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  • cell
  • Expressed on tissue-resident macrophages, the receptor tyrosine kinase, recepteur d'orgine nantais (RON), functions to maintain inflammation homeostasis by activating genes that promote wound repair and resolve inflammation while repressing genes that perpetuate tissue damage and cell death. (jimmunol.org)
  • 2015. Protein tyrosine phosphatases in mast cell signaling. . (icord.org)
  • function
  • Furthermore, PTPa has been linked to the function of a pain-mediating receptor (N-methyl-D-aspartate, NMDA) and could lead to improved treatments for long-term persistent pain. (icord.org)
  • induces
  • Stimulation of B lymphocytes through their antigen receptor (BCR) result in rapid increases and induces both an increase of phosphatidylinositol and mobilization of cytoplasmic free calcium. (nii.ac.jp)
  • EphB4
  • Using immunohistochemistry and Western analysis techniques with an EphB4-specific antibody, we also show that this receptor is expressed in the epithelial cells of the tumour tissue and either not at all, or in only low levels, in the normal tissue. (biomedcentral.com)
  • molecule
  • The binding of a signaling molecule with a receptor causes a change in the conformation of the receptor, known as receptor activation. (wikipedia.org)
  • It also the receptor by which Kaposi sarcoma-associated herpesvirus (KSHV) enters host cells and small molecule inhibitors of EphA2 have shown some ability to block KSHV entry into human cells. (wikipedia.org)
  • One protein molecule, molecule A is shown in yellow and the other, molecule B in grey. (wikipedia.org)
  • signal transduction
  • which has a distinct structural character, that is the presence of the second src homology region 2 (SH2) instead of SH3, from other members of this group of PTK.Our efforts have in large part focused on the relationship between Syk in the context of surface receptor-initiated signal transduction in B cell and platelet because of their abundant localization. (nii.ac.jp)
  • genes
  • The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. (uniprot.org)
  • When antigen binds to T-cell receptor, Lck becomes autophosphorylated and phosphorylates the zeta chain of the T-cell receptor, subsequently another nRTK, Zap70, binds to this T-cell receptor and then participates in downstream signaling events that mediate transcriptional activation of cytokine genes. (wikipedia.org)
  • At the molecular level, such responses include changes in the transcription or translation of genes, and post-translational and conformational changes in proteins, as well as changes in their location. (wikipedia.org)
  • In the case of steroid hormone receptors, their stimulation leads to binding to the promoter region of steroid-responsive genes. (wikipedia.org)
  • The genes that encode the ephrin-A and ephrin-B proteins are designated as EFNA and EFNB respectively. (wikipedia.org)
  • Molecular
  • With state-of-the art molecular biology and protein biochemistry labs, we work with our clients to rapidly evaluate in parallel to identify the optimal expression system for candidate proteins. (abgent.com)
  • The major sperm protein (MSP) is a nematode specific small protein of 126 amino acids with a molecular weight of 14 kDa. (wikipedia.org)
  • The fully glycosylated RET protein is reported to have a molecular weight of 170 kDa although it is not clear to which isoform this molecular weight relates. (wikipedia.org)
  • motility
  • The two main differences between actin and MSP is that MSP does not bind ATP and the lack of polarity in MSP, thus disabling motility through motor proteins, such as myosin. (wikipedia.org)
  • Mutations
  • These types of mutations are associated with papillary thyroid carcinoma (PTC), and the fusion oncoproteins generated are termed RET/PTC proteins. (wikipedia.org)
  • epidermal growth f
  • Most studies have looked at the receptor tyrosine kinases and examples of these are platelet derived growth factor receptor (PDGFR) pathway and epidermal growth factor receptor (EGFR). (wikipedia.org)
  • It is mainly used to treat cases of NSCLC that harbour mutations in the epidermal growth factor receptor (EGFR) gene. (wikipedia.org)
  • verification needed] Phase II results for breast cancer that over-expresses the protein human epidermal growth factor receptor 2 (Her2-positive breast cancer) were described as promising by the authors, with 19 of 41 patients achieving benefit from afatinib. (wikipedia.org)
  • 1999).[supplied by OMIM] CBLC has been shown to interact with FYN and Epidermal growth factor receptor. (wikipedia.org)
  • adhesion
  • Many essential receptor tyrosine kinases such as vascular endothelial development aspect (VEGF) receptor-1 (VEGFR-1), VEGFR-2, and VEGFR-2, and cell adhesion elements (Cameras), including cadherins, integrins, selectins, and immunoglobulin (Ig) superfamily protein, all are included in angiogenesis (Bach et al . (code3systems.com)
  • Vascular endothelial cadherin (VE-cadherin), an endothelium-specific member of the cadherin family members of adhesion protein (Bach et al . (code3systems.com)
  • 2008 ). In this research we discovered a previously uncharacterized receptorimmunoglobulin-containing and proline-rich receptor-1 (IGPR-1)as a story adhesion molecule with a wide phrase in epithelial and endothelial cells. (code3systems.com)
  • oxidative
  • NB: [http://en.wikipedia.org/wiki/Threonine 'Tyrosine is not an alcohol but a phenol, since its hydroxyl group is bonded directly to an aromatic ring, giving it different acid/base and oxidative properties). (openwetware.org)
  • Signaling
  • 3 (SH3)Ccontaining signaling protein, including SH3 proteins interacting with Nck (SPIN90/Desire), bullous pemphigoid antigen-1, and calcium supplement funnel 2. (code3systems.com)
  • Interferons (IFNs) are a group of signaling proteins made and released by host cells in response to the presence of several pathogens, such as viruses, bacteria, parasites, and also tumor cells. (wikipedia.org)
  • He and his team discovered that inhibiting a key player in the signaling system (called vascular endothelial growth factor receptor or VEGFR) suppresses the generation of blood vessels in tumors and slows down cancer cell growth. (wikipedia.org)
  • fluorescent proteins
  • Genetic combinatorial marking using lentiviral vectors encoding fluorescent proteins (FPs) enabled cell fate mapping through advanced microscopy imaging. (jove.com)
  • transcript
  • These IRES-containing bicistronic vectors allow the simultaneous induced expression of two proteins separately but from the same RNA transcript. (clontech.com)
  • Thus, two proteins are expressed simultaneously from the same bicistronic mRNA transcript. (clontech.com)
  • Two transcript variants encoding the same protein have been found for this gene. (wikipedia.org)
  • vascular
  • These include all receptors for platelet-derived growth factor (PDGFR) and vascular endothelial growth factor receptors (VEGFR), which play a role in both tumor angiogenesis and tumor cell proliferation. (wikipedia.org)
  • mRNA
  • GHS receptor (GHS-R) mRNA has been identified mainly in the arcuate nucleus (Arc) and ventromedial nucleus of the hypothalamus and in the pituitary. (jci.org)
  • We have created transgenic (Tg) rats expressing an antisense GHS-R mRNA under the control of the promoter for tyrosine hydroxylase (TH), thus selectively attenuating GHS-R protein expression in the Arc. (jci.org)
  • promoter
  • When expressing the Tet-On 3G transactivator protein from the EF-1 alpha promoter, 83% of the Jurkat Tet-On 3G clones showed strong inducible expression and 33% demonstrated very high inducibility (greater than 2,000-fold). (clontech.com)
  • Engineering Deceit with the Clouds: The H3 receptor site is an inducible metabolic promoter for orthogonal drug delivery and prokariotic gene regulation using Lactose derived repressors: An hypothesis. (openwetware.org)
  • selectively
  • The BLOOM trial, having met all of its primary endpoints and the FDA categorical efficacy benchmark as stated in their guidance, suggests lorcaserin has the potential to become the first in a new class of effective and very well tolerated weight management therapeutics that selectively target the serotonin 2C receptor," said William R. Shanahan, M.D., Arena's Vice President and Chief Medical Officer. (drugs.com)
  • angiogenesis
  • These features of IGPR-1 recommend that IGPR-1 is certainly a story receptor that has an RHOA essential function in cellCcell relationship, cell migration, and angiogenesis. (code3systems.com)
  • 1998 ), and various other Camera protein, such as PECAM-1, ICAM-1, and Alogliptin IC50 JAM-A, are also connected to angiogenesis Alogliptin IC50 (Bach et al . (code3systems.com)
  • Even more significantly, IGPR-1 colleagues with many SH3-formulated with protein and adjusts angiogenesis in vivo and in vitro. (code3systems.com)
  • phenotype
  • 290. Mitra S., Ghantasala S., Sameer Kumar GS, Lakshmi BJ, Thakur SS, Kumar S. Absence of Wdr13 gene predisposes mice to mild social isolation - chronic stress, leading to depression-like phenotype associated with differential expression of synaptic proteins. (gov.pl)
  • Matveeva, E.A.;Price, D.A.;Whiteheart, S.W.;Vanaman, T.C.;Gerhardt, G.A.;Slevin, J.T. "Reduction of vesicle-associated membrane protein 2 expression leads to a kindling-resistant phenotype in a murine model of epilepsy. (uky.edu)
  • nutrients
  • Thus, the activation of the HBP by nutrients represents a biochemical link between nutrient availability, mitochondrial proteins, and energy expenditure, and it is likely to play an important role in the regulation of energy balance. (jci.org)
  • vesicular
  • A second major area of study concerns depolarization depemndent reversible phodsphorylation of various protein factors of the vesicular neurosecretory apparatus and the possible dysfunction in this system in epilepsy. (uky.edu)
  • regulatory
  • The structure, function and molecular biology of Ca2+ dependent regulatory proteins (particularly calmodulin) and the target proteins which they regulate is under study. (uky.edu)
  • cell growth
  • The relevant proteins are those involved in regulating cell growth and division via signalling pathways whereby one protein changes the behavior of potentially many others. (wikipedia.org)
  • human
  • Recombinant A2/B5 heterodimeric glycoproteins, purified using cation exchange and size fractionation chromatography, activated human TSH receptors, but not LH and FSH receptors, and showed high affinity to TSH receptors in a radioligand receptor assay. (jci.org)
  • Based on the type of receptor through which they signal, human interferons have been classified into three major types. (wikipedia.org)
  • So CCDS's gene number prediction represents a lower bound on the total number of human protein-coding genes. (wikipedia.org)
  • thus
  • Its localization and possible interacting partners (other than Htt) have since been characterised, thus elucidating a possible role for this protein in HD pathogenesis. (wikipedia.org)
  • molecules
  • IFNs belong to the large class of proteins known as cytokines, molecules used for communication between cells to trigger the protective defenses of the immune system that help eradicate pathogens. (wikipedia.org)
  • The BCR-ABL protein can be inhibited by various small molecules. (wikipedia.org)
  • subcellular
  • Src contains at least three flexible protein domains, which, in conjunction with myristoylation, can mediate attachment to membranes and determine subcellular localization. (wikipedia.org)
  • Gutekunst and colleagues used immunogold labeling to identify subcellular localization of both HAP1 and muHtt, and identified a close similarity of the distribution of the two proteins. (wikipedia.org)
  • expression
  • Conversely, the expression of uncoupling protein-1 and of the same mitochondrial genes was increased in brown adipose tissue. (jci.org)
  • The expression of thyrostimulin in the anterior pituitary known to express TSH receptors suggested a paracrine mechanism. (jci.org)
  • 631166 and 631346), or you can monitor co-induced expression of your transgene with a fluorescent protein using kits that contain pTRE3G-mCherry (Cat. (clontech.com)
  • One candidate master regulator is an oestrogen-receptor that is involved in breast cancer that controls the expression of many genes. (wikipedia.org)
  • Elevated protein expression of alpha II-spectrin has been detected in cerebrospinal fluid in patients with Guillain-Barré syndrome. (wikipedia.org)
  • known
  • In addition, interferons induce production of hundreds of other proteins-known collectively as interferon-stimulated genes (ISGs)-that have roles in combating viruses and other actions produced by interferon. (wikipedia.org)
  • Some known and suspected master regulators are in protein classes that are difficult to affect with drugs. (wikipedia.org)
  • Domains
  • This induces long-range allostery via protein domain dynamics, causing the structure to be destabilized, resulting in the opening up of the SH3, SH2 and kinase domains and the autophosphorylation of the residue tyrosine 416. (wikipedia.org)