AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation Science
Estrogen Receptor betaInterleukin-18 Receptor beta SubunitInterleukin-10 Receptor beta SubunitEstrogen Receptor alphaOncostatin M Receptor beta SubunitMacromolecular SubstancesReceptor, InsulinCytokine Receptor Common beta SubunitReceptors, Interleukin-3Receptors, GlycineMolecular Sequence DataBase SequenceTyrosinePhosphorylationInterleukin-2 Receptor beta SubunitCell LineSignal TransductionTransfectionCells, CulturedKineticsAmino Acid SequenceProtein-Tyrosine KinasesPhosphotyrosineReceptors, Platelet-Derived Growth FactorThyroid Hormone Receptors betaProtein SubunitsRNA, MessengerReceptors, InterleukinReceptors, Retinoic AcidInsulinRecombinant ProteinsBinding SitesInterleukin-1betaCloning, MolecularGene Expression RegulationProtein BindingInterleukin-1Interleukin-13 Receptor alpha1 SubunitChorionic Gonadotropin, beta Subunit, HumanInterleukin-12 Receptor beta 1 SubunitMutationPPAR alphaMice, Inbred C57BLTranscription, GeneticInterleukin-13 Receptor alpha2 SubunitInterleukin-2Transcription FactorsReceptors, Interleukin-2Mice, KnockoutGene ExpressionRetinoid X Receptor alphaReceptors, Interleukin-12Promoter Regions, GeneticRecombinant Fusion ProteinsInterleukin-6Proton-Translocating ATPasesProtein ConformationThyroid Hormone Receptors alphaReverse Transcriptase Polymerase Chain ReactionSequence Homology, Amino AcidBlotting, WesternLigandsDNADNA PrimersReceptors, EstrogenReceptors, Cytoplasmic and NuclearTumor Cells, CulturedMutagenesis, Site-DirectedCytokinesReceptors, GABA-AIntegrinsElectrophoresis, Polyacrylamide GelT-LymphocytesEstradiolalpha 1-AntitrypsinDNA-Binding ProteinsReceptors, NicotinicProtein Structure, TertiaryPeptide FragmentsDose-Response Relationship, DrugPolymerase Chain ReactionEscherichia coliPPAR-betabeta 2-MicroglobulinImmunohistochemistryTumor Necrosis Factor-alphaMolecular WeightReceptor, Platelet-Derived Growth Factor betaInterleukin-12 Receptor beta 2 SubunitGenes, T-Cell Receptor betaIntegrin alpha5beta1DNA, ComplementaryModels, MolecularCell Line, TumorAntibodies, MonoclonalFollicle Stimulating Hormone, beta SubunitIntegrin beta3Receptors, Antigen, T-Cell, alpha-betaCell DivisionStructure-Activity Relationship
CytokineIL10RBProto-oncogeneHeterodimericInterferon gammaHigh affinityTyrosineChemokineAntigensComplexesAffinityGammaGlycoproteinAntagonistCD25Antigen receptorImmunityIFNAR2PrecursorProtein-coupled receptorImmuneGeneDeficiencyCytokinesInsulin ReceptorPattern recognitInhibitionMiceAntigenicSource:HGNC SymbolTumor necroProteinsATPaseTypeMonocytesHypothesisNuclearMoleculesLigandDiseasesAngiotensinMembraneEnzymesAntibodiesModulationRegulatesCellsComplementTranscriptionSignalSignalsColonyKinase
Cytokine17
  • This gene encodes a member of the type II cytokine receptor family. (nih.gov)
  • The encoded protein is a subunit of the receptor for interleukin 20, a cytokine that may be involved in epidermal function. (nih.gov)
  • The Periodic Table of Cytokine and Chemokine Families poster includes members of the tumor necrosis factor (TNF) superfamily, and cytokines belonging to the different families of interleukins, interferons, and chemokines. (rndsystems.com)
  • Within each square, the full name of the cytokine is listed, along with its alternate names, a symbol to signify its structure, and the receptors that it utilizes to activate downstream signaling. (rndsystems.com)
  • Additionally, it is shown whether each cytokine belongs to the beta-trefoil, four helix bundle, or cysteine-knot superfamily and their subfamily designation. (rndsystems.com)
  • This superfamily is further subdivided into the class I and class II cytokine receptor families. (rndsystems.com)
  • Ligands for the class I cytokine receptor family include short-chain and long-chain helical cytokines. (rndsystems.com)
  • The short-chain helical cytokine family includes members of the common gamma-chain and common beta-chain families of cytokines. (rndsystems.com)
  • Ligands for the class II cytokine receptor family includes the IL-10 family cytokines, along with the type I, type II, and type III interferons, which are shown in columns three, four, and nine of the poster. (rndsystems.com)
  • A low affinity interleukin-5 receptor subunit that combines with the CYTOKINE RECEPTOR COMMON BETA SUBUNIT to form a high affinity receptor for INTERLEUKIN-5. (harvard.edu)
  • Interleukin-2 receptor (IL-2R) is a heterotrimeric protein expressed on the surface of certain immune cells, such as lymphocytes, that binds and responds to the cytokine IL-2. (transcriptionfactor.org)
  • The α and β chains are involved in binding IL-2, while signal transduction following cytokine interaction is carried out by the γ-chain, along with the β subunit. (transcriptionfactor.org)
  • The β and γ chains of the IL-2R are members of the type I cytokine receptor family. (transcriptionfactor.org)
  • Interleukin 22 binding protein (IL-22BP), also known as CRF2-10, CRF2-X, and IL-22 RA2, is a 35-45 kDa secreted glycoprotein in the type II cytokine receptor family (CRF). (rndsystems.com)
  • CD25 (IL2 receptor alpha chain/IL2RA) is a cytokine that plays a role in the proliferation of T and B lymphocytes. (thermofisher.com)
  • The receptor of this cytokine (IL2RA) is a heterotrimeric protein complex with a gamma chain also shared by interleukin 4 (IL4) and interleukin 7 (IL7). (thermofisher.com)
  • Interleukin (IL)-23, a heterodimeric cytokine, is composed of an IL-23-specific subunit p19 and an IL-12-common subunit p40 [ 10 ]. (oncotarget.com)
IL10RB1
  • The top five most associated protein-coding genes were Interferon Alpha and Beta Receptor Subunit 2 (IFNAR2), 2'-5'-Oligoadenylate Synthetase 3 (OAS3), mucin 1 (MUC1), Interleukin 10 Receptor Subunit Beta (IL10RB), and Napsin A Aspartic Peptidase (NAPSA). (cdc.gov)
Proto-oncogene1
Heterodimeric3
  • The interleukin 20 receptor is a heterodimeric complex consisting of the encoded protein and interleukin 20 receptor beta. (nih.gov)
  • Members of the common beta-chain family signal through heterodimeric receptor complexes that contain the common beta-chain subunit, while members of the common gamma-chain family signal through heterodimeric or heterotrimeric receptor complexes that contain the common gamma-chain subunit. (rndsystems.com)
  • Members of the IL-10 family cytokines have structural similarities and signal through heterodimeric receptor complexes with common subunits. (rndsystems.com)
Interferon gamma2
  • The potential causal genes were enriched in biological processes related to type I interferons, interferon gamma inducible protein 10 production, and chemokine (C-X-C motif) ligand 2 production. (cdc.gov)
  • Seder, R. A., Gazzinelli, R., Sher, A. & Paul, W. E. Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming. (nature.com)
High affinity2
  • However, CD25 associates with CD122 (IL-2 receptor beta chain) and CD132 (common gamma chain) to form the high affinity IL-2 receptor. (thermofisher.com)
  • IL2RA, IL2R beta chain (IL2RB), and the IL2R gamma chain (IL2RG), constitute the high-affinity IL2 receptor. (thermofisher.com)
Tyrosine3
  • The four short-chain helix bundle cytokines that signal through class III receptor tyrosine kinases include M-CSF, SCF, Flt-3 Ligand, and IL-34, and are shown in columns four and five of the poster. (rndsystems.com)
  • The receptors for these cytokines contain extracellular Ig-like domains, similar to the IL-1 R family, but they have cytoplasmic domains with tyrosine kinase activity. (rndsystems.com)
  • discoidin domain receptor tyrosine kin. (gsea-msigdb.org)
Chemokine1
Antigens1
  • or actively by prior immunization of the recipient with graft antigens which evoke specific antibodies and form antigen-antibody complexes which bind to the antigen receptor sites of the T-cells and block their cytotoxic activity. (lookformedical.com)
Complexes3
  • IL-10 R beta is also a component of the receptor complexes for IL-10, IL-26, IL-28, and IL-29 (1, 2). (rndsystems.com)
  • Complement and complement receptors play a critical role in immune defense by initiating the rapid destruction of invading microorganisms, amplifying the innate and adaptive immune responses, and mediating solubilization and clearance of immune complexes. (medscape.com)
  • The CR1 receptor preferentially binds C3b that is covalently attached to immune complexes, and it has a weaker affinity for bound C4b and iC3b. (medscape.com)
Affinity2
  • The S1 subunit (PDB I.D-6VSB) of the spike protein being reported to acts as receptor binding domain (RBD), binding to ACE-2 receptor with higher affinity. (ijpsonline.com)
  • Homodimeric IL2RA chains result in low-affinity receptor, while homodimeric IL2RB chains produce a medium-affinity receptor. (thermofisher.com)
Gamma2
Glycoprotein2
  • Contagious human coronavirus (SARS-CoV-2) binds to the receptors of human host cells by transmembrane spike glycoprotein that makes homotrimers protruding from viral surface region[ 9 , 10 ]. (ijpsonline.com)
  • Spike glycoprotein has two subunits, S1-responsible for its binding to host cell membrane receptors and S2-responsible for the fusion of viral and host cellular membrane[ 8 , 11 ]. (ijpsonline.com)
Antagonist1
CD251
Antigen receptor1
  • CR2/CD21 interacts with C3b degradation products C3dg and C3d and can act synergistically with the B-cell antigen receptor (BCR) in B-cell activation. (medscape.com)
Immunity1
  • The complement system, interacting with its regulatory molecules and cellular receptors, plays a central role in the induction and regulation of immunity. (medscape.com)
IFNAR21
  • The actions of IFNT are mediated by the interferon (alpha and beta) receptor (IFNAR), which consists of two subunits, IFNAR1 and IFNAR2. (dna-pksignal.com)
Precursor1
Protein-coupled receptor2
  • His study of G protein-coupled receptor is a part of Receptor. (research.com)
  • His G protein-coupled receptor research is multidisciplinary, incorporating perspectives in PELP-1 and Immune receptor. (research.com)
Immune4
  • About 90% of those infected result in latent infections, and about 10% of latent infections develop active diseases when their immune system is impaired due to the age, other diseases such as AIDS or exposure to immunosuppressive drugs. (genome.jp)
  • Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (T h 1)-specific immune responses and inhibits the development of IL-4-producing Th cells. (nature.com)
  • Defects in the expression of complement or complement receptors may result in loss of tolerance to self-proteins and the development of immune complex-mediated autoimmune diseases such as systemic lupus erythematosus (SLE). (medscape.com)
  • CR1 and CR2 have been shown to influence the immune environment in a B-cell receptor-independent manner. (medscape.com)
Gene4
  • This gene and interleukin 20 receptor beta are highly expressed in skin, and are upregulated in psoriasis. (nih.gov)
  • His Molecular biology research integrates issues from Alpha, Gene expression, Complementary DNA, Protein kinase C and Gene isoform. (research.com)
  • A second trial (SCIDn2) was carried out to treat SCID-X1 using an improved self-inactivated vector in which the LTR strong enhancer sequences were deleted [ 19 ], and a promoter comprised of the short elongation factor 1 alpha (EF1a) promoter, devoid of enhancer regions, was used to express the therapeutic IL2RG gene. (europeanhealthjournal.com)
  • Mutations in this gene are associated with interleukin 2 receptor alpha deficiency. (thermofisher.com)
Deficiency1
  • Note the image below, as well as the article Pediatric Complement Receptor Deficiency may be helpful. (medscape.com)
Cytokines4
  • The final family of interleukins shown in the poster is the IL-17 family cytokines listed in column 10. (rndsystems.com)
  • These cytokines belong to the cysteine-knot superfamily and bind to members of the IL-17 receptor family. (rndsystems.com)
  • Interleukin-12 (IL-12) and interleukin-23 (IL-23), which belong to the IL-12 family of cytokines, have a key role in intestinal homeostasis and inflammation and are implicated in the pathogenesis of inflammatory bowel disease. (nature.com)
  • While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging. (lookformedical.com)
Insulin Receptor1
Pattern recognit1
  • However, the bacterial compounds and the type of pattern recognition receptor involved in the inducible expression of IL-23p19 in Paneth cells remain unclear. (oncotarget.com)
Inhibition1
Mice3
  • A specific S. salivarius protein, RSSL-01370, contains regions with homology to the Spike receptor-binding domain, and immunization of mice with RSSL-01370 elicited anti-Spike IgG antibodies in the serum. (bvsalud.org)
  • Impaired thymopoiesis in interleukin-7 receptor transgenic mice is not corrected by Bcl-2. (ouhsc.edu)
  • Mice with C5a receptor-deficient dendritic cells promote induction of Treg and Th17 cells. (medscape.com)
Antigenic2
  • Because of their high numbers, red blood cells express an average of 90% of the CR1 receptors despite their having a lower number of antigenic sites per cell. (medscape.com)
  • [ 1 , 2 ] Although the chief target of the autoimmune attack in most cases is the skeletal muscle nicotinic acetylcholine receptor (nAChR), other antigenic targets that are components of the neuromuscular junction (NMJ) have also been implicated. (medscape.com)
Source:HGNC Symbol3
Tumor necro3
  • A tumor necrosis factor receptor subtype that has specificity for TUMOR NECROSIS FACTOR ALPHA and LYMPHOTOXIN ALPHA. (childrensmercy.org)
  • Progressive biliary destruction is independent of a functional tumor necrosis factor-alpha pathway in a rhesus rotavirus-induced murine model of biliary atresia. (childrensmercy.org)
  • Tumor Necrosis Factor Alpha Antagonism Reveals a Gut/Lung Axis That Amplifies Regulatory T Cells in a Pulmonary Fungal Infection. (uc.edu)
Proteins2
  • Effector proteins interacting with the Fc portion of immunoglobulin M (IgM) include complement and complement receptors. (medscape.com)
  • Partial or complete deficiencies of the components of the complement system, including its receptors and regulatory proteins, are now described in humans and may be of a genetic or familial origin or acquired. (medscape.com)
ATPase1
Type9
  • anti-Mullerian hormone receptor type 2. (gsea-msigdb.org)
  • collagen type IV alpha 5 chain [Source. (gsea-msigdb.org)
  • Receptors, Tumor Necrosis Factor, Type I" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (childrensmercy.org)
  • This graph shows the total number of publications written about "Receptors, Tumor Necrosis Factor, Type I" by people in this website by year, and whether "Receptors, Tumor Necrosis Factor, Type I" was a major or minor topic of these publications. (childrensmercy.org)
  • Below are the most recent publications written about "Receptors, Tumor Necrosis Factor, Type I" by people in Profiles. (childrensmercy.org)
  • GxxxA design at the correct position in TM1 of 1 imparts a new function to the 1 subunit that's perhaps not seen in the wild type protein. (plasignaling.com)
  • SARS-CoV-2 infects alveolar epithelial cells [mainly alveolar epithelial type 2 (AEC2) cells] through the angiotensin-converting enzyme 2 (ACE2) receptor. (kegg.jp)
  • Upon the occupancy of ACE2 by SARS-CoV-2, the increased serum level of free Angiotensin II (Ang II) due to a reduction of ACE2-mediated degradation promotes activation of the NF-kappa B pathway via Ang II type 1 receptor (AT1R), followed by interleukin-6 (IL-6) production. (kegg.jp)
  • The density of CR1 receptors on cell surfaces varies with the cell type and with the activation of the cell for neutrophils and monocytes. (medscape.com)
Monocytes1
  • Note: Certain human cell lines or cell types (e.g., neutrophils, monocytes) can first be treated with reagents that block receptors for the Fc regions of immunoglobulin to avoid nonspecific immunofluorescent staining mediated by Fc receptors (for example see Browning et al). (bdbiosciences.com)
Hypothesis1
  • A straightforward hypothesis to explain this big difference is that the 6 subunit interacts directly with 3. (plasignaling.com)
Nuclear1
  • A beta-hairpin comprising the nuclear localization sequence sustains the self-associated states of nucleosome assembly protein 1. (colorado.edu)
Molecules1
Ligand1
  • Here we show that the mRNA expression of IL-23p19 was increased in Paneth cell (PC)-like cells stimulated by Toll-like receptor 2 (TLR2) ligands, peptidoglycan (PGN) and Pam3CSK4, and was further increased in the presence of nucleotide-binding oligomerization domain 2 (NOD2)-ligand muramyl dipeptide (MDP). (oncotarget.com)
Diseases1
  • Toll-like diseases and causes severe and long-lasting health problems in the case of chronifi- receptor. (cdc.gov)
Angiotensin1
  • SARS-CoV-2 uses angiotensin converting enzyme-2 (ACE-2) receptor, for entry in human host[ 11 , 12 ]. (ijpsonline.com)
Membrane1
  • Normal neuromuscular junction showing a presynaptic terminal with a motor nerve ending in an enlargement (bouton terminale): Synaptic cleft and postsynaptic membrane with multiple folds and embedded with several acetylcholine receptors. (medscape.com)
Enzymes1
  • Enzymes and receptors of prostaglandin pathways with arachidonic acid-derived versus eicosapentaenoic acid-derived substrates and products. (research.com)
Antibodies1
  • Antibodies against SARS-CoV-2 spike receptor-binding domain were quantified in serum. (bvsalud.org)
Modulation2
  • Regulation of myelopoiesis through syntenin-mediated modulation of IL-5 receptor output. (harvard.edu)
  • However, a subsequent study challenged the significance with this residue in B subunit induced modulation ofCaV1. (plasignaling.com)
Regulates1
  • In vivo , it regulates the proinflammatory effects of IL-22 ( e.g. neutrophil infiltration) but not of IL-10 (7). (rndsystems.com)
Cells7
  • The various areas that John W. Regan examines in his Cell biology study include HEK 293 cells, Downregulation and upregulation and EP4 Receptor. (research.com)
  • Upon their secretion by antigen-presenting cells, they exert both pro-inflammatory and anti-inflammatory receptor-mediated effects. (nature.com)
  • BANNER described subunits were transiently expressed inHEK293 cells that stably expressed 3. (plasignaling.com)
  • Although the medicine mentioned above can partially restore the function of bone cells through different pharmacological mechanisms, the obvious side effects such as gastrointestinal stimulation, renal toxicity or mandibular joint necrosis cannot be ignored [10]. (researchsquare.com)
  • Measured by its ability to inhibit IL-22-induced IL-10 secretion by COLO 205 human colorectal adenocarcinoma cells. (rndsystems.com)
  • Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. (thermofisher.com)
  • Among healthy individuals, the number of CR1 receptors on the red blood cells varies widely, yet the phenotypic expression, regulated by 2 codominant alleles, is stable. (medscape.com)
Complement2
  • Complement receptors have only been identified in the last 2 decades. (medscape.com)
  • Four distinct complement receptors, CR1, CR2, CR3, and CR4, have been described for the surface-bound complement fraction C3 and its cleavage fragments. (medscape.com)
Transcription1
  • it inhibits transcription for genes that encode IL-3, IL-4, IL-5, GM-CSF, and TNF-alpha (all involved in early T-cell activation). (medscape.com)
Signal3
Signals2
  • The activated receptor signals via a conserved death domain that associates with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM. (childrensmercy.org)
  • IL-22 signals through a receptor complex consisting of IL-22 R and IL-10 R beta. (rndsystems.com)
Colony2
  • colony stimulating factor 2 receptor s. (gsea-msigdb.org)
  • Below are the most recent publications written about "Receptor, Macrophage Colony-Stimulating Factor" by people in Profiles. (rush.edu)
Kinase1
  • His work carried out in the field of Receptor brings together such families of science as Prostaglandin E, Prostaglandin and Kinase. (research.com)