Receptor gamma 1996 antibody genes t cell receptor gamma. Medical search. Frequent questions

Panel 3: Two-color contour plots show the correlated expression patterns of IgG2a Control (Left) or ROR γ t (Right) staining versus IL-17A in Th17-polarized CD3+CD4+ cells. (bdbiosciences.com)

The CD64 proteins are high affinity receptors (~10 -8 ‑10 -9 M) capable of binding monomeric IgG, whereas the CD16 and CD32 proteins bind IgG with lower affinities (~10 -6 ‑10 -7 M) only recognizing IgG aggregates surrounding multivalent antigens (1, 4). (novusbio.com)
Apfel R, Lottspeich F, Hoppe J, Behl C, Durr G, Bogdahn U. Purification and analysis of growth regulating proteins secreted by a human melanoma cell line. (2medicalcare.com)
In animals, cadherin domain-containing proteins are adhesion molecules that modulate a wide variety of processes including cell polarization and migration but they have also been identified in yeast and magnetotactic bacteria. (embl.de)
1994). These proteins interact in the regulation of several host cell act and responses as chaperones. (thetechnoant.info)
Both proteins are stress-induced antigens expressed mainly in gastrointestinal epithelium, where they are recognized by V-delta1 subset of gamma/delta T cells, and also on diverse epithelial tumor cells. (exbio.cz)

The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkynje cells in the cerebellum. (exbio.cz)
Separation of chemotherapy plus G-CSF-mobilized peripheral blood mononuclear cells by counterflow centrifugal elutriation: in vitro characterization of two different CD34+ cell populations. (ntu.ac.uk)
RhG-CSF-mobilized peripheral blood haemopoietic progenitors reside in G0/G1 phase of cell cycle independently of the expression of myeloid antigens. (ntu.ac.uk)
Endogenous cytokine levels after immunoselected CD34+ peripheral blood progenitor cell transplantation. (ntu.ac.uk)
Pleiotropic effects of IL-18 has also been reported, such as, enhancement production of IFN-gamma and GM-CSF in peripheral blood mononuclear cells, production of Th1 cytokines, IL-2, GM-CSF and IFN-gamma in T cells, enhancement of Fas ligand expression by Th1 cells. (rndsystems.com)
In the groups (both the initiation and the progression) receiving recombinant IL-27 administration, the formation of atherosclerotic plaques was suspended, and the percentage of regulatory T cells (LAP + or Foxp3 + ) in the spleen and peripheral blood was increased. (hindawi.com)

Additional cell types that have been shown to express CXCL10 include activated T-lymphocytes, splenocytes, keratinocytes, osteoblasts, astrocytes, and smooth muscle cells. (rndsystems.com)
A chemokine receptor specific for CXCL10 and Mig has been cloned and shown to be highly expressed in IL-2-activated T-lymphocytes. (rndsystems.com)
Receptor mobility and receptor-cytoplasmic interactions in lymphocytes. (academicinfluence.com)
Multiple sclerosis (MS) is a neuroinflammatory disease with an autoimmune component that is characterised by activation of self-reactive lymphocytes, which enter the central nervous system (CNS) and cause destruction of myelin producing cells and neurons leading to the formation of inflammatory lesions. (nature.com)
In addition to lymphocytes, dendritic cells can also produce LT α [ 15 ]. (hindawi.com)
IL-27 binds to IL-27ra and gp-130 complex, which is expressed on multiple cell types, including T lymphocytes [ 2 ]. (hindawi.com)
The demonstration of antibodies, mixed T-helper (Th) type 1/2 responses diisocyanate occupational asthma in a murine model after sub- and the involvement of CD8 T lymphocytes in chronic inhalation exposure at relevant exposure levels should diisocyanate OA. (cdc.gov)

The Armenian hamster monoclonal antibody 145-2C11 reacts with an extracellular epitope of murine CD3 (epsilon subunit). (exbio.cz)
Isolation and characterization of an oligodendrocyte precursor-derived B-cell epitope in multiple sclerosis. (2medicalcare.com)
Epitope mapping of new monoclonal antibodies recognizing distinct human FcRII (CD32) isoforms. (uni-bielefeld.de)
Indirect immunofluorescence experiments using either Axl2p tagged with three copies of a hemagglutinin epitope or high-copy AXL2 and anti-Axl2p antibodies reveal a unique localization pattern for Axl2p. (embl.de)
The mouse monoclonal antibody 6D4 recognizes a common extracellular epitope on MICA and MICB glycoproteins, transmembrane ligands of CD314 (NKG2D), and is able to block CD314-mediated activation of NK cells and cytotoxic T cells. (exbio.cz)

The immunoglobulin (Ig) variable region (V) genes expressed by IgM chronic lymphocytic leukemia (CLL) B cells display little or no somatic mutations. (omicsdi.org)
Neural cell adhesion molecule: structure, immunoglobulin-like domains, cell surface modulation, and alternative RNA splicing. (academicinfluence.com)
Crystal structure of the soluble form of the human fcgamma-receptor IIb: a new member of the immunoglobulin superfamily at 1.7 A resolution. (uni-bielefeld.de)
In vivo and in vitro specificity of protein tyrosine kinases for immunoglobulin G receptor (FcgammaRII) phosphorylation. (uni-bielefeld.de)

However, due to intricacies of solid tumors and their locations in the human body, treatment of solid tumors with CAR-T cells is facing multiple obstacles, such as the hostile tumor microenvironment, on-tumor/off-tumor toxicities, and undesired antigen specificity [ 2 ]. (ijbs.com)
Cattle Fc gamma RII: molecular cloning and ligand specificity. (uni-bielefeld.de)

Receptors for the Fc region of IgG (Fc gamma Rs) are members of the Ig superfamily that function in the activation or inhibition of immune responses such as degranulation, phagocytosis, ADCC (antibody-dependent cellular toxicity), cytokine release, and B cell proliferation (1‑3). (novusbio.com)
Vossen AC, Tibbe GJ, Kroos MJ, van de Winkel JG, Benner R, Savelkoul HF: Fc receptor binding of anti-CD3 monoclonal antibodies is not essential for immunosuppression, but triggers cytokine-related side effects. (exbio.cz)
Interleukin 18 (IL-18) is a 18 kDa cytokine which identified as a costimulatory factor for production of interferon-gamma (IFN-gamma ) in response to toxic shock and shares functional similarities with IL-12. (rndsystems.com)

IFN-gamma activates macrophages, enhances NK activity and B cell maturation, proliferation and Ig secretion, induces MHC class I and II antigens, and inhibits osteoclast activation. (rndsystems.com)
Most patients with primary Sjogren syndrome have two specific antibodies: against Ro (SS-A) and La (SSB) antigens. (medscape.com)
Sixty percent of cases express 1 or more T-cell antigens (CD3 + , CD43, or CD45RO). (medscape.com)

CXCL10 was originally identified as an IFN-gamma -inducible gene in monocytes, fibroblasts and endothelial cells. (rndsystems.com)
Bayas A, Hummel V, Kallmann BA, Karch C, Toyka KV, Rieckmann P. Human cerebral endothelial cells are a potential source for bioactive BDNF. (2medicalcare.com)
The CD31 antigen is expressed on platelets and endothelial cells at high levels, as well as on T-lymphocyte subsets, monocytes, and granulocytes. (thetechnoant.info)
Current pathophysiology studies are focused on the origin of the antibody response, the nature of the antigenic complex and pathologic epitopes, the mechanisms of interindividual differences in platelet activation, and the functions of monocytes and endothelial cells. (immune-source.com)

Three primary pathologic features are found in scleroderma and include increased collagen deposition, perivascular mononuclear cell infiltration, and vascular abnormalities. (medscape.com)

Human high-affinity Fc gamma RI (CD64) gene mapped to chromosome 1q21.2-q21.3 by fluorescence in situ hybridization. (uni-bielefeld.de)

CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. (exbio.cz)
IL-15 is considered superior to IL-2 for cancer immunotherapy due to its strong bioactivity in improving CD8 + T and natural killer (NK) cell survival, proliferation and cytotoxic function ( 8 ). (frontiersin.org)
In this study, we found that peritoneal B1a cells underwent proliferation and migrated to the inflamed joint tissue with upregulated RANKL expression during collagen-induced arthritis (CIA) development in mice. (oncotarget.com)
These molecular defects interfere with lymphocyte development and function, blocking the differentiation and proliferation of T cells and, in some types, of B cells and NK cells. (medscape.com)
In X-linked SCID, loss of IL-2 receptor (IL-2R) function leads to the loss of a lymphocyte proliferation signal. (medscape.com)
Meanwhile IL-27 exerts proinflammatory effects by promoting Th1, CD8, natural killer (NK), T follicular helper (Tfh), and B cell proliferation/functions and by inhibiting Treg and Th2 cell generation in parasites infection [ 4 ]. (hindawi.com)

Interferon gamma receptor 1 ( IFNGR1 ) also known as CD119 ( C luster of D ifferentiation 119 ), is a protein that in humans is encoded by the IFNGR1 gene . (wikidoc.org)
Interferon gamma receptor 1 has been shown to interact with Interferon-gamma . (wikidoc.org)
The human interferon-gamma receptor. (wikidoc.org)
In bone tissue marrow ST 2825 produced murine macrophage lines, interferon gamma (IFN-) elevated bradyzoite antigen appearance and this were linked to nitric oxide (NO) creation (Bohne et al. (thetechnoant.info)

Chronic human heart failure is characterized by abnormalities in beta-adrenergic receptor (betaAR) signaling, including increased levels of betaAR kinase 1 (betaARK1), which seems critical to the pathogenesis of the disease. (duke.edu)
They also suggest that Ag may play a role in the clonal selection of some of these isotype-switched leukemic cells, but bcl-1 and bcl-2 oncogene rearrangements and p53 tumor suppressor gene mutation are not associated with the pathogenesis of isotype-switched CLLs. (omicsdi.org)
Dysregulated functions of B1 cells have been implicated in the disease progression of various autoimmune disorders, but it remains largely unclear whether B1 cells are involved in the pathogenesis of autoimmune arthritis. (oncotarget.com)
Recent studies have identified the important contribution of conventional B (B2) cells to the development of autoimmune disease, but our current understanding for the role of B1 cells in autoimmune pathogenesis is still limited [ 1 , 2 ]. (oncotarget.com)
Although B1 cells have been recognized for their protective functions against viruses, bacteria and parasites by producing natural IgM antibodies [ 3 ], increasing evidence indicates that B1 cells, especially the highly polyspecific B1a cells, play a role in autoimmune pathogenesis [ 4 ]. (oncotarget.com)
Importantly, recent studies have shown that the importance of type 17 T helper cells (Th17 cells) and regulatory T cells (Tregs) in the pathogenesis of various immune disorders, particularly in atherosclerosis. (hindawi.com)

Production and characterization of monoclonal antibodies to the extracellular domain of P0. (2medicalcare.com)
Molecular characterization of IgA- and/or IgG-switched chronic lymphocytic leukemia B cells. (omicsdi.org)
Chemical characterization of a neural cell adhesion molecule purified from embryonic brain membranes. (academicinfluence.com)
Purification and characterization of a cell adhesion molecule from neural retina. (academicinfluence.com)

The beta-adrenergic receptor kinase 1 (beta ARK1) is a member of the G protein-coupled receptor kinase (GRK) family that mediates the agonist-dependent phosphorylation and desensitization of G protein-coupled receptors. (duke.edu)

Also present in actin staining test allows the identification of strains that pro- the EAF plasmid is the cluster of genes that encode bundle- duce A/E lesions, through detection of aggregated actin fila- forming pili (BFP), which interconnect bacteria within micro- ments beneath the attached bacteria (3). (cdc.gov)
Flow cytometric detection of CD44 (H-CAM) in hairy cell leukemia. (ntu.ac.uk)
Detection and quantification of antibodies to the extracellular domain of P0 during experimental allergic neuritis. (2medicalcare.com)
Targeting classic Tregs is limited by the detection of Foxp3 and surface Treg markers on activated cells. (hindawi.com)
Progress in therapy is usually hampered by the difficulties of inadequate positive predictive value of antibody detection and clinical scores in suspected HIT, very limited availability of practical platelet activation assays, and the paucity of new agents in human clinical trials. (immune-source.com)

Interleukin (IL)-12, which is secreted by antigen-presenting cells, acts via signal transducer and activator of transcription (STAT)4 to promote the differentiation of naïve T cells into Th1 cells ( 9 - 11 ). (frontiersin.org)
T helper cells recognize antigen presented in the context of major histocompatibility complex II on antigen-presenting cells in a T cell receptor-dependent fashion (not shown). (frontiersin.org)
IL-27 is a member of the IL-12 family and is composed of Epstein-Barr virus-induced gene3 (EBI3) and p28 subunits, which are produced by active antigen-presenting cells [ 1 ]. (hindawi.com)
T cells are primed by antigen-presenting cells in the T cell zones of the periarteriolar lymphoid sheaths of the spleen, the paracortex of LNs, and the dome area of Peyer's patches (PPs) * lining the intestine. (rupress.org)

1996) J. Biol. (rndsystems.com)

This antibody is commonly used as a phenotypic marker for murine T cells. (exbio.cz)
It is reported that IL-18 is produced from Kupffer cells, activated macrophages, keratinocytes, intestinal epithelial cells, osteoblasts, adrenal cortex cells and murine diencephalon. (rndsystems.com)
The goal of this study was to examine the activity of IL-15/IL-15Rα complex (IL-15cx) to CD8 + T cells and evaluate its potential efficacy in murine breast cancer models. (frontiersin.org)
Toll-like receptor 7/8 agonist R848 alters the immune tumor microenvironment and enhances SBRT-induced antitumor efficacy in murine models of pancreatic cancer. (rochester.edu)

He was involved in early work demonstrating the importance of CaMKII- (1992) and the NMDA receptor-dependent synaptic plasticity (1996) in memory formation. (wikipedia.org)
Turnock-Jones JJ, Jennings CA, Robbins MJ, Cluderay JE, Cilia J, Reid JL, Taylor A , Jones DN, Emson PC , Southam E. Increased expression of the NR2A NMDA receptor subunit in the prefrontal cortex of rats reared in isolation. (neurotree.org)

A novel pathogenic mutation on the interleukin-7 receptor has been described in a newborn. (medscape.com)
Interleukin (IL)-12 and IL-23, cytokines induced during early stages of IBD, play important roles in differentiation of interferon (IFN)-γ/tumor necrosis factor (TNF)-producing Th1 cells as well as IL-17-producing Th17 cells. (frontiersin.org)

In 1983, Tonegawa also discovered a transcriptional enhancer element associated with antibody gene complex, the first cellular enhancer element. (wikipedia.org)
This demonstrated for the first time that memory information is stored in specific cellular ensembles in the hippocampus, now frequently called memory engram cells. (wikipedia.org)
The cellular data indicate that B cells with lesser amounts of surface membrane IgD and higher IgM/IgD ratios are more likely to undergo this switching process. (omicsdi.org)
Binding of neural cell adhesion molecules (N-CAMs) to the cellular prion protein. (academicinfluence.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
Significantly, PF4As inhibited ULC formation at all PF4 : Hep ratios tested, and both antagonists prevented cellular activation by ULC and HIT antibodies. (immune-source.com)
TCDD for every step of the mechanism described for 2,3,7,8-TCDD carcinogenesis in humans including receptor binding, gene expression, protein activity changes, cellular replication, oxidative stress, promotion in initiation-promotion studies and complete carcinogenesis in laboratory animals. (who.int)

Susumu Tonegawa (利根川進, Tonegawa Susumu, born September 5, 1939) is a Japanese scientist who was the sole recipient of the Nobel Prize for Physiology or Medicine in 1987 for his discovery of V(D)J recombination, the genetic mechanism which produces antibody diversity. (wikipedia.org)
Henrickson M, Reid J, Bellet JS, Sawchuk SS, Hirsch R: Comparison of in vivo efficacy and mechanism of action of antimurine monoclonal antibodies directed against TCR alpha beta (H57-597) and CD3 (145-2C11). (exbio.cz)

Structure/function relationships of Fc gamma receptors in phagocytosis. (uni-bielefeld.de)

Mouse monoclonal to CD31.COB31 monoclonal reacts with human CD31, a 130-140kD glycoprotein, which is also known as platelet endothelial cell adhesion molecule-1 (PECAM-1). (thetechnoant.info)

Effects of Lipofectamine 2000/siRNA complexes on autophagy in hepatoma cells Mol Biotechnol. (usc.edu)

Localization of phosphatidylinositol phosphate kinase IIgamma in kidney to a membrane trafficking compartment within specialized cells of the nephron. (neurotree.org)

Comparing the DNA of B cells (a type of white blood cell) in embryonic and adult mice, he observed that genes in the mature B cells of the adult mice are moved around, recombined, and deleted to form the diversity of the variable region of antibodies. (wikipedia.org)
Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice. (duke.edu)
Enhancement of hepatitis B virus replication by androgen and its receptor in mice J Virol. (usc.edu)
Whilst IFN-γ is typically considered to be a pro-inflammatory product of effector T cells, it has been also been demonstrated that IFN-γ −/− mice develop more severe EAE than wild type (WT) controls 5 , highlighting alternate, IFN-γ-dependant negative feedback mechanisms that can constrain EAE disease activity. (nature.com)
Adoptive transfer of B1a cells exacerbated arthritic severity and joint damage while intraperitoneal depletion of B1 cells ameliorated both arthritic symptoms and joint pathology in CIA mice. (oncotarget.com)
In culture, RANKL-expressing B1a cells significantly promoted the expansion of osteoclasts derived from bone marrow cells, which were in accord with the in vivo findings of increased osteoclastogenesis in CIA mice transferred with B1a cells. (oncotarget.com)
In mice, B1 cells mainly reside in the peritoneal and pleural cavities, but aberrant B1a cell migration has been found in the pancreas of non-obese diabetic (NOD) mice [ 5 ], and in the kidney, thymus and lung of NZBW F1 mice [ 6 - 8 ]. (oncotarget.com)
The migration of inflammatory leukocytes, including dendritic cells, neutrophils, and macrophages, to the peritoneal mesentery has been shown to be promoted in LAT −/− (lack mature T cells) mice but inhibited in μ MT (lack mature B cells) mice during the pristane-induced immune response [ 10 ]. (hindawi.com)
A metabolomic study of brain tissues from aged mice with low expression of the vesicular monoamine transporter 2 (VMAT2) gene. (neurotree.org)
Differential gene expression in the striatum of mice with very low expression of the vesicular monoamine transporter type 2 gene. (neurotree.org)
However, study on the effects of IL-27/anti-IL-27 antibody (anti-IL-27p28-Ab) administration to atherosclerosis model in ApoE -/- mice has not been reported. (hindawi.com)
Here we report that when mice lacking the RelA subunit of NF-κB are brought to term by breeding onto a tumor necrosis factor receptor (TNFR)1-deficient background, the mice that are born lack lymph nodes, Peyer's patches, and an organized splenic microarchitecture, and have a profound defect in T cell-dependent antigen responses. (rupress.org)

Intraperitoneal administration of IL-15cx results in a moderate inhibition of breast cancer growth that is associated with an increase in the frequency of cytotoxic CD8 T cells and the improvement of their function. (frontiersin.org)
An early increase of local cytotoxic cells correlates with GET treatment and an increase of long-term memory T cells results from animals with complete tumor regression. (frontiersin.org)
It also delivers its function without activating regulatory T cells (Tregs) ( 9 ) and mediating activation-induced cell death of effector cytotoxic T cells ( 10 ). (frontiersin.org)
These cells primarily produce interferon (IFN)-γ and tumor necrosis factor (TNF) that, respectively, activate macrophages and direct cytotoxic CD8 + T cell responses, that in turn promote elimination of intracellular pathogens such as viruses and bacteria ( 8 ). (frontiersin.org)

Mutations in the IFNGR1 gene can lead to extreme susceptibility to Mycobacterial infections. (wikidoc.org)
In all other class-switched CLLs, the Ig VH segment gene was mutated, but the point mutations were not associated with intraclonal diversification. (omicsdi.org)
These switched transcripts do not reveal evidence for the accumulation of significant numbers of new V(H) gene mutations. (omicsdi.org)
The occurrence of switching without the accumulation of V gene mutations indicates that the processes of differentiation and diversification are not linked. (omicsdi.org)
SCID results from mutations in any of more than 15 known genes. (medscape.com)
Retinitis pigmentosa (RP) is an inherited neurodegenerative disease involving progressive vision loss, and is often linked to mutations in the rhodopsin gene. (jneurosci.org)

The gene IFNGR1 encodes IFN-γR1, which is the ligand-binding chain (alpha) of the heterodimeric gamma interferon receptor, which is found on macrophages . (wikidoc.org)
IFNGR2 , encodes IFN-γR2, the non-ligand-binding partner of the heterodimeric receptor. (wikidoc.org)
The standard model of Wnt signaling specifies that after receipt of a Wnt ligand at the membranous receptor complex, downstream mediators inhibit a cytoplasmic destruction complex, allowing β-catenin to accumulate in the cytosol and nucleus and co-activate Wnt target genes. (silverchair.com)

The loss of TNF α delayed the recruitment of neutrophils and macrophages to the spleen and inhibited the recruitment of neutrophils, macrophages, B cells, and T cells. (hindawi.com)
The loss of TNF α receptor 1/2 resulted in reduced recruitment of neutrophils, macrophages, and dendritic cells into the spleen, but only neutrophil recruitment was inhibited in the peritoneal cavity. (hindawi.com)
Similarly, a lack of B cells significantly impeded the recruitment of neutrophils, macrophages, and dendritic cells to the spleen. (hindawi.com)
LT α is also required for the recruitment of dendritic cells, neutrophils, and macrophages to the mesentery in response to pristane [ 10 ]. (hindawi.com)

Kinetics of homophilic binding by embryonic and adult forms of the neural cell adhesion molecule. (academicinfluence.com)

Separation of HEK-293 cells (red-filled) from human peripheral whole blood cells (black-dashed) in flow cytometry analysis (surface staining) of human peripheral whole blood stained using anti-human MICA/MICB (6D4) PE-Cy™7 antibody (concentration in sample 0,56 μg/ml). (exbio.cz)

Heart failure is accompanied by severely impaired beta-adrenergic receptor (betaAR) function, which includes loss of betaAR density and functional uncoupling of remaining receptors. (duke.edu)
Antibody production is severely impaired even when mature B cells are present, because of the lack of T-cell help. (medscape.com)

PD-L1 is expressed mainly on tumor-infiltrating immune cells in roughly 41% of patients with triple negative breast cancer ( 5 ). (frontiersin.org)
With the advances in BMT and gene therapy, patients now have a better likelihood of developing a functional immune system in a previously lethal genetic disease. (medscape.com)
Inflammatory bowel disease is a complex set of diseases that includes Crohn's disease (CD) and ulcerative colitis (UC), each with multiple bacterial, immune, and non-immune cell types contributing to inflammation. (frontiersin.org)
Atherosclerosis, which is characterized by chronic inflammation in the arterial wall, is driven by immune cells and cytokines. (hindawi.com)
Many studies have indicated that numerous immune cells promote chronic inflammation and progressive plaque growth [ 4 ]. (hindawi.com)
Ritter C, Fan K, Paulson KG, Nghiem P, Schrama D, Becker JC: Reversal of epigenetic silencing of MHC class I chain-related protein A and B improves immune recognition of Merkel cell carcinoma. (exbio.cz)
HIT pathophysiology has an initiation phase, immunization to produce pathologic antibodies, then platelet activation by IgGCPF4CHep immune complexes. (immune-source.com)

This antibody reacts with mouse IL-18 on Western blotting. (rndsystems.com)

These B cells appear to be blocked at the antigen receptor-expressing stage of B cell differentiation and are thought not to undergo an isotype class switch to IgG or IgA production. (omicsdi.org)
Finally, a number of biologics that target CD4 + T cell differentiation into inflammatory subsets or their byproducts (i.e., cytokines) have shown efficacy in treating patients with IBD ( 5 - 7 ). (frontiersin.org)
STAT4 also signals activation of the TF T-bet, a lineage-defining factor for Th1 differentiation, which upregulates the IL-12 receptor, IFN-γ expression, and causes further expansion of Th1 cells (Figure 1 ) ( 12 ). (frontiersin.org)
Critical factors in the differentiation of effector Th cells during inflammatory bowel disease (IBD). (frontiersin.org)
CD80/86-CD28 interaction and others), these signals initiate a program of cell division and differentiation. (frontiersin.org)
1993). These stressors most likely function by slowing replication enabling differentiation that occurs at a specific stage in the cell routine (Bohne et al. (thetechnoant.info)
Here, they undergo antigen-driven clonal expansion and differentiation into plasma and memory cells. (rupress.org)

Shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. (exbio.cz)

Given the lack of access, and the dispersed nature of brain tumor cells, we explore the possibility of electric fields inducing directed tumor cell migration. (nature.com)
To further understand electrotactic migration of tumor cells, we performed RNA-sequencing for pathway discovery to identify signaling that is differentially affected by the exposure of direct-current electrical fields. (nature.com)
ALCL was recognized in 1985, when tumor cells consistently demonstrated labeling by the monoclonal antibody Ki-1, a marker later shown to recognize the CD30 antigen. (medscape.com)

The distinction between Takayasu and giant cell arteritis is primarily the clinical pattern of vessels involved. (medscape.com)
Cancer immunotherapy by chimeric antigen receptor-modified T (CAR-T) cells has shown exhilarative clinical efficacy for hematological malignancies. (ijbs.com)
Encouragingly and optimistically, in this landscape, more than forty clinical trials in treatment of solid tumors by CAR-T cells have been registered in China alone (Table 1 ) [ 6 ]. (ijbs.com)
Our data have provided evidence for a comparable prediction of clinical outcome in CMF-treated breast cancer patients using conventional clinical variables and gene expression based markers. (lu.se)

These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. (exbio.cz)

The Esp molecules (EspA, B, and D) are involved in the formation of a translocon that delivers effector molecules to the host cell and disrupts the cytoskeleton, sub- verting the host cell functions (7). (cdc.gov)
Edelman's Nobel Prize-winning research concerned discovery of the structure of antibody molecules. (academicinfluence.com)
Cell adhesion molecules. (academicinfluence.com)
Cell adhesion molecules: implications for a molecular histology. (academicinfluence.com)
Cell adhesion molecules in the regulation of animal form and tissue pattern. (academicinfluence.com)
Cell adhesion molecules in early chicken embryogenesis. (academicinfluence.com)

Each group may be encoded by multiple genes and exist in different isoforms depending on species and cell type. (novusbio.com)

these groups are designated Fc gamma RI (also known as CD64), Fc gamma RII (CD32), and Fc gamma RIII (CD16). (novusbio.com)

Pathologic changes involved in Takayasu arteritis are the same as for giant cell arteritis. (medscape.com)

IL-18 acts on T helper type-1 (Th1) T cells and in combination with IL-12 strongly induces them to produce IFN-gamma. (rndsystems.com)

Cell Immunol. (rndsystems.com)

Infiltrating monocytes take up the modified low-density lipoproteins and become foam cells, which make plaques unstable, resulting in acute myocardial infarction [ 5 ]. (hindawi.com)

probably through the influence of a cluster of plasmid-borne basis of similar studies carried out in São Paulo (11-15) and regulatory genes ( per A , B , C ) that increase expression of the the United Kingdom (14) and on a smaller scale in Rio de Jan- chromosomal LEE genes (1). (cdc.gov)
Helminth infections associated with multiple sclerosis induce regulatory B cells. (uni-bielefeld.de)
Together, these findings provide insight into regulatory myeloid cell activities amplified by MIS416-mediated NOD-2 and TLR-9 signalling and highlight the potential importance of these cells in accessing the brain where they may act locally and contribute to the control of neuroinflammation. (nature.com)

Fc gamma Rs that deliver an activating signal either have an intrinsic immunoreceptor tyrosine-based activation motif (ITAM) within their cytoplasmic domains or associate with one of the ITAM-bearing adapter subunits, FcR gamma or zeta (3, 5). (novusbio.com)

The beta-adrenergic receptor kinase is an enzyme, possibly analogous to rhodopsin kinase, that multiply phosphorylates the beta-adrenergic receptor only when it is occupied by stimulatory agonists. (duke.edu)

TNF α plays an important role in the formation of primary B cell follicles and follicular dendritic cells [ 16 ]. (hindawi.com)
Primed T cells and antigen-activated B cells then migrate into the primary follicles where they associate with follicular dendritic cells (FDCs), giving rise to germinal centers (GCs). (rupress.org)

Functionally active targeting domain of the beta-adrenergic receptor kinase: an inhibitor of G beta gamma-mediated stimulation of type II adenylyl cyclase. (duke.edu)
Atezolizumab, an anti-PD-L1 antibody is the first checkpoint inhibitor approved by FDA in combination with chemotherapy to treat triple-negative and PD-L1 positive metastatic breast cancer. (frontiersin.org)

Jacobs H, Vandeputte D, Tolkamp L, de Vries E, Borst J, Berns A: CD3 components at the surface of pro-T cells can mediate pre-T cell development in vivo. (exbio.cz)
Examples of in vivo isotype class switching in IgM+ chronic lymphocytic leukemia B cells. (omicsdi.org)
To test the hypothesis that in vivo isotype class switching occurs in IgM+ B-type CLL cells, we analyzed the PBMC of 19 CLL patients for the presence of transcripts encoding the rearranged CLL V(H)DJ(H) associated with either gamma or alpha H chains. (omicsdi.org)
IL-15cx shows superior in vivo bioactivity to expand CD8 T cells in comparison to an equimolar single chain IL-15. (frontiersin.org)
T-bet is partially involved in CD8 T cell expansion ex vivo and in vivo due to IL-15 or IL-15cx. (frontiersin.org)

Diagram of the main genes of the locus of enterocyte effacement (LEE) region and the entero- pathogenic Escherichia coli (EPEC) adherence fac- tor (EAF) plasmid. (cdc.gov)

T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. (exbio.cz)

Assessing the Magnitude of Immunogenic Cell Death Following Chemotherapy and Irradiation Reveals a New Strategy to Treat Pancreatic Cancer. (rochester.edu)

Anatomy32

Organisms15

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Chemicals and Drugs117

Analytical, Diagnostic and Therapeutic Techniques and Equipment24

Phenomena and Processes66

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Proteins5

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Lymphocytes7

Epitope5

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Specificity2

Cytokine3

Antigens3

Endothelial cells4

Mononuclear1

High affinity1

Proliferation6

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Pathogenesis6

Characterization4

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Detection5

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20001

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CD641

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