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  • binds
  • The elastin receptor complex contains a component of 67 kilodaltons that binds to a glycoconjugate affinity column containing beta-galactoside residues and is eluted from this column with lactose. (sciencemag.org)
  • We hypothesize that bone morphogenetic protein 9 (BMP9), a ligand of the TGF-β family that binds to the activin receptor-like kinase 1 (ALK1)-BMP receptor type 2 (BMPR2) receptor complex, may be a novel therapeutic option for BPD. (frontiersin.org)
  • Sp1 has been used as a control protein to compare with when studying the increase or decrease of the aryl hydrocarbon receptor and/or the estrogen receptor, since it binds to both and generally remains at a relatively constant level. (wikipedia.org)
  • activator
  • Recent studies suggest that UV radiation blocks transforming growth factor- beta Type II receptor/Smad signaling (10), activates activator protein (AP)-1 that in turn is activated by a series of mitogen- activated protein kinases (MAPKs). (redorbit.com)
  • 34 OPG was first shown to function as an antagonistic "faux receptor" of receptor activator of nuclear factor κB ligand (RANKL), the TNF superfamily member that signals via its receptor activator of nuclear factor κB on monocyte/macrophage progenitors to promote the formation of bone-resorbing osteoclasts. (ahajournals.org)
  • murine
  • Only detects murine TLR-4 when complexed to MD-2. (abcam.com)
  • 10 Furthermore, we highlight differences between the low-density lipoprotein receptor (LDLR)-deficient and apolipoprotein E (apoE)-deficient murine models ( Table 2 ) that help articulate the multifaceted contributions of dyslipidemia, diabetes mellitus, and uremia to arterial calcium deposition. (ahajournals.org)
  • arterial
  • Comparison between fresh and digested tissues shows that, at 35% strain, a minimum of 48% of the arterial load is carried by elastin, and a minimum of 43% of the change in stiffness of arterial tissue is due to the change in elastin stiffness. (wikipedia.org)
  • lipid
  • In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane. (abcam.com)
  • Metastasis
  • Tumor cell metastasis is a complex, multi-step process that is a major cause of morbidity and death amongst cancer patients. (aacrjournals.org)
  • An understanding of ECM structure and composition also helps in comprehending the complex dynamics of tumor invasion and metastasis in cancer biology as metastasis often involves the destruction of extracellular matrix by enzymes such as serine proteases, threonine proteases, and matrix metalloproteinases. (wikipedia.org)
  • antibody
  • Ab9105 is a TLR4 function blocking antibody that is useful for studies on the role of TLR4 as a receptor fpr LPS induced cytokine production by TLR4 bearing cells. (abcam.com)
  • tissue
  • Elastin is also an important load-bearing tissue in the bodies of vertebrates and used in places where mechanical energy is required to be stored. (wikipedia.org)
  • endothelial
  • Expression of the BMP9 receptor complex and TMEM100 was studied in human endothelial and epithelial cell cultures and the effect of BMP9 on inflammatory cytokine production and TMEM100 expression was studied in endothelial cell cultures. (frontiersin.org)
  • cells
  • The S-Gal protein is a peripheral membrane protein that functions as part of an elastin receptor complex on the surface of cells. (wikipedia.org)
  • Digestive enzymes are secreted by different exocrine glands including: Salivary glands Secretory cells in the stomach Secretory cells in the pancreas Secretory glands in the small intestine Complex food substances that are taken by animals and humans must be broken down into simple, soluble, and diffusible substances before they can be absorbed. (wikipedia.org)
  • For instance, IKK2 is found to be mainly responsible for phosphorylating serine 536 in monocytes and macrophages, or in CD40 receptor binding in hepatic stellate cells. (wikipedia.org)
  • glands
  • Amylase, produced by the salivary glands, breaks complex carbohydrates to smaller chains, or even simple sugars. (wikipedia.org)
  • novel
  • The high-throughput nature of this assay should allow for large-scale genetic and chemical screens to identify novel longevity modifiers for further testing in more complex organisms. (jove.com)
  • process
  • Since lactose also blocks elastic fiber formation by cultured chondroblasts, the galactoside-binding property of the elastin receptor is implicated in this process. (sciencemag.org)
  • Biomineralization is a complex, regulated process occurring widely throughout nature. (ahajournals.org)
  • This entire process is aided by the presence of reactive oxygen species that inhibits protein-tyrosine phosphatases via oxidation, thereby resulting in the up-regulation of the above-mentioned receptors. (wikipedia.org)
  • component
  • This protein component is also released from the surface of cultured chondroblasts by incubation with lactose, and its association with immobilized elastin is inhibited by lactose. (sciencemag.org)
  • Estrogen
  • Sp1 has been used as a control protein to compare with when studying the increase or decrease of the aryl hydrocarbon receptor and/or the estrogen receptor, since it binds to both and generally remains at a relatively constant level. (wikipedia.org)
  • soluble
  • Digestive enzymes are secreted by different exocrine glands including: Salivary glands Secretory cells in the stomach Secretory cells in the pancreas Secretory glands in the small intestine Complex food substances that are taken by animals and humans must be broken down into simple, soluble, and diffusible substances before they can be absorbed. (wikipedia.org)
  • important
  • Elastin is also an important load-bearing tissue in the bodies of vertebrates and used in places where mechanical energy is required to be stored. (wikipedia.org)
  • small
  • Cathepsin S cleaves the remaining fragment of Ii (IiP1) and leaves a small part of Ii known as CLIP which stays directly associated with the complex. (wikipedia.org)
  • sites
  • No regular secondary structures are gained upon phosphorylation and the different phosphorylation sites interchange in the complex. (wikipedia.org)
  • load
  • Comparison between fresh and digested tissues shows that, at 35% strain, a minimum of 48% of the arterial load is carried by elastin, and a minimum of 43% of the change in stiffness of arterial tissue is due to the change in elastin stiffness. (wikipedia.org)
  • active
  • while inactivating neutrophil CXCR2 receptor, generates an active C5a fragment of C5 (although inactivating C5b). (wikipedia.org)
  • different
  • In a polymorphic complex, the protein adopts two or more different conformations upon binding to the same partner, and these conformations can be resolved. (wikipedia.org)