Estrogen and progesteroneAnti-Progesterone ReceptorSteroid-receptorGeneMembrane ComponentHer2ProteinHormonalNormal progesteroneTumor receptor statusNuclearSelectiveStromal cellsHumansSubtypesPGRMC1AndrogenOestrogenMonoclonalUterusAffinityHormone receptor statusSubstancesPolymorphismOvariectomyExpressionPrognosticHumanNeuronsAntagonistsDeciduaPhysiologicalProteinsStatusDimerizationSignalingInhibitionInduceOutcomesSignificanceBreast cancersPostmenopausalCancersSurvivalPathway
Estrogen and progesterone5
- ER/PR tests look for receptors that attach to the hormones estrogen and progesterone in a sample of breast cancer tissue. (medlineplus.gov)
- Estrogen and progesterone play key roles in a woman's sexual development and reproductive functions. (medlineplus.gov)
- The negative and positive feedback actions of estrogen and progesterone on the hypothalamus may be mediated in part by the endogenous opiate system. (illinois.edu)
- Estrogen and progesterone suppress physiological responses to the administration of opiate peptides. (illinois.edu)
- this may be in part because they have a higher rate of triple-negative breast cancer (negative for estrogen and progesterone receptors and human epidermal growth factor receptor [HER2] oncogene), which has a poorer prognosis than other types. (msdmanuals.com)
Anti-Progesterone Receptor3
- Western blot using anti-Progesterone Receptor antibody 14B3 (Ab03318). (absoluteantibody.com)
- Immunofluorescence staining of MCF7 cells with anti-Progesterone Receptor antibody 14B3 (Ab03318). (absoluteantibody.com)
- Flow cytometry using anti-Progesterone Receptor antibody 14B3 (Ab03318). (absoluteantibody.com)
Steroid-receptor2
- This segment is not present in the receptor-A. As demonstrated in progesterone receptor-deficient mice, the physiological effects of progesterone depend completely on the presence of the human progesterone receptor (hPR), a member of the steroid-receptor superfamily of nuclear receptors. (wikipedia.org)
- Thus, in amphibians, it has been assumed for a long time, that the actinomycin D-insensitive progesterone-induced oocyte maturation [ 4 ] was mediated by a membrane steroid receptor rather than a nuclear receptor. (biomedcentral.com)
Gene8
- Several studies have now shown no association between progesterone receptor gene +331G/A polymorphisms and breast or endometrial cancers. (wikipedia.org)
- A key hormone receptor evolved quickly as or early humans migrated from Africa, producing localized gene changes that may affect modern women's risk of preterm birth, according to a Stanford-led study. (stanford.edu)
- The researchers found that East Asian populations have one version of the progesterone receptor gene that appears to protect them against giving birth prematurely, whereas other populations with European or African ancestry have a higher prematurity risk and other versions of this gene. (stanford.edu)
- The variations in the progesterone receptor gene - consisting of single nucleotide polymorphisms, or one-letter changes in the genetic code - were found in regions of the gene that regulate when it is switched on and off. (stanford.edu)
- The recent cloning and sequencing of a gene coding for a membranous progesterone receptor [ 5 ] in African clawed frog ( Xenopus laevis ) brought evidence for the existence of both intracellular and membrane progestin receptors [ 6 ]. (biomedcentral.com)
- The progesterone receptor gene (PROGINS) has been identified as a risk modifier for benign and malignant gynecological diseases. (unifesp.br)
- The mechanisms whereby progesterone (P 4 ), acting via the progesterone receptor (PR), inhibits proinflammatory/contractile gene expression during pregnancy are incompletely defined. (elsevierpure.com)
- They also express the immediate early gene c-FOS, a molecular marker indicative of intense neural activation, at the time of the OVX+E±progesterone-evoked LH surge. (jneurosci.org)
Membrane Component1
- Progesterone receptor membrane component 1 (PGRMC1) contains a cytochrome b5 domain fold and belongs to the so-called membrane-associated progesterone receptor (MAPR) protein family that is widespread in eukaryotes. (edu.au)
Her24
- Co-administering Melatonin With an Estradiol-Progesterone Menopausal Hormone Therapy Represses Mammary Cancer Development in a Mouse Model of HER2-Positive Breast Cancer. (melatoninfacts.org)
- Several prognostic models have been reported, and some variables including node status, residual tumor size, Ki-67, hormonal receptor and human epidermal growth factor receptor-2 (HER2) have been shown to be potentially prognostic [ 3 ]. (oncotarget.com)
- MammaPrint/BluePrint subtyping classified patients into four molecular subgroups: Luminal A, Luminal B, HER2 (human epidermal growth factor receptor 2), and Basal type. (nih.gov)
- 08/14/23 gen, progesterone hormone receptors, and human epidermal growth factor receptor 2 (HER2). (bvsalud.org)
Protein3
- The progesterone receptor (PR), also known as NR3C3 or nuclear receptor subfamily 3, group C, member 3, is a protein found inside cells. (wikipedia.org)
- Its receptor, a protein expressed in tissues such as the uterus, ovary and cervix, binds to the hormone and sends signals that keep pregnant women from going into labor too soon. (stanford.edu)
- PR is a protein molecule, a cellular core receptor belonging to a steroidal superfamily, which can be bonded to the corresponding hormone to form a hormone-receptor complex, enabling hormones to exert their biological effects. (absoluteantibody.com)
Hormonal2
- We investigated the effect of ovariectomy (OVX) and hormonal treatment for 10 weeks by estradiol and progesterone on muscarinic M 4 receptor subtype in different brain areas of female rats. (uaeu.ac.ae)
- This type happens when the cancer cells don't have the right hormonal receptors. (webmd.com)
Normal progesterone1
- We also found that SRC-3 depletion in cultured HESCs results in a significant attenuation in the induction of a wide-range of established biomarkers of decidualization, despite exposure of these cells to a deciduogenic stimulus and normal progesterone receptor expression. (frontiersin.org)
Tumor receptor status2
- Breast cancer is subdivided into categories based on the tumor receptor status. (cancer-research-network.com)
- Mixture analysis using principal components suggested co-exposures to multiple airborne heavy metals may drive associations with tumor receptor status. (cdc.gov)
Nuclear2
- The DNA binding domain (DBD) of nuclear hormone receptors contains a highly conserved globular domain and a less conserved carboxyl-terminal extension (CTE). (nih.gov)
- Despite previous observations that the CTEs of some classes of nuclear receptors are structured and interact with DNA outside of the hexanucleotide hormone response element (HRE), there has been no evidence for such a CTE among the steroid receptors. (nih.gov)
Selective5
- Selective ablation of PR-A in a mouse model, resulting in exclusive production of PR-B, unexpectedly revealed that PR-B contributes to, rather than inhibits, epithelial cell proliferation both in response to estrogen alone and in the presence of progesterone and estrogen. (wikipedia.org)
- As progesterone is known to play a key role in promoting myoma growth, the goal of the study was to analyze the efficacy of selective progesterone receptor modulators (SPRMs). (minervamedica.it)
- Donnez J, Donnez O, Courtoy GE, Dolmans MM. The place of selective progesterone receptor modulators in myoma therapy. (minervamedica.it)
- Receptor quantification in the hippocampus, frontal cortex, parietal cortex, amygdala and hypothalamus was done by receptor autoradiography using a selective ligand for muscarinic M 4 receptors. (uaeu.ac.ae)
- Receptor quantification in the hippocampus, frontal cortex, parietal cortex, amygdala and hypothalamus was done by receptor autoradiography using a selective ligand for muscarinic M4 receptors. (uaeu.ac.ae)
Stromal cells1
- Using primary cultures, we show that modest levels of reactive oxygen species (ROS) increase sumoylation in human endometrial stromal cells (HESCs), leading to enhanced modification and transcriptional inhibition of the progesterone receptor (PR). (warwick.ac.uk)
Humans2
- Humans have unexpectedly high genetic variation in the receptor for a key pregnancy-maintaining hormone, according to research led by scientists at the Stanford University School of Medicine . (stanford.edu)
- Kisspeptin and its receptor GPR54 have recently been identified as key signaling partners in the neural control of fertility in animal models and humans. (jneurosci.org)
Subtypes1
- The pattern of the association was quite homogeneous by BC subtypes based on hormone receptor status. (springer.com)
PGRMC11
- Ironically, despite being the archetypal member of the MAPR family, it has yet to be demonstrated that PGRMC1 exhibits specific progesterone binding. (edu.au)
Androgen2
Oestrogen1
- When analysing separately subgroups, according to the oestrogen receptor (ER) status both approaches could predict clinical outcome more easily for the ER-positive than for the ER-negative cohort. (lu.se)
Monoclonal1
- Recombinant monoclonal antibody to Progesterone Receptor. (absoluteantibody.com)
Uterus1
- Progesterone acts on the UTERUS, the MAMMARY G. (targetmol.com)
Affinity2
- These results, taken together, support the notion that sequences outside of the HREs influence the DNA binding affinity and specificity of steroid receptors. (nih.gov)
- 1991. Effects of polychlorinated biphenyls with Ah receptor affinity on lymphoid development in the thymus and the bursa of Fabricius on chick embryos in ovo and in mouse thymus anlagen in vitro . (cdc.gov)
Hormone receptor status3
- Test results are frequently referred to as the hormone receptor status. (medlineplus.gov)
- If your hormone receptor status shows you have one or both of these receptors on your cancer cells, you may respond well to certain types of treatments. (medlineplus.gov)
- Knowing your hormone receptor status will help your health care provider decide how to treat it. (medlineplus.gov)
Substances1
- Receptors are proteins that attach to certain substances. (medlineplus.gov)
Polymorphism1
- BACKGROUND: The single-nucleotide polymorphism (SNP) 5p12-rs10941679 has been found to be associated with risk of breast cancer, particularly estrogen receptor (ER)-positive disease. (ox.ac.uk)
Ovariectomy2
- Ovariectomy up-regulated M 4 receptors in the dentate gyrus, CA1, CA3, frontal cortex and hypothalamus whereas the estrogen treatment restored M 4 binding to that of the sham group. (uaeu.ac.ae)
- Progesterone treatment had no effect on the ovariectomy-induced up-regulation of M 4 receptors. (uaeu.ac.ae)
Expression2
- In addition, we show that both mPR beta and PGMRC1, two members of distinct membrane-bound progestin receptor classes, exhibit highly similar ovarian expression profiles during the reproductive cycle with maximum levels during vitellogenesis and a down-expression during late vitellogenesis. (biomedcentral.com)
- 1994. Ah receptor in embryonic mouse palate and effects of TCDD on receptor expression. (cdc.gov)
Prognostic1
- Background: Estrogen receptor (ER) status and progesterone receptor (PgR) status are strong prognostic and predictive markers in breast carcinomas. (mindunwindart.com)
Human3
- Previous studies have implicated receptor tyrosine kinases in progesterone-induced [Ca2+]i signalling, and consequent induction of the acrosome reaction, in human spermatozoa. (dundee.ac.uk)
- Orthologous to human FZD4 (frizzled class receptor 4). (nih.gov)
- 1999. Transactivation activity of human, zebrafish, and rainbow trout aryl hydrocarbon receptors expressed in COS-7 cells: Greater insight into species differences in toxic potency of polychlorinated dibenzo- p -dioxin, dibenzofuran, and biphenyl congeners. (cdc.gov)
Neurons3
- The mechanism of the WNT5A and FZD4 receptor mediated WNT/β-catenin pathway in the degeneration of ALS spinal cord motor neurons. (nih.gov)
- Dual-label immunocytochemistry experiments showed that 40-60% of kisspeptin neurons in the rostral periventricular area of the third ventricle (RP3V) expressed estrogen receptor α and progesterone receptors. (jneurosci.org)
- First, we set out to determine whether kisspeptin neurons in mice expressed the appropriate receptors required for gonadal steroid positive feedback, and whether they were activated at the time of the LH surge, as had been found previously in the rat. (jneurosci.org)
Antagonists1
- Progesterone antagonists prevent the structural reconfiguration. (wikipedia.org)
Decidua1
- Survival of the conceptus is dependent on continuous progesterone signaling in the maternal decidua but how this is achieved under conditions of oxidative stress that characterize early pregnancy is unknown. (warwick.ac.uk)
Physiological1
- This steroid induced suppression of opiate receptors appears to have important physiological repercussions and provides a basis for the steroid-induced differential sensitivity to exogenous opiates that has been observed previously. (illinois.edu)
Proteins1
- Assessment of tyrosine phosphorylation of two sperm proteins (p105/81) showed greatly increased levels of phosphotyrosine in response to capacitation but a negligible increase in response to progesterone stimulation. (dundee.ac.uk)
Status4
- The Progesterone Receptor (PR) status obtained from a PATIENT with breast cancer during a Breast Cancer Care Spell. (datadictionary.nhs.uk)
- BREAST PROGESTERONE RECEPTOR STATUS is the same as attribute BREAST PROGESTERONE RECEPTOR STATUS . (datadictionary.nhs.uk)
- receptor status. (mindunwindart.com)
- Race-specific case proportions and incidence rates based on estrogen receptor (ER) status and histologic grade were estimated. (cdc.gov)
Dimerization1
- After progesterone binds to the receptor, restructuring with dimerization follows and the complex enters the nucleus and binds to DNA. (wikipedia.org)
Signaling1
- Thus, JNK silencing uncouples ROS signaling from the SUMO conjugation pathway and maintains progesterone responses and cellular homeostasis in decidual cells under oxidative stress conditions imposed by pregnancy. (warwick.ac.uk)
Inhibition1
- Previous reports of modulation of the progesterone-induced [Ca2+]i signal by tyrosine kinase inhibition probably reflect inhibition of the acrosome reaction. (dundee.ac.uk)
Induce1
- The PR-B is the positive regulator of the effects of progesterone, while PR-A serve to antagonize the effects of PR-B. Progesterone is necessary to induce activation of the progesterone receptors. (wikipedia.org)
Outcomes1
- 1999. Adverse reproductive outcomes in the transgenic Ah receptor-deficient mouse. (cdc.gov)
Significance2
- It is currently unknown which if any polymorphisms in this receptor are of significance to cancer. (wikipedia.org)
- The effect of estrogen on the hippocampal muscarinic M 4 receptor subtype is a novel finding and may have functional significance for cholinergic receptors especially in relation to postmenopausal memory problems and neurodegenerative disease like Alzheimer's disease. (uaeu.ac.ae)
Breast cancers2
- About 70 percent of all breast cancers in women have receptors that attach to estrogen and/or progesterone. (medlineplus.gov)
- About 80 percent to 90 percent of breast cancers in men have these receptors. (medlineplus.gov)
Postmenopausal1
- Biocon Biologics Ltd), BT-ON014 - in combination with docetaxel for the treatment of those patients who have not received chemotherapy for their metastatic disease - in combination with an aromatase inhibitor for the treatment of postmenopausal patients with hormone-receptor positive MBC, not previously treated with trastuzumab. (who.int)
Cancers1
- Cancers that have one or both types of these receptors. (medlineplus.gov)
Survival1
- Progesterone receptor loss identifies luminal-type local advanced breast cancer with poor survival in patients who fail to achieve a pathological complete. (oncotarget.com)
Pathway1
- clarification needed] During rodent perinatal life, progesterone receptor (PR) is known to be transiently expressed in both the ventral tegmental area (VTA) and the medial prefrontal cortex (mPFC) of the mesocortical dopaminergic pathway. (wikipedia.org)