• Background E-cadherin is a calcium-dependent intercellular adhesion molecule encoded by the CDH1 gene and present on epithelial cells. (qedbio.com)
  • In practical applications, E-cadherin is used as a phenotypic marker of the lobular subtype of cancer, where loss of hetero zygosity in chromosome region 16q22.1, the gene region encoding E-cadherin ( CDH1 ) is frequent ( 6 ). (iiarjournals.org)
  • P. D. Pharoah, P. Guilford and C. Caldas, "Incidence of Gastric Cancer and Breast Cancer in CDH1 (E-Cadherin) Mutation Carriers from Hereditary Diffuse Gastric Cancer Families," Gastroenterology, Vol. 121, No. 6, 2001, pp. 1348-1353. (scirp.org)
  • Hereditary diffuse gastric cancer is associated with a mutation in the cadherin 1 gene ( CDH1 ) and has no precursor lesion. (msdmanuals.com)
  • We show that two cadherin superfamily members, Fat and Dachsous, and the transmembrane/secreted protein Four-jointed play important roles in this process. (nih.gov)
  • N-cadherins are most commonly expressed on both the presynaptic active zone and postsynaptic density (PSD) regions, and contain both extracellular Ca2+ binding domains as well as intracellular domains for binding their protein partners. (wikipedia.org)
  • One mode of cadherin regulation is surface stabilization, a fairly rapid process (occurring approximately 100 minutes after activity) that is independent of protein synthesis. (wikipedia.org)
  • Protocadherin-alpha and protocadherin-gamma interact to form a protein complex that enhances the surface expression of each cadherin subtype. (wikipedia.org)
  • Internalization is dependent on protein synthesis, and p120 catenin proteins (p120ctn) are implicated in the turnover, degradation and 'clustering' of cadherins into the adhesive junctions at the synapse. (wikipedia.org)
  • However, hormone receptor negative (triple negative) tumors overwhelmingly overexpress p53 protein in tumor cells. (cancerindex.org)
  • In vitro, we show that 1,25D3 to modestly increase the expression of E-cadherin mRNA and protein in SK-MEL-28, but remained absent in A375, a cell line that expresses relatively higher levels of EMT transcription factors including SNAI1 and ZEB1. (bl.uk)
  • Binding of the extracellular sequence of EphB4 receptor to its transmembrane ligand ephrinB2 protein on the surface of endothelial cells of blood vessels, stimulates angiogenesis and growth of new vessels from existing vasculature. (neurodegenerationresearch.eu)
  • Sections were immunostained for estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (Her2), basal cytokeratin CK5, nuclear protein Ki67 and E-cadherin with a Leica Bond-Max autostainer. (iiarjournals.org)
  • Cadherins form protein complexes with cytoplasmic proteins (catenins) that convert the specific, homophilic-binding capacity of the extracellular domain into stable cell adhesion. (embl.de)
  • TCDD for every step of the mechanism described for 2,3,7,8-TCDD carcinogenesis in humans including receptor binding, gene expression, protein activity changes, cellular replication, oxidative stress, promotion in initiation-promotion studies and complete carcinogenesis in laboratory animals. (who.int)
  • Patients with E-cadherin-positive tumors have significantly better 3- and 5-year survival rates than patients with E-cadherin-negative tumors [28]. (betadesks.com)
  • Apc Min/+ Ffar2 -/- mice developed significantly more spontaneous colon tumors than Apc Min/+ mice and had increased gut permeability before tumor development, associated with reduced expression of E-cadherin. (nih.gov)
  • and tumors with chromosomal instability showing aneuploidy and amplifications of genes encoding receptor tyrosine kinases, the researchers said. (genomeweb.com)
  • It remains unclear, whether N-cadherin gene (CDH2) is a direct transcriptional target of AR variants or whether the observed upregulation is due to indirect effects through additional regulatory factors. (oncotarget.com)
  • The gene that encodes AZD3463 for N-cadherin (shSMAD4) was discovered from your He et al. (tam-receptor.com)
  • Shiu, S. H. & Bleecker, A. B. Receptor-like kinases from Arabidopsis form a monophyletic gene family related to animal receptor kinases. (nature.com)
  • The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. (nih.gov)
  • Appearance of N-cadherin on the top of epithelial cells facilitates AZD3463 motility and invasion and we showed that knockdown of SMAD4 causes reduced N-cadherin appearance which leads to reduced migration and invasion of individual pancreatic ductal epithelial cells. (tam-receptor.com)
  • Jointly these findings claim that SMAD4 is crucial for the TGF-β-powered upregulation of N-cadherin as well as the resultant intrusive phenotype of individual pancreatic ductal epithelial cells during EMT. (tam-receptor.com)
  • Similar alterations within the VDR signalling pathway are known to occur in the context of colon cancer, in which a diminished response of 1,25D3 signal is associated with increased expression of the epithelial mesenchymal transcription factor (EMT) SNAIL1, which can directly inhibit the activities of VDR and E-cadherin, resulting in epithelial cells to lose their polarity. (bl.uk)
  • By forming complexes with intracellular catenin proteins, neural cadherins (N-cadherins) serve as a link between synaptic activity and synaptic plasticity, and play important roles in the processes of learning and memory. (wikipedia.org)
  • Blocking cadherin function with specific proteins does not affect basal synaptic properties, but it can impair the induction of LTP. (wikipedia.org)
  • N-cadherins are transmembrane proteins expressed in the majority of CNS synapses. (wikipedia.org)
  • A common binding partner for Cadherins are intracellular catenin proteins, specifically the three different subtypes, α-catenins, β-catenins, and p120ctn family catenins. (wikipedia.org)
  • P120 ctn proteins are thought to either inhibit endocytosis of neural cadherins, or act at the cell surface to control cadherin turnover. (wikipedia.org)
  • In separate work, my team identified a set of secreted proteins overexpressed in the tumor microenvironment, and developed antibodies to block their cognate receptors for therapeutic gain. (gene.com)
  • These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. (nih.gov)
  • Biological Function Cadherins are calcium-dependent cell adhesion proteins (PubMed:11976333). (qedbio.com)
  • Cadherins are a group of transmembrane proteins that serve as the major adhesion molecules located within adherens junctions. (embl.de)
  • Cadherins are evolutionary related to the desmogleins which are component of intercellular desmosome junctions involved in the interaction of plaque proteins. (embl.de)
  • However, proteins are designated as members of the broadly defined cadherin family if they have one or more cadherin repeats. (embl.de)
  • This entry represents the extracellular repeated domains found in cadherins and related proteins. (embl.de)
  • Tyrosine kinase inhibitors (TKIs) against the human epidermal growth factor receptor (EGFR) are now standard treatment in the clinic for patients with advanced EGFR mutant non-small-cell lung cancer (NSCLC). (researchgate.net)
  • In the 1990's, the Human Genome Project inspired my team to discover several novel members of the TNF cytokine superfamily, most notably, Apo2L/TRAIL and its "death" and "decoy" receptors. (gene.com)
  • The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. (nih.gov)
  • Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members. (nih.gov)
  • Cadherin superfamily genes: functions, genomic organization, and neurologic diversity. (nih.gov)
  • Members of cadherin superfamily involved in cell adhesion and cell-cell interactions in neural development. (bvsalud.org)
  • Immunohistochemical (IHC) analysis demonstrates that the levels of E-cadherin expression, ERK1/2 phosphorylation, and cytoplasmic PKM2 expression were correlated with each other. (betadesks.com)
  • TGF-β dimers bind to TGF-β type II receptors which phosphorylate TGF-β type I receptors via serine/threonine kinase activity which in turn phosphorylate cytoplasmic SMAD2 and SMAD3. (tam-receptor.com)
  • Intriguingly, loss of N-cadherin caused a significant decrease in VE-cadherin and its cytoplasmic binding partner, p120ctn. (rupress.org)
  • Cytoplasmic interactions can influence the function of the ectodomain by a number of potential mechanisms, including redistribution of binding sites into clusters, providing cytoskeletal anchorage, and mediating physiological regulation of cadherin function. (embl.de)
  • X. Trefoil peptide and EGF receptor/ligand transgenic mice. (embl.de)
  • This review highlights some of the major findings pertinent to the epidermal growth factor (EGF) receptor and its ligands, particularly the major gut ligand transforming growth factor-alpha, as well as the trefoil peptides. (embl.de)
  • thus acting as both receptor and ligand. (embl.de)
  • E-cadherin manifestation was improved while N-cadherin was decreased, FANCB indicating a more epithelial phenotype. (cancer-pictures.org)
  • Inhibition of N-cadherin binding via blocking antibodies prevents the induction of late phase L-long term potentiation, suggesting that the adhesive property of dimeric N-cadherin is necessary for late phase L-LTP. (wikipedia.org)
  • The human parathyroid calcium sensing receptor (CaSR) senses minute changes in extracellular Ca 2+ concentration and functions to tightly regulate systemic Ca 2+ homeostasis (1) . (aacrjournals.org)
  • Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium. (embl.de)
  • Cadherins depend on calcium for their function: calcium ions bind to specific residues in each cadherin repeat to ensure its proper folding, to confer rigidity upon the extracellular domain and is essential for cadherin adhesive function and for protection against protease digestion. (embl.de)
  • The extracellular domains of cadherins form parallel dimers that possess intrinsic homophilic-binding activity. (embl.de)
  • Moreover, the specific contribution of full-length AR and AR variants in N-cadherin regulation in PCa has never been explored deeply. (oncotarget.com)
  • Down-regulation of p120 ctn leads to greater cadherin endocytosis and prevents adhesion between the pre and post-synaptic neuron. (wikipedia.org)
  • The down-regulation of both VE-cadherin and p120ctn was confirmed in cultured endothelial cells using small interfering RNA to knockdown N-cadherin. (rupress.org)
  • One quality phenotypic transformation of EMT may be the upregulation of N-cadherin. (tam-receptor.com)
  • to estrogen receptor alpha (ER). (cancer-pictures.org)
  • miR-221/222 Appearance is Reduced using the Mixture Treatment CP-724714 of SAHA and EGCG MCF-7 breasts cancer cells possess low endogenous appearance of compared to the triple-negative breasts cancer tumor cell lines where estrogen receptor, , is normally repressed partly by miR-221/222 [18]. (cancer-pictures.org)
  • To explore the CP-724714 consequences of decreased miR-221/222 manifestation further, qRT-PCR and European blot analysis had been performed on three immediate focuses on of miR-221/222: p27, PTEN, and estrogen receptor (ER). (cancer-pictures.org)
  • Additionally, KCl depolarization of the presynaptic axon both confers protease resistance to N-cadherins and disperses them throughout the PSD from their original clustering in synaptic puncta, thus increasing their efficacy for cell adhesion. (wikipedia.org)
  • NE cleaves and activates protease-activated receptor-2, leading to actomyosin cytoskeletal activation, cell junction molecule VE-cadherin degradation, and increased endothelial permeability. (bu.edu)
  • Here, we show that the non-receptor Src family tyrosine kinases, SRC64B and SRC42A, are involved in WNT5-mediated signaling through Derailed in the Drosophila embryonic central nervous system. (biologists.com)
  • Redistribution of the Novel Clostridioides difficile Spore Adherence Receptor E-Cadherin by TcdA and TcdB Increases Spore Binding to Adherens Junctions. (tamu.edu)
  • Molecular and functional analysis of cadherin-based adherens junctions. (embl.de)
  • Adherens junctions are specialized forms of cadherin-based adhesive contacts important for tissue organization in developing and adult organisms. (embl.de)
  • During embryonic development, cadherins are initially widely distributed, but they become gradually more localized to pre- and post-synaptic sites while synapses are being formed. (wikipedia.org)
  • Loss of N-cadherin in endothelial cells results in embryonic lethality at mid-gestation due to severe vascular defects. (rupress.org)
  • These findings provide a novel paradigm by which N-cadherin regulates angiogenesis, in part, by controlling VE-cadherin expression at the cell membrane. (rupress.org)
  • Betacellulin (BTC) belongs to the epidermal growth factor (EGF) family of peptide ligands that are characterised by a six-cysteine consensus motif that forms three intra-molecular disulfide bonds crucial for binding the ErbB receptor family. (embl.de)
  • The role of receptor interaction in the process of protoxin activation was analyzed. (unboundmedicine.com)
  • Each catenin subtype and its interaction with cadherins plays a distinct role in the mediation of synaptic plasticity and spine structure. (wikipedia.org)
  • A knockdown of SNAI1 and, independently of ZEB1, in A375 cells is insufficient to recover E-cadherin expression. (bl.uk)
  • Se subdividen en protocadherinas agrupadas (Pcdh-a) y protocadherinas no agrupadas (Pcdh-na) dependiendo de si sus genes están dispuestos en tándem en los vertebrados. (bvsalud.org)
  • Although these receptors are structurally similar, they determine specificity for four ligands-GDNF, Neurturin (NRTN), Artemin (ARTN) and Persephin (PSPN). (medsci.org)
  • In metazoans, intracellular receptors recognize these molecules. (nature.com)
  • Ca 2+ strongly induced E-cadherin expression and inhibited the expression of the nuclear transcription factor, TCF4. (aacrjournals.org)
  • cadherins which are transmembrane glycoproteins that mediate calcium-dependent cell-cell adhesion. (tam-receptor.com)
  • Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. (embl.de)
  • Incubation of Cry1Ab protoxin with a single chain antibody that mimics the cadherin-like receptor and treatment with Manduca sexta midgut juice or trypsin, resulted in toxin preparations with high pore-forming activity in vitro. (unboundmedicine.com)
  • Recent studies show that the human parathyroid calcium sensing receptor (CaSR) is expressed in human colon epithelium and functions to regulate epithelial proliferation and differentiation. (aacrjournals.org)
  • NMDAR activity reduces phosphorylation of β-catenin at tyr-654, thereby inhibiting N-cadherin endocytosis and facilitating surface retention and expression. (wikipedia.org)
  • Binding of KLRG1 to E-, N-, or R- cadherins blocks phosphorylation of Akt and increases the expression of cell cycle inhibitors. (biolegend.com)
  • The hormonally active form of vitamin D, 1,25-dihydroxyvitamin D (1,25D3), has shown to induce anti-cancerous effects through its cognate vitamin D receptor (VDR), in part through inducing the cell-cell adhesion molecule E-cadherin and inhibiting Wnt/β-catenin signalling. (bl.uk)
  • and Vascular Endothelial cadherin (VE-cadherin) and we made the novel observation (preliminary data) that treatment of endothelial cell cultures with EphB4 increases these angiogenic complexes. (neurodegenerationresearch.eu)
  • Contrary to previous studies, we found that N-cadherin localizes to endothelial cell-cell junctions in addition to its well-known diffusive membrane expression. (rupress.org)
  • We also show that N-cadherin is important for endothelial cell proliferation and motility. (rupress.org)
  • Selective loss of E-cadherin can cause de-differentiation and invasiveness in human carcinomas, leading this marker to be classified as a tumor suppressor ( 5 ). (iiarjournals.org)
  • Solution structure of the epithelial cadherin domain responsible for selective cell adhesion. (embl.de)
  • Killer cell lectin-like receptor subfamily G member 1 (KLRG1) is a 30 kD, type II membrane glycoprotein with one C-type lectin domain and one immunoreceptor tyrosine-based inhibititory motif (ITIM). (biolegend.com)
  • Plants, however, perceive steroids at membranes, using the membrane-integral receptor kinase BRASSINOSTEROID INSENSITIVE 1 (BRI1). (nature.com)
  • A membrane receptor reagent and assay is disclosed in which liposomes are bound to an evanescent wave emitting surface. (google.com)
  • In addition I observed that no nuclear GSK-3β in combination with moderate membrane E-cadherin is associated with good prognosis in Duke´s B colon cancer patients. (lu.se)
  • It was also found that LTD4 could induce Epithelial-Mesenchymal Transition (EMT) in SW480 colon cancer cells by i) reducing membrane E-cadherin, ii) increase levels of nuclear β-catenin, iii) increase EMT marker such as vimentin and snail which leads to increase migration of SW480 colon cancer cells. (lu.se)
  • Constitutively active androgen receptor (AR) variants have been involved in the expression of mesenchymal markers such as N-cadherin in prostate cancer (PCa). (oncotarget.com)
  • Our data also revealed a distinctive mode of action between full-length AR and AR variants to regulate N-cadherin expression. (oncotarget.com)
  • Correlation between the degree of E-cadherin expression and the grade of tumor differentiation, as well as the histological type according to the Lauren and the WHO ?classifications. (betadesks.com)
  • PKM2 expression might be an adverse prognostic factor for signet-ring cell carcinomas, which lack E-cadherin [7]. (betadesks.com)
  • We know that RKO cells lack the expression of E-cadherin [33]. (betadesks.com)
  • During the progression of the tumor, a lack of or very low expression of E-cadherin induces an aggressive function of PKM2 in the tumor. (betadesks.com)
  • Cadherin expression is also regulated by activity-induced internalization, which occurs much later than surface stabilization (an average of 4 hours after the stimulus). (wikipedia.org)
  • 1,25(OH) 2 D 3 was weaker in its effect on E-cadherin and was not able to inhibit TCF4 expression. (aacrjournals.org)
  • In this thesis we specifically investigated whether 1) EMT drivers, such as SNAI1, have any impact on VDR signalling and modulation of E-cadherin expression within metastatic melanoma and whether 2) the presence of a constitutively active MAPK function (BRAFV600E) have relevance to VDR signalling in metastatic melanoma. (bl.uk)
  • We also determined the absence of E-cadherin expression in A375 to not be regulated by methylation. (bl.uk)
  • Loss of E-cadherin function or expression has been implicated in cancer progression and metastasis. (qedbio.com)
  • When compared with invasive ductal carcinoma, E-cadherin expression is markedly reduced or absent in the great majority of invasive lobular carcinomas when studied by immunohistochemistry. (qedbio.com)
  • In this study, we genetically manipulate N-cadherin expression in vivo and in vitro to examine its function in ECs. (rupress.org)
  • BT-474 cells, obtained expression of the receptor has important implications for their biology from American Type Culture Collection, were maintained in RPMI 1640 and therapy (1). (lu.se)
  • The aim of this study was to determine the evolution of E-cadherin expression in no special type (NST) primary breast carcinoma and to correlate this with that in distant, paired nodal metastases (LNM) and molecular classification. (iiarjournals.org)
  • Conclusion: E-Cadherin expression is not stable during the metastatic process. (iiarjournals.org)
  • E-Cadherin expression in primary sites positively correlates with E-cadherin from LNM. (iiarjournals.org)
  • The GDNF family ligands (GFLs) function through a glycosyl-phosphatidylinositol-(GPI) anchored coreceptor, GDNF family receptor alpha (GFRα), and rearranged during transfection (RET), a well-known receptor tyrosine kinase involved in kidney development, spermatogonial stem cell maintenance, and the development and maintenance of the sympathetic, parasympathetic, and enteric nervous systems [ 1 , 2 ]. (medsci.org)
  • E-cadherin downregulation decreases the strength of cellular adhesion within a tissue, resulting in an increase in cellular motility. (qedbio.com)
  • There is increasing evidence to suggest that the function of the CaSR is diverse, extends beyond the systemic control of Ca 2+ homeostasis, and is contingent on the tissue type in which the receptor is expressed (2-5) . (aacrjournals.org)
  • Thus far, no reports have shown that MAPK can influence VDR function however, it is known that MAPK can phosphorylate a subgroup of nuclear receptors, which VDR is a member of, and thereby alter their signalling. (bl.uk)
  • in contrast, the AGS cells were derived from malignant gastric adenocarcinoma Title Loaded From File tissue and lack E-cadherin-mediated cell adhesion [31]. (betadesks.com)
  • Glial cell line-derived neurotrophic factor family receptor alpha (GFRα) members have been widely connected to the mechanisms contributing to cell growth, differentiation, cell migration and tissue maturation. (medsci.org)
  • Based on whether it cooperates with the second receptor RET, GFRα has also been widely linked to the mechanisms that contribute to cell growth, differentiation and migration and tissue maturation. (medsci.org)
  • Miembros de la superfamilia de cadherinas implicados en la adhesión celular y las interacciones intercelulares en el desarrollo neural. (bvsalud.org)
  • They defined subtype 2 as representing immune response-related processes (antigen presentation, BCR/TNF/Toll-like receptor signaling, TCR signaling, and phagosome). (genomeweb.com)
  • Association of p53 Overexpression with Hormone Receptor Status and Triple Negative Breast Carcinoma. (cancerindex.org)
  • To determine association of p53 overexpression with hormone receptor status in breast carcinoma. (cancerindex.org)
  • Interestingly, high levels of the pro-inflammatory mediator leukotriene D4 (LTD4) in association with its receptor CysLT1 goes with poor prognosis for colon cancer patient. (lu.se)
  • Furthermore, LTD4 decrease both membranous E-cadherin and β-catenin which lead to an increase migration of HCT116 colon cancer. (lu.se)
  • At basal levels of synaptic activity, N-cadherins are largely monomers and are thus weakly adhesive to cadherins located in the cell on the opposite side of the synapse. (wikipedia.org)
  • When GFLs bind with GFRα, they form complexes and associate with the RET receptor, subsequently activating downstream signaling. (medsci.org)
  • The experimental and physiological observations regarding the tumor-suppressor role of E-cadherin are often interpreted in the context of the epithelial-mesenchymal transition. (iiarjournals.org)
  • We hypothesize that PKM2 attenuates cell motility and invasion when E-cadherin is present. (betadesks.com)
  • Description: A sandwich ELISA for quantitative measurement of Porcine Cadherin EGF LAG seven pass G type receptor 2(CELSR2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (tuberculosisdrugresearch.org)
  • Single-cell transcriptomic profiling of Drosophila olfactory receptor neurons. (elifesciences.org)
  • Three types of olfactory receptor neurons (ORNs) are portrayed in three different colors (green, magenta, and blue) and their cell bodies are housed in the antennae and maxillary palps. (elifesciences.org)
  • My postdoc studies on neurotransmitter receptors led to papers in Science, Nature and Cell, and earned the 1988 Boeringer Ingelheim Award. (gene.com)
  • Li Q, Cao Z, Zhao S. The Emerging Portrait of Glial Cell Line-derived Neurotrophic Factor Family Receptor Alpha (GFRα) in Cancers. (medsci.org)
  • The elevated virulence of rhinovirus C derives from its unique reliance on the cadherin-related family member 3 (CDHR3) receptor for host cell binding ( 6 ). (cdc.gov)
  • These receptors, which include Toll-like receptors, are portion of an internal sponsor defense Paroxetine HCl realizing nucleic acids aberrantly present in the cytoplasm from illness or cell stress. (columbiagypsy.net)
  • cadherins may thus contribute to the sorting of heterogeneous cell types. (qedbio.com)
  • The adherens junction provides strong cell-cell adhesion mediated by the cadherin-catenin complex via its linkage to the actin cytoskeleton ( Wheelock and Johnson, 2003 ). (rupress.org)
  • however, the interrelationship and functional contribution of the individual cadherins in cell adhesion and signaling is poorly understood. (rupress.org)
  • N-cadherin is normally concentrated at cell-cell contact sites in most cell types where it is expressed. (rupress.org)
  • N. den Elzen, C. V. Buttery, M. P. Maddugoda, G. Ren and A. S. Yap, "Cadherin Adhesion Receptors Orient the Mitotic Spindle during Symmetric Cell Division in Mammalian Epithelia," Molecular Biology of the Cell, Vol. 20, No. 16, 2009, pp. 3740-3750. (scirp.org)
  • Overexpression of an N-cadherin mutant incapable of adhesion prevents spine head expansion, demonstrating N-cadherin's essential role in this process. (wikipedia.org)
  • Indeed, VE-cadherin was significantly down-regulated in the mutant embryos, demonstrating that N-cadherin is genetically upstream of VE-cadherin. (rupress.org)
  • Phenotypic characterization and predictive analysis of p.Asp47Asn LDL receptor mutation associated with Familial Hypercholesterolemia in a Chilean population. (cdc.gov)
  • Evidence suggest that N-Cadherins stabilize the connection between the presynaptic terminal and postsynaptic spine and that this stabilization increases the likelihood that released glutamate will bind receptors on the postsynaptic neuron. (wikipedia.org)
  • Dimerized cadherins readily bind to their presynaptic cadherin partners. (wikipedia.org)
  • Members of the RYK/Derailed family have recently been shown to regulate axon guidance in both Drosophila and mammals by acting as Wnt receptors. (biologists.com)
  • Although the role of E-cadherin as a tumor suppressor has been established, in recent years, alternative roles for E-cadherin in tumor progression have become apparent. (iiarjournals.org)