Receptor ligand genes t cell receptor alpha. Medical search. Frequent questions

Microfilaments, microtubules, and intermediate filaments serve as the cytoskeleton of the cell and form a complex network by interacting with cytoskeleton-associated proteins. (doria.fi)
This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. (cancerindex.org)
The effects of POP inhibition and knockdown on the proliferation of cultured human estrogen receptor-positive (ER+) MCF7 and T47D, and ER-negative (ER-) MDA-MB-231 breast cancer cell lines and the MCF12A non-tumorigenic epithelial cell line were tested by analyzing their influence on cell proliferation (WST-1 assay), cell viability (trypan blue exclusion assay), and cell cycle arrest (cell cycle analysis, cell cycle regulator proteins expression). (cancerindex.org)
There are 70993 Int_alpha domains in 14903 proteins in SMART's nrdb database. (embl.de)
Taxonomic distribution of proteins containing Int_alpha domain. (embl.de)
The complete taxonomic breakdown of all proteins with Int_alpha domain is also avaliable . (embl.de)
Click on the protein counts, or double click on taxonomic names to display all proteins containing Int_alpha domain in the selected taxonomic class. (embl.de)
These AKT proteins therefore regulate a wide variety of cellular functions including cell proliferation, survival, metabolism, and angiogenesis in both normal and malignant cells. (senescence.info)
AKT proteins are recruited to the cell membrane by phosphatidylinositol 3,4,5-trisphosphate (PIP3) after phosphorylation of phosphatidylinositol 4,5-bisphosphate (PIP2) by PI3K. (senescence.info)
In particular, ESRR alpha (ESRRa) and ESRR gamma (ESRRg) are key metabolic regulators of energy homeostasis and abnormal functions of these proteins are linked to metabolic syndromes including diabetes and fatty liver disease 5 . (nature.com)
There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. (nih.gov)
Fibroblast Growth Factors (FGFs) comprise a family of at least eighteen structurally realted proteins that are involved in a multitude of physiological and pathological cellular processes, including cell growth, differentation, angiogenesis, wound healing and tumorgenesis. (prospecbio.com)
Also, SPR and virtual screening techniques utilized in this study may potentially be applied to other peptide-drug screening processes against membrane receptor proteins. (phoenixpeptide.com)
Interferon-alpha (IFN-alpha), also known as leukocyte interferon, represents a group of related but distinct proteins that share over 95% amino acid sequence homology. (rndsystems.com)
Interferons (IFNs) are natural proteins produced by the cells of the immune system of most vertebrates in response to challenges by foreign agents such as viruses , parasites and tumor cells. (wikidoc.org)
Your P1 proteins seemed to be EPZ015938 cell line essentially the most dominant within P2, despite the fact that added proteins of 6-7 KDa had been in addition well known. (kspinhibitors.com)
Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. (arigobio.cn)
Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. (arigobio.cn)
Chimeric antigen receptors (CAR) recognize specific proteins on the surface of tumor cells. (msdmanuals.com)
In contrast to TCR T cells, CAR T cells recognize only relatively large proteins on the surface of tumor cells. (msdmanuals.com)

They are members of the type I interferon family which share a common cell surface receptor composed of two subunits, a 100 kDa ligand-binding subunit (IFN-alpha R2) and a 125 kDa ligand binding and signal transduction subunit (IFN-alpha R1) that is involved both in ligand binding and signal transduction. (rndsystems.com)
Inclusion of IFN-gamma RII increases the binding affinity for ligand and the efficiency of signal transduction. (rndsystems.com)
In preparation to apply various toxicants to the developed in vitro human neuronal stem cells, the team has characterized a number of PCB's and PAH compounds for their ability to (a) induce various signal transduction mechanisms and (b) inhibit gap junctional intercellular communication regulating cell proliferation, differentiation, and apoptosis. (nih.gov)
MW) chemicals interact with host cells and molecules and In our daily life, we are confronted with a plethora of natural influence biologic processes such as signal transduction. (cdc.gov)

To understand the functional interactions between the TrkA and p75 nerve growth factor (NGF) receptors, we stably transfected LAN5 neuroblastoma cells with an expression vector for ET-R, a chimeric receptor with the extracellular domain of the epidermal growth factor receptor (EGFR), and the TrkA transmembrane and intracellular domains. (umassmed.edu)

Activation of the peroxisome proliferator-activated receptor alpha (PPAR alpha) modulates lipid and glucose homeostasis, cell proliferation and differentiation, and inflammation. (cdc.gov)
Mounting experimental animal evidence suggests PPAR alpha independence of some immune effects. (cdc.gov)
This evidence originates primarily from studies with PPAR alpha knockout models exposed to PFOA that demonstrate hepatic peroxisome proliferation, reduced lymphoid organ weights, and altered antibody synthesis. (cdc.gov)
As human PPAR alpha expression is significantly less than that of rodents, potential PPAR alpha independence indicates that future research must explore mechanisms of action of these compounds, including PPAR alpha-dependent and -independent pathways. (cdc.gov)
This multiauthored review contains brief descriptions of current and recently published work exploring immunomodulation by PFOA and PFOS, as well as a short overview of other PPAR alpha ligands of therapeutic and environmental interest. (cdc.gov)
We show that the human CYP27 gene is under coupled regulation by retinoids and ligands of PPARs via a PPAR-retinoic acid receptor response element in its promoter. (nih.gov)
Here we report that antidiabetic thiazolidinediones (TZDs) and other ligands for the nuclear receptor PPARγ dramatically upregulate oxidized LDL receptor 1 (OLR1) in adipocytes by facilitating the exchange of coactivators for corepressors on the OLR1 gene in cultured mouse adipocytes. (jci.org)
OLR1 expression in white adipose tissue is increased in obesity and is further induced by PPARγ ligand treatment in vivo. (jci.org)
These data identify OLR1 as a novel PPARγ target gene in adipocytes. (jci.org)
While the physiological role of adipose tissue in cholesterol and oxLDL metabolism remains to be established, the induction of OLR1 is a potential means by which PPARγ ligands regulate lipid metabolism and insulin sensitivity in adipocytes. (jci.org)
Peroxisomal proliferator activator receptor alpha (PPARα) is a ligand-activated transcription factor that plays a major role in the regulation of lipid metabolism. (wur.nl)
Gene expression studies performed on PPARα null mice have shed light into a variety of genes regulated by PPARα. (wur.nl)
A comprehensive understanding of the physiological and molecular function of PPARα target genes is needed for the accurate development of therapeutical strategies. (wur.nl)
The research contained in this thesis first sought to improve our current knowledge on the transcriptional regulation by peroxisome proliferator-activated receptors (PPAR)-α activation on human liver in vivo using a novel humanized-liver mouse model. (wur.nl)
Then, we pursued to expand our understanding on the physiological and molecular function of two PPARα target genes, Hilpda and Slc25a47. (wur.nl)
The role of PPARα in gene regulation in mouse liver is well characterized. (wur.nl)
Model systems to study PPARα in human liver vary from hepatoma cell lines, human primary hepatocytes, human precision cut liver slices, and mice expressing human PPARα. (wur.nl)
A novel model to study in vivo PPARα activation in human liver is a chimeric mouse carrying human liver cells. (wur.nl)
Our results support the major role of PPARα in regulating hepatic lipid metabolism, highlight the more modest effect of PPARα activation on gene regulation in human liver compared to mouse liver, and indicate that PPARα may have a suppressive effect on DNA synthesis in human liver. (wur.nl)
This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. (caslab.com)
This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. (caslab.com)
Theca cells are the sole ovarian site of synthesis of DHEA, which is both a precursor of androstenedione and an essential ligand for peroxisome proliferator-activated receptor alpha (PPARα), the key promoter of genes affecting fatty acid metabolism and fat transport and genes critical to mitochondrial function. (biomedcentral.com)

Proliferation of breast cancer cells directed by constrained ligands is associated with DNA binding, coactivator recruitment and activation of the estrogen-induced gene GREB1, reflecting a highly interconnected signaling network. (rcsb.org)
In contrast, proliferation driven by dynamic ligands is associated with induction of ERα-mediated transcription in a DNA-binding domain (DBD)-dependent manner. (rcsb.org)
The prolyl oligopeptidase inhibitor SUAM-14746 attenuates the proliferation of human breast cancer cell lines in vitro. (cancerindex.org)
They activate mitogenic responses and regulate growth and proliferation of many cells. (nih.gov)
Results: We find that Bregs exhibit a unique set of 149 genes differentially expressed and which are implicated in proliferation, apoptosis, metabolism, and altered antigen presentation capacity consistent with their differentiated B cells profile. (bvsalud.org)
Notably, Bregs induced a strong inhibition of T cell genes associated to proliferation, activation, inflammation and apoptosis compared to total B cells. (bvsalud.org)
In addition, their osteogenic differentiation potential was increased, and genes involved in cell adhesion, FGF-2 signalling, cell cycle, stemness, cell differentiation, and cell proliferation were upregulated, compared to that of the MSCs cultured on uncoated plates. (hindawi.com)

Our findings suggest that nuclear receptor-regulated CYP27 expression is likely to be a key integrator of retinoic acid receptor-PPARgamma-LXR signaling, relying on natural ligands and contributing to lipid metabolism in macrophages. (nih.gov)
INDIGO Bioscience's nuclear receptor reporter assays are all-inclusive cell-based assay systems. (thomassci.com)
It may function as an integrator of transcription repression and nuclear receptor signaling. (caslab.com)
The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function. (kpu.ac.jp)
Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor. (kpu.ac.jp)

In the canonical signaling pathway , binding of a ligand to a cell surface receptor such as a member of the Toll-like receptor superfamily leads to the recruitment of adaptors (such as TRAF) to the cytoplasmic domain of the receptor (Figure 1). (abcam.com)
IFNAR is a heteromeric cell surface receptor composed of two subunits, referred to as the low affinity subunit, IFNAR1 , and the high affinity subunit, IFNAR2 . (wikidoc.org)
All type I IFNs bind to a specific cell surface receptor complex known as the IFN-α receptor ( IFNAR ) that consists of IFNAR1 and IFNAR2 chains. (wikidoc.org)
CD42b, also known as GP1Ba (GP1B alpha, Glycoprotein 1Ba) is a single pass transmembrane glycoprotein that functions as the key ligand binding subunit of the GP1B platelet surface receptor. (peprotech.com)

EGF may induce a limited number of neuronal cells because it also enhanced apoptosis. (umassmed.edu)
These results demonstrate that TrkA kinase initiates differentiation, and p75 enhances differentiation by rescuing differentiating cells from apoptosis via the PI3K pathway. (umassmed.edu)
Brain-derived neurotrophic factor also enhanced cell survival, indicating that in differentiated cells, NGF acts through the p75 receptor to prevent apoptosis. (umassmed.edu)
Sodium butyrate induces mitophagy and apoptosis of bovine skeletal muscle satellite cells through the mammalian target of rapamycin signaling pathway. (usda.gov)

Vitamin A is also important for embryonic development and the regulation of adult genes. (medscape.com)
Particle stimulation leads to a significant dose-dependent increase of RANKL mRNA in both cell-particle ratios and a significant down-regulation of OPG mRNA in cell-particle concentrations of 1:500. (nih.gov)
Peroxisome proliferator-activated receptor gamma (PPARgamma) and liver X receptor alpha (LXRalpha) have been linked to the regulation of these processes. (nih.gov)
The role of ESRRa in cellular metabolism is largely dependent on its transcriptional regulation of mitochondrial function and biogenesis through collaboration with the peroxisome proliferator-activated receptor γ coactivator-1 alpha (PGC1a) 6 . (nature.com)
The ability to create artificial menstrual cycles in the rhesus monkey provides a model for studies on the regulation of genes and gene networks by estradiol or progesterone (P) in the primate endometrium. (umassmed.edu)
Although placental protein 14, leukemia inhibitory factor and 17-beta hydroxysteroid dehydrogenase displayed highly upregulated levels in PcDNA (P-activated genes), there was little or no up-regulation in IcDNA. (umassmed.edu)
This latter result suggests that low levels of circulating P are sufficient for expression of this gene, whereas high sustained P levels result in an autologous down-regulation. (umassmed.edu)
These data show that the regulation of genes that may play pivotal roles in endometrial maturation are differentially expressed in IcDNA vs. PcDNA and may, in part, characterize improper endometrial maturation. (umassmed.edu)
It plays a key function in host defense by promoting the development and activation of Th1 cells, chemoattraction and activation of monocytes and macrophages, up‑regulation of antigen presentation molecules, and immunoglobulin class switching in B cells. (rndsystems.com)

What pathways are this gene/protein implicaed in? (cancerindex.org)
Thus, ligand dynamics directs unique signaling pathways and reveals a new role of the DBD in allosteric control of ERα-mediated signaling. (rcsb.org)
AKT/PI3K forms a key component of many signalling pathways that involve the binding of membrane-bound ligands such as receptor tyrosine kinases, G-protein coupled receptors, and integrin-linked kinase. (senescence.info)
Activation of various innate immune signaling pathways ( TLR3 , TLR4 , TLR7 , TLR8 , TLR9 , cGAS , RIG-I , MDA-5 ) leads to the rapid induction of type I IFNs due to their (mostly) intronless gene structure. (wikidoc.org)
This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. (arigobio.cn)
The signaling inhibitory antibody quickly induces ligand-independent receptor clustering and internalization via each caveolin and clathrin-mediated pathways. (kashbiotech.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)

To define the domain(s) responsible for this unusual binding property, we constructed a series of M alpha 2-10H/human alpha 2-C10 chimeric receptors. (aspetjournals.org)

It functions as an activator of gene expression by retinoid alpha-receptor transcription factor and ligand-dependent transcription factor. (medscape.com)
Primary human osteoblasts were stimulated by UHMWPE particles (cell/particle ratios 1:100 and 1:500) and different doses of alpha-CGRP (10(-7 )M, 10(-9 )M, 10(-11 )M). Receptor activator of nuclear factor-κB ligand (RANKL) and osteoprotegerin (OPG) mRNA expression and protein levels were measured by RT-PCR and Western blot. (nih.gov)

PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. (caslab.com)

Mechanistically, the CCL20/CCR6 signaling pathway upregulates HIF-1α by stimulating nuclear factor kappa B-driven transactivation of the HIF1A gene. (cancerindex.org)

Hypoxia stimulates cancer cells to acquire a more malignant phenotype via activation of hypoxia-inducible factor 1 (HIF-1). (cancerindex.org)
It remains to be identified how activation of these receptors is connected and regulated by endogenous lipid molecules. (nih.gov)
RelA, c-Rel, and RelB contain C-terminal transcriptional activation domains (TADs), which enable them to activate target gene expression. (abcam.com)
NF-κB activation leads to expression of the IκBα gene, which functions as a negative feedback loop to sequester NF-κB subunits, terminating signaling unless a persistent activation signal is present. (abcam.com)
Ligand binding to a receptor leads to the recruitment and activation of an IKK complex comprising IKK alpha and/or IKK beta catalytic subunits and two molecules of NEMO. (abcam.com)
Subsequent phosphorylation of both threonine residue 308 and serine residue 473 is required for full activation of the AKT1 protein encoded by this gene. (senescence.info)
Activation of adiponectin receptors (AdipoRs) by its natural ligand, adiponectin has been known to be involved in modulating critical metabolic processes such as glucose metabolism and fatty acid oxidation as demonstrated by a number of in vitro and in vivo studies over last two decades. (phoenixpeptide.com)
Ligand binding to either subunit is required for and precedes dimerization and activation of the receptor. (wikidoc.org)
They are antiviral and possess antioncogenic properties, macrophage and natural killer lymphocyte activation, and enhancement of major histocompatibility complex glycoprotein classes I and II, and thus presentation of foreign (microbial) peptides to T cells . (wikidoc.org)
The dsRNA acts like a trigger for the production of interferon (via Toll Like Receptor 3 ( TLR 3 ) a pattern recognition receptor of the innate immune system which leads to activation of the transcription factor IRF3 and late phase NF kappa Beta). (wikidoc.org)
For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. (arigobio.cn)
The binding of von Willebrand factor (VWF) to its platelet receptor initiates the primary mechanism for the adhesion of platelets to a site of vascular injury and subsequent platelet activation. (peprotech.com)
A CBP Integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. (kpu.ac.jp)
Mouse splenocytes either (A) stimulated for 4 hours with Cell Activation Cocktail 500x ( 5476 ) or (B) unstimulated were stained with Rat Anti-Mouse IFN-gamma Alexa Fluor® 700-conjugated Monoclonal Antibody (Catalog # IC485N) and Rat Anti-Mouse CD4 PE-conjugated Monoclonal Antibody ( FAB554P ). (rndsystems.com)
After activation C3b can bind covalently, via its reactive thiolester, to cell surface carbohydrates or immune aggregates. (lu.se)

INDIGO's panel of TR reporter assays utilizes non-human mammalian cells engineered to express human thyroid hormone receptors alpha (NR1A1) and beta (NR1A2), ligand-dependent transcription factors commonly referred to as TRα and TRβ. (thomassci.com)
Both p53 and AR are transcription factors and can affect the expression of a broad array of genes. (oncotarget.com)

[7] Each type I IFN ligand contains a "hotspot", or a sequence of conserved amino acids that are involved in binding to the receptor, specifically the high affinity receptor IFNAR2, which determines the affinity of each ligand for the receptor. (wikidoc.org)
The other clone (M alpha 2-10H) closely resembles the human alpha 2-C10 subtype in sequence but binds with significantly lower affinity to yohimbine and rauwolscine, members of a distinct class of bulky alpha 2-selective antagonists commonly used to evaluate alpha 2-AR function in vivo. (aspetjournals.org)
Analysis of these receptors identified a conservative Cys201 to Ser201 change in the fifth transmembrane domain of M alpha 2-10H as being responsible for the low affinity of the mouse receptor for yohimbine. (aspetjournals.org)
Fc-ARMs are composed of an Fc-binding peptide and a concentrating on ligand , enabling the exploitation of endogenous antibodies via fixed affinity to the Fc area of antibodies, whose sequence is conserved in distinction to the Fab area. (kashbiotech.com)
IL-10 binds specifically and with high affinity to cell-surface receptors. (bio-techne.com)
Recombinant IL-10 soluble receptor, consisting of the extracellular domain of IL-10 R, binds IL-10 with high affinity in solution and is a potent IL-10 antagonist. (bio-techne.com)

This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. (cancerindex.org)
Interferons assist the immune response by inhibiting viral replication within host cells, activating natural killer cells, increasing antigen presentation to lymphocytes, and inducing the resistance of host cells to viral infection. (wikidoc.org)
Clear cell acanthoma usually stains positively for epithelial membrane antigen and negatively for carcinoembryonic antigen. (medscape.com)

Loss of function analysis shows that knockdown of esrra impairs expression of genes including sox9, col2a1, sox5, sox6, runx2 and col10a1 thus induces abnormally formed cartilage in pharyngeal arches. (nature.com)
Butyrate induces modifications of the CTCF-binding landscape in cattle cells. (usda.gov)

[8] The evolutionary conservation of type I IFN subtypes binding the same IFNAR receptor at the same site with differing affinities suggests that type I IFNs are nonredundant and potentially regulate different cellular responses. (wikidoc.org)

The biological activities of the FGFs are mediated by a family if type I transmembrane tyrosine kinases which undergo dimerization and autophosphorylation after ligand binding. (prospecbio.com)

Human and mouse IL-10 receptors are structurally related to the IFN-gamma receptor. (bio-techne.com)
A family of structurally related cell-surface receptors that signal through an intrinsic PROTEIN-TYROSINE KINASE. (bvsalud.org)

If a preponderance of genes in any of these predefined groups of genes (gene sets) is coordinately differentially expressed, it may be reasonable to hypothesize that the biological characteristic upon which that gene set was defined is relevant to the experimental perturbation. (biomedcentral.com)
trol spots, and images were screened for changes in A total of 173 genes were differentially expressed, expression values of at least 2-fold. (cdc.gov)
These novel changes induced by WNV may serve as of 173 cellular genes were identified by ArrayTools to be biomarkers and help explain the neuropathologic features differentially expressed in the WNV-infected A172 cells. (cdc.gov)

NF-κB then translocates to the nucleus to activate target genes. (abcam.com)

Sequence homology and ligand binding data allow the assignment of one clone (M alpha 2-4H) as the mouse homolog of the human alpha 2-C4 subtype. (aspetjournals.org)
The 2.3 genotype of ESRRA23, a 23-bp sequence in the 5'-flanking region of the ERRalpha gene, is associated with a higher body mass index than the 2.2 genotype. (kpu.ac.jp)
This composite promoter comprises the Elongation Factor-1α (EF-1α) core promoter [3] and the R segment and part of the U5 sequence (R-U5') of the Human T-Cell Leukemia Virus (HTLV) Type 1 Long Terminal Repeat [4]. (invivogen.com)
The deduced amino acid sequence of human IL-10 R is approximately 60% identical to mouse IL-10 R. Although human IL-10 has cross-species activities and is active on mouse cells, mouse IL-10 is species-specific in its actions and does not bind to the human IL-10 receptor. (bio-techne.com)

This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. (cancerindex.org)
This gene encodes a member of the heterogeneous family of basic, proline-rich, human salivary glycoproteins. (cancerindex.org)
This gene encodes one of the three members of the human AKT serine-threonine protein kinase family which are often referred to as protein kinase B alpha, beta, and gamma. (senescence.info)
This gene encodes alpha-1A-adrenergic receptor. (nih.gov)

Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. (nih.gov)
These receptors are members of the class II subgroup of the cytokine receptor superfamily. (bio-techne.com)

NGF, which can bind to endogenous p75, did not induce differentiation but enhanced the EGF-induced response, leading to differentiation of almost all cells. (umassmed.edu)
Even though both EGF and NGF are required for differentiation of LAN5/ET-R cells, only NGF is required for survival of the differentiated cells. (umassmed.edu)
Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. (arigobio.cn)
The differentiation of mesenchymal stem cells (MSCs) into multiple cell lineages can be exploited as an attractive strategy for cell-based therapy and regenerative medicine [ 1 ]. (hindawi.com)
The ECM provides structural and biochemical support to the cells and has various other functions including cell adhesion, cell to cell communication, and differentiation [ 17 , 18 ]. (hindawi.com)
The prevention of adipose differentiation of 3T3-L1 cells caused by retinoic acid is elicited through retinoic acid receptor alpha. (kpu.ac.jp)
Brain and muscle Arnt-like protein-1 ( BMAL1 ) knockout mice exhibit accelerated aging, abnormal glucose metabolism, and impaired adipocyte differentiation, among other phenotypes, which are effects associated with the BMAL1 gene. (go.jp)

It was also shown that inhibition of the p16 tumour suppressor gene delays growth arrest and therefore senescence of MSC [ 16 ]. (hindawi.com)
Fig. 2: SST+ cell-mediated "blanket of inhibition" regulates temporal and spatial signal to noise ratio: effects of depression and of α5-PAM versus α5-NAM. (nature.com)
Here we analyze the effects of p53 inhibition in PC cells and show that it has significant consequences for both the interaction between AR, and chromatin and the proliferative capacity of these cells. (oncotarget.com)
Inhibition of p53 expression enabled LNCaP cells to proliferate independently of androgens. (oncotarget.com)

Each subunit of IFNAR contains an N-terminal ligand binding domain (with two or four fibronectin type II-like subdomains, for IFNAR2 and IFNAR1, respectively), a transmembrane (TM) domain, and a cytoplasmic domain. (wikidoc.org)

The androgen receptor (AR) is known to play a critical role in prostate cancer (PC). (oncotarget.com)
The majority of CRPCs continue to express the androgen receptor (AR) and are dependent on AR signaling for malignant progression [ 3 - 5 ]. (oncotarget.com)

Astrocyte-derived chemokine C-C motif ligand 20 (CCL20) was identified using cytokine arrays, and its role in glioblastoma development was evaluated in orthotopic xenografts. (cancerindex.org)
The potential causal genes were enriched in biological processes related to type I interferons, interferon gamma inducible protein 10 production, and chemokine (C-X-C motif) ligand 2 production. (cdc.gov)

Be the first to review Human IFN-alpha 6/IFNA6 (NP_066282.1) VersaClone cDNA and earn rewards! (rndsystems.com)
Have you used Human IFN-alpha 6/IFNA6 (NP_066282.1) VersaClone cDNA? (rndsystems.com)
1988). SR alpha promoter: an efficient and versatile mammalian cDNA expression system composed of the simian virus 40 early promoter and the R-U5 segment of human T-cell leukemia virus type 1 long terminal repeat. (invivogen.com)
Mouse and human cDNA clones encoding the ligand-binding IL-10 receptor (IL-10 R) have been isolated. (bio-techne.com)

This protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. (wikipedia.org)
The interferon-α/β receptor (IFNAR) is a virtually ubiquitous membrane receptor which binds endogenous type I interferon (IFN) cytokines. (wikidoc.org)
Redirecting endogenous antibodies in the bloodstream to tumor cells utilizing artificial molecules is a promising strategy to set off anti-tumor immune responses. (kashbiotech.com)
Animal studies have shown that LAK cells are more effective against cancer cells than are the original endogenous T cells, presumably because of their greater number. (msdmanuals.com)

ABSTRACT Reported associations between vitamin D receptor (VDR) polymorphism and type 1 diabetes mellitus vary across ethnic groups. (who.int)

Type I IFN receptor forms a ternary complex, composed of its two subunits IFNAR1 and IFNAR2, and a type I IFN ligand. (wikidoc.org)
The top five most associated protein-coding genes were Interferon Alpha and Beta Receptor Subunit 2 (IFNAR2), 2'-5'-Oligoadenylate Synthetase 3 (OAS3), mucin 1 (MUC1), Interleukin 10 Receptor Subunit Beta (IL10RB), and Napsin A Aspartic Peptidase (NAPSA). (cdc.gov)

Concentrations of cholesterol and triglycerides are strongly correlated in the adipocyte, but little is known about mechanisms regulating cholesterol metabolism in fat cells. (jci.org)

The suggested osteoprotective influence of alpha-CGRP on the catabolic effects of ultra-high molecular weight polyethylene (UHMWPE) particles is analyzed in this study in primary human osteoblasts. (nih.gov)
Alpha-CGRP in all tested concentrations showed a significant depressive effect on the expression of RANKL mRNA in primary human osteoblasts under particle stimulation. (nih.gov)
Moreover, human macrophage-rich atherosclerotic lesions have an increased level of retinoid-, PPARgamma-, and LXR-regulated gene expression and also enhanced CYP27 levels. (nih.gov)
A curated database of candidate human ageing-related genes and genes associated with longevity and/or ageing in model organisms. (senescence.info)
Database of human genes associated with cellular senescence. (senescence.info)
Introduction: Human Granzyme B (GZMB) regulatory B cells (Bregs) have suppressive properties on CD4+ effector T cells by a mechanism partially dependent on GZMB. (bvsalud.org)
NMR structure of the interferon-binding ectodomain of the human interferon receptor. (wikidoc.org)
100.000 cCREs in total), dispersed within the genome and present in cis-regulatory regions of ~81% of human genes, as calculated following gene enrichment analysis. (mdpi.com)
TLR1-GFP fusion gene was generated by fusing the green fluorescent protein (GFP) gene to the C terminus of human Toll-like receptor 1 (TLR1) gene. (invivogen.com)
GFP fusion gene was generated by fusing at the C terminus of the human TLR1 gene to a GFP variant. (invivogen.com)
1990). Use of the human elongation factor 1 alpha promoter as a versatile and efficient expression system. (invivogen.com)
To demonstrate the utility of openSESAME, we used gene expression signatures of two biological perturbations to query a set of 75,164 human expression profiles that were generated using Affymetrix microarrays and deposited in GEO. (biomedcentral.com)
Detects human IL-10 R alpha in direct ELISAs and Western blots. (bio-techne.com)
In direct ELISAs, no cross-reactivity with recombinant mouse IL-10 R alpha or recombinant human (rh) IL-10 R beta is observed. (bio-techne.com)
Detection of IL-10 R alpha in Human Blood Lymphocytes by Flow Cytometry. (bio-techne.com)
The human IL-10 R gene has been mapped to chromosome 11q23.3. (bio-techne.com)
Explore the normal functions of human genes and the health implications of genetic changes. (medlineplus.gov)
We conducted a glob- ing to prevent skew in the results due to bias in CyDye al transcriptional analysis of human glioblastoma cell incorporation. (cdc.gov)
CAR T cell immunotherapy for human cancer. (msdmanuals.com)

Functional analysis using specific inhibitors was used to test their suppressive properties and we identified Lymphotoxin alpha (LTA) as a new and potent Breg ligand implicated in Breg suppressive properties. (bvsalud.org)
Discovery of a novel potent peptide agonist to adiponectin receptor 1. (phoenixpeptide.com)
A potent peptide as adiponectin receptor 1 agonist to against fibrosis. (phoenixpeptide.com)

Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia. (cancerindex.org)

INDIGO's TR reporter cells include the luciferase reporter gene functionally linked to a responsive promoter. (thomassci.com)
Hypermethylation in the promoter region of the ADRA1A gene is associated with opioid use disorder in Han Chinese. (nih.gov)
The TLR1-GFP fusion gene is cloned in the pUNO plasmid under the control of the strong and ubiquitous mammalian promoter EF1α/HTLV. (invivogen.com)
GFP fusion gene is under the control of the strong and ubiquitous hEF1/HTLV promoter. (invivogen.com)

Furthermore, interferon leads to upregulation of MHC I and therefore to increased presentation of viral peptides to cytotoxic CD8 T cells, as well as to a change in the proteasome (exchange of some beta subunits by b1i, b2i, b5i - then known as the immunoproteasome) which leads to increased production of MHC I compatible peptides. (wikidoc.org)

Retinoic acid receptor gamma 2 gene expression is up-regulated by retinoic acid in 3T3-L1 preadipocytes. (kpu.ac.jp)

This enables the active NF-κB transcription factor subunits to translocate to the nucleus and induce target gene expression. (abcam.com)
[9] For example, type I IFNs induce interferon-stimulated gene ( ISG ) expression, classically resulting in a robust anti-viral immune response. (wikidoc.org)
Mouse splenocytes either (A) stimulated to induce Th1 cells or (B) unstimulated were stained with Rat Anti-Mouse IFN-gamma Alexa Fluor® 700-conjugated Monoclonal Antibody (Catalog # IC485N) and Rat Anti-Mouse CD4 PE-conjugated Monoclonal Antibody (Catalog # FAB554P ). (rndsystems.com)
NOTCH3-ADCs internalize into receptor and ligand cells impartial of signaling and induce cell dying in each cell sorts representing an atypical mechanism of ADC cytotoxicity. (kashbiotech.com)

The first query, using a signature of estradiol treatment, identified experiments in which estrogen signaling was perturbed and also identified differences in estrogen signaling between estrogen receptor-positive and -negative breast cancers. (biomedcentral.com)

Alternatively spliced transcript variants that encode the same protein have been described for this gene. (cancerindex.org)
Breast cancer risk is influenced by rare coding variants in susceptibility genes, such as BRCA1, and many common, mostly non-coding variants. (cancerindex.org)
Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding properties. (nih.gov)
Variants of the clear cell acanthoma have been noted and include polypoid, giant, multiple, and eruptive. (medscape.com)

Lymphokine-activated killer (LAK) cells are produced from the patient's T cells which are extracted from the tumor and grown in a cell culture system with the lymphokine interleukin-2 (IL-2). (msdmanuals.com)

Vitamin D receptor gene expression is up-regulated by 1, 25-dihydroxyvitamin D3 in 3T3-L1 preadipocytes. (kpu.ac.jp)

Furthermore, while differential effects manifest after several days of chronic stimulation, changes to receptor structure, orientation, or stoichiometry have not elucidated the cause for differential signaling via different type I IFN subtypes. (wikidoc.org)
Structural analysis of type I IFN receptor with different type I IFN ligand subtypes revealed a similar binding site for the different agonists. (wikidoc.org)
[9] Importantly, structural studies have not revealed differences in ternary complex structures with IFNAR and various type I IFN subtypes, despite differences in ligand affinities. (wikidoc.org)
Cloning of two mouse genes encoding alpha 2-adrenergic receptor subtypes and identification of a single amino acid in the mouse alpha 2-C10 homolog responsible for an interspecies variation in antagonist binding. (aspetjournals.org)
Molecular cloning and ligand binding studies have shown the alpha 2 class of adrenergic receptor (alpha 2-AR) to be a family of at least three related subtypes in humans. (aspetjournals.org)
To begin this process, we have isolated two mouse genomic clones encoding alpha 2-AR subtypes and expressed these genes in COS-7 cells for binding studies. (aspetjournals.org)

Estrogen-related receptor alpha (ESRRa) regulates a number of cellular processes including development of bone and muscles. (nature.com)
Cellular senescence, which is morphologically characterized by an enlarged and flattened cell shape, was first described by Hayflick [ 9 ]. (hindawi.com)
Cellular senescence refers to active cells that eventually enter a state of irreversible growth arrest. (hindawi.com)
In passive cellular immunotherapy, specific effector cells are directly infused and are not induced within the patient. (msdmanuals.com)
In passive cellular immunotherapy, specific effector cells. (msdmanuals.com)

Alpha-endosulfine is a protein that in humans is encoded by the ENSA gene. (wikipedia.org)
Clinical trials of LAK cells in humans are ongoing but this approach has not gained widespread use and is generally considered less effective than other cell therapies. (msdmanuals.com)

As well as, DLL4 ligand binding to the NOTCH3 receptor mediates transendocytosis of NOTCH3-ADCs into ligand-expressing cells. (kashbiotech.com)

Immunoblotting, reporter assays, quantitative RT-PCR, and chromatin immunoprecipitation were performed to evaluate HIF-1 signaling in glioblastoma cells. (cancerindex.org)

The in-vivo use of alpha-CGRP, which leads to down-regulated RANKL in-vitro, might inhibit the catabolic effect of particles in conditions of particle induced osteolysis. (nih.gov)
These studies have not, however, identified distinct subtype-specific functions for these receptors in vivo. (aspetjournals.org)

Ligand-binding dynamics control allosteric signaling through the estrogen receptor-α (ERα), but the biological consequences of such dynamic binding orientations are unknown. (rcsb.org)
however, some biological effects may occur independently of the receptor. (cdc.gov)
Based on crystal structure of AdipoR1, we designed AdipoR1's peptide agonists using protein-peptide docking simulation and screened their receptor binding abilities and biological functions via surface plasmon resonance (SPR) and biological analysis. (phoenixpeptide.com)
Identifying similarities between patterns of differential gene expression provides an opportunity to identify similarities between the experimental and biological conditions that give rise to these gene expression alterations. (biomedcentral.com)
openSESAME is a tool for leveraging the growing body of publicly available microarray data to discover relationships between different biological states based on common patterns of differential gene expression. (biomedcentral.com)
However, a challenge for scientists performing genome-wide gene expression microarray analysis has been using these data to generate hypotheses about biological processes responsible for the patterns of differential gene expression associated with a particular trait or experimental variable. (biomedcentral.com)
One approach to this problem is to create sets of genes with common biological characteristics, such as chromosomal location, biochemical function, or observed differential expression in some experimental condition, and then to determine whether the genes in these sets are coordinately induced or repressed. (biomedcentral.com)

C3 precursor is first processed by the removal of 4 Arg residues, forming two chains, beta and alpha, linked by a disulfide bond. (lu.se)

[2] IFNAR agonism results in transcriptional changes, with the potential to increase or suppress the transcription of over 2000 different genes. (wikidoc.org)
The differentially regu- many of which were not found in previous transcriptional lated genes were separately uploaded into EASE (4) to studies of other flaviviruses (3). (cdc.gov)

Correspondence with low molecular weight chemicals that results in the priming of chemical-specific, Prof. Dr. Stefan F. Martin, Allergy Research skin-homing CD8+ Tc1/Tc17 and CD4+ Th1/Th17 cells. (cdc.gov)

[3] [4] The regulatory elements upstream of type I IFN genes differ, allowing differential transcription of type I IFNs in response to stimuli. (wikidoc.org)
These relationships may serve to generate hypotheses about the causes and consequences of specific patterns of observed differential gene expression. (biomedcentral.com)

The gene is preferentially expressed by immature dendritic cells and memory T cells. (cancerindex.org)

Anatomy32

Organisms13

Diseases4

Chemicals and Drugs120

Analytical, Diagnostic and Therapeutic Techniques and Equipment28

Phenomena and Processes61

Disciplines and Occupations1

Information Science3

Proteins20

Signal transduction4

Epidermal growth f1

PPAR22

Proliferation7

Nuclear receptor5

Surface receptor4

Apoptosis4

Regulation9

Pathways7

Chimeric1

Activator2

PPARs1

Signaling pathway1

Activation15

Transcription factors2

Affinity6

Antigen3

Induces2

Regulate1

Tyrosine kinases1

Structurally related2

Differentially expressed3

Target genes1

Sequence4

Encodes4

Superfamily2

Differentiation7

Inhibition4

Cytoplasmic domain1

Androgen receptor2

Chemokine2

CDNA4

Endogenous4

Abstract1

IFNAR22

Metabolism1

Human19

Potent3

Chronic lymphocyt1

Promoter4

Peptides1

Retinoic Acid1

Induce4

Estrogen receptor-positive1

Variants4

Interleukin1

Vitamin D recept1

Subtypes6

Cellular5

Humans2

Mediates1

Reporter assays1

Vivo2

Biological7

Residues1

Transcriptional2

Molecular1

Differential2

Dendritic cells1