• binds
  • The elastin receptor complex contains a component of 67 kilodaltons that binds to a glycoconjugate affinity column containing beta-galactoside residues and is eluted from this column with lactose. (sciencemag.org)
  • We hypothesize that bone morphogenetic protein 9 (BMP9), a ligand of the TGF-β family that binds to the activin receptor-like kinase 1 (ALK1)-BMP receptor type 2 (BMPR2) receptor complex, may be a novel therapeutic option for BPD. (frontiersin.org)
  • Sp1 has been used as a control protein to compare with when studying the increase or decrease of the aryl hydrocarbon receptor and/or the estrogen receptor, since it binds to both and generally remains at a relatively constant level. (wikipedia.org)
  • deposition
  • 10 Furthermore, we highlight differences between the low-density lipoprotein receptor (LDLR)-deficient and apolipoprotein E (apoE)-deficient murine models ( Table 2 ) that help articulate the multifaceted contributions of dyslipidemia, diabetes mellitus, and uremia to arterial calcium deposition. (ahajournals.org)
  • arterial
  • Comparison between fresh and digested tissues shows that, at 35% strain, a minimum of 48% of the arterial load is carried by elastin, and a minimum of 43% of the change in stiffness of arterial tissue is due to the change in elastin stiffness. (wikipedia.org)
  • activator
  • Recent studies suggest that UV radiation blocks transforming growth factor- beta Type II receptor/Smad signaling (10), activates activator protein (AP)-1 that in turn is activated by a series of mitogen- activated protein kinases (MAPKs). (redorbit.com)
  • 34 OPG was first shown to function as an antagonistic "faux receptor" of receptor activator of nuclear factor κB ligand (RANKL), the TNF superfamily member that signals via its receptor activator of nuclear factor κB on monocyte/macrophage progenitors to promote the formation of bone-resorbing osteoclasts. (ahajournals.org)
  • interactions
  • It is suggested that both AP-1 and NF-kappaB that are activated by ROS may provide the complex driving force that results in a series of complex biologic interactions leading to skin- related diseases, most notably skin cancer (2,3,11,12). (redorbit.com)
  • lipid
  • We evaluated the consequences of EDP accumulation in mice and of elastin receptor complex (ERC) activation on lipid storage in hepatocytes, inflammation, and fibrosis development. (diabetesjournals.org)
  • In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane. (abcam.com)
  • activation
  • The nociceptive activity results from cathepsin S functioning as a signaling molecule via activation of protease-activated receptors 2 and 4 members of the G-protein coupled receptor family. (wikipedia.org)
  • UV exposure would also lead to the activation of receptors for epidermal growth factor, IL-1, and TNF-α in keratinocytes and fibroblasts, which then activates signaling kinases throughout the skin via an unknown mechanism. (wikipedia.org)
  • RELA and p50 is the mostly commonly found heterodimer complex among NF-κB homodimers and heterodimers, and is the functional component participating in nuclear translocation and activation of NF-κB. (wikipedia.org)
  • IKK1 functions as the major kinase phosphorylating serine 536 under different stimuli, such as the ligand activation of the lymphotoxin-β receptor (LTβR). (wikipedia.org)
  • antibody
  • Ab9105 is a TLR4 function blocking antibody that is useful for studies on the role of TLR4 as a receptor fpr LPS induced cytokine production by TLR4 bearing cells. (abcam.com)
  • tissue
  • Elastin is also an important load-bearing tissue in the bodies of vertebrates and used in places where mechanical energy is required to be stored. (wikipedia.org)
  • endothelial
  • Expression of the BMP9 receptor complex and TMEM100 was studied in human endothelial and epithelial cell cultures and the effect of BMP9 on inflammatory cytokine production and TMEM100 expression was studied in endothelial cell cultures. (frontiersin.org)
  • cells
  • The S-Gal protein is a peripheral membrane protein that functions as part of an elastin receptor complex on the surface of cells. (wikipedia.org)
  • For instance, IKK2 is found to be mainly responsible for phosphorylating serine 536 in monocytes and macrophages, or in CD40 receptor binding in hepatic stellate cells. (wikipedia.org)
  • major
  • Tumor cell metastasis is a complex, multi-step process that is a major cause of morbidity and death amongst cancer patients. (aacrjournals.org)
  • glands
  • Amylase, produced by the salivary glands, breaks complex carbohydrates to smaller chains, or even simple sugars. (wikipedia.org)
  • important
  • These results are consistent with an important role for elastin in general, and fibrillin-1 in particular, in the pathogenesis of atherosclerosis. (ahajournals.org)
  • novel
  • The high-throughput nature of this assay should allow for large-scale genetic and chemical screens to identify novel longevity modifiers for further testing in more complex organisms. (jove.com)
  • process
  • Biomineralization is a complex, regulated process occurring widely throughout nature. (ahajournals.org)
  • This entire process is aided by the presence of reactive oxygen species that inhibits protein-tyrosine phosphatases via oxidation, thereby resulting in the up-regulation of the above-mentioned receptors. (wikipedia.org)
  • activity
  • Alteration, truncation or removal of conformationally ambiguous regions impacts the activity of the corresponding complex. (wikipedia.org)