• inhibition
  • knocking out of the beta1/2 (zeige TFAP2B Antikörper ) receptor significantly diminished the ST25 acupuncture-induced inhibition of gastric motility and jejunal motility without significantly altering the enhancement of colonic motility induced by acupuncture at ST25. (antikoerper-online.de)
  • atrial fibrillation
  • There is little evidence of beta-blocker treatment benefit in patients with heart failure and reduced left ventricular ejection fraction (HFREF) and atrial fibrillation (AF). (pubmedcentralcanada.ca)
  • Atrial fibrillation (AF) occurs in 10-40% of patients with chronic HF (HF) and has been associated with poor outcomes including death and HF progression in patients with reduced 1 - 5 (HFREF) or preserved 6 (HFPEF) left ventricular ejection fractions (LVEFs). (pubmedcentralcanada.ca)
  • blockers
  • Although the available treatments (beta-blockers, BBs) improve the evolution of the disease, they do not protect MFS patients from progression of ARD and dissection. (clinicaltrials.gov)
  • A key molecule that negatively influences cell growth, differentiation, survival and death in MFS is TGFb which is antagonised by existing drugs employed in the clinical practice, the Angiotensin II receptor blockers (ARB). (clinicaltrials.gov)
  • Levobetaxolol has fewer cardiovascular side effects than other beta blockers. (wikipedia.org)
  • blocker
  • We investigated the effects of bucindolol in HFREF patients with AF enrolled in the Beta-blocker Evaluation of Survival Trial (BEST). (pubmedcentralcanada.ca)
  • In HFREF, beta-blocker therapy is associated with improved outcomes and ventricular reverse remodelling, 7 - 12 but there is little evidence of benefit if AF is also present. (pubmedcentralcanada.ca)
  • Although stratification will be done so patients treated with beta-receptor blocker carvedilol will be divided the same between the study groups. (clinicaltrials.gov)
  • The investigators designed a clinical trial in which a new generation Beta-Blocker Nebivolol with expected effects on shear stress, heart rate and potential anti-stiffness benefits is compared to Losartan, and Angiotensin receptor blocker anti TGF-beta effects, and to the association of both molecules in patients with Marfan Syndrome. (clinicaltrials.gov)
  • Levobetaxolol is a beta-adrenergic receptor inhibitor (beta blocker). (wikipedia.org)
  • sympathetic
  • The binding to these receptors by catecholamines will generally stimulate the sympathetic nervous system, the arm of the autonomic nervous system responsible for the fight-or-flight response. (wikipedia.org)
  • Sympathetic nervous system activity, which also controls blood pressure, acting through the β1 adrenergic receptors. (wikipedia.org)
  • peripheral
  • It stimulates α1 and α2 adrenergic receptors to cause blood vessel contraction, thus increases peripheral vascular resistance and resulted in increased blood pressure. (wikipedia.org)
  • Renin can be referred to as a hormone even though it has no peripheral receptors and rather has an enzymatic activity with which it hydrolyzes angiotensinogen to angiotensin I. The primary structure of renin precursor consists of 406 amino acids with a pre- and a pro-segment carrying 20 and 46 amino acids, respectively. (wikipedia.org)
  • selectivity
  • Nebivolol shows the highest selectivity for ß1 receptors among the currently available BBs, influences the arterial stiffness through an agonistic effect on ß2-receptors and preserves the arterial compliance. (clinicaltrials.gov)
  • activation
  • His research focusses on the role of receptors in heart failure and on the mechanisms of their activation and inactivation. (wikipedia.org)
  • Vilardaga JP, Bünemann M, Krasel C, Castro M, Lohse MJ (2003): Measurement of the millisecond activation switch of G-protein-coupled receptors in living cells. (wikipedia.org)
  • Lohse MJ, Nuber S, Hofmann C (2012): Fluorescence/bioluminescence resonance energy transfer techniques to study G-protein-coupled receptor activation and signaling. (wikipedia.org)
  • HUMAN
  • The combination of these two properties can result in bimodal effects on receptor activity that are meaningful for basal activity and chronotropic catecholamine responses of human cardiomyocytes. (wikipedia.org)
  • cardiovascular
  • β 1 389-Arg/Arg AF patients had nominally significant reductions in all-cause mortality/HF hospitalization and cardiovascular mortality/hospitalization with bucindolol (HR 0.23, P = 0.037 and 0.28, P = 0.039), whereas Gly carriers did not. (pubmedcentralcanada.ca)
  • Laboratory models have revealed a mechanism by which adrenergic autoantibodies accomplish their effects on the cardiovascular system. (wikipedia.org)
  • domain-bindi
  • The PDZ domain-binding motif mediates competitive interactions with GOPC, MAGI3 and DLG4 and plays a role in subcellular location of the receptor. (abcam.com)
  • renal
  • Renin is secreted from juxtaglomerular kidney cells, which sense changes in renal perfusion pressure, via stretch receptors in the vascular walls. (wikipedia.org)
  • Interaction
  • Interaction between testosterone and β-1 ARs have been shown in anxiolytic behaviors in the basolateral amygdala. (wikipedia.org)
  • correlation
  • We sought a possible correlation between genotype at codon 389 of this receptor with clinical response to topical 0.25% betaxolol (Betoptic-S, Alcon) in a small, pilot study of normal volunteers. (arvojournals.org)
  • Future research solidifying this correlation of CFS with autoantibodies to adrenergic receptors would be useful to clinicians tackling this difficult-to-treat condition that affects 200,000 people per year in the US. (wikipedia.org)