Receptor study angiotensin ii. Medical search. Frequent questions

Angiotensin II receptor blockers (ARBs), formally angiotensin II receptor type 1 (AT1) antagonists, also known as angiotensin receptor blockers, angiotensin II receptor antagonists, or AT1 receptor antagonists, are a group of pharmaceuticals that bind to and inhibit the angiotensin II receptor type 1 (AT1) and thereby block the arteriolar contraction and sodium retention effects of renin-angiotensin system. (wikipedia.org)
Angiotensin II receptor blockers are used primarily for the treatment of hypertension where the patient is intolerant of ACE inhibitor therapy primarily because of persistent and/or dry cough. (wikipedia.org)
The angiotensin II receptor blockers have differing potencies in relation to blood pressure control, with statistically differing effects at the maximal doses. (wikipedia.org)
Those patients taking angiotensin receptor blockers (ARBs) were 35 to 40% less likely to develop AD than those using other antihypertensives. (wikipedia.org)
Objective To determine whether disrupting the renin angiotensin system with angiotensin receptor blockers will improve clinical outcomes in people with covid-19. (bmj.com)
Participants Participants were at least 18 years old, previously untreated with angiotensin receptor blockers, with a laboratory confirmed diagnosis of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection who had been admitted to hospital for management of covid-19. (bmj.com)
Intervention Oral angiotensin receptor blockers (telmisartan in India) or placebo (1:1) for 28 days. (bmj.com)
Results Between 3 May 2020 and 13 November 2021, 2930 people were screened for eligibility, with 393 randomly assigned to angiotensin receptor blockers (of which 388 (98.7%) to telmisartan 40 mg/day) and 394 to the control group. (bmj.com)
We conducted a meta-analysis to explore the benefits of angiotensin-converting enzyme inhibitors (ACEIs)/angiotensin II receptor blockers (ARBs) combined with calcium channel blockers (CCBs) on metabolic, renal, and cardiovascular outcomes in hypertensive patients. (unboundmedicine.com)
Most patients were on clopidogrel (Plavix), statins, or angiotensin converting enzyme inhibitors/angiotensin II receptor blockers at baseline. (medpagetoday.com)
first-line antihypertensive medications include angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, dihydropyridine calcium-channel blockers and thiazide diuretics. (nature.com)
Treatment targeted a systolic blood pressure ≤ 135 mm Hg and a diastolic blood pressure ≤ 85 mm Hg by using drugs other than angiotensin converting enzyme (ACE) inhibitors, angiotensin receptor blockers, and calcium channel blockers, if necessary. (bmj.com)
Beta-blockers bind to beta-adrenoceptors, which inhibit normal sympathetic effects that act through the receptors norepinephrine and epinephrine. (uspharmacist.com)
Nonselective beta-blockers block both beta receptors, whereas cardioselective beta-blockers bind to the beta-adrenoceptor and partially activate the receptor while preventing other receptor agonists from binding. (uspharmacist.com)
Four drug classes were evaluated in the trials: thiazides (21 trials), beta-adrenergic blockers (5), calcium-channel blockers (4) and angiotensin-converting-enzyme (ACE) inhibitors (1). (cmaj.ca)
Hypertensive patients were divided into three groups according to the type of drug(s) being taken: a calcium antagonist group, an angiotensin II receptor blocker group, and a combination therapy group of calcium antagonists and angiotensin II receptor blockers. (scirp.org)
In conclusion, skin blood flow can be a useful tool to evaluate sympathetic activity and combination therapy with calcium antagonists and angiotensin II receptor blockers were the most useful therapy for suppressing the hemodynamic response to mental stress. (scirp.org)
Two classes of drugs commonly used in Japan are calcium channel blockers (CCBs) and angiotensin II receptor blockers (ARBs). (scirp.org)
Studies of beta-blockers, angiotensin-converting enzyme inhibitors, and angiotensin II receptor blockers have been unsuccessful in this group of patients. (the-hospitalist.org)
Tadalafil tablets are not recommended in combination with alpha-blockers for the treatment of BPH because efficacy of the combination has not been adequately studied and because of the risk of blood pressure lowering. (nih.gov)
We compared the effect of aliskiren, a direct renin inhibitor (DRI), with that of angiotensin receptor blockers (ARBs) on albuminuria and urinary excretion of angiotensinogen , a marker of intrarenal renin-angiotensin system activity. (bvsalud.org)
Angiotensin receptor blockers are relatively stable and can reach the aquatic environment at concentrations higher than that of many other pharmaceuticals. (janusinfo.se)
Based on the information, none of the angiotensin receptor blockers can be attributed to 'high' environmental risk, at the same time irbesartan stands out as a substance with higher risk than the others, based on available data. (janusinfo.se)
Finally, the development of newer immunosuppressants, such as tacrolimus and interleukin (IL)-2 receptor blockers, has paved the way for further growth in this field. (medscape.com)
Beneficial Effects of Angiotensin II Receptor Blockers on Mortality in Patients with COVID-19: A Retrospective Study from 2019 to 2020 in China. (cdc.gov)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) invades human cells expressing angiotensin-converting enzyme 2 (ACE2) ( 4 ). (frontiersin.org)
ACE2 is abundantly expressed in intestinal epithelial cells, such as the small and large intestines ( 4 ), and previous reports have shown that SARS-CoV-2 can infect the cells of the gastrointestinal tract ( 5 - 7 ). (frontiersin.org)
Viral host receptor angiotensin-converting enzyme 2 (ACE2) and viral nucleocapsid protein stained positive in specimens, making gastrointestinal infection with COVID-19-and fecal-oral transmission-likely. (medscape.com)
Analysis of the Angiotensin converting enzyme 2 receptor (ACE2) binding in dromedaries predicted potential binding affinity to the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) receptor binding domain (RBD), however some other studies predicted the contrary. (fao.org)
They identified a new association with a rare genetic variant at the Xp22.2 locus (rs190509934) that downregulates the expression of angiotensin-converting enzyme 2 (ACE2). (cdc.gov)
ABP 300 neutralizes COVID-19 by binding to the Receptor Binding Domain (RBD) of the SARS-CoV-2 spike protein, blocking the viral interaction with the angiotensin-converting enzyme 2 (ACE2) receptors of host which are critical for viral entry and infection. (globenewswire.com)
ABP 300 disrupts the interaction of the viral receptor binding domain (RBD) with host angiotensin-converting enzyme 2 (ACE2) receptor and has shown neutralizing efficacy in vivo against COVID-19 by blocking viral entry into cells. (globenewswire.com)
Some researchers hypothesized that the virus enters neuronal tissue from the circulation and binds angiotensin-converting enzyme 2 receptors (ACE2), which are located in the capillary endothelium. (hindawi.com)
Published in the Journal of Medical Virology , the study explains how the angiotensin-converting enzyme 2 (ACE2) receptor, which has a high affinity for SARS-CoV-2, expresses not only in the lungs but also the cells of testicular tissue. (newstarget.com)
The number of children infected with SARS-CoV-2 is relatively small, perhaps due to the lower expression of Angiotensin Converting Enzyme 2 (ACE2) in children compared to adults. (bvsalud.org)
Histopathology and localization of SARS-CoV-2 and its host cell entry receptor ACE2 in tissues from naturally infected US- farm ed mink (Neovison vison). (cdc.gov)
We characterized the pathological findings in 72 mink from US farm s with SARS-CoV-2 outbreaks, localized SARS-CoV-2 and its host cellular receptor angiotensin-converting enzyme 2 (ACE2) in mink respiratory tissues, and evaluated the utility of various test methods and specimens for SARS-CoV-2 detection in necropsy tissues. (cdc.gov)
The SARS-CoV-2 receptor ACE2 was extensively detected by IHC within turbinate epithelium, with decreased detection in lower respiratory tract epithelium and alveolar macrophages. (cdc.gov)

The issue of whether angiotensin II receptor antagonists slightly increase the risk of myocardial infarction (MI or heart attack) is currently being investigated. (wikipedia.org)
Novel AT1 receptor antagonists bearing substituted 4-phenylquinoline moieties instead of the classical biphenyl fragment were designed and synthesized as the first step of an investigation devoted to the development of new antihypertensive agents and to the understanding of the molecular basis of their pharmacodynamic and pharmacokinetic properties. (unict.it)
Chronic administration of alpha 1-receptor antagonists is associated with loss of clinical efficacy, especially in congestive heart failure, although the mechanism is uncertain. (jci.org)
Functional analysis using the cell-based assay receptor selection and amplification technology (R-SAT) revealed that three variants (AT 1 -G45R, AT 1 -F204S, and AT 1 -C289W) displayed altered responses to Ang II and other AT 1 receptor agonists and antagonists. (aspetjournals.org)
Comparative assessment of environmental risk when using angiotensin II antagonists candesartan, losartan, valsartan, irbesartan, eprosartan and telmisartan from a Swedish perspective. (janusinfo.se)
Strippoli Giovanni FM, Bonifati Carmen, Craig Maria E, Navaneethan Sankar D, Craig Jonathan C. Angiotensin converting enzyme inhibitors and angiotensin II receptor antagonists for preventing the progression of diabetic kidney disease. (bvs.br)

Angiotensin II, through AT1 receptor stimulation, is a major stress hormone and, because (ARBs) block these receptors, in addition to their eliciting anti-hypertensive effects, may be considered for the treatment of stress-related disorders. (wikipedia.org)
A 2014 Cochrane systematic review based on randomized controlled trials reported that when comparing patients taking ACE inhibitors to patients taking ARBs, fewer ARB patients withdrew from the study due to adverse events compared to ACE inhibitor patients. (wikipedia.org)
Some studies suggest ARBs can increase the risk of MI. (wikipedia.org)
Outpatients with essential hypertension treated with CCBs or ARBs at Wakayama Medical University Hospital were enrolled continuously in this study for six month. (scirp.org)

The angiotensin-converting enzyme 2 receptor of white-tailed deer is closely homologous to that of humans. (cdc.gov)

[ 2 ] The percentage of patients engaged in hypertension treatment increased from 35% to 79% during this period. (medscape.com)
however, the age- and sex-adjusted rates of stage 2 hypertension decreased among non-Hispanic whites between 1988-1992 and 1999-2000, whereas they were unchanged for black and Hispanic persons. (medscape.com)
[ 4 ] A multinational study in high-, middle-, and low-income countries showed that 46.5% of participants with hypertension were aware of their diagnosis, with BP control in only 32.5% of those being treated. (medscape.com)
AT 1 receptors are involved in the pathogenesis of several cardiovascular diseases, including hypertension, cardiac hypertrophy, and congestive heart failure, which are characterized by significant interindividual variation in disease risk, progression, and response to pharmacotherapy. (aspetjournals.org)
For many decades Ang II was mainly perceived as a regulator of the cardiovascular system, an important factor in the pathogenesis of hypertension, atherosclerosis, and angiogenesis. (spandidos-publications.com)
In the present study, we evaluate the effects of FG-4592 on hypertension. (jci.org)
Therefore, in addition to its role in treating CKD anemia, FG-4592 could be explored as a treatment for hypertension associated with high renin angiotensin system (RAS) activity or eNOS defects. (jci.org)
It is also indicated for the treatment of renal disease in adult patients with hypertension and type 2 diabetes mellitus as part of an antihypertensive medicinal product regimen (see sections 4.3, 4.4, 4.5 and 5.1). (medicines.org.uk)
This cross sectional study suggests that chronic intermittent hypoxia plays an important role in OSAS-related hypertension. (ersjournals.com)
Cardiovascular diseases represent an important comorbidity and there is evidence that OSAS independently relates to prevalent and incident systemic hypertension in many [ 3 , 4 ], but not all [ 5 , 6 ] population-based studies. (ersjournals.com)
Effective treatment for OSAS with continuous positive airway pressure (CPAP) is associated with considerable benefits in cardiovascular comorbidity, particularly hypertension, both in short-term randomised controlled studies and in long-term observational studies [ 8 - 12 ]. (ersjournals.com)
However, the respective contribution of these mechanisms to established hypertension is unclear, and previous population studies of the association of hypertension and OSAS have not addressed this question in detail [ 4 , 20 ]. (ersjournals.com)
QUESTION: In patients with type 2 diabetes mellitus, diabetic nephropathy, and hypertension, what effect does the angiotensin II receptor antagonist (ARA) irbesartan and the calcium channel blocker amlodipine have on renal disease? (bmj.com)
1715 patients between 30 and 70 years of age (mean age 59 y, 66% men) who had type 2 diabetes, hypertension, proteinuria defined as a urinary protein excretion rate ≥ 900 mg/24 hours, and serum creatinine concentrations between 88 and 265 μmol/l in women and between 106 and 265 μmol/l in men. (bmj.com)
In patients with type 2 diabetes, nephropathy, and hypertension, irbesartan was more effective in reducing progression of nephropathy independent of the effect on blood pressure than was amlodipine or placebo. (bmj.com)
Methods: We conducted a retrospective cohort study of adults with pulmonary hypertension having surgery at a single large medical referral center. (researchsquare.com)
Because of fundamental differences in pathophysiologic changes, including in right ventricular afterload in postcapillary PH, patients with established group 2 PH (pulmonary venous hypertension) were not included [12]. (researchsquare.com)
2 While studies have shown that the rates of hypertension in the elderly have not changed since 1999, the number of elderly affected continues to grow due to this aging population. (uspharmacist.com)
2 High blood pressure in childhood commonly leads to hypertension in adulthood, 3 and adult hypertension is the leading cause of premature death around the world. (aafp.org)
In one study, hypertension was diagnosed in only 26 percent of children with documented high blood pressure in an electronic medical record. (aafp.org)
Previous studies have identified hypertension from electronic health records (EHRs), but the effects of analytic decisions on prevalence estimates have not been characterized, and a consensus definition has not been established. (cdc.gov)
Decisions included 1) whether to restrict surveillance to patients with recent blood pressure measurements, 2) varying the number and recency of encounters to define the population at risk of hypertension, 3) how to define hypertension (diagnosis codes, antihypertensive medication, blood pressure measurements, or combinations of these), and 4) how to handle multiple blood pressure measurements on the same day. (cdc.gov)
A hypertension surveillance strategy that includes a population with at least 1 clinical encounter with measured blood pressure in the previous 2 years and identifies hypertension using all available data (≥1 diagnosis code, ≥1 antihypertensive medication, and ≥2 elevated blood pressure values ≥140/90 mm Hg on separate days) generated estimates in line with population-based survey data. (cdc.gov)
The objectives of our study were to use cross-sectional baseline data from the CCHC to determine the extent to which 3 chronic diseases -- diabetes, hypertension, and hypercholesterolemia -- are undiagnosed and untreated in this minority population with severe health disparities and what factors influence failure to diagnose and treat these diseases. (cdc.gov)

Adult (20 weeks) and senescent (20 months) spontaneously hypertensive rats (SHRs) were treated with either the AT(1)R antagonist, candesartan cilexetil (2 mg/kg/day), the AT(2)R antagonist, PD123319 (10 mg/kg/day), or a combination of the 2 compounds. (monash.edu)
Candesartan cilexetil is a potent, long acting angiotensin II (AT1) receptor antagonist. (fip.org)
Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes. (bmj.com)
Reduction of skin blood flow by mental stress was suppressed in both the angiotensin II blocker group and the combination therapy group compared with the calcium antagonist group. (scirp.org)
Background and aimsThe CRTH2 antagonist timapiprant improved lung function and asthma control in a phase 2 study, with evidence suggesting reduced exacerbations. (imperial.ac.uk)

Figure 3: Role of the renin-angiotensin-aldosterone system in the regulation of blood pressure. (nature.com)
Angiotensin II (Ang II) is the major octapeptide of the renin-angiotensin system (RAS). (spandidos-publications.com)
there is an increased risk of severe hypotension and renal insufficiency when patients with bilateral renal artery stenosis or stenosis of the artery to a single functioning kidney are treated with medicinal products that affect the renin-angiotensin-aldosterone system. (medicines.org.uk)
Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus. (nih.gov)
Dual inhibition of the renin-angiotensin system: increased risk of renal impairment, hypotension, syncope, and hyperkalemia. (nih.gov)
Comparative Effects of Direct Renin Inhibitor and Angiotensin Receptor Blocker on Albuminuria in Hypertensive Patients with Type 2 Diabetes. (bvsalud.org)
An increased renin-angiotensin system activity has been reported to play an important role in the pathological processes in these conditions. (bvsalud.org)
This protein is part of the renin-angiotensin system, which regulates blood pressure and the balance of fluids and salts in the body. (medlineplus.gov)
Through a series of steps, the renin-angiotensin system produces a molecule called angiotensin II, which attaches (binds) to the AT1 receptor, stimulating chemical signaling. (medlineplus.gov)
Renal tubular dysgenesis can be caused by mutations in both copies of any of the genes involved in the renin-angiotensin system. (medlineplus.gov)
The AGTR1 gene mutations that cause this disorder likely change or block the AT1 receptor's ability to stimulate signaling, which results in a nonfunctional renin-angiotensin system. (medlineplus.gov)
Ding W, Wang F, Fang Q, Zhang M, Chen J, Gu Y. Association between two genetic polymorphisms of the renin-angiotensin-aldosterone system and diabetic nephropathy: a meta-analysis. (medlineplus.gov)
Mutations in genes in the renin-angiotensin system are associated with autosomal recessive renal tubular dysgenesis. (medlineplus.gov)
Dual blockade of renin-angiotensin system increases risks of hypotension, hyperkalemia, and renal impairment. (medscape.com)

1 Academic Unit of Cardiovascular Studies. (portlandpress.com)
Once end stage renal disease (ESRD) has developed, the median survival of patients with type 2 diabetes is 2 years, and most of these deaths are from cardiovascular disease. (bmj.com)
Consider for example the different treatment hierarchies in figure 1 obtained by different ranking metrics for a network of nine antihypertensives for primary prevention of cardiovascular disease 12 13 (network graph shown in figure 2 ). (bmj.com)
If a man gets jabbed, then gets sick, his sperm count will likely decrease in the same way it would following infection with SARS-CoV-2, which the study says is linked to "many diseases such as respiratory diseases, cardiovascular diseases, and gastrointestinal diseases. (newstarget.com)
Mexican Americans, the largest ethnically distinct subgroup among Hispanics, are at high risk for becoming overweight or obese, predisposing them to type 2 diabetes and metabolic and cardiovascular disease (2). (cdc.gov)
We know, from our own studies and experience, that four main noncommunicable diseases (cardiovascular disease, cancer, diabetes and obstructive pulmonary disease) account for more than 65% of all deaths in Seychelles. (who.int)

In a study comparing beta-blocker carvedilol with valsartan, the angiotensin II receptor blocker not only had no deleterious effect on sexual function, but actually improved it. (wikipedia.org)

In the second study, we collected ileum and colon tissue samples from patients with critical COVID-19 who required colonoscopy due to severe gastrointestinal symptoms and analyzed mucosal gene expression. (frontiersin.org)
Using semi-quantitative reverse-transcription polymerase chain reaction (RT-PCR) and western blots experiments, we compared changes in ETS-1 and ETS-2 expression, their protein levels, and the regulation of some of their target gene expressions at different stages of the ocular tumoral progression in the transgenic mouse model, Tyrp-1-TAg, with those in normal eyes from control mice of the same age. (molvis.org)
b) investigation of whether a positive or negative correlation exists between angiotensin II receptor gene polymorphisms and human lung cancer in lung cancer patients and corresponding normal control subjects. (k-state.edu)
For example, two variants of IFNAR2 , a gene involved in the pathway for early immune response to viral infections, are associated with severe COVID-19. (cdc.gov)
The AGTR1 gene provides instructions for making a protein called the angiotensin II receptor type 1 (AT1 receptor). (medlineplus.gov)
The most studied AGTR1 gene variation associated with these conditions changes a single DNA building block (nucleotide) in the gene. (medlineplus.gov)
Angiotensin II type 1 receptor gene polymorphisms in humans: physiology and pathophysiology of the genotypes. (medlineplus.gov)

However, growth studies (28-32 days) of fish for four of the substances (candesartan, losartan, valsartan, irbesartan) show low toxicity, but mechanism-based efficacy data are completely lacking for all. (janusinfo.se)

Such variation could arise from genomic polymorphisms in the AT 1 receptor. (aspetjournals.org)

Irbesartan and losartan have trial data showing benefit in hypertensive patients with type 2 diabetes,[citation needed] and may delay the progression of diabetic nephropathy. (wikipedia.org)
In hypertensive type 2 diabetic patients, therapy should be initiated at 150 mg irbesartan once daily and titrated up to 300 mg once daily as the preferred maintenance dose for treatment of renal disease. (medicines.org.uk)
The demonstration of renal benefit of Irbesartan Zentiva in hypertensive type 2 diabetic patients is based on studies where irbesartan was used in addition to other antihypertensive agents, as needed, to reach target blood pressure (see sections 4.3, 4.4, 4.5 and 5.1). (medicines.org.uk)
Lewis EJ, Hunsicker LG, Bain RP, Rohde RD. The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy. (bvs.br)

abstract = "Cardiac AT(2)R expression is upregulated in the normal process of aging. (monash.edu)

In this study we determined the contribution of AT(2)R to chronic antihypertensive and remodelling effects of AT(1)R blockade in aged hypertensive rats. (monash.edu)
These results suggest that AT(2)R stimulation does not significantly influence the antihypertensive effect of chronic AT(1)R blockade, but plays a role in the regulation of vascular structure. (monash.edu)
There have been a number of systematic reviews of the effectiveness of antihypertensive therapy, but most have focused on overall effectiveness [ 1 , 2 ] or effectiveness in special groups such as elderly patients. (cmaj.ca)
Only 2 reviews have attempted to distinguish between the effectiveness of antihypertensive therapies used as first-line agents. (cmaj.ca)
Studies have also given some information regarding the effect of antihypertensive drugs on variation and thus ultimately, on outcome. (escardio.org)
The aim of this study was to clarify the response of sympathetic activity to antihypertensive drugs using a mental stress test in hypertensive patients and to determine the effects of antihypertensive drugs on the sympathetic activitymediated hemodynamic response to mental stress. (scirp.org)
In the present study, the response of blood pressure, pulse rate [12] , and skin blood flow to the CWC test was evaluated to determine the sympathetic response to mental stress in essential hypertensive patients treated with different types of antihypertensive drugs. (scirp.org)

Mechanism of sodium modulation of glomerular angiotensin receptors in the rat. (jci.org)
Specific binding of 125I-angiotensin to high affinity glomerular receptors varies directly with the level of dietary sodium. (jci.org)
To investigate the mechanism of sodium regulation of glomerular angiotensin receptors, groups of Sprague-Dawley rats were maintained on one of three levels of sodium intake for at least 5 d: high sodium (7.39 meq/24 h), moderate sodium (0.88 meq/24 h), and low sodium diets (0.01 meq/24 h). (jci.org)
To dissociate the effects of dietary sodium from those of circulating angiotensin II levels on glomerular receptor regulation, a fifth group was placed on high sodium diet and given a continuous infusion of angiotensin via an implanted minipump (100 ng/min) for 21 d. (jci.org)
There was a strong negative correlation (r = -0.98, P less than 0.01) between plasma angiotensin II and glomerular angiotensin receptor density. (jci.org)
The time course of sodium regulation of glomerular angiotensin II receptors was studied in rats switched from a moderate sodium to either a high sodium diet or a low sodium diet plus furosemide. (jci.org)
Additional studies were undertaken to demonstrate that glomerular angiotensin II receptors are down-regulated by circulating hormone. (jci.org)
Taken together, these studies suggest that Gα12 activation promotes glomerular injury without podocyte depletion through a novel mechanism regulating collagen (α)IV expression, and supports the notion that glomerular damage may accrue through persistent GPCR activation in podocytes. (medscape.com)

However, the devil is in the details of this study, he suggested, as not all outcomes were consistently improved with rivaroxaban. (medpagetoday.com)
Our institution reported that abdominal pain is a risk factor for severe disease outcomes in COVID-19 ( 2 ). (frontiersin.org)
Most endometrial cancer cases are diagnosed in the early stages and therefore result in favourable clinical outcomes ( 2 ). (spandidos-publications.com)
However, few studies have analyzed the relationship between clinical presentation of PH and outcomes after noncardiac surgery [6, 11]. (researchsquare.com)
1 2 To determine which treatment is the most preferable, decision-makers must account for both the quantity and the quality of the available evidence by considering both efficacy and safety outcomes as well as assessing the confidence in the obtained results. (bmj.com)
Early in the COVID-19 pandemic, we explored the rationale for host genomic studies to our understanding of COVID-19 occurrence and outcomes. (cdc.gov)
Two recent studies published in Nature Genetics used large sample sizes and a range of health outcomes to expand our knowledge base on host genomics and COVID-19. (cdc.gov)
For example, the authors compared positive COVID-19 cases with household exposure to COVID-19 cases without household exposure to understand genetic susceptibility to study post-infection protection from severe outcomes. (cdc.gov)
Association between Human Leukocyte Antigen (HLA) DQB1*06 and HLA DQB1*03 and adverse outcomes in a group of critically ill patients with COVID-19 in Tunisia: a cross-sectional study. (cdc.gov)

Here we report two monoclonal antibodies (mAbs) cloned from memory B cells of patients recently recovered from COVID-19, and both mAbs specifically bind to the spike (S) protein of SARS-CoV-2, block the binding of receptor binding domain (RBD) of SARS-CoV-2 to human angiotensin converting enzyme 2 (hACE2), and effectively neutralize S protein-pseudotyped virus infection. (medrxiv.org)
White-tailed deer are susceptible to experimental infection with SARS-CoV-2, subsequently shedding infectious virus and infecting naive conspecifics ( 5 - 7 ). (cdc.gov)
Surveillance studies have demonstrated SARS-CoV-2 infection in free-ranging and captive white-tailed deer in the United States and Canada, determined by viral RNA detection, antibodies to SARS-CoV-2, or virus isolation ( 8 - 11 ). (cdc.gov)
Because that respiratory pattern was present before study commencement, we did not attribute it to SARS-CoV-2 infection. (cdc.gov)
Mule deer 2 was euthanized 3 days after infection. (cdc.gov)
Moreover, it is unknown whether AKI results from a direct infection of the kidney by SARS-CoV-2 or it is a consequence of the physiologic disturbances and therapies used to treat COVID-19. (frontiersin.org)
Most common adverse reactions (incidence ≥2% and greater than placebo) are dizziness, upper respiratory infection, cough, and back pain. (nih.gov)
Furthermore, several studies reported evidence of camel infection by other human CoVs, animal CoVs or unknown coronaviruses. (fao.org)
conformational changes, energy-driven molecular motors, and receptor-triggered infection machines. (mdpi.com)
This finding pointed to the importance of interferons (IFNs), during the initial infection, for clearing SARS-CoV-2 and concerns about using glucocorticoids, which could inhibit IFN signaling in COVID-19 treatment. (cdc.gov)
The proactive approach to international collaboration and sharing of resources have enabled the discovery of previously unknown pathophysiological mechanisms of SARS-CoV-2 infection and revealed the complex genetic architecture of COVID-19. (cdc.gov)
While we have made an impressive sprint to uncover the genetic anchors for response to COVID-19 infection just two years into the pandemic, the next major challenge is to use these biologic findings to inform treatment and prevention. (cdc.gov)
In the hope of revealing new directions for therapies, the group studies molecular biomarkers identified from tissue and brain imaging that are associated with memory problems related to HIV infection, aging , dementia, mental illness and traumatic brain injury. (hopkinsmedicine.org)
Interstitial lung disease and associated fibrosis occur in a proportion of individuals who have recovered from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection through unknown mechanisms. (imperial.ac.uk)
Individuals with covert severe acute respiratory syndrome coronavirus 2 infection: Are they a critical booby-trap? (scielo.br)
Numerous researchers assume that there is an unobserved pool of these carriers because in many cases, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections could not be related to contact with persons with infection or to travel to epidemic areas. (scielo.br)
On February 14, 2020, the first case of SARS-CoV-2 infection was confirmed in Egypt in a Chinese national 2 2. (scielo.br)
At that time, not a single case of SARS-CoV-2 infection had been recorded in Egypt, which raises many inquiries. (scielo.br)
At that time, no cases of SARS-CoV-2 infection had been officially reported by the Egyptian Health Authorities. (scielo.br)
We present two cases of benign paroxysmal positional vertigo (BPPV), which developed within two weeks of SARS-COVID-19 infection, manifesting with mild disease severity in early November 2020. (hindawi.com)
In adults, olfactory loss is one of the earliest and most frequent acute clinical manifestations of SARS-CoV-2 infection. (bvsalud.org)
Genetic variants associated with SARS-CoV-2 infection also affect lung function and asthma severity. (cdc.gov)
This study expands on the knowledge of the pathology and pathogenesis of natural SARS-CoV-2 infection in mink and supports their further investigation as a potential animal model of SARS-CoV-2 infection in humans. (cdc.gov)

Therefore, the presence of SARS-CoV-2 in the gastrointestinal tract could be involved in COVID-19 pathogenesis. (frontiersin.org)
This offers significant advantages for studying tumor pathogenesis and molecular mechanisms of oncogenesis caused by a single initiating oncogenic event introduced through the mouse germ line. (molvis.org)

All components of the RAS (angiotensinogen, angiotensin converting enzyme, angiotensin receptors) are expressed in many types of tumours, including endometrial cancer ( 2 , 4 ). (spandidos-publications.com)

In vascular smooth muscle cells, FG-4592 treatment reduced angiotensin receptor type 1 (AGTR1) and increased AGTR2 levels, while preventing Ang II-induced oxidative stress. (jci.org)
Effects of FG-4592 on the regulation of AGTR1, AGTR2, eNOS, p-eNOS, and HIF1α in aorta tissue of mice challenged with Ang II. (jci.org)

These AT1 receptor binding studies revealed nanomolar affinity in several of the compounds under study. (unict.it)
Finally, the most relevant structure-affinity relationship data were rationalized by means of computational studies performed on the isolated ligands as well as by computational simulations on the ligands complexed with a theoretical AT1 receptor model. (unict.it)

The Collaborative Study Group. (bvs.br)

The angiotensin II type 1 (AT 1 ) receptor is the primary effector for angiotensin II (Ang II), a key peptide regulator of blood pressure and fluid homeostasis. (aspetjournals.org)
Targeting activated Gα subunits to specific cells in vivo permits identification of downstream effector pathways independent of receptor activation, and thus permits insight into disease mechanisms otherwise impossible to study in vivo . (medscape.com)

ETS-1 and ETS-2 mRNA and protein levels were much higher in the ocular tissues of Tyrp-1-TAg mice than in control ocular tissues from wild-type mice. (molvis.org)
Biased ligands at G-protein-coupled receptors: promise and progress. (nih.gov)
However, a retrospective study comparing cohorts infected with either seasonal influenza or the more pathogenic influenza A/ H1N1 behind a 2009 pandemic found that the latter resulted in a greater degree of inflammation/C-reactive protein elevation. (medscape.com)
Profiling humoral responses to COVID-19 immunization in Kawasaki disease using SARS-CoV-2 variant protein microarrays. (cdc.gov)
Gα12 couples to numerous G-protein-coupled receptors (GPCRs) and regulates multiple epithelial responses, including proliferation, apoptosis, permeability and the actin cytoskeleton. (medscape.com)
Many of these molecules activate G-protein-coupled receptors (GPCRs), which couple to multiple Gα subunits. (medscape.com)

These data demonstrate that polymorphic variation in the human AT 1 receptor induces loss of functional phenotypes, which may constitute the molecular basis of variability of AT 1 receptor-mediated physiological responses. (aspetjournals.org)
However, the mechanism through which angiotensin 1-7 induces its powerful hypotensive effect were unclear," explains Dr. Eric Ronken, Principal Scientist at Solvay. (scanbalt.org)

This study demonstrates that pharmacological tolerance to the alpha 1-adrenoceptor blocking action of terazosin occurs in man and may be responsible for loss in efficacy with chronic therapy. (jci.org)
This study evaluated the efficacy and safety of quarterly and monthly treatment with fremanezumab compared to placebo in adult patients with migraine and documented inadequate response to 2-4 classes of prior preventive migraine treatments. (tevausa.com)

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic of novel corona virus disease (COVID-19). (medrxiv.org)
In addition to the respiratory system, ACE-2 and TMPRSS-2 are also expressed in the gastrointestinal tract, brain, and vessels ( 2 - 5 ). (frontiersin.org)
Regarding the induction of inflammation, SARS-CoV-2 causes acute respiratory distress syndrome by activating the NLR family pyrin domain containing 3 (NLRP3) inflammasome, which activates interleukin (IL)-1β and IL-18 via caspase-1 ( 11 , 12 ), and the NLRP3 inflammasome is known to be an important molecule involved in intestinal homeostasis ( 13 ). (frontiersin.org)
Fecal shedding of viral RNA was also found in 20% of patients with COVID-19, despite real-time reverse transcriptase polymerase chain reaction testing from two sequential respiratory tract specimens collected at least 24 hours apart being negative. (medscape.com)
Coronavirus disease-19 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-COVID-19). (hindawi.com)
Vertigo presented as an initial COVID-19 symptom in three patients and followed respiratory symptoms in two patients [ 7 ]. (hindawi.com)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes respiratory disease in mink similar to human COVID-19. (cdc.gov)
In formalin-fixed paraffin-embedded (FFPE) upper respiratory tract (URT) specimens, conventional reverse transcription-polymerase chain reaction (cRT-PCR) was more sensitive than in situ hybridization (ISH) or immunohistochemistry (IHC) for detection of SARS-CoV-2. (cdc.gov)

Page 2 fibrillation or flutter, previous myocardial infarction, rheumatic valvular heart disease and Author Manuscript prosthetic heart valve) and psychosocial stress/depression [3]. (cdc.gov)

The severe degree of cardiac perivascular fibrosis in senescent animals was regressed by AT(1)R blockade and this effect was reversed by simultaneous AT(2)R inhibition, demonstrating an antifibrotic role of AT(2)R stimulation in the aging hypertensive heart. (monash.edu)
The AT1 receptor mediates vasoconstriction upon stimulation, whereas the AT2 receptor is implicated in hypotensive effects. (scanbalt.org)

Current therapies for comorbid diseases, such as statins and peroxisome proliferator-activated receptor-agonists, may provide unexpected benefits for COPD patients. (ersjournals.com)

To evaluate changes in venous alpha 1-adrenoceptor responsiveness during chronic alpha 1-adrenoceptor blockade, dose-response curves to phenylephrine and angiotensin II were constructed in 10 healthy subjects before, during, and after administration of terazosin 1 mg orally for 28 d. (jci.org)

A retrospective study of 1968 stroke patients revealed that prestroke treatment with ARB may be associated with both reduced stroke severity and better outcome. (wikipedia.org)

We conducted two single-center observational studies of patients with COVID-19. (frontiersin.org)

We use a variety of techniques including neuropsychological assessments, experimental behavioral assessments and particularly advanced neuroimaging methods to study these questions in young and older adults and patients with mild cognitive impairment, Alzheimer's disease, Parkinson's disease and epilepsy. (hopkinsmedicine.org)

DRI and ARB reduced albuminuria in hypertensive patients with type 2 diabetes . (bvsalud.org)

Stool metabolomic analysis showed that the level of indole-3-propionic acid, a ligand for aryl hydrocarbon receptor (AhR), was markedly decreased in the critical group compared to that in the non-critical group ( P = 0.01). (frontiersin.org)

The aim of our study was to evaluate in patients with obesity and chronic osteoarthritis the impact on quality of life and metabolic control of a dietary intervention with a hypocaloric commercial formula. (isciii.es)
Approximately 70% of participants had 1 or more of the 3 chronic diseases studied. (cdc.gov)

Depending on how major bleeding was counted in the study, patients on the direct oral anticoagulant either fared similarly to the placebo arm (TIMI major bleeding 2.65% vs 1.87%, HR 1.43, 95% CI 0.97-2.10) or were worse off (ISTH major bleeding 5.94% vs 4.06%, HR 1.42, 95% CI 1.10-1.84). (medpagetoday.com)

We studied individuals with severe coronavirus disease 2019 (COVID-19) after recovery from acute illness. (imperial.ac.uk)
A small proportion of patients may develop significant complications such as bilateral pneumonia, accompanied by shortness of breath, chest pain, and a characteristic finding of ground-glass opacity on CT, which indicates severe viral pneumonia [ 2 , 3 ]. (hindawi.com)
A Multiple Dose Study in Participants with Severe Alcohol-Associated Hepatitis to Assess the Safety and the Way the Body Absorbs, Distributes, and Eliminates the drug SZN-043. (who.int)
This community experiences severe disparities in income, education, and health care access (7,8) Ninety-two percent of Brownsville's estimated population of 170,000 is Mexican American and have low high school graduation rates and low incomes (8,13). (cdc.gov)

We aimed to estimate the prevalence of AKI since it varies by geographical settings, time periods, and populations studied and to investigate whether clinical information and laboratory findings collected at hospital admission might influence AKI incidence (and mortality) in a particular point in time during hospitalization for COVID-19. (frontiersin.org)

Moreover, some selected compounds were evaluated for antagonism of Ang II-induced contraction in rabbit aortic strips, and the most potent compounds in the binding test 4b,t were slightly more potent than losartan in inhibiting Ang II-induced contraction. (unict.it)

The Bionas system allows us to extend and optimize target validation studies by bringing the targets back into their physiological context", says Dr. Eric Ronken. (scanbalt.org)
Recently, a number of studies have shown that Ang II plays an important role in proliferation, invasiveness and migration of tumour cells, alteration of expression of cancer-related genes, as well as in physiological tissue remodelling. (spandidos-publications.com)

ACE-2 and TMPRSS-2, surface cell proteins expressed by various tissues, are targeted by SARS-CoV-2. (frontiersin.org)
Suppurative rhinitis, lymphocytic perivascular inflammation in the lungs, and lymphocytic infiltrates in other tissues were common in both SARS-CoV-2-positive and SARS-CoV-2-negative animals. (cdc.gov)

The newly synthesized compounds were tested for their potential ability to displace [125I]Sar1,Ile8-Ang II specifically bound to AT1 receptor in rat hepatic membranes. (unict.it)

Citations to Pharmacological tolerance to alpha 1-adrenergic receptor antagonism mediated by terazosin in humans. (jci.org)

Dietary sodium, potassium, or water consumption did not correlate with angiotensin II receptor concentration. (jci.org)

Currently, the following studies are in progress: a) determination of whether pharmacological and/or genetic intervention (up-regulation of angiotensin II type 2 receptor function) attenuate chemical carcinogen-induced tumorigenesis in the lung (Kanehira et al. (k-state.edu)
One major study design for host genomics studies has been the genome wide association study (GWAS) , an approach for evaluating genetic variants across the human genome for association with a disease or particular trait. (cdc.gov)
The study used granular case and control definitions for the COVID-19 phenotype and identified distinct patterns of genetic association. (cdc.gov)

The Cameron County Hispanic Cohort (CCHC), initiated in 2003, is an ongoing study of Mexican American participants from randomly selected households in Brownsville, Cameron County, Texas, on the US-Mexico border (8). (cdc.gov)

Also being presented are five posters based on a patient survey following the one-year Phase III HALO long-term study that examined the impact of fremanezumab on functioning and productivity in migraine patients. (tevausa.com)
We are committed to studying this burdensome disease and strive to lead the way in migraine research. (tevausa.com)
We are proud to share a broad range of new fremanezumab data at this year's IHC from, amongst others, the largest study to date in patients who have responded inadequately to 2-4 classes of prior preventive migraine treatments. (tevausa.com)
A patient survey following the one-year Phase III HALO long-term study evaluated patient satisfaction with fremanezumab treatment, and impact on quality of life, and patient preferences for dosing regimens in the preventive treatment of migraine. (tevausa.com)

In a large, unpublished cohort study conducted at Leeds, Dr. Kearney and colleagues evaluated how many patients met criteria for heart failure with reduced ejection fraction or heart failure with preserved ejection fraction after undergoing a BNP measurement. (the-hospitalist.org)
This is a retrospective comparative analytical cohort study of 300 newborns exposed and unexposed to COVID-19 during pregnancy. (bvsalud.org)

Type 2 diabetes mellitus causes microvascular and macrovascular complications that pose public health concerns worldwide. (bmj.com)
Iranian population of patients with type 2 diabetes mellitus. (who.int)
The high prevalence of CVD in Iranian patients with type 2 diabetes underscores the importance of better detection and treatment of metabolic risk factors of CVD in these patients. (who.int)
Preventing microalbuminuria in type 2 diabetes. (bvs.br)

Furthermore, ACE-2 is highly expressed in renal proximal tubules, where SARS-CoV-2 particles were detected postmortem in podocytes of COVID-19 patients, suggesting that the kidneys could also be one of the targets of SARS-CoV-2 ( 6 , 7 ). (frontiersin.org)
Gα12/13 are expressed in podocytes and couple to angiotensin II, thrombin, endothelin and LPA receptors, which are important in renal injury. (medscape.com)

As for the file of Institutional review board statement, it is not applicable to my study because no human subjects were analyzed in my study. (wjgnet.com)
We have studied the transgenic mouse strain, Tyrp-1-TAg, to try to gain insight into possible molecular mechanisms common to pigmented ocular neoplasms occurring spontaneously in the eyes of these mice and human choroidal melanoma. (molvis.org)
The aim of the present study was to evaluate the influence of angiotensin II (Ang II) on human EC cells. (spandidos-publications.com)
ABP300 is currently being studied in a Phase 1 clinical study in healthy human subjects. (globenewswire.com)

To pursue this notion, we have pharmacologically characterized seven known and putative nonsynonymous AT 1 receptor variants. (aspetjournals.org)

New data from Chinese colleagues working at the forefront of the COVID-19 outbreak, and studies of earlier viral outbreaks, provide important insight into the hepatotoxic and gastrointestinal implications of this pandemic. (medscape.com)

This is the first study describing the production and distribution of ETS-1 and ETS-2 mRNAs and proteins using in situ hybridization and immunohistochemistry in murine ocular tissue sections of normal control eyes and tumoral eyes from mice of the same age. (molvis.org)

accordingly, its epidemiology has been well studied in the United States and internationally. (medscape.com)
Mule deer shed and transmitted virus and mounted pronounced serologic responses and thus could play a role in SARS-CoV-2 epidemiology. (cdc.gov)

Anatomy35

Organisms15

Diseases18

Chemicals and Drugs109

Analytical, Diagnostic and Therapeutic Techniques and Equipment30

Psychiatry and Psychology2

Phenomena and Processes37

Disciplines and Occupations1

Information Science1

Health Care4

Geographicals1

Blockers25

ACE213

Antagonists6

ARBs4

Enzyme 2 receptor1

Hypertension24

Antagonist5

Renin14

Cardiovascular6

Blocker1

Gene7

Candesartan1

Polymorphisms1

Diabetic4

Abstract1

Antihypertensive7

Glomerular8

Outcomes9

Infection23

Pathogenesis2

Angiotensinogen1

AGTR12

Affinity2

Collaborative Study Group1

Effector2

Protein6

Induces2

Efficacy2

Respiratory8

Myocardial infarction1

Stimulation2

Agonists1

Blockade1

Retrospective study1

Observational studies1

Methods1

Hypertensive1

0.011

Chronic2

Oral1

Severe4

Mortality1

Inhibiting Ang II-induced1

Physiological2

Tissues2

Hepatic1

Antagonism1

Dietary1

Genetic3

Randomly1

Migraine4

Cohort2

Type 2 diabet4

Podocytes2

Human4

Variants1

Insight1

Situ hybridization1

Epidemiology2