Receptor stress mechanical. Medical search. Frequent questions

Although glucocorticoid receptors (GRs) in the hippocampus play a vital role in the regulation of physiological and behavioural responses to stress, the regulation of receptor expression remains unclear. (karger.com)
Other research that compared the brains of people who committed suicide found fewer glucocorticoid receptors (stress receptors) in persons who had a history of childhood abuse compared with those who didn't. (medscape.com)

In this article, the authors presented "a method to quantify cell-generated mechanical stresses exerted locally within living embryonic tissues, using fluorescent, cell-sized oil microdroplets with defined mechanical properties and coated with adhesion receptor ligands. (genengnews.com)
Atherosclerosis starts with dysfunctional changes in the endothelium induced by disturbed shear stress which can lead to endothelial and platelet activation, adhesion of monocytes on the activated endothelium, and differentiation into proinflammatory macrophages, which increase the uptake of oxidized LDL (oxLDL) and turn into foam cells, exacerbating the inflammatory signalling. (hindawi.com)
Adhesion receptors are proteins in the plasma membrane that mediate cell binding to other cells or to the extracellular matrix. (utah.edu)

Activation of membrane receptors leads to NFKBI phosphorylation and ubiquitination, and its subsequent proteasomal degradation. (frontiersin.org)
Some of the receptors are cation channels, which can directly depolarize the nociceptor upon activation, while other receptors activate second messenger systems to change neuronal excitability by changing expression of, or modifying the function of, other cation channels. (frontiersin.org)
TRPV4 activation increases vascular permeability and can be triggered by both chemical and mechanical cues. (google.com)
Lymphocyte activation involves the binding of specialized receptors (TCR in T cells and BCR in B cells) with antigen on the surface of antigen presenting cells. (ibecbarcelona.eu)
This leads to changes in cell morphology and the movement and assembly of receptors, scaffold proteins and enzymes into signaling microclusters, which are essential for immune cell activation. (ibecbarcelona.eu)
Specifically, I will highlight the distinct roles of the actin and microtubule cytoskeleton in the exertion of mechanical stresses that support signaling activation, microcluster assembly and receptor movement in T and B lymphocytes. (ibecbarcelona.eu)
Recent studies have advanced our understanding of the molecular mechanisms underlying receptor activation and signal transduction of AT 1 and AT 2 receptor in the cardiovascular system. (current-pharmaceutical-design.com)
Interestingly, however, MRTF\mediated activation of the TEAD\YAP activity requires a direct connection between MRTFs and YAP as well as the recruitment of nuclear receptor co\activator 3 (NCOA3) to the DNA\bound TEAD\YAP transcription complex (Fig?1). (rawveronica.com)
At the center stage of this regulation is definitely YAP, whose nuclear translocation, activation, and assembly into transcriptionally active complexes are controlled by mechanical cues. (rawveronica.com)
Since tumor behavior isn't just INNO-406 inhibitor database affected by biophysical cues but also by metabolic stress, hormones, inflammation, it is?likely the mechanosignaling\induced activation of transcriptional co\activators cooperates with additional transcriptional regulators with the task to integrate almost all environmental cues into growth\ and migration\promoting signaling outputs, a realistic possibility awaiting long term scrutiny. (rawveronica.com)
In addition, surface iron speciation and content were a driving factor of oxidative stress induced macrophage activation. (cdc.gov)

Systemic blockade of corticotropin-releasing factor (CRF) type 1 receptors (CRFR1s) reduces stress-induced thermal hyperalgesia. (nature.com)
Cannabinoid type-1 receptor blockade restores neurological phenotypes in two models for Down syndrome. (upf.edu)
Carcolé M, Zamanillo D, Merlos M, Fernández-Pastor B, Cabañero D, Maldonado R. Blockade of the sigma-1 receptor relieves cognitive and emotional impairments associated to chronic osteoarthritis pain. (upf.edu)
Second messenger signaling bypasses CGRP receptor blockade to provoke migraine attacks in humans. (iasp-pain.org)

The paper's authors reported that after applying their oil-drop method, they were able to quantify the anisotropic stresses generated by mammary epithelial cells cultured within 3D aggregates. (genengnews.com)
We show in Caenorhabditis elegans that the force of hypergravity is translated into biological signaling via a genetic pathway involving three factors: the degenerin/epithelial Na + channel (DEG/ENaC) class of mechanosensory channels of touch receptor neurons, the neurotransmitter serotonin, and the FoxO transcription factor DAF-16 known to regulate development, energy metabolism, stress responses, and aging. (elsevierpure.com)
The manuscript demonstrates that a mechanical stretch down-regulates cathelicidin antimicrobial peptide expression and activates a pro-inflammatory response in the human bronchial epithelial cell line model VA10. (peerj.com)
Zasloff M ( 2015 ) Peer Review #3 of 'Cyclic mechanical stretch down-regulates cathelicidin antimicrobial peptide expression and activates a pro-inflammatory response in human bronchial epithelial cells (v0.2)' . (peerj.com)
Mice lacking the epidermal growth factor receptor (EGFR) develop epithelial defects and a neurodegenerative disease and die within the first month of birth. (silverchair.com)

Carcolé M, Kummer S, Gonçalves L, Zamanillo D, Merlos M, Dickenson AH, Fernández-Pastor B, Cabañero D, Maldonado R. Sigma-1 receptor modulates neuroinflammation associated with mechanical hypersensitivity and opioid tolerance in a mouse model of osteoarthritis pain. (upf.edu)

This is mostly due to surface toll-like receptors (TLRs) that can recognize both extracellular highly conserved microorganism structures or PAMPs (pathogen-associated molecular patterns) and alarmins further activating transcription factors of the same proinflammatory genes coding the production of proinflammatory regulatory substances, including cytokines and chemokines [ 4 , 5 ]. (hindawi.com)
Our results suggest that in response to stretch, MMP-2 responds rapidly by inhibiting conversion of a MMP-2 to the active form, while a slower up-regulation of MMP-9 may play a role in the long-term remodeling of extracellular matrix in response to continuous mechanical loading. (allenpress.com)
2 The cooperative effects of collagenases, gelatinases, and stromelysins-in combination with mechanical forces-suggest a role in MMP-dependent degradation of the extracellular matrix as an important determinant of implant failure due to excess occlusal forces. (allenpress.com)

This investigation evaluates the effects of mechanical deformation on in vitro osteoblasts by assessing changes in MMP gene expression and enzyme activity. (allenpress.com)
We seeded mouse neonatal calvarial osteoblasts onto flexible 6-well plates and subjected to continuous cyclic mechanical stretching. (allenpress.com)
Previous studies have demonstrated changes in the RNA expression in cyclically stressed osteoblasts obtained from mouse calvaria. (allenpress.com)

The relationship of vitamin D3 with the duration of mechanical ventilation and mortality is still unknown. (vitamindwiki.com)
Therefore, this study aimed to determine the effect of using high-dose vitamin D on the duration of mechanical ventilation among the patients admitted to the intensive care unit. (vitamindwiki.com)
Also duration of mechanical ventilation and mortality rate were recorded. (vitamindwiki.com)
The mean duration of the mechanical ventilation was 17.63 ± 14 days in the intervention group versus 27.72 ± 22.48 days in the control group (p = 0.06). (vitamindwiki.com)
Despite decrease of 10 days in duration of mechanical ventilation, the difference was not statistically significant. (vitamindwiki.com)
Intubation, with subsequent mechanical ventilation, is a common life-saving intervention in the emergency department (ED). Given the increasing length of stay of ventilated patients in EDs, it is necessary for emergency practitioners to have a good understanding of techniques to optimize mechanical ventilation and minimize complications. (medscape.com)
While the fundamental principles underlying mechanical ventilatory support have changed little over the decades, much progress has been made in our understanding of the secondary pathophysiologic changes associated with positive-pressure ventilation. (medscape.com)
Several recent clinical trials have demonstrated that optimizing ventilatory parameters reduces overall duration of mechanical ventilation and organ failure. (medscape.com)
Because intubation and mechanical ventilation alter first-line patient defenses, they greatly increase the risk for nosocomial bacterial pneumonia. (cdc.gov)
Although the primary audience is industrial hygienists, the guide can also be useful to other occupational, environmental health and safety (OEHS) professions, such as healthcare workers and infection preventionists, and non-OEHS professionals, like architects, mechanical engineers, and ventilation specialists. (cdc.gov)

Therefore, spinal AMPA receptor phosphorylation contributes to the mechanisms underlying stress-induced pain transition. (jneurosci.org)
This work investigates the molecular mechanisms underpinning stress-induced changes in hippocampal GR mRNA levels in vivo. (karger.com)
Early life stress (ELS) is a risk-factor for the development of IBS, however the mechanisms responsible for the persistent effects of ELS on visceral perception in adulthood remain incompletely understood. (frontiersin.org)
In rodent models, stress in adult animals induced by restraint and water avoidance has been employed to investigate the mechanisms of stress-induce pain. (frontiersin.org)
While there are relatively few studies examining epigenetically mediated mechanisms involved in visceral nociception, stress-induced visceral pain has been linked to alterations in DNA methylation and histone acetylation patterns within the brain, leading to increased expression of pro-nociceptive neurotransmitters. (frontiersin.org)
This review will discuss the potential neuronal pathways and mechanisms responsible for stress-induced exacerbation of chronic visceral pain. (frontiersin.org)
Additionally, we will review the importance of specific experimental models of adult stress and ELS in enhancing our understanding of the basic molecular mechanisms of pain processing. (frontiersin.org)
The underlying mechanisms involved in genomic stability, apoptosis and oxidative stress-related signaling were further analyzed by Western blotting, flow cytometry and immunofluorescence assays. (biomedcentral.com)
Unfortunately, the biophysical and conformational mechanisms by which adhesions reinforce in response to stress are not fully understood. (utah.edu)

Electrical stimulation of CeA in rodents produces analgesic effects that are blocked either by lidocaine 'silencing' of PAG or by blocking opioid receptors in PAG, suggesting that CeA-to-PAG projections are critical for the role of CeA signaling in modulating the nocifensive response ( Oliveira and Prado, 2001 ). (nature.com)

However, it remains unknown whether the pineal gland is able to respond to inflammatory mediators or whether it contains the receptors and the downstream mechanism(s) that mediate the pro-inflammatory agent-induced suppression of the nocturnal melatonin surge. (frontiersin.org)

Here we showed that social defeat stress enhanced plantar incision-induced AMPA receptor GluA1 phosphorylation at the Ser831 site in the spinal cord and greatly prolonged plantar incision-induced pain. (jneurosci.org)
Interestingly, targeted mutation of the GluA1 phosphorylation site Ser831 significantly inhibited stress-induced prolongation of incisional pain. (jneurosci.org)
In addition, stress hormones enhanced GluA1 phosphorylation and AMPA receptor-mediated electrical activity in the spinal cord. (jneurosci.org)

GV196771A, an NMDA receptor/glycine site antagonist, attenuates mechanical allodynia in neuropathic rats and reduces tolerance induced by morphine in mice. (curehunter.com)
Finally, intra-CeA infusion of tetrodotoxin produced thermal hyperalgesia in unstressed rats and blocked the anti-hyperalgesic effect of systemic CRFR1 antagonist in stressed rats. (nature.com)
Anakinra is a recombinant and slightly modified version of the human interleukin 1 receptor antagonist protein. (springwise.com)

Central sensitization is a process whereby nociceptive neurons and circuits exhibit increased function in response to activity, inflammation, or injury through a variety of processes that include changes in receptor field size, increases in neuronal excitability, increases in synaptic efficiency/coupling, and changes in neuronal connectivity ( Latremoliere and Woolf, 2009 ). (nature.com)

Specifically, integrins transmit mechanical and biochemical information. (utah.edu)
Integrins undergo drastic, long-range changes in response to biochemical signals or mechanical stresses. (utah.edu)
Integrins are transmembrane receptors that sense, resist and transmit cytoskeletal contractility to the substrate and respond to substrate rigidity via changes in conformation and ligand binding affinity. (utah.edu)

AVM cells were isolated from three patients and exposed to cyclic mechanical stretching for 24 h. (researchgate.net)
3 Because this bone cell culture model demonstrates a capacity to respond to mechanical changes, we hypothesize that this model may also show differences in expression of metalloproteinases in response to cyclic mechanical stretch that can be used to model changes at the bone-implant interface. (allenpress.com)
Conclusions Cyclic mechanical Bazedoxifene acetate stretch out promoted the cell and proliferation routine and reversely inhibited the apoptosis of NP cells. (oscars2019info.com)

Astragaloside IV might suppress autophagy initiation directly or indirectly through suppressing the oxidative stress and inflammatory response, which further enhances the cell viability and tight junction and reduces apoptosis in LPS-stimulated pulmonary endothelial ARDS cell model, thus exerting its therapeutic function in ARDS. (karger.com)
The experimental approach focused on several classes of extensively used nanoparticle s, with biological endpoints involving oxidative stress and inflammatory responses of aluminosilicate catalysts, titania, quantum dots, silver and carbon. (cdc.gov)

Evidence suggests that long term stress facilitates pain perception and sensitizes pain pathways, leading to a feed-forward cycle promoting chronic visceral pain disorders such as irritable bowel syndrome (IBS). (frontiersin.org)
Here we will briefly review visceral pain pathways and their modulation by (i) stress in adulthood and (ii) following exposure to neonatal stress. (frontiersin.org)
These results reveal a novel physiological role of the mechanosensory channel, showing that the perception of mechanical stress controls FoxO signaling pathways and that inactivation of DEG/ENaC may decouple mechanical loading and physiological responses. (elsevierpure.com)

GFP nuclear accumulation induced by hypergravity but did not affect DAF-16 response to other stresses. (elsevierpure.com)
NCOA3 is definitely a member of steroid receptor co\activator (SRC) family that interacts with several nuclear receptors including estrogen receptor alpha (ER) to enhance the manifestation of their cognate target genes (Chang & Wu, 2012). (rawveronica.com)

We aim to determine the properties of acupoint catgut embedding (ACE) on cold stress-induced mice fibromyalgia (FM) and surveyed the character of TRPV1 and linked molecules in chronic FM pain. (bvsalud.org)
METHODS: Intermittent cold stress (ICS) was used to induce mice FM model. (bvsalud.org)

Interestingly, aux depletion causes a dramatic increase in EGFR signaling, with a strong accumulation of EGFR at the plasma membrane and an increased expression of EGFR ligands in response to tissue stress. (sdbonline.org)

The Yes\associated protein (YAP) can be an important transcriptional co\activator that mediates the cellular response to mechanical and cytoskeletal cues. (rawveronica.com)
Mechanical cues can promote MRTF\mediated recruitment of NCOA3 towards the TEAD\YAP complicated also, which can fortify the TEAD\YAP\mediated transcriptional activity further. (rawveronica.com)
Integrin resists to contractility and this makes the receptor a cell mechanosensors, responding to mechanical cues with specific kinetic activities. (utah.edu)

This project aims to understanding how biological materials respond to mechanical force. (utah.edu)

Ang II activates Ang II type 1 (AT 1 ) receptor and type 2 (AT 2 ) receptor, both of which belong to the seven-transmembrane, G protein-coupled receptor family. (current-pharmaceutical-design.com)

The gravity response is an array of behavioral and physiological plasticity elicited by changes in ambient mechanical force and is an evolutionarily ancient adaptive mechanism. (elsevierpure.com)

Stress modifies nociception, and humans with post-traumatic stress disorder (PTSD) exhibit co-morbid chronic pain and amygdala dysregulation. (nature.com)
In concert with chronic visceral pain, there is a high comorbidity with stress-related psychiatric disorders including anxiety and depression. (frontiersin.org)
We will provide an evidenced-based argument for the use of specific experimental models to advance the understanding of stress-induced chronic pain. (frontiersin.org)
We will explain the unique aspects of these models that allows for a carefully crafted investigation of the female vulnerability to stress-induced chronic visceral pain. (frontiersin.org)
Atherosclerosis is a chronic vascular inflammatory disease associated to oxidative stress and endothelial dysfunction. (hindawi.com)
Chronic over-expression of heat shock protein 27 attenuates atherogenesis and enhances plaque remodeling: a combined histological and mechanical assessment of aortic lesions. (ohri.ca)

The inducible regulation of gene transcription is a central element in the defense of multicellular organisms against environmental, mechanical, chemical, and microbiological stresses. (frontiersin.org)
This study suggests that the regulation of metalloproteinases at both the mRNA and protein level are important in the response of bone to mechanical stress. (allenpress.com)

After a droplet is introduced between cells in a tissue," the authors continued, "local stresses are determined from droplet shape deformations, measured using fluorescence microscopy and computerized image analysis. (genengnews.com)
However, in some pathological situations, AT 2 receptor shows an increase in tissue expression and functions to antagonize the actions induced by AT 1 receptor. (current-pharmaceutical-design.com)

We hypothesized that CRF-CRFR1 signaling in central amygdala (CeA) mediates stress-induced hyperalgesia in rats with high stress reactivity. (nature.com)
Adult male Wistar rats were exposed to predator odor stress in a conditioned place avoidance paradigm and indexed for high (Avoiders) and low (Non-Avoiders) avoidance of predator odor-paired context, or were unstressed Controls. (nature.com)
These data suggest that rats with high stress reactivity exhibit hyperalgesia that is mediated by CRF-CRFR1 signaling in CeA. (nature.com)

Central elements of cell-substrate adhesions are transmembrane receptors, that form physical links between cell cytoskeleton and external binding partners. (utah.edu)

In response to mechanical stress, VEGF gene and protein expression increased in patient AVM endothelial cells. (researchgate.net)
Bevacizumab inhibited circular network formation of endothelial AVM cells and lowered VEGF gene and protein expression, even though the cells were exposed to mechanical stress. (researchgate.net)

Simultaneous stimulation of toll-like receptors (TLRs) and triggering receptor expressed on myeloid cells (TREM-1) activating receptor on monocytes results in the amplification of the inflammatory signal and multiple increase in proinflammatory cytokine production. (hindawi.com)

Acute stress results in decreased GR mRNA expression specifically in the dentate gyrus. (karger.com)
Acute stress gastritis, a form of erosive gastritis, occurs in about 5% of critically ill patients. (msdmanuals.com)
Bleeding is usually mild to moderate, although it can be massive if deep ulceration is present, particularly in acute stress gastritis. (msdmanuals.com)
Prophylaxis with acid-suppressive medications can reduce the incidence of acute stress gastritis. (msdmanuals.com)

These receptors sense and transmit forces between cells and the external environment. (utah.edu)

For example, the section on exposure assessment introduces the source-pathway-receptor paradigm. (cdc.gov)

Molecular imprinting is a technology that facilitates the production of artificial receptors toward compounds of interest. (mdpi.com)

Bone to mechanical loading elicits a biological response that has clinical significance for several areas in dental medicine, including orthodontic tooth movement, tempromandibular joint disease, and endosseous dental implant osseointegration. (allenpress.com)
The team engineered the cells to release an anti-inflammatory drug called anakinra in response to this stress. (springwise.com)
it changes your stress response system, your sort of 'fight or flight' type of response, and it also changes your sympathetic nervous system," said Dr Tietjen. (medscape.com)

Via cranial and spinal nerves (nerves of the Central and Peripheral nervous systems that relay sensory information to and from the brain and body), the different types of sensory receptor cells (such as mechanoreceptors, photoreceptors, chemoreceptors, thermoreceptors) in sensory organs transduct sensory information from these organs towards the central nervous system, finally arriving at the sensory cortices in the brain, where sensory signals are processed and interpreted (perceived). (wikipedia.org)
The Arthritis Foundation (AF) recommends moderate pressure to stimulate receptors under the skin that reduce pain and stress signals to the brain. (medicalnewstoday.com)

Bones vary widely in size, ranging from the tiny inner ear bones that are responsible for transmitting mechanical sound waves to the sensory organs to the large (nearly 2 ft long) femur bone that is strong enough to withstand 30 times one's body weight. (medscape.com)

Hyperproduction of proinflammatory cytokines, oxidative stress, and protease storm are essential pathogenetic components of the hyperergic phase of systemic inflammation. (hindawi.com)
Therefore, with the aim to summarize the current knowledge on the initiation of the atherosclerotic process, in this paper, we review the early markers of atherosclerosis and we address the main therapeutic targets for preventing atheroma formation at its very initial stages focusing on inflammation, oxidative stress, endothelial dysfunction, and the interaction between platelets and endothelium. (hindawi.com)
While the inflammation associated with the excessive stress of arthritis normally causes cartilage to break down, the drug blocks cartilage damage. (springwise.com)

The molecularly imprinted polymers act as artificial antibodies, artificial receptors, or artificial enzymes with the added benefit over their biological counterparts of being highly durable. (mdpi.com)

Due to the high vascular pressure endothelial cells of AVMs are exposed to mechanical stress. (researchgate.net)
Graphical abstract Mechanical stress increases VEGF expression in endothelial AVM cells, possibly causing the VEGF upregulation in the microenvironment of AVM cells. (researchgate.net)

When gels are made responsive to stimuli, these mechanical properties can be controlled. (fu-berlin.de)
Supramolecular gels are expected to be stimuli-responsive per se, for example to temperature, mechanical stress, or an environment that is competitive with the non-covalent interactions connecting the low-molecular weight gelators. (fu-berlin.de)
It would be much more promising to equip the gel with additional receptor sites that offer selectivity for a broader variety of chemical stimuli. (fu-berlin.de)

One potential mechanism underlying the persistent effects of stress on visceral sensitivity could be epigenetic modulation of gene expression. (frontiersin.org)

The overarching objective of this research is to understand, at near-atomic level, how integrin conformation is modulated by mechanical force and how the resultant conformational transitions regulate cell behavior. (utah.edu)

the recent approval by the US Food and Drug Administration (FDA) of the first "artificial pancreas" [ 1 ] provides promise that closed-loop mechanical systems may enable tight glycemic control with minimal patient intervention. (medscape.com)

Besides promising to explicate the role of cell-generated mechanical forces in embryonic development, this technique may advance knowledge regarding other processes including birth defects, tumor growth and metastasis, and diseases in which imbalanced cellular forces play a role. (genengnews.com)
The technique was described in an article published December 8 in Nature Methods, in an article entitled "Quantifying cell-generated mechanical forces within living embryonic tissues. (genengnews.com)
Cyclic mechanised stress significantly marketed the cell routine changeover of NP cells in the S stage towards the G2/M stage. (oscars2019info.com)
catch-bond kinetics is responsible for integrin-based mechanosensing, leading to enhanced cell spreading and traction stress. (utah.edu)

The dynamics of those receptors expression on monocyte surface of patients with uncomplicated SIRS course followed coronary artery bypass surgery (CABG) was studied. (hindawi.com)
Overall, mechanical stress increases VEGF expression in the microenvironment of AVM cells. (researchgate.net)

Diseases1

Analytical, Diagnostic and Therapeutic Techniques and Equipment3

Phenomena and Processes8

Glucocorticoid receptors2

Adhesion3

Activation11

Blockade4

Epithelial5

Modulates1

Extracellular3

Osteoblasts3

Ventilation10

Mechanisms9

Opioid1

Mediators1

Phosphorylation3

Antagonist3

Neuronal excitability1

Integrins3

Cyclic mechanical3

Oxidative stress and inflammatory2

Pathways3

Nuclear2

Mice2

Ligands1

Cues3

Respond to mechanical1

Activates1

Physiological1

Chronic6

Regulation2

Tissue2

Rats3

Cytoskeleton1

Protein2

Stimulation1

Acute Stress4

Transmit1

Paradigm1

Facilitates1

Response3

Signals2

Sensory organs1

Inflammation3

Enzymes1

Endothelial2

Stimuli3

Mechanism1

Behavior1

Artificial1

Cell4

Expression2