• genes
  • We recently reported an Expressed Sequence Tag (EST) approach on male antennae of the noctuid moth, Spodoptera littoralis , with which we could identify a large array of chemosensory genes in a species for which no genomic data are available. (ijbs.com)
  • From a molecular point of view, we recently sequenced an Expressed sequence tag (EST) library prepared from male S. littoralis antennae, leading to the identification of a partial repertoire of genes putatively involved in odorant and pheromone detection [ 8 ]. (ijbs.com)
  • 1995). "Prediction of the coding sequences of unidentified human genes. (wikipedia.org)
  • Moreover, the JA/ET signaling pathway-related genes PR3, PDF 1.2, ERF1 and the SA-related genes PR1 and PR2 were constitutively expressed in transgenic plants. (frontiersin.org)
  • A comparative analysis of OBPs between closely related species may help explain how these genes evolve and are maintained under natural selection and how differences in these proteins can affect olfactory responses. (beds.ac.uk)
  • We identified 23 different OBP sequences from Anastrepha fraterculus and 24 from A. obliqua , which correspond to 20 Drosophila melanogaster OBP genes. (beds.ac.uk)
  • Inferences on tertiary structures of putative proteins from these genes revealed that at least one positively selected change involves the binding cavity (the odorant binding region) in the plus-C OBP50a . (beds.ac.uk)
  • A partial expressed sequence tag database, created as part of the genome project, revealed the transcription of meiosis-specific genes and other genes related to sexual reproduction. (genetics.org)
  • The ortholog of Ste3, an a -factor pheromone receptor, was cloned and genes surrounding the ste3 locus were examined. (genetics.org)
  • Dcr3 was identified in 1998 by the search of genes with homology to the TNFR gene superfamily in expressed sequence tag (EST) database. (wikipedia.org)
  • Type I IFNs, including IFNα and IFNβ, are cytokines that are transcriptionally induced during viral infection and that signal through the type I IFN α/β receptor (IFNAR) to activate transcription of a large set of genes important in antiviral responses ( 2 ). (rupress.org)
  • The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. (wikipedia.org)
  • The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. (wikipedia.org)
  • 1999
  • Although actin remodeling is thought to be essential for T cell activation (see Penninger and Crabtree 1999 ), it is not known how T cell receptor (TCR) signaling is linked to the rearrangement of the actin cytoskeleton. (rupress.org)
  • death receptors
  • Death receptors were initially recognised as potent inducers of apoptotic cell death and soon ambitious attempts were made to exploit selective ignition of controlled cellular suicide as therapeutic strategy in malignant diseases. (mdpi.com)
  • At the time of discovery, a subgroup of the TNFRSF, the so-called death receptors (DR), attracted considerable interest as robust cell-death induction upon ligand binding was recognised and triggered the ambitious goal for exploitation in therapeutic settings such as cancer therapy. (mdpi.com)
  • It acts as a decoy receptor that competes with death receptors for ligand binding. (wikipedia.org)
  • encodes
  • The open reading frame of TNFRSF6B encodes 300 amino acids with a 29-residue signal sequence and four tandem cystein-rich repeats. (wikipedia.org)
  • endogenous
  • I want to do a couple things: 1) screen cell lysates to see which proteins associate with this cytoplasmic domain, 2) transduce the cytoplasmic domain into cells via a cell-penetrating TAT sequence to determine if it is inhibitory (by sequestering binding proteins from the endogenous receptor). (protocol-online.org)
  • apoptosis
  • Receptor-ligand systems of this group are critically involved in various cellular signalling pathways such as inflammation, lymphocyte homeostasis, apoptosis and tissue development [ 2 , 3 ]. (mdpi.com)
  • human
  • The G-protein-coupled receptors in the human genome form five main families. (springer.com)
  • The human and the murine GPR84 ORFs both encode proteins of 396 amino acid residues length with 85% identity and are therefore considered as orthologs. (wikipedia.org)
  • The Locus158062 and Unigene cluster information usually are not shown in Fig. one, but can be found at the National Center for Biotechnology Information The human LCN6 sequence is based mostly on in excess of ten clones we isolated through library screening. (pdgfreceptor.com)
  • LTB4R protein, human at the US National Library of Medicine Medical Subject Headings (MeSH) Receptors, Leukotriene B4 at the US National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text from the United States National Library of Medicine, which is in the public domain. (wikipedia.org)
  • ChemR23, also known as Dez in mouse ( 9 ), was shown to constitute a minor coreceptor for a subset of human immunodeficiency viruses ( 10 ), but no ligand, either natural or synthetic, has been so far identified for this receptor. (rupress.org)
  • Towards a proteome-scale map of the human protein-protein interaction network. (genes2cognition.org)
  • Here we describe an initial version of a proteome-scale map of human binary protein-protein interactions. (genes2cognition.org)
  • OR2A4 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text from the United States National Library of Medicine, which is in the public domain. (wikipedia.org)
  • structurally
  • Of those structures, bovine lipocalin allergen, pig odorant binding protein, and mouse major urinary protein 1 in Protein Information Financial institution were structurally closest to LCN6. (pdgfreceptor.com)
  • ChemR23 is structurally related to receptors for chemokines and other chemoattractant molecules and was therefore expected, given its distribution, to specifically attract APCs in response to an unknown mediator. (rupress.org)
  • The protein encoded by this gene is structurally related to regulatory factors X1, X3, X4, and X5. (wikipedia.org)
  • family proteins
  • In activated T cells, Fyb/SLAP associates with Ena/VASP family proteins and is present within biochemical complexes containing WASP, Nck, and SLP-76. (rupress.org)
  • In mammalian cells, overexpression of COOH-terminal fragments of WASP family proteins leads to delocalization of the Arp2/3 complex, resulting in the complete loss of lamellipodia and stress fibers ( Machesky and Insall 1998 ). (rupress.org)
  • selective
  • Mechanistically, these findings raised the question how multipurpose receptors can ensure selective activation of a particular pathway. (mdpi.com)
  • Concomitant with the awareness that DR signalling can be considered as a double-edged sword, the question how these multipurpose receptors ensure selective activation of a particular pathway raised. (mdpi.com)
  • One of these functional differences is the expression of differential sets of chemoattractant receptors, which is responsible for the selective recruitment of specific cell subpopulations according to their lineage, origin, and maturation state ( 2 ). (rupress.org)
  • postsynaptic
  • Also, through crosslinking another multimeric protein Shank, it is proposed to comprise a core of the postsynaptic density. (wikipedia.org)
  • He found that postsynaptic proteins were degraded in the hippocampus by polyubiquitination after the retrieval of contextual fear memory. (wikipedia.org)
  • transcriptome
  • 18,342 ESTs were sequenced and their assembly with our previous male ESTs led to a total of 13,685 unigenes, greatly improving our description of the S. littoralis antennal transcriptome. (ijbs.com)
  • He started by establishing an expressed sequence tag database and transcriptome analyses of Aplysia. (wikipedia.org)
  • soluble
  • OBPs are small soluble globular proteins (10-30 kDa), with six highly conserved cysteine residues (referred to as C1 to C6) in characteristic positions of all known insect OBPs. (beds.ac.uk)
  • Phylogenetic
  • Phylogenetic analysis separated Anastrepha OBPs sequences in four branches that represent four subfamilies: classic, minus-C, plus-C and dimer. (beds.ac.uk)
  • molecular
  • Molecular modeling Fold recognition solutions based on sequence derived properties offered by 3D PSSM, GenTHREADER, Fugue profile library search, and also the Bioinbgu server had been utilised to predict the construction of hLCN6. (pdgfreceptor.com)
  • This technology opened up a new era of molecular studies on the memory mechanisms in Aplysia, as well as of functional studies of receptors, signaling molecules, and ion channels, which play key roles in neuronal functions. (wikipedia.org)
  • Signalling
  • However, the complexity of death receptor signalling has increased substantially during recent years. (mdpi.com)
  • A growing body of evidence points to an elegant spatiotemporal regulation of composition and assembly of the receptor-associated signalling complex. (mdpi.com)
  • In this review, we will summarise the current concepts of death receptor trafficking and its implications on receptor-associated signalling events. (mdpi.com)