Secondly, certain surface receptors lacking a cytoplasmic domain can transduce signals through ligand binding. (wikipedia.org)
  • In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. (wikipedia.org)
  • embryonic
  • We generated a series of mutated H3 receptors and their functions were examined in human embryonic kidney (HEK) 293 cells. (aspetjournals.org)
  • This study compares the regulation of basal signaling of MOR, δ-(DOR), and κ-(KOR) opioid receptors after pretreatment with morphine or receptor-selective agonists, in transfected human embryonic kidney 293 cell membranes. (aspetjournals.org)
  • Co-receptors prominent in embryonic tissue have an essential role in morphogen gradient formation or tissue differentiation. (wikipedia.org)
  • Co-receptors have been identified as participants in cell signalling cascades, embryonic development, cell adhesion regulation, gradient formation, tissue proliferation and migration. (wikipedia.org)
  • signal transduction
  • The intracellular signal transduction events triggered by AT 1 receptors are well characterized and include G-protein coupling, as well as activation of several tyrosine kinases. (aspetjournals.org)
  • The term co-receptor is prominent in literature regarding signal transduction, the process by which external stimuli regulate internal cellular functioning. (wikipedia.org)
  • 1995
  • In contrast to the AT 1 subtype, the physiological role of the AT 2 receptor is still unclear ( Nahmias and Strosberg, 1995 ). (aspetjournals.org)
  • angiotensin
  • Angiotensin II via its type 1 (AT 1 ) receptor stimulation may contribute to the pathogenesis of CNS disorders and cognitive decline by promoting hypertension, vascular inflammation, oxidative stress, and neuronal damage. (ahajournals.org)
  • antagonists
  • In contrast, H3 antagonists (thioperamide, ciproxifan, and GT2016) with inverse agonism displayed increased K i values against the MT6 receptors (2.5- to 5.8-fold), demonstrating more a prominent effect of inverse agonists to the constitutive active receptor. (aspetjournals.org)
  • For a one-receptor system, the Schild regression has a slope of unity and an intercept of K B for competitive antagonists. (aspetjournals.org)
  • Moreover, naloxone, naltrexone, and related antagonists were compared for binding potency and effect on basal and agonist-stimulated receptor signaling, measuring guanosine 5′- O -(3-[ 35 S]thio)triphosphate binding. (aspetjournals.org)
  • Activity profiles at the three opioid receptors under different conditions could lead to antagonists with optimal clinical properties in treatment of addiction and adverse opioid effects. (aspetjournals.org)
  • Activation of P2Y1R increased [Ca 2+ ] i , which was prevented by the P2Y1R antagonists pyridoxalphosphate-6-azophenyl-2′,4′-disulfonic acid (PPADS) (10 μM) and N 6-methyl 2′-deoxyadenosine 3′,5′-bisphosphate (MRS2179) (10 μM) and by pretreatment with P2Y1R antisense oligodeoxynucleotides. (aspetjournals.org)
  • interacts
  • The CD4 receptor in particular interacts with murine MHC-II following the "ball-on-stick" model, where the Phe-43 ball fits into the conserved hydrophobic α2 and β2 domain residues. (wikipedia.org)
  • genes
  • Partial list of the genes located on p-arm (short arm) of human chromosome 3: ALAS1: aminolevulinate, delta-, synthase 1 APEH: encoding enzyme Acylamino-acid-releasing enzyme ARPP-21: Cyclic AMP-regulated phosphoprotein, 21 kDa AZI2: encoding protein 5-azacytidine-induced protein 2 BRK1: SCAR/WAVE actin nucleating complex subunit BRPF1: bromodomain and PHD finger containing 1 BTD: biotinidase C3orf14-Chromosome 3 open reading frame 14: predicted DNA binding protein. (wikipedia.org)
  • A full classification includes histopathological type, grade, stage (TNM), receptor status, and the presence or absence of genes as determined by DNA testing: Histopathology. (wikipedia.org)
  • integrin
  • ANGPTL4 disrupts endothelial cell junctions by directly interacting with integrin, VE-cadherin and claudin-5 in a sequential manner to facilitate metastasis. (wikipedia.org)
  • interaction
  • therefore, in the present study we sought to investigate the role of CB2 receptors in the interaction of melanoma cells with the brain endothelium. (jove.com)
  • whereas
  • Whereas agonist pretreatment desensitizes receptors to subsequent agonist stimulation, basal signaling of μ-opioid receptor (MOR) was shown to increase. (aspetjournals.org)
  • However, we observed that, in the presence of CFTR, the G-protein-coupling selectivity of native P2Y1R shifted from G q/11 - to G i/o -protein-coupling, whereas that of P2Y2R remained unaltered, suggesting that the presence of CFTR may influence G-protein-coupling selectivity of P2Y nucleotide receptors, a previously unsuspected aspect of CFTR regulatory function. (aspetjournals.org)
  • viral
  • McKeating's research focuses on the molecular biology of hepatitis B (HBV) and hepatitis C (HCV), particularly the role of cell surface receptors in the viral life cycle. (wikipedia.org)
  • stimulation
  • yet, we have shown that release of calmodulin from the receptor by agonist stimulation uncovered the innate basal activity of MOR in the dependent state (Wang et al. (aspetjournals.org)
  • Barrier
  • 1 , 2 Diabetic macular edema (DME) is the leading cause of vision loss in DR, 3 - 5 and it results from compromise of the blood retinal barrier (BRB) and/or impaired fluid removal from the retina. (arvojournals.org)
  • characterization
  • Here we report the construction and characterization of a highly constitutive active H3 receptor (MT6), in which the 357 alanine residue was converted to lysine (A357K). (aspetjournals.org)