• cisplatin
  • This is a Phase 3, multicenter, randomized, parallel-group, double-blind, active-controlled study of rolapitant in subjects receiving HEC (≥60 mg/m2 of cisplatin-based chemotherapy). (clinicaltrials.gov)
  • EA was performed at CV12 (n=12), bilateral PC6 (n=12), or sham points (n=12) 3 days before and 1-2 days after cisplatin administration (4-5 times in total), at 0.5-1 mA intensity and 2/15 Hz frequency for 10 min. (bmj.com)
  • EA at CV12 also attenuated the cisplatin-induced increase in 5-HT in the duodenum and suppressed c-Fos expression in the NTS. (bmj.com)
  • Serotonin (5-hydroxytryptamine, 5-HT) is an important neurotransmitter, which is implicated in cisplatin-induced emesis. (bmj.com)
  • tract
  • Approximately 80% of total body serotonin is found in the GI tract, the remainder being divided between the platelets, which avidly take up free serotonin, and the central nervous system. (wiley.com)
  • mainly
  • Serotonin is metabolized mainly to 5-HIAA, chiefly by the liver. (wikipedia.org)
  • It has been known for more than 25 years that there is a substantial amount of serotonin (5-hydroxytrypamine or 5HT) in the gut, distributed mainly in the enteroendocrine cells with a small amount in the enteric nervous system. (wiley.com)
  • Structures
  • Classical cannabinoid agonists (structures shown in Table 1 ) bind to and activate cannabinoid receptors 1 and 2 (CB1, CB2) that modulate signal transduction cascades to produce various physiological and pathological outcomes. (frontiersin.org)
  • THEREOF
  • 16. A method of treatment of a 5-HT3 receptor-mediated disorder comprising the administration of a therapeutically effective amount of a compound as recited in claim 1 to a patient in need thereof. (patentsencyclopedia.com)
  • treatment
  • This has lead to a number of significant advances including 5HT 3 antagonists for the treatment of functional diarrhoea, 5HT 4 agonists for the treatment of constipation and 5HT 1 agonists for the treatment of impaired fundal relaxation. (wiley.com)
  • occurs
  • In physiologic states, vasodilation occurs through the serotonin mediated release of nitric oxide from endothelial cells. (wikipedia.org)
  • protein
  • Except for the 5-HT3 receptor, a ligand-gated ion channel, all other 5-HT receptors are G-protein-coupled receptors (also called seven-transmembrane, or heptahelical receptors) that activate an intracellular second messenger cascade. (wikipedia.org)
  • The binding of 5-HT to G protein receptors (Go, G¡, etc.) that are coupled to adenylyl cyclase (AC) and phospholipase C-B (PLC-15) will result in the production of a cascade of second-messenger and cellular effects. (pharmacologicalsciences.us)
  • platelets
  • The serotonin is secreted luminally and basolaterally which leads to increased serotonin uptake by circulating platelets and activation after stimulation, which gives increased stimulation of myenteric neurons and gastrointestinal motility. (wikipedia.org)
  • When the platelets bind to a clot, they release serotonin, where it can serve as a vasoconstrictor and/or a vasodilator while regulating hemostasis and blood clotting. (wikipedia.org)
  • However
  • However, it has become clear that not all effects of cannabinoid drugs are attributable to their interaction with CB1 and CB2 receptors. (frontiersin.org)
  • 5 However, the mechanism underlying the antiemetic effect of acupuncture remains unclear. (bmj.com)
  • effects
  • The antimigraine effects of this agent are likely mediated by local activation of this receptor subtype on blood vessels, which results in their constriction. (pharmacologicalsciences.us)
  • Cannabinoids produce many of their cellular and organ system effects by interacting with the well-characterized CB1 and CB2 receptors. (frontiersin.org)
  • major
  • Modulation of serotonin at synapses is thought to be a major action of several classes of pharmacological antidepressants. (wikipedia.org)
  • see Figure 1-4A later in this chapter), leading to the suggestion that 5-HT exerts a major modulatory role throughout the CNS (Reader 1980). (pharmacologicalsciences.us)
  • different
  • Initial difficulties in understanding its role was inevitable, given that it is now recognized that there are over 21 different receptor subtypes. (wiley.com)
  • effect
  • Serotonin's presence in insect venoms and plant spines serves to cause pain, which is a side-effect of serotonin injection. (wikipedia.org)
  • Serotonin is produced by pathogenic amoebae, and its effect in the human gut is diarrhea. (wikipedia.org)
  • EA at PC6 influenced kaolin intake (on day 1 only) and c-Fos expression, but had no statistically significant effect on food intake, bodyweight or 5-HT expression. (bmj.com)
  • The anti-emetic effect of EA may be mediated through inhibition of 5-HT secretion in the duodenum and activity of the NTS. (bmj.com)
  • cancer
  • Considering the CNS and cancer together allow identification of non-cannabinoid receptor targets that are shared and divergent in both systems. (frontiersin.org)
  • agent
  • 20. The method as recited in claim 18 wherein said additional therapeutic agent is a H1-receptor antagonist selected from the group consisting of levocetirizine, desloratadine, and fexofenadine, astemizole, terfenadine, loratadine, and cetirizine. (patentsencyclopedia.com)
  • role
  • Serotonin is also a growth factor for some types of cells, which may give it a role in wound healing. (wikipedia.org)
  • It is now becoming relevant therefore for clinicians to understand the role of serotonin in the normal gut function. (wiley.com)
  • specific
  • As more specific agonists and antagonists have become available more discriminating studies have become possible to define these many separate and sometimes conflicting responses. (wiley.com)
  • initial
  • Initial enthusiasm has been somewhat dented by the withdrawal of alosetron because of ischaemic colitis, but it remains to be seen whether this adverse event will be seen with other 5HT 3 antagonists. (wiley.com)