• Nuclear
  • It has been associated with heterochromatin and PML-NBs (Promyelocytic Leukaemia nuclear bodies) and has been implicated in many nuclear processes including transcription and cell cycle regulation. (wikipedia.org)
  • When the cell is treated with TGF-β, HIPK2, a nuclear kinase, phosphorylates Daxx and the activated Daxx in turn activates the JNK pathway (see "The Daxx Pathway" figure). (wikipedia.org)
  • monoclonal
  • Pembrolizumab is an immunoglobulin G4, with a variable region against the human programmed cell death 1 receptor, a humanized mouse monoclonal [228-L-proline(H10-S>P)]γ4 heavy chain (134-218') disulfide and a humanized mouse monoclonal κ light chain dimer (226-226:229-229)-bisdisulfide. (wikipedia.org)
  • affinity
  • This results in the formation of GC, where antigen-activated B cells are trapped to undergo somatic mutation, positive and negative selection, isotype switching, and differentiation into high-affinity plasma cells and memory B cells. (wikipedia.org)
  • Those cells that demonstrate a high affinity for this self antigen are often subsequently deleted so they cannot create progeny, which helps protect the host against autoimmunity. (wikipedia.org)
  • If they demonstrate high affinity for self-antigen, one method of preventing autoimmunity is through clonal deletion. (wikipedia.org)
  • Sequences
  • Applications of phage display technology include determination of interaction partners of a protein (which would be used as the immobilised phage "bait" with a DNA library consisting of all coding sequences of a cell, tissue or organism) so that the function or the mechanism of the function of that protein may be determined. (wikipedia.org)
  • bone-marrow
  • The main phenotype found in IL-6-sIL-6R mice was a dramatic increase of extramedullary hematopoietic progenitor cells in liver and spleen but not in the bone marrow.The high numbers of hematopoietic progenitor cells were reflected by a strong increase of peripheral blood cell numbers.Therefore, activators of the gp130 signal transducer like the IL-6-IL-6R complex may represent most powerful stimulators for extramedullary hematopoietic progenitor cells. (nih.gov)
  • defective
  • These effects may be mediated by the defective functioning of estrogen via the estrogen receptor, which contains a zinc finger protein. (wikipedia.org)
  • Nature 2010;467:328 Kim, H-J, Wang X, Radfar S, Sproule TJ, Roopenian DC, Cantor H. CD8+ T regulatory cells express the Ly49 class I MHC receptor and are defective in autoimmune prone B6-Yaa mice. (wikipedia.org)
  • Expression
  • Right) For the same tube, the same populations were visualized on the basis of right-angle light scatter ( y axis) versus the level of cell surface CD33-PE expression ( x axis). (asmscience.org)
  • Follicular DCs have high expression of complement receptors CR1 and CR2 (CD 35 and CD 21 respectively) and Fc-receptor FcγRIIb (CD32). (wikipedia.org)
  • they increase host defenses by up-regulating antigen presentation by virtue of increasing the expression of major histocompatibility complex (MHC) antigens. (wikipedia.org)
  • The p120 protein displays a dramatic increase in expression at the G1/S transition suggesting that p120 regulates the cell cycle and nucleolar activity that is required for cell proliferation. (wikipedia.org)
  • molecular
  • Conversely, under other circumstances CD34 has been shown to act as molecular "Teflon" and block mast cell, eosinophil and dendritic cell precursor adhesion, and to facilitate opening of vascular lumina. (wikipedia.org)
  • lymphoid
  • Follicular dendritic cells (FDCs) are cells of the immune system found in primary and secondary lymph follicles of the B cell areas of the lymphoid tissue. (wikipedia.org)
  • Follicular DCs are a non-migratory population found in primary and secondary follicles of the B cell areas of lymph nodes, spleen, and mucosa-associated lymphoid tissue (MALT). (wikipedia.org)
  • B and T cells are presented with self antigen after developing receptors while they are still in the primary lymphoid organs. (wikipedia.org)
  • Separation
  • Supposedly, this separation from the sites of earliest antigen processing and capture provide a protected environment in which opsonized antigens can be displayed for a long time without being proteolyzed or removed by phagocytic cells. (wikipedia.org)
  • Mice
  • Mice lacking plakoglobin have cell adhesion defects in many tissues, although β-catenin substitutes for plakoglobin at many cellular junctions. (wikipedia.org)
  • Furthermore, mice lacking LT or LT receptors, which are devoid of FDC, develop generalized lymphocytic infiltrates, which are suggestive of autoimmunity. (wikipedia.org)
  • Experimental production of mice deprived of selected T-cell subclasses. (wikipedia.org)
  • cells
  • Pasireotide works by binding to a protein called somatostatin receptor, which is expressed in many tissues throughout the body including thyroid cancer cells. (clinicaltrials.gov)
  • The high numbers of hematopoietic progenitor cells were reflected by a strong increase of peripheral blood cell numbers. (nih.gov)
  • For instance, when an epithelial layer is complete and the adherens junctions indicate that the cell is surrounded, β-catenin may play a role in telling the cell to stop proliferating, as there is no room for more cells in the area. (wikipedia.org)
  • In F9 cells lacking both β-catenin and plakoglobin, very little E-cadherin and α-catenin accumulated at the cell surface. (wikipedia.org)
  • Noncognate[clarification needed] B cells play a significant role as an antigen transporter to FDCs. (wikipedia.org)
  • B cells lacking CXCR5, the receptor for CXCL13, still enter the white pulp, but are mislocalized and disorganized. (wikipedia.org)
  • These B cells do not pose a threat, even in the periphery, because they cannot be activated without an autoreactive T cell to stimulate them. (wikipedia.org)
  • Between 2% and 5% of T cells develop auto-reactive receptors. (wikipedia.org)
  • However, the infected cell can prepare neighboring cells against a potential infection by the virus by releasing interferons. (wikipedia.org)
  • The presence of CD34 on non-hematopoietic cells in various tissues has been linked to progenitor and adult stem cell phenotypes. (wikipedia.org)
  • In particular, his research addressed whether the multiple immunological functions of T cells were invested in a single lineage or represented the specialized activities of distinct T cell subsets. (wikipedia.org)
  • HUMAN
  • Based on the type of receptor through which they signal, human interferons have been classified into three major types. (wikipedia.org)
  • Cellular
  • While less attention is directed at α-catenin in studies involving cell adhesion, it is nonetheless an important player in cellular organization, function and growth. (wikipedia.org)
  • phenotypes
  • With the implicit understanding that monocytes and granulocytes represent distinct cell lineages, this chapter reviews laboratory procedures which can be utilized to assess their functions and phenotypes. (asmscience.org)
  • chromosome
  • These changes include an extra copy of part of chromosome 7 in each cell (partial trisomy 7) or a missing segment of the chromosome in each cell (partial monosomy 7). (wikipedia.org)
  • occurs
  • Positive selection occurs in the thymic cortex, which suggests it is possible for a cell to undergo positive selection within the cortex and then negative selection in the medulla via clonal deletion. (wikipedia.org)
  • adhesion
  • Cell-cell adhesion complexes are required for simple epithelia in higher organisms to maintain structure, function and polarity. (wikipedia.org)
  • Keratinocytes engineered to not express alpha-catenin have disrupted cell adhesion and activated NF-κB. (wikipedia.org)
  • complex
  • Interferon type III: Signal through a receptor complex consisting of IL10R2 (also called CRF2-4) and IFNLR1 (also called CRF2-12). (wikipedia.org)
  • the phosphorylated eIF-2 forms an inactive complex with another protein, called eIF2B, to reduce protein synthesis within the cell. (wikipedia.org)
  • known
  • Nevertheless, it is not known whether the Fas-receptor stimuli or the ASK1 overexpression are caused by ROS or CRM1 mediated export. (wikipedia.org)
  • These complexes, which help regulate cell growth in addition to creating and maintaining epithelial layers, are known as adherens junctions and they typically include at least cadherin, β-catenin, and α-catenin. (wikipedia.org)
  • Biology
  • Nitroglycerin-induced endothelial dysfunction and tolerance involve adverse phosphorylation and S-glutathionylation of endothelial nitric oxide synthase: beneficial effects of therapy with the AT1 receptor blocker telmisartan," Arteriosclerosis, Thrombosis, and Vascular Biology , vol. 31, no. 10, pp. 2223-2231, 2011. (hindawi.com)