• antibody
  • Western blot analysis of IL-22 receptor expression in human HepG2 cell lysate with IL-22 receptor antibody at 1 μg /ml. (genetex.com)
  • Immunocytochemistry of IL-22 receptor in HepG2 cells with IL-22 receptor antibody at 10 μg/mL. (genetex.com)
  • It is a 144 kDa glycoprotein obtained from fermentation of an established mouse myeloma cell line genetically engineered to express plasmids containing the human heavy and light chain constant region genes and mouse heavy and light chain variable region genes encoding the RFT5 antibody that binds selectively to the IL-2R alpha. (drugbank.ca)
  • approximately 10
  • They reported a P value of approximately 10 −24 for rs12979860, the most strongly associated single-nucleotide polymorphism (SNP) in patients of European ancestry. (wiley.com)
  • The following approximately 10 days help the patient to recover between treatments. (wikipedia.org)
  • cytokines
  • These type 2 receptors have the ability to bind both IL-4 and IL-13, two cytokines with closely related biological functions. (wikipedia.org)
  • Further investigation has shown that IL-10 predominantly inhibits lipopolysaccharide (LPS) and bacterial product mediated induction of the pro-inflammatory cytokines TNFα, IL-1β, IL-12, and IFNγ secretion from Toll-Like Receptor (TLR) triggered myeloid lineage cells. (wikipedia.org)
  • IL-10 is capable of inhibiting synthesis of pro-inflammatory cytokines such as IFN-γ, IL-2, IL-3, TNFα and GM-CSF made by cells such as macrophages and Th1 T cells. (wikipedia.org)
  • IL-10 is linked to the myokines, as exercise provokes an increase in circulating levels of IL-1ra, IL-10, and sTNF-R, suggesting that physical exercise fosters an environment of anti-inflammatory cytokines. (wikipedia.org)
  • expression
  • The expression of IL-10 is minimal in unstimulated tissues and seems to require triggering by commensal or pathogenic flora. (wikipedia.org)
  • IL-10 expression is tightly regulated at the transcriptional and post-transcriptional level. (wikipedia.org)
  • IL-10 may autoregulate its expression via a negative feed-back loop involving autocrine stimulation of the IL-10 receptor and inhibition of the p38 signaling pathway. (wikipedia.org)
  • Additionally, IL-10 expression is extensively regulated at the post-transcriptional level, which may involve control of mRNA stability via AU-rich elements and by microRNAs such as let-7 or miR-106. (wikipedia.org)
  • Expression of IL-10 from transfected tumor cell lines. (wikipedia.org)
  • signaling pathway
  • IL-10 can block NF-κB activity, and is involved in the regulation of the JAK-STAT signaling pathway. (wikipedia.org)
  • We also identified eight growth factors and growth factor receptor genes that are significantly altered by each of the HDIs, including Frizzled related proteins 1 and 4, which modulate the Wnt signaling pathway. (springer.com)
  • heterodimer
  • Our laboratory continues to work on fundamental processes by which T lymphocytes recognize foreign pathogens including viruses such as smallpox, vaccinia, HIV, and influenza A. We have analyzed the basic function and structure of the T cell receptor (TCR) components: TCRalphabeta heterodimer, CD3epsilongamma and CD3epsilondelta heterodimers, and CD3zetazeta homodimer. (dana-farber.org)
  • secretion
  • An increase in repair macrophages (M2) is coupled with secretion of IL-10 and TGF-β that result in a diminution of pathological inflammation. (wikipedia.org)
  • adenylate cyclase
  • The receptor for this group is the CGMPR family secretin like which uses various G proteins (Gas) to activate/deactivate adenylate cyclase as well as cause calcium release. (brainscape.com)
  • proteins
  • Calcineurin alters proteins by removing phosphate groups, shortening duration of NMDA channel opening, resulting in synaptic desensitisation of NMDA receptors. (thefreedictionary.com)
  • stimulation
  • Interleukin 4 has many biological roles, including the stimulation of activated B-cell and T-cell proliferation, and the differentiation of B cells into plasma cells. (wikipedia.org)
  • membrane
  • Ligands for rhodopsin like GPCR's release an alpha unit (Gaq11) which activates phospholipase C, which cleaves PIP2, releasing IP3 which opens calcium channels, and DAG, which attracts PKC to the cell membrane. (brainscape.com)
  • transcription
  • IL-1 receptors and TLR receptors then bind MYD88, TRAF3, TRAF6, IRAK resulting in the generation of transcription factors NF kB and AP1. (brainscape.com)
  • IL-10 induction involves ERK1/2, p38 and NF-κB signalling and transcriptional activation via promoter binding of the transcription factors NF-κB and AP-1. (wikipedia.org)