Receptor drug synergism. Medical search. Frequent questions

This model facilitates understanding the mixture interactions and the potential for additivity, synergism or antagonism from multi-OP exposures. (cdc.gov)
This system allows us to test direct agonism/antagonism of CB1 receptors and the interaction with other components of cannabinoid signaling, including potential synergism with endocannabinoids. (fabbs.org)

In this context, a novel series of conformationally restricted N-arylpiperazine derivatives (5a-f) with a good affinity for D2/D3 dopamine receptors is reported herein. (bvsalud.org)
In the next series of experiments, coapplication of dopamine and 1 S ,3 R -ACPD, but not application of either drug alone, consistently induced LTD without tetani or even single test stimuli during drug application, suggesting that coactivation of dopamine receptors and the mGluRs is sufficient for LTD induction. (jneurosci.org)
Immunoblot analyses with anti-active mitogen-activated protein kinases (MAP-Ks) revealed that D1 receptors, D2 receptors, group I mGluRs, and group II mGluRs all contribute to MAP-K activation in prefrontal cortex, and that combined activation of dopamine receptors and mGluRs synergistically or additively activate MAP-Ks. (jneurosci.org)
Our results suggest that dopamine receptors and groups I and II mGluRs cooperate to induce LTD through converging postsynaptic activation of MAP-Ks. (jneurosci.org)

Preferential inhibition of viability was observed in Ba/F3 cells expressing erythropoietin receptor (EpoR) when stimulated with Epo compared to stimulation with interleukin-3 (IL3). (eurekaselect.com)

2016. Conformational modulation of the farnesoid X receptor by prenylflavonoids: Insights from hydrogen deuterium exchange mass spectrometry (HDX-MS), fluorescence titration and molecular docking studies. . (oregonstate.edu)
Significant impacts of interventions on intestinal bile acid metabolism, farnesoid X receptor (Fxr) signalling in the intestine and liver, and hepatic expression of fatty acid transporters (Fabp4, Vldlr, Cd36) were also evident. (nih.gov)

The effectiveness of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blocker AT-1 (ARBs) in reducing the systemic hypertension (SH) is widely known. (intechopen.com)

Together, these results suggest a strong possibility of synergistic efficacy of GSE and Dox combination for breast cancer treatment, independent of estrogen receptor status of the cancer cell. (nih.gov)
Drug synergistic effects were observed when cells were stimulated to proliferate through both the IL3 and TpoR pathways. (eurekaselect.com)
We employed combinatorial drug screening to identify synergistic combination partners to enhance the efficacy of venetoclax in T-PLL patients. (haematologica.org)
Synergistic activation of estrogen receptor with combinations of environmental chemicals. (cdc.gov)

For instance, a receptor antagonist is an agent that reduces the response that a ligand produces when the receptor antagonist binds to a receptor on a cell. (wikipedia.org)
An example of this is the interleukin-1 receptor antagonist. (wikipedia.org)
E5555 is a potent protease-activated receptor (PAR-1) antagonist targeting the G-coupled receptor and modulating thrombin-platelet-endothelial interactions. (uea.ac.uk)

Δ9-THC, the main psychoactive constituent of cannabis, binds to CB1 receptors in the endogenous cannabinoid signaling system. (fabbs.org)
THC binds to a receptor in the cerebral cortex known as C-1 and is responsible for the psychoactive effects of the plant. (onefarm.com)
It preferentially binds to C-2 receptors but has a low affinity for binding to C-1 receptors. (onefarm.com)

TNF-alpha generally inhibits the growth of primitive murine hematopoietic progenitor cells (Lin-Scal+) in response to multiple cytokine combinations, and the p75 TNF receptor is essential in signaling such inhibition. (ox.ac.uk)
In vitro, we found that combinations of M85 and oseltamivir have strong synergism. (inrae.fr)
Multi-targeted drug therapy holds more promise than single-class drug regimens (Lapchak 2011 ) since some drug combinations exhibit pharmacological synergism, translating into lower doses, fewer adverse side effects, and extending the therapeutic window (Saleh et al. (springer.com)

A synergism between labetalol HCl and halothane anesthesia has been shown (see PRECAUTIONS: Drug Interactions ). (druglib.com)
The most clinically important interactions involve drugs with a low therapeutic ratio (ie, toxic levels are close to therapeutic levels). (msdmanuals.com)

For this reason, the dopaminergic system and dopamine receptor ligands play a key role in the treatment of such disorders. (bvsalud.org)
Drugs of the so-called targeted therapy operate selectively by either inhibiting receptors and ligands or molecules of the signaltransduction. (uni-marburg.de)

In this study, we identified an antiviral compound, M85, that targets host kinases, epidermal growth factor receptor (EGFR), and phosphoinositide 3 class II β (PIK3C2β) and is not susceptible to resistance by viral mutations. (inrae.fr)
Anti-epidermal growth factor receptor (EGFR) therapy is an effective way to inhibit proliferation of many cancer types such as non-small cell lung cancer (NSCLC) and colorectal cancer [ 1 ]. (biomedcentral.com)

With an approach to enhance the efficacy of chemotherapy agents against breast cancer treatment, here, we investigated the anti-cancer effects of grape seed extract (GSE) and doxorubicin (Dox), either alone or in combination, in estrogen receptor-positive MCF-7 and receptor-negative MDA-MB468 human breast carcinoma cells. (nih.gov)
This was further confirmed in another estrogen receptor-negative MDA-MB231 cell line, in which GSE and Dox combination strongly inhibited cell growth but did not show any increase in apoptotic cell death caused by Dox. (nih.gov)

Methodological problems, as well as the relationships between acute and chronic drug effects, alterations in normal subjects and patients, CNS effects and therapeutic efficacy will be discussed. (ecnsweb.com)
Furthermore, venoms and their toxins have been considered good tools for prospecting for new active drugs or models for new therapeutic drugs. (scielo.br)

Labetalol hydrochloride's beta 1 -receptor blockade in man was demonstrated by a small decrease in the resting heart rate, attenuation of tachycardia produced by isoproterenol or exercise, and by attenuation of the reflex tachycardia to the hypotension produced by amyl nitrite. (nih.gov)
Beta 2 -receptor blockade was demonstrated by inhibition of the isoproterenol-induced fall in diastolic blood pressure. (nih.gov)
Selective blockade of platelet receptors suggests unique antiplatelet properties of E5555 as a potential addition to current antithrombotic regimens. (uea.ac.uk)

The production records why it features clinical to do and be amphiphilic output, taking the F of causal receptor assembly in congestive macrophages of furosemide hormone, decision, and yellowish problem unconsciousness. (siriuspixels.com)
outbreaks of response and disease heart versus heart Also on CVD P and congestive levosimendan hyperopia in receptors with vector late-life: the Plavix Use for Treatment Of Congestive Heart growth( PLUTO-CHF) dentistry. (seabaygame.com)

Affinity values below 1 µM for both target receptors and distinct profiles of intrinsic efficacy were found. (bvsalud.org)
Specifically, one may determine at an early stage of drug development whether a drug is effective on the central nervous system (CNS) compared with placebo, what its clinical efficacy will be like, at which dosage it acts, when it acts and the equipotent dosages of different galenic formulations. (ecnsweb.com)
Clinical and antioxidant efficacy of 4% mangosteen gel as a local drug delivery in the treatment of chronic periodontitis: A placebo-controlled, split-mouth trial. (medlineplus.gov)

The most potent extracts was tested along with gemcitabine using our established drug combination analysis. (rcsi.com)

For example, not only do angiotensin receptor blockers, and angiotensin-converting enzyme (ACE) inhibitors work to lower blood pressure, but they also counter the effects of renal disease in diabetic and non-diabetic patients. (wikipedia.org)
Either increases effects of the other by pharmacodynamic synergism. (medscape.com)
Imaging of drug effects on the regional brain electrical activity of healthy subjects by means of EEG tomography such as low-resolution electromagnetic tomography (LORETA) has been used for identifying brain areas predominantly involved in psychopharmacological action. (ecnsweb.com)
Since clinical trials involving ibudilast have shown no adverse side effects and the drug readily penetrates the blood brain barrier, treatment of GBM with this combination is clinically achievable. (nature.com)
Our previous study reported its anti-inflammatory effects were caused by inhibiting Toll-like Receptor-4 (TLR-4) activation. (rcsi.com)
Almost all studies suggested that taking all kinds of illicit drugs with the effects on different parts of the male reproductive system can result in subfertility or complete infertility in the consumers. (magiran.com)
In addition to the aging phenomenon, stem cell senescence has been investigated in various concepts such as cancer, adverse drug effects, and as a limiting factor in cell therapy. (magiran.com)
Overall, the present study demonstrates strong antinociceptive synergism between curcumin and piperine in mouse models with no potential CNS side effects, suggesting its possible use in clinical trials. (biomedcentral.com)
Δ9-THC exerts its psychoactive effects primarily through cannabinoid CB1 receptors (Matusuda et al. (fabbs.org)
1994. Ah receptor in embryonic mouse palate and effects of TCDD on receptor expression. (cdc.gov)
CBD creates most of its clinical effects by binding to the 5HT1A receptor, which produces antidepressant, anti-anxiety and neuro-protective effects. (onefarm.com)
Via flow cytometry in both cell lines a clear transformation of cell cycle induced by treatment with the drugs could be demonstrated, but these effects seem to be rather a single effect of flavopiridol. (uni-marburg.de)

Labetalol hydrochloride tablets, USP are an adrenergic receptor blocking agent that has both selective alpha 1 -adrenergic and nonselective beta-adrenergic receptor blocking actions in a single substance. (nih.gov)
Due to the alpha 1 -receptor blocking activity of labetalol hydrochloride, blood pressure is lowered more in the standing than in the supine position, and symptoms of postural hypotension (2%), including rare instances of syncope, can occur. (nih.gov)
Labetalol hydrochloride injection is prepared for continuous intravenous infusion by diluting the drug with commonly used intravenous fluids (see below). (pfizermedicalinformation.com)

BACKGROUND: L-proline transporter (PROT/SLC6A7) is closely associated with glutamatergic neurotransmission, where L-proline modulates the NMDA receptor (NMDAR) function. (bvsalud.org)

C/EBPα and the Vitamin D Receptor Cooperate in the Regulation of Cathelicidin in Lung Epithelial Cells. (oregonstate.edu)

Conclusion: This screen has identified a monoamine receptor inhibitor that can inhibit viability of cells with active TpoR or EpoR signalings. (eurekaselect.com)
Combined signaling through interleukin-7 receptors and flt3 but not c-kit potently and selectively promotes B-cell commitment and differentiation from uncommitted murine bone marrow progenitor cells. (ox.ac.uk)
Tumor necrosis factor-alpha (TNF-alpha) potently enhances in vitro macrophage production from primitive murine hematopoietic progenitor cells in combination with stem cell factor and interleukin-7: novel stimulatory role of p55 TNF receptors. (ox.ac.uk)
The synergism was independent of TLR-4 expression in pancreatic cancer cells. (rcsi.com)
For example, most chemotherapeutic drugs work by impairing mitosis (cell division), effectively targeting fast-dividing cells. (justia.com)
As these drugs cause damage to cells they are termed cytotoxic. (justia.com)
Lipid-sensing G-protein-coupled receptors (GPCRs) are highly expressed in pancreatic β-cells and implicated with metabolic symdroms [ 9 ]. (biomedcentral.com)
in BG1-cells combining both drugs led to a rise of necrosis and a reduction of vital cells. (uni-marburg.de)
in BG1-cells evidence for a synergism of Flavopiridol and Lonafarnib was found. (uni-marburg.de)

A recent hypothesis proposes that the seasonal variation in the incidence of some infectious diseases is attributable to seasonal variation in host physiology, such as the density of a cellular receptor or the activity of the immune response ( 7 ). (cdc.gov)
Tumor necrosis factor-alpha (TNF-alpha) is a bifunctional regulator of hematopoiesis, and its cellular responses are mediated by two distinct cell surface receptors. (ox.ac.uk)
In this model, autaptic hippocampal neurons express CB1 receptors, the cellular machinery to synthesize and metabolize the endocannabinoid 2-AG, and several other forms of CB1-mediated neuronal plasticity (Kellogg et al. (fabbs.org)

2021 ). Moreover, the resolution of inflammation is not passive as it engages a biosynthetically active process, regulated by specific mediators and receptor-signaling pathways and driven by specialized pro-resolving mediators (SPMs) (Serhan and Petasis 2011 ). (springer.com)

Apalutamide induces UGT and may decrease systemic exposure of drugs that are UGT substrates. (medscape.com)
Also, other drugs can increase or decrease levels of antibiotics. (msdmanuals.com)

In the present study we show the reverse phenomenon in that TNF-alpha on the same progenitor cell population in combination with stem cell factor (SCF) and interleukin-7 (IL-7) through the p55 TNF receptor can recruit additional progenitors to proliferate. (ox.ac.uk)

In the scope of an academic drug discovery program, we describe here the design, synthesis, in vitro metabolism prediction and pharmacological characterization of a new piperazine compound, 1-(4-methoxyphenyl)-4-((1-phenyl-1H-pyrazol-4-yl)methyl)piperazine (LQFM005), and of its main putative metabolite, 4-(4-((4-(4-methoxyphenyl)piperazin-1-yl)methyl)- 1H-pyrazol-1-yl)phenol (LQFM235). (bvsalud.org)

Docking studies revealed that Compounds 5a-f present a different binding mode with dopamine D2 and D3 receptors, mainly as a consequence of the conformational restriction imposed on the flexible spacer groups of 2 and 3. (bvsalud.org)

Our compound specifically targets monoamine receptors in the rhodopsin-like receptor family of G protein-coupled receptor. (eurekaselect.com)
Moreover, curcumin is considered a safe compound and authorized as a GRAS compound (generally recognized as safe) by US FDA (United States Food and Drug Administration) [ 7 ]. (biomedcentral.com)

Class I and class II molecules allow antigen presentation to the specific T-cell receptor via a specific structural groove in its tertiary structure. (medscape.com)

PECAM-I, GP IIb/IIIa antigen, and activity with PAC-1, GPIb, thrombospondin, vitronectin receptor expression, and formation of platelet-monocyte aggregates were also significantly reduced by E5555. (uea.ac.uk)

4 Here ibrutinib demonstrated the strongest synergism with venetoclax, whereas cisplatin appeared the most antagonistic ( Figure 1B and C, Online Supplementary Figure S1B ). (haematologica.org)
Cisplatin is a platinum-based chemotherapeutic drug that has been used as the standard of care in late stages of NSCLC in combination with paclitaxel, vinorelbine, gemcitabine, docetaxel, pemetrexed, or irinotecan [ 20 ]. (biomedcentral.com)

However, it is unclear whether lycopene can act as an adjuvant to increase the anti-metastatic activity of anticancer drugs. (frontiersin.org)
To this topic, lycopene had been demonstrated to have synergism from the combination of oxaliplatin in a human ovarian cancer cell line ( 20 ), suggesting that the adjuvant property on the anticancer of lycopene. (frontiersin.org)

Synergism between curcumin and piperine has been found in several animal models but not in periodontal disease and diabetes, and the antinociceptive interaction is still unknown. (biomedcentral.com)

Twenty-four candidate compounds were selected based on their clinical approval status, literature data, and mechanisms of drug action. (haematologica.org)
In the present paper two attempts to transfer pharmaco-EEG methods to psychiatric clinical routine will be described: 1) monitoring of psychotropic drug toxicity at the central nervous system level, and 2) prediction of clinical response to treatment with psychotropic drugs. (ecnsweb.com)
EEG studies of recreational drugs are flawed by several limitations, and failed, so far, to identify reliable indices of CNS toxicity to be used in clinical settings. (ecnsweb.com)
Sociodemographic and clinical data, comorbidities, drug therapy in use (long-term use and self-medication), and lifestyle habits were recorded through face-to-face interviews. (zhihuiya.com)

The search for new active drugs that can alleviate or cure different diseases is a constant challenge to researchers in the biological area and to the pharmaceutical industry. (scielo.br)

Avoid or Use Alternate Drug. (medscape.com)
Therefore, it is recommended that couples, who are planning to conceive, avoid taking any illicit drugs before and during treatment. (magiran.com)

Ibudilast showed modest anti-proliferative activity however, when combined with TMZ, significant synergism was observed, resulting in cell cycle arrest and apoptosis. (nature.com)
This study supports evidence in literature pointing to a certain activity of these drugs and at the same time emphasizes the different sensibility of human ovarian cancer cell lines to targeted therapeutics in vitro. (uni-marburg.de)
Although drugs within each class share structural and functional similarities, they often have different pharmacology and spectra of activity. (msdmanuals.com)
Whether chosen according to culture results or not, drugs with the narrowest spectrum of activity that can control the infection should be used. (msdmanuals.com)

2013. Curcumin induces human cathelicidin antimicrobial peptide gene expression through a vitamin D receptor-independent pathway. . (oregonstate.edu)

Background: Rather than a Janus Kinase 2 inhibitor (ruxolitinib), a specific thrombopoietin receptor (TpoR) inhibitor would be more specific for the treatment of myeloproliferative neoplasms due to TpoR mutations. (eurekaselect.com)
Drug combination treatment study was performed using ruxolitinib and the indole analog. (eurekaselect.com)
Two classes of antivirals targeting the viral neuraminidase (NA) and endonuclease are currently the only clinically useful drugs for the treatment of influenza. (inrae.fr)
Anti-fibrotic drugs such as pirfenidone have been developed for the treatment of idiopathic pulmonary fibrosis. (biomedcentral.com)
In 2011, pirfenidone was the first drug approved in Europe for the treatment of idiopathic pulmonary fibrosis [ 18 ] following its approval in the United States in 2014. (biomedcentral.com)
It is known that adjuvant is defined as a substance that helps and enhances the effect of a drug or treatment ( 19 ). (frontiersin.org)

Compounds were designed as interphenylene analogs of the drugs aripiprazole (2) and cariprazine (3), presenting a 1,3-benzodioxolyl subunit as a ligand of the secondary binding site of these receptors. (bvsalud.org)
Many natural compounds have been investigated as drug candidates to prevent human immunodeficiency virus (HIV) with low cytotoxicity. (ophrp.org)

Ligand-dependent activation of the G-protein coupled receptor 119 (GPR119) lowers blood glucose via glucose-dependent insulin secretion and intestinal glucagon-like peptide-1 production. (biomedcentral.com)

Register your specific details and specific drugs of interest and we will match the information you provide to articles from our extensive database and email PDF copies to you promptly. (dovepress.com)
By considering these differences between psychotropic drugs and placebo in normal subjects, as well as between mental disorder patients and normal controls, it may be possible to choose the optimum drug for a specific patient according to a key-lock principle, since the drug should normalize the deviant brain function. (ecnsweb.com)

The drug is currently being tested in phase II trials in patients with coronary artery disease (CAD) and has potential antithrombotic and anti-inflammatory benefits. (uea.ac.uk)
Patients should always be kept in a supine position during the period of intravenous drug administration. (pfizermedicalinformation.com)
Cases were defined as patients with a diagnosis of UGIB and controls as patients admitted for reasons unrelated to gastrointestinal bleeding, gastric concerns, or complications associated with low-dose aspirin (LDA) or nonsteroidal anti-inflammatory drugs (NSAIDs) use. (zhihuiya.com)
La présente analyse récapitule les facteurs pathologiques majeurs liant l'obésité au diabète, en se concentrant sur les données épidémiologiques actuelles relatives aux patients diabétiques obèses dans le monde arabe, l'étiologie de la maladie et les déterminants génétiques du diabète et de l'obésité. (who.int)
it exposes patients to drug complications without any benefit and contributes to bacterial resistance. (msdmanuals.com)

Low-dose aspirin is a non-steroidal anti-inflammatory drug. (zhihuiya.com)

Although the data in this field are not decisive and there are some confounding factors in human studies, it can be inferred that the use of any illicit drug with an effect on male sexual health reduces fertility potency. (magiran.com)
it's made within the human body and occupies THC receptors. (onefarm.com)

And I was able to, I did get the surgery, and then after the surgery, even though I was taking, I mean literally probably [0:05:05] ______ bottles of anti-inflammatory drugs and pain medication, my mom introduced me to these essential oils and I found relief from pain for the first time. (bengreenfieldlife.com)
A new generation of drugs is likely to emerge from peptides, including those found in animal venoms. (scielo.br)

Potential for additive opioid receptor anatagonism and increased risk of opioid withdrawal. (medscape.com)
Because activated fibroblasts in inflammatory conditions have similar characteristics as cancer-associated fibroblasts (CAFs) and CAFs contribute actively to the malignant phenotype, we believe that anti-fibrotic drugs have the potential to be repurposed as anti-cancer drugs. (biomedcentral.com)
In the 1970s, the THC portion of the plant was classified by the Drug Enforcement Administration (DEA) as a Schedule I drug, which by definition means the DEA feels it has no medicinal use and a high potential for abuse. (onefarm.com)

Anatomy4

Organisms5

Chemicals and Drugs32

Analytical, Diagnostic and Therapeutic Techniques and Equipment4

Phenomena and Processes18

Technology, Industry, Agriculture1

Information Science2

Antagonism2

Dopamine receptors4

Erythropoietin receptor1

Farnesoid X recept2

Angiotensin II recep1

Synergistic4

Antagonist3

Binds3

Combinations3

Interactions2

Ligands2

EGFR2

Estrogen receptor2

Therapeutic2

Blockade3

Congestive2

Efficacy3

Extracts1

Effects12

Labetalol3

Modulates1

Cooperate1

Cells9

Cellular3

Pathways1

Decrease2

Stem Cell F1

Metabolism1

Conformational1

Compound2

Molecules1

Antigen1

Cisplatin2

Anticancer2

Interaction1

Clinical4

Diseases1

Avoid2

Activity4

Antimicrobial1

Treatment6

Compounds2

Activation1

Specific2

Patients5

Aspirin1

Human2

Found2

Potential3