• Human alveolar macrophages from bronchoalveolar lavage are usually poor accessory cells for antigen-induced T-lymphocyte proliferation and poor stimulators of allogeneic mixed leukocyte reactions (MLR) when compared to peripheral blood monocytes. (elsevierpure.com)
  • In children who have completed immunizations with diphtheria, pertussis, and tetanus (DPT) or Hib-conjugated vaccines, the antibody response to protein antigens can be tested in adults and older children by measuring IgG antibodies to tetanus or diphtheria toxoid and H influenzae type b (Hib) polysaccharide antigen. (medscape.com)
  • Hepatitis B is not a reliable antigen for testing immune competence because of the high frequency of nonresponders in the population, particularly in persons older than 40 years. (medscape.com)
  • In 2006 administration of normal circulating lymphocytes transduced with a retrovirus encoding a T-cell receptor (TCR) that recognized the MART-1 melanoma-melanocyte antigen, mediated tumor regression. (wikipedia.org)
  • In 2010 administration of lymphocytes genetically engineered to express a chimeric antibody receptor (CAR) against B cell antigen CD19 was shown to mediate regression of an advanced B cell lymphoma. (wikipedia.org)
  • In 2016, CD19-specific chimeric antigen receptor (CAR)-modified T cells were used to treat patients with relapsed and refractory CD19+ B cell malignancies, including B cell acute lymphoblastic leukemia (B-ALL) harboring rearrangement of the mixed lineage leukemia (MLL) gene with CD19 CAR-T cells. (wikipedia.org)
  • Finally, we investigated the impact of natural CD25(+) Treg cells on the production of T-helper (Th)1 and Th2 cytokines in mixed lymphocyte cultures between C57BL/6 CD4(+) CD25(-) T cells as responders and bm12 or (C57BL/6X bm12)F1 antigen-presenting cells as stimulators. (ox.ac.uk)
  • Furthermore, similar to T cells, specific recognition and elimination of cancer cells by NK cells can be markedly enhanced through expression of chimeric antigen receptors (CARs), which provides an opportunity to generate NK-cell therapeutics of defined specificity for cancer immunotherapy. (frontiersin.org)
  • The use of CD20 as suicide gene was investigated in CMV specific T cells and in T cells genetically modified with an antigen specific T-cell receptor. (haematologica.org)
  • T-cell receptor (TCR) gene transfer is an attractive strategy for rapid in vitro generation of high numbers of antigen specific T cells. (haematologica.org)
  • Although human CD20 has previously been described as functional selection marker and suicide gene after retroviral transfer to T lymphocytes, 9 , 10 the specificities of these T cells were unknown, and therefore a potential effect of CD20 on antigen-specific T-cell functions could not be investigated. (haematologica.org)
  • CD71 antigen expression is low on normal resting lymphocytes and is expressed on all cells upon activation. (nordicmubio.com)
  • Recently, the complete medical oncology field continues to be revolutionized with the launch of immune system checkpoint inhibitors, including T cell VEGFA inhibitory receptors such as for example cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and designed cell loss of life-1 (PD-1) or its ligand (PDL-1). (nonamimaho.com)
  • CD152, also known as Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4), is a 33 kD member of the immunoglobulin superfamily. (biolegend.com)
  • Point-of-care antigen tests are an important tool for SARS-CoV-2 detection. (cdc.gov)
  • Antigen tests are less sensitive than real-time reverse-transcriptase PCR (rRT-PCR). (cdc.gov)
  • Data on the performance of the BinaxNOW antigen test compared to rRT-PCR and viral culture by symptom and known exposure status, timing during disease or exposure period and demographic variables are limited. (cdc.gov)
  • During November 3(rd)-17(th), 2020, we collected paired upper respiratory swab specimens to test for SARS-CoV-2 by rRT-PCR and Abbott BinaxNOW (BinaxNOW) antigen test at two community testing sites in Pima County, Arizona. (cdc.gov)
  • Point-of-care antigen tests have a shorter turn-around time compared to laboratory-based nucleic acid amplification tests, which allows for more rapid identification of infected individuals. (cdc.gov)
  • Antigen test sensitivity limitations are important to consider when developing a testing program. (cdc.gov)
  • Currently, there are three basic types of tests to determine if an individual has been infected with SARS-CoV-2: viral nucleic acid (RNA) detection, viral antigen detection, and detection of antibodies to the virus. (medscape.com)
  • Viral tests (nucleic acid or antigen detection tests) are used to assess acute infection, whereas antibody tests provide evidence of prior infection with SARS-CoV-2. (medscape.com)
  • n = 50), which was considerably superior to that produced by stimulation with IL-2, IL-12, IL-15, and/or IL-21 and caused no proliferation of CD3 + lymphocytes. (aacrjournals.org)
  • MZB was found to inhibit both humoral and cellular immunity by selectively inhibiting lymphocyte proliferation, which led to its development as an immunosuppressive agent. (hindawi.com)
  • MZB has a very specific mechanism of action on the lymphocytes that inhibits their proliferation without interfering with purine synthesis in other cell types. (hindawi.com)
  • Moreover, thrombin-treated MSCs maintained the phenotypic features, in vitro osteogenesis and adipogenesis capacities, and inhibitory activity on Phytohemagglutinin-induced allogeneic lymphocyte proliferation. (biomedcentral.com)
  • 4,19-21 The immunosuppressive ability of AM to inhibit a mixed lymphocyte reaction appears to be partly mediated by a soluble factor, resulting in decreased alloreactive T-cell proliferation and Th1 and Th2 cytokine production. (touchophthalmology.com)
  • In vitro studies based on MCF-7 cell proliferation and induction of vitellogenin in primary culture of rainbow trout hepatocytes. (cdc.gov)
  • The ability of MSC in co-culture to suppress PBMC PS+ externalization compared favorably to two concomitant assays for MSC co-culture suppression of PBMC proliferation, at 72 h by ATP assay, or at 96 h by fluorescently labeled protein signal dilution. (bvsalud.org)
  • RESULTS: PBMC proliferation in response to PHA gave a robust ATP signal by 72 h, which was suppressed by co-culture with densely plated MSCs. (bvsalud.org)
  • Lymphocytes infiltrating the stroma of growing, transplantable tumors provided a concentrated source of tumor-infiltrating lymphocytes (TIL) and could stimulate regression of established lung and liver tumors. (wikipedia.org)
  • In contrast to other cancers such as adenocarcinomas of the lung or melanoma, primary brain tumors like GB and low grade gliomas (LGG) are known as rather immunologically "cold" tumors, typically with low numbers of tumor-infiltrating lymphocytes (TILs) ( 4 ), and the mere amount of TILs is not associated with patient survival ( 5 ). (frontiersin.org)
  • research showed an elevated responsiveness of human being tumor-infiltrating lymphocytes when PBF-509 was coupled with anti-PD-L1 or anti-PD-1. (nanoker-society.org)
  • Methods We used several in vitro methods including Caco-2/THP-1 leaky gut model, AhR activation, PBMC assay and mixed lymphocyte reaction (MLR) to assess the impact of a MET-C candidate (MaaT03X) on gut homeostasis and immune activation. (bmj.com)
  • Test collection (clean and/or archival tissues, PBMC, serum, plasma, stool, etc.) at particular CP 316311 factors of treatment is certainly important for analyzing feasible biomarkers and learning the systems of responsiveness, level of resistance, relapse and toxicity. (nonamimaho.com)
  • Positive selection of human CD8+ T lymphocytes from PBMC. (bdbiosciences.com)
  • All assays used the same initial experimental conditions: cryopreserved PBMCs from 8 to 10 pooled donors, co-culture with and without MSCs in 96-well plates, and PBMC stimulation with mitogen for 2-72 h. (bvsalud.org)
  • METHODS: Pooled human PBMCs and MSCs were co-cultured at different MSC:PBMC ratios and harvested from 0 to 120 h, with and without phytohaemagglutin A (PHA) stimulation. (bvsalud.org)
  • IDO activity in MSCs co-cultured with PBMCs correlated with PBMC suppression. (bvsalud.org)
  • We conclude that there are potent accessory cells in human lung that are loosely adherent, Fc receptor negative, and poorly phagocytic, and thus are dissimilar from classic macrophages. (elsevierpure.com)
  • 1980. "Lymphokine Enhances the Expression and Synthesis of Ia Antigens on Cultured Mouse Peritoneal Macrophages. (rockefeller.edu)
  • CD20-transduced T cells with and without co-transferred T-cell receptor were efficiently eliminated by complement dependent cytotoxicity induced by therapeutic anti-CD20 antibody rituximab. (haematologica.org)
  • 6 SAR156497 7 SP has SAR156497 an autocrine regulation role in macrophage function (8 9 For example in the macrophage cell line P388D1 anti-SP antibody depletion of macrophage-secreted SP from the culture resulted in abrogation of SP-increased IL-1 production (8). (opioid-receptors.com)
  • Annunziata (21) demonstrated that SP has a critical function in HIV gp120-induced boosts in permeability of rat human brain endothelium cultures which aftereffect of SP on gp120-induced upsurge in albumin permeability is certainly abrogated with the SP antagonist (spantide) and/or anti-SP polyclonal antibody. (opioid-receptors.com)
  • The blood samples were identified as HIV-1 antibody unfavorable by anonymous testing with the ELISA method (Coulter). (opioid-receptors.com)
  • The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography. (bdbiosciences.com)
  • Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis . (biolegend.com)
  • The fluorochrome-labeled L3D10 antibody is useful for immunofluorescent staining and flow cytometric analysis to identify CTLA-4-producing cells within mixed cell populations. (biolegend.com)
  • The methods used to directly quantify antibody internalization are currently painstaking, time-consuming and not suitable for testing several antibodies at once. (news-medical.net)
  • Commercially available test antibodies included CD71 clone 1a, 2, CD20 (Sigma), clone 3-5 (Abcam), CD3, CD45 (Biolegend), human IgG isotype control (Absolute Antibody), mouse IgG1 isotype control (R&D Systems). (news-medical.net)
  • Store undiluted at 4°C. The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography. (bdbiosciences.com)
  • Applications Tested: The PK136 antibody has been tested by flow cytometric analysis of C57Bl/6 mouse splenocytes and can be used at less than or equal to 0.5 µg per test. (thermofisher.com)
  • A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. (thermofisher.com)
  • Humanized B-hCD40 mice were treated with different doses of an anti-human CD40 antibody, and the percentage of receptor occupancy on B cells isolated from peripheral blood mononuclear cells (PBMCs) was assessed by flow cytometry. (biocytogen.com)
  • The US Food and Drug Administration [FDA] has not authorized the use of antibody tests for the diagnosis of acute infection. (medscape.com)
  • Renal epidermal growth factor receptor (EGFR) signaling is activated in models of diabetic nephropathy (DN), and inhibition of the EGFR signaling pathway protects against the development of DN. (diabetesjournals.org)
  • We have now determined that in cultured podocytes, high glucose led to increases in activation of EGFR signaling but decreases in autophagy activity as indicated by decreased beclin-1 and inhibition of LC3B autophagosome formation as well as increased rubicon (an autophagy inhibitor) and SQSTM1 (autophagy substrate). (diabetesjournals.org)
  • Mice lacking the epidermal growth factor receptor (EGFR) develop epithelial defects and a neurodegenerative disease and die within the first month of birth. (silverchair.com)
  • PMA/Ionomycin-stimulated human peripheral blood lymphocytes were stained with anti-human CD4 APC, then fixed, permeabilized and intracellularly stained with anti-CD152 (CTLA-4) (clone L3D10) PE (left) or Mouse IgG1, κ isotype control PE (right). (biolegend.com)
  • We also present the data of our own research concerning evaluation of the prognostic role of cytokines and lymphocyte subpopulations in peripheral blood of the TNBC patients. (cttjournal.com)
  • T lymphocytes and cytokines are believed to cause the characteristic inflammatory changes appreciated on histopathologic examination of lesions. (medscape.com)
  • Les numérations plaquettaire et leucocytaire ainsi que la concentration en cytokines (IL-2R, IL-8 et TNF-) ont été me- surées. (who.int)
  • NK1.1 (Killer cell lectin-like receptor subfamily B, member 1, KLRB1, NKR-P1A, CD161, cluster of differentiation 161), refers to Natural Killer (NK) cells, lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. (thermofisher.com)
  • Besides CD19 + CD138 − B cells, plasmablasts, and plasma cells were enriched in the tongue of mice colonized with C. albicans suggesting a potential role of B lymphocytes during oral fungal colonization. (frontiersin.org)
  • To investigate this possibility we isolated lymphocytes from the brain and spinal cord of clinically healthy 4 well perfused MBP TCR1 transgenic mice on the Rag+/+ background. (mdm2-inhibitors.com)
  • Lymphocytes from individual animals were analyzed to avoid mixing cells from any mice that had preclinical spontaneous EAE with cells from healthy mice. (mdm2-inhibitors.com)
  • 1982, studies demonstrated that intravenous immune lymphocytes could treat bulky subcutaneous FBL3 lymphomas. (wikipedia.org)
  • NK cells contribute to cancer immune surveillance not only by their direct natural cytotoxicity which is triggered rapidly upon stimulation through germline-encoded cell surface receptors, but also by modulating T-cell mediated antitumor immune responses through maintaining the quality of dendritic cells and enhancing the presentation of tumor antigens. (frontiersin.org)
  • We therefore postulated that SP and its receptors are actively involved in HIV contamination of human immune cells such as MDM. (opioid-receptors.com)
  • The mixed lymphocyte reaction (MLR) assay typically involves co-incubation of immune cell subtypes to trigger their activation. (biocytogen.com)
  • Maraviroc tablet is a CCR5 co-receptor antagonist indicated in combination with other antiretroviral agents for the treatment of only CCR5-tropic HIV-1 infection in adults and pediatric patients 2 years of age and older weighing at least 10 kg. (drugs.com)
  • Flumazenil Injection, USP is a benzodiazepine receptor antagonist. (nih.gov)
  • The anti-inflammatory activity of AM is attributed to numerous mediators, including interleukin (IL)-1 receptor antagonist, IL-10, activin, inhibin, and inter-α-trypsin inhibitor. (touchophthalmology.com)
  • Herpes simplex virus thymidine kinase (HSV-tk) is a well-established suicide gene that has been successfully used to control GvHD following donor lymphocyte infusions (DLI) after allogeneic stem cell transplantation. (haematologica.org)
  • In autologous cancer immunotherapy, T cells are extracted from the patient, genetically modified and cultured in vitro and returned to the same patient. (wikipedia.org)
  • 3 Autologous lymphocytes genetically modified with the TCR for MART-1/Melan-A have been adoptively transferred to patients with advanced melanoma. (haematologica.org)
  • Loosely adherent cells (LAM) were obtained after an overnight incubation on plastic culture dishes of initially adherent mononuclear cells. (elsevierpure.com)
  • Enrichment for Fc receptor negative or for nonphagocytic cells further enhanced the MLR-stimulating capacity of LAM. (elsevierpure.com)
  • Attempts to use T cells to treat transplanted murine tumors required cultivating and manipulating T cells in culture. (wikipedia.org)
  • A novel retrovirus, human T -celllymphomaleukemia virus (HTLV), has been isolated from the fresh and cultured cells of two of these patients. (science-connections.com)
  • Subsequent characterization of this virus has shown that it is not significantly related to any known animal retrovirus, is not an endogenous (genetically transmitted) virus of man, and so far has been associated only with fresh or cultured T -cells from patients with T -cell neoplasia. (science-connections.com)
  • 1975) have required the establishment of continuously growing cell lines from the disease of origin or cocultivation of these cells with previously established cell lines, the ability to grow malignant T -cells in long-term culture could facilitate the isolation of retroviruses from these diseased states. (science-connections.com)
  • Although there are many immunologic and cytochemical differences between mature hu man T- and B-Iymphocytes, human T -cells are primarily distinguished by their participation in cell mediated immunity and possession of receptors for sheep red blood cells. (science-connections.com)
  • The elaboration of immunoglobulins and presence of receptors for EBV are most characteristic of human B-cells. (science-connections.com)
  • Finally, natural CD25(+) Treg cells inhibited the production of interleukin (IL)-2, interferon-gamma, IL-5, and IL-13 in mixed lymphocyte culture in a dose-dependent manner. (ox.ac.uk)
  • 1 In humans, glucocorticoid receptors have been shown in many different cells, including those of the granulocyte-macrophage lineage and lympho cytes. (bmj.com)
  • For erythroid colony forming unit (CFU-E) quantification, we used 2000 cells/ml, while for erythroid burst forming units (BFU-E), colony forming units mix (CFU-mix), and granulocyte-macrophage colony-forming unit's (CFU-GM), we used 7000 cells/ml. (bmj.com)
  • After colony enumeration, BFU-E and CFU-mix plates were washed and total cells counted using a cell analyser (Coulter Electronics, Inc., Chicago, IL). (bmj.com)
  • Sigma-Aldrich) was added after 48 h of culture and cells were harvested 12-16 h later. (mdm2-inhibitors.com)
  • The stromal cell requirement for androgen-mediated effects was confirmed in vivo by experiments using chimeric animals created by bone marrow transplantation in which androgen receptor expression was restricted to either the stromal or lymphoid cells of the bone marrow. (jci.org)
  • These experiments suggest that effects of androgens on developing B cells are mediated through androgen receptors in bone marrow stromal cells. (jci.org)
  • The levels of three other non-major histocompatibility complex (MHC) antigens, including the trypsin-resistant Fc receptor, were similar in cells exposed to both sources of LK. (rockefeller.edu)
  • Interactions of HLA-C with killer immunoglobulin-like receptors (KIR) on natural killer cells or natural killer T cells can be deregulated by streptococcal infection. (medscape.com)
  • EBV-transformed B cells (EBV-LCL) were cultured in IMDM (Cambrex, Verviers, Belgium) with 10% Fetal Bovine Serum (FBS). (haematologica.org)
  • The transferrin receptor is essential for iron transport into proliferating cells, such as mitogen-activated and alloantigen-activated lymphoblasts. (nordicmubio.com)
  • The transferrin receptor is also present on early erythroid cells but is lost as reticulocytes differentiate into mature erythrocytes. (nordicmubio.com)
  • Natural killer cells activated in a human mixed lymphocyte response culture identified by expression of Leu-11 and class II histocompatibility antigens. (nordicmubio.com)
  • We typically use 1 × 10^6 cells in a 100-µl experimental sample (a test). (bdbiosciences.com)
  • The results that we report here provide rationale and practical platform for clinical testing of expanded and activated NK cells for cell therapy of cancer. (aacrjournals.org)
  • This study tested the hypothesis that double overexpression of miR-19a & miR-20a (dOex-mIRs) in human induced pluripotent stem cell (iPS)-derived mesenchymal stem cells (MSCs) effectively preserved left-ventricular-ejection-fraction (LVEF) in dilated cardiomyopathy (DCM) (i.e., induced by doxorubicin) rat. (researchsquare.com)
  • The following were grown in 75 cm 2 tissue culture treated flasks: BT-474 cells (DMEM+10% FCS), HT1080 cells (F12K+10% FCS, 1% glutamax, 1 u/mL pen/strep), Jurkat and Raji cells (both RPMI 1640+10% FCS). (news-medical.net)
  • Mesenchymal stem cells (MSCs) are adult multipotent cells that were initially isolated from bone marrow[ 1 ] and characterized by the fibroblast-like appearance in culture and the capacities to form bone, adipose and cartilage. (biomedcentral.com)
  • Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. (thermofisher.com)
  • Diagnosis is by detecting lymphopenia, absence or a very low number of T cells, and impaired lymphocyte proliferative responses to mitogens. (msdmanuals.com)
  • The effects of DP on the clonal growth of erythroid and granulocyte-macrophage progenitors were investigated using clonogenic assays according to procedures previously tested in our laboratory. (bmj.com)
  • cAMP Build up Inhibition Assay These assays had been performed with SCH-527123 (Navarixin) adenosine receptors transfected utilizing a cAMP enzyme immunoassay package (Amersham Biosciences). (nanoker-society.org)
  • We have a dedicated team that provides support for ex vivo pharmacodynamic (PD) and pharmacokinetic (PK) studies, and in vitro primary and cultured cell-based assays. (biocytogen.com)
  • Description of T cell growth factor interleukin-2 (IL-2) in 1976 allowed T lymphocytes to be grown in vitro, often without loss of effector functions. (wikipedia.org)
  • We employed in vitro cultures and two in vivo models to investigate whether androgens exert these effects directly on marrow lymphoid precursors or whether actions on marrow stromal elements are required. (jci.org)
  • This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. (nordicmubio.com)
  • These reagents allow a generic single-step, no-wash, labeling protocol for the whole range of isotype matched, Fc-containing test antibodies. (news-medical.net)
  • LK-induced Ia-bearing Mphi were tested as primary mixed leukocyte reaction stimulators. (rockefeller.edu)
  • We undertook this study to investigate receptor (IL-2R) accumulation is related to whether the cytokine accumulation in PCs the leukocyte content of the platelet comc obtained from single apheresis donors was ponent and can be reduced by prestorage beyond the acceptable limits of WBC conc leukocyte depletion [ 3 ]. (who.int)
  • For testing human soluble CTLA-4 in serum, plasma or cell culture supernatant, LEGEND MAX™ Human Soluble CTLA-4 ELISA Kit with Pre-coated Plates (Cat. (biolegend.com)
  • Synergistic activation of estrogen receptor with combinations of environmental chemicals. (cdc.gov)
  • METHODS: We compared survival times of male CBA/Ca skin grafts in female CBA/Ca recipients expressing a transgenic anti-HY T-cell receptor on a RAG-1(+/+) (A1[M]RAG+) or a RAG-1(-/-) (A1[M]RAG-) background. (ox.ac.uk)
  • 5 - 8 A drawback of TCR gene therapy is the formation of mixed TCR dimers, consisting of transgenic and endogenous TCR α and β chains. (haematologica.org)
  • pH 7.4) and preincubated with assay medium containing 30 M rolipram and test compounds at 37C for quarter-hour. (nanoker-society.org)
  • Prior to initiation of maraviroc tablets for treatment of HIV-1 infection, test all patients for CCR5 tropism using a highly sensitive tropism assay. (drugs.com)
  • Its effects are mediated through specific glucocorticoid receptors. (bmj.com)
  • Diurnal enhancement of pain hypersensitivity is mediated by glucocorticoid-induced enhancement of the extracellular release of ATP in the spinal cord, which stimulates purinergic receptors on microglia in the dorsal horn. (nature.com)
  • Temporal elevations in glucocorticoid levels enhance the extracellular release of ATP in the spinal cord, which stimulates purinergic receptors on microglia in the dorsal horn. (nature.com)
  • Introduction tions of T-cell derived IL-2R are increased in mixed lymphocyte cultures. (who.int)
  • Every cell line was supplied by ATCC with culture reagents sourced from Life Technologies. (news-medical.net)
  • This review summarizes the published findings on the efficacy of MZB for renal disease including IgA nephropathy, lupus nephritis, and NS, as well as of oral MZB pulse therapy for severe lupus nephritis and NS, and also the mechanism of the effect of oral MZB pulse therapy on the lymphocyte cell cycle. (hindawi.com)
  • They are generally considered factors that are expressed by one cell and are responded to by receptors on another nearby cell. (curehunter.com)
  • The focus of Dr. Berg's work is on the signaling proteins and pathways regulating T lymphocyte development, differentiation, activation, and migration, with a strong emphasis on T-cell receptor (TCR) signaling. (cuanschutz.edu)
  • The positive predictive value for recovery of virus in cell culture was 56.7% for BinaxNOW-positive and 35.4% for rRT-PCR-positive specimens. (cdc.gov)
  • Cell culture isolation of SARS-CoV-2 is possible, but the Centers for Disease Control and Prevention (CDC) recommends that clinical laboratories not attempt this unless it is performed in a biosafety level 3 (BSL-3)-certified laboratory. (medscape.com)
  • PCR was performed to detect the expression of the protease-activated receptors (PARs) in MSCs. (biomedcentral.com)
  • Thrombin treatment enhanced MSCs to express FN at mRNA and protein levels and promoted FN secretion by MSCs, accompanied by potent adherence to the culture plastic. (biomedcentral.com)
  • MSCs increased the secretion of IL-10 and IL-6 from stimulated co-cultures and decreased TNF-α secretion. (bvsalud.org)
  • Transferrin receptor on endothelium of brain capillaries. (nordicmubio.com)
  • Can the disease process be related to a molecular defect such as a defect in an enzyme pathway, structural protein, or molecular receptor? (vin.com)
  • We observed a strong and dose-dependent activation of AhR receptor upon MaaT03X conditioned medium treatment. (bmj.com)
  • Clinicians should not refer patients to CDC to find out where or how to get tested for COVID-19 or how to get COVID-19 test results. (cdc.gov)
  • Not recommended in patients with dual/mixed- or CXCR4-tropic HIV-1. (drugs.com)
  • We investigated the use of human CD20 as suicide gene in T-lymphocytes. (haematologica.org)
  • NKR-P1A, the receptor encoded by the KLRB1 gene, recognizes Lectin Like Transcript-1 (LLT1) as a functional ligand. (thermofisher.com)
  • It results from a mutation in the IL-2 receptor gamma gene ( IL-2RG ). (msdmanuals.com)
  • CD71 is specific for the human transferrin receptor, MW 190 kdaltons (kDa), 90 kDa reduced. (nordicmubio.com)
  • Syngeneic lymphocytes were transferred from rodents heavily immunized against the tumor to inhibit growth of small established tumors, becoming the first example of ACT. (wikipedia.org)
  • HIV-1 Vif appears to be required in the course of the late levels of virus manufacturing for the suppression of an innate antiviral phenotype that resides in human T lymphocytes . (hoxyl.pl)
  • This clone has been tested in-house and determined to not be suitable for applications in immunohistochemistry of frozen or paraffin-embedded tissue sections (IHC-F or IHC-P). (biolegend.com)
  • Although the AM is not sterilized during its processing, the tissue undergoes microbiological testing prior to its release. (touchophthalmology.com)
  • We evaluated the performance of self-collected anterior nasal swab (ANS) and saliva samples compared with healthcare worker-collected nasopharyngeal swab specimens used to test for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). (cdc.gov)
  • Because the signs and symptoms of coronavirus disease 2019 (COVID-19) may overlap with those of other respiratory pathogens, it is important to perform laboratory testing to specifically identify symptomatic individuals infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). (medscape.com)
  • While many mixed breed dogs have a significantly lower degree of inbreeding, many populations such as local stray cat populations may actually have a higher than expected degree of inbreeding. (vin.com)
  • However, dominant disease and polygenetic diseases may be just as likely to be seen in mixed breed populations as they are in more inbred populations depending upon the disease and the population. (vin.com)
  • Specimens positive by either test were analyzed by viral culture. (cdc.gov)
  • ADCC, ADCP (1, 2, 3)), as well as for driving the internalization of receptors linked to tumor survival (e.g. (news-medical.net)
  • 1994. Ah receptor in embryonic mouse palate and effects of TCDD on receptor expression. (cdc.gov)
  • MaaT Pharma, a clinical-stage biotech pioneer in the development of Microbiome Ecosystem Therapies TM (MET) in oncology, has developed a unique, ground-breaking, patented pooled co-culture process (MET-C). This technology allows to replicate and leverage, at large industrial scale, the diversity of native-based microbiome ecosystems while tuning the resulting product according to indication-specific compositions. (bmj.com)
  • With any type of laboratory test, the clinical accuracy or reliability depends on performance characteristics such as sensitivity and specificity, as well as the pretest probability that a person has SARS-CoV-2 infection and the prevalence of COVID-19 in the local community. (medscape.com)
  • Comparisons (Student's t test) were made between control (no DP added) plates and those with DP added. (bmj.com)
  • The Student's test was used for a comparison of the means between sample groups. (mdm2-inhibitors.com)
  • sCTLA-4 immunoreactivity was inhibited by its binding to B7.1, suggesting that sCTLA-4 is a functional receptor. (biolegend.com)