Receptor degradation lysosomes. Medical search. Frequent questions

As incubation time increased, the nanoconstruct complexes were found in vesicular structures, starting from early endosomes to lysosomes as visualized by confocal fluorescence and differential interference contrast microscopy. (northwestern.edu)
Molecules are also transported to endosomes from the trans Golgi network and either continue to lysosomes or recycle back to the Golgi apparatus. (wikipedia.org)
Endosomes provide an environment for material to be sorted before it reaches the degradative lysosome. (wikipedia.org)
Upon reaching early endosomes, the LDL dissociates from the receptor, and the receptor can be recycled to the cell surface. (wikipedia.org)
Early endosomes then mature into late endosomes before fusing with lysosomes. (wikipedia.org)
Removal of recycling molecules such as transferrin receptors and mannose 6-phosphate receptors continues during this period, probably via budding of vesicles out of endosomes. (wikipedia.org)
Finally, the endosomes lose RAB5A and acquire RAB7A, making them competent for fusion with lysosomes. (wikipedia.org)
Fusion of late endosomes with lysosomes has been shown to result in the formation of a 'hybrid' compartment, with characteristics intermediate of the two source compartments. (wikipedia.org)
For example, lysosomes are more dense than late endosomes, and the hybrids have an intermediate density. (wikipedia.org)
In early endosomes some ligand-receptor complexes dissociate due to the reduced pH of the endosomal lumen. (wormbook.org)
Many receptors then recycle to the plasma membrane either directly or indirectly via recycling endosomes. (wormbook.org)
Many ligands do not recycle but instead are transported from early to late endosomes and eventually to lysosomes for degradation. (wormbook.org)
Late endosomes are then thought to fuse with pre-lysosomes to form "hybrid" organelles, which mature back into lysosomes through sorting and fission. (wormbook.org)
Some cargos are further transported to lysosomes through late endosomes. (wormbook.org)
Multivesicular bodies, or late endosomes, deliver membrane proteins to lysosomes for degradation, and Aβ42 co-localizes strongly with markers of late endosomes. (alzforum.org)
The transferrin receptor (TfR) is processed by the recycling of early endosomes, and the epidermal growth factor receptor (EGFR) is shuttled through late endosomes. (alzforum.org)
APP similarly retarded degradation of TrkB receptors through late endosomes. (alzforum.org)
How autophagosomes gain competence to fuse with late endosomes and lysosomes is not known. (rupress.org)
Src is associated and trafficked together with activated PAR1 to early endosomes and then sorted to lysosomes for degradation. (tmu.edu.tw)
Others are degraded via the vacuolar pathway which includes endosomes, lysosomes, and the endoplasmic reticulum. (novusbio.com)
3) Late endosomes can also fuse with lysosomes to degrade their cargo. (biomedcentral.com)
During this process, Rab7 promotes the assembly of HOPS, which mediates lysosomal tethering with endosomes by pairing an R-SNARE on a lysosome (VAMP7 or VAMP8) with three Q-SNAREs on an endosome (syntaxin-7, VTI1b, syntaxin-8). (biomedcentral.com)

Lysosomes are also used to destroy defective or damaged organelles in a process called autophagy . (wikipedia.org)
Macroautophagy/autophagy involves the formation of an autophagosome, a double-membrane vesicle that delivers sequestered cytoplasmic cargo to lysosomes for degradation and recycling. (nih.gov)
During autophagy, phagophores capture portions of cytoplasm and form double-membrane autophagosomes to deliver cargo for lysosomal degradation. (rupress.org)
Macroautophagy/autophagy is a conserved transport pathway where targeted structures are sequestered by phagophores, which mature into autophagosomes, and then delivered into lysosomes for degradation. (rug.nl)
Several lysosomal inhibitors such as bafilomycin A(1) (BafA(1)), protease inhibitors and chloroquine (CQ), have been used interchangeably to block autophagy in in vitro experiments assuming that they all primarily block lysosomal degradation. (rug.nl)
We show that CQ mainly inhibits autophagy by impairing autophagosome fusion with lysosomes rather than by affecting the acidity and/or degradative activity of this organelle. (rug.nl)
During bulk autophagy, autophagosomes fuse with lysosomes or vacuoles resulting in the degradation of the cargo. (hypothes.is)
While during selective autophagy, the cargo is distinguished (mitochondria, ER, ribosomes, peroxisomes and etc.) and recognized by specific cargo receptors, or selective autophagy receptors, to connect with the autophagosome for degradation. (hypothes.is)
TRPML1-mediated lysosomal calcium release can also dephosphorylate TFEB and promote its nuclear translocation and regulate lysosome biogenesis, autophagy, and lipid metabolism. (biomedcentral.com)
One possible way to activate autophagy is through the enhancement of autophagosome-lysosome fusion to become autolysosome. (mtak.hu)
Autophagy allows the degradation of cytosolic endogenous and exogenous material in the lysosome. (lih.lu)
Depending on the involvement of specific receptor proteins, autophagy occurs in a selective or nonselective manner. (lih.lu)

Most of these proteins mature in the Golgi apparatus before going to their final destination which may be to lysosomes , peroxisomes , or outside of the cell. (wikipedia.org)
For many proteins ubiquitin is critical for controlling the degradation of receptors, but it is unknown what proteins are responsible for controlling this (e.g. the nature of the ubiquitin ligase) The images show a clear requirement for receptor (green) to be ubiquitinated or it remains on the endosome limiting membrane. (abdn.ac.uk)
Many receptors and their associated ligands cluster into clathrin-coated pits by association with clathrin adaptor proteins such as the four-subunit complex AP2. (wormbook.org)
Trafficking of yolk and yolk receptors also depends critically upon the activities of the endocytic Rab proteins RAB-5 , RAB-7 , and RAB-11 , known modulators of endocytosis in all eukaryotes ( Grant and Hirsh, 1999 ). (wormbook.org)
In other proteins the di-leucine motif beckons proteins called GGAs (Golgi-localized γ-ear-containing ARF binding proteins), which are known for shepherding acid hydrolase enzymes through the trans-Golgi network toward lysosomes. (alzforum.org)
Additional work suggests that GGAs direct endosomal proteins, such as epidermal growth factor receptors, to the lysosome, as well. (alzforum.org)
Lysosomal function is critical for organismal homeostasis-mutations in genes encoding lysosomal proteins cause severe human disorders known as lysosomal storage diseases, and lysosome dysfunction is implicated in age-associated diseases including cancer, neurodegeneration and metabolic syndrome. (stanford.edu)
The first lysosome-targeting chimeras (LYTACs) targeted extracellular and membrane proteins for degradation by bridging a target protein to the cation-independent mannose-6-phosphate receptor (CI-M6PR). (stanford.edu)
More recently, the concept of lysosomal storage disease has been expanded to include deficiencies or defects in proteins necessary for the normal post-translational modification of lysosomal enzymes (which themselves are often glycoproteins), activator proteins, or proteins important for proper intracellular trafficking between the lysosome and other intracellular compartments. (medscape.com)
Proteolytic degradation is critical to the maintenance of appropriate levels of short-lived and regulatory proteins as important and diverse as those involved in cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signalling factors. (novusbio.com)
An enzymatic cascade is responsible for the attachment of multiple ubiquitin molecules to lysine residues of proteins targeted for degradation. (novusbio.com)
To degrade the misfolded proteins and maintain the ER homeostasis, the cellular signaling will turn on the unfolded protein response to help the cell deals with problematic proteins for recycle and degradation. (hypothes.is)
The HOPS complex forms a bridge between lysosome and autophagosome with the assistance of small GTPase Rab (Ras-associated binding) proteins. (mtak.hu)
Thus, Rab proteins are essential for autolysosome maturation, and among Rab proteins, Rab2 is required for the degradation of autophagic cargo. (mtak.hu)
Using this strategy, we uncovered a basal, housekeeping mitophagy pathway that involves piecemeal degradation of mitochondrial proteins in a LC3C- and p62-dependent manner and contributes to mitochondrial homeostasis maintenance when cells rely on oxidative phosphorylation. (lih.lu)

Nanoconstructs consisting of anti-HER2 aptamer (human epidermal growth factor receptor 2, HApt) densely grafted on gold nanostars (AuNS) first targeted HER2 and then were internalized via HER2-mediated endocytosis. (northwestern.edu)
After internalization by adsorptive ENDOCYTOSIS they are delivered to LYSOSOMES for degradation. (harvard.edu)
Biological processes such as transmembrane signaling and receptor mediated endocytosis revolve around the function of cell surface receptors. (bdbiosciences.com)
I received my B.Sc in Pharmacology from the University of Bristol in 1997, before going on to undertake a Ph.D in the department of Medicine, also at the University of Bristol, under the supervision of Prof Craig McArdle, where I investigated the role of endocytosis in the function of the Gonadotropin Releasing Hormone Receptor. (abdn.ac.uk)
Although a great deal of progress has been made in understanding the processes underlying receptor endocytosis, including the critical role of receptor kinases and arrestin, comparatively little is known about the processes determining the postendocytic fate of GPCRs. (abdn.ac.uk)
Following endocytosis GPCRs can undergo recycling to the plasma membrane (1) (possibly regulated by the retromer) or sorting to the lysosome. (abdn.ac.uk)
Blocking agonist-induced endocytosis of PAR1 by inhibition of dynamin activity suppresses PAR1-induced degradation of Src. (tmu.edu.tw)
We show that PAR1 activation triggers endocytosis-dependent lysosomal degradation of Src in both human embryonic kidney 293 and human umbilical vein endothelial cells. (tmu.edu.tw)
However, several studies have established that the ErbB2 receptor is either endocytosis-impaired or undergoes rapid recycling, suggesting that the strategies to enhance receptor internalization and lysosomal routing could further enhance the efficacy of cytotoxic drug being delivered. (dtic.mil)
Following endocytosis, the complex may be directed to the canalicular membrane for release into the bile or to the lysosomes for degradation. (diff.org)
Hepatocytes clear ferritin by a method involving binding to a specific ferritin receptor followed by endocytosis. (diff.org)
Lactoferrin appears to be cleared via receptor-mediated endocytosis regardless of its binding site. (diff.org)

These food vacuoles fuse with lysosomes which break down the components so that they can be used in the cell. (wikipedia.org)
Phagophores seal to become autophagosomes, which then fuse with lysosomes to deliver their contents for degradation. (nih.gov)
The uncoated transport vesicles can fuse with autophagosome or heterophagosome to form autophagolysosome, heterophagic lysosome or phagolysosome. (biomedcentral.com)
5) Lysosomes can also fuse with the plasma membrane to mediate membrane repair or discharge contents outside the cell, such as cathepsins or immune factors. (biomedcentral.com)
Substrates are engulfed by double-membrane vesicles, coined autophagosomes, which subsequently fuse with lysosomes. (lih.lu)

A network of molecular machinery directs the intracellular trafficking of receptors during their biosynthesis and mediates signaling downstream of receptors. (bdbiosciences.com)
RME-2 contains a typical NPXY internalization motif in its intracellular domain that is known to direct other members of the LDL-receptor family into clathrin-coated pits. (wormbook.org)
The intracellular RNase T2 is mainly localized in lysosomes, mitochondria, vacuoles, and other organelles. (frontiersin.org)
The intracellular distribution pattern suggests that RNase T2 may be involved in degrading exogenous or endogenous RNAs in lysosome and regulating mitochondrial RNA metabolism ( 6 - 8 ). (frontiersin.org)
Lysosomes are an important component of the inner membrane system and participate in numerous cell biological processes, such as macromolecular degradation, antigen presentation, intracellular pathogen destruction, plasma membrane repair, exosome release, cell adhesion/migration and apoptosis. (biomedcentral.com)
Lysosomes were previously believed to be the sites of the degradation of intracellular and extracellular substances. (biomedcentral.com)
Emerging evidence suggests that lysosomes may also be the cellular center for intracellular transport (Fig. 1 ), signaling (Fig. 2 ), and metabolism. (biomedcentral.com)
Lysosomes play a crucial role in intracellular transport. (biomedcentral.com)
Lysosomes function as an intracellular signal transduction platform. (biomedcentral.com)
The antigen uptake is an endocytotic process that involves intracellular lysosomes. (medscape.com)

In addition to this, the late endosomal membrane (and consequently the lysosome) contains a peculiar and unique lipid named BMP or LBPA, which is not found in any other organelle membrane. (wikipedia.org)
The phox homology (PX) domain-dependent, 3-phosphoinositide-mediated association of sorting nexin-1 with an early sorting endosomal compartment is required for its ability to regulate epidermal growth factor receptor degradation. (bdbiosciences.com)
On completion of my PhD, I took a postdoctoral position at the University of California, San Francisco, where I continued my training in the laboratory of Prof Mark von Zastrow, a renowned leader in the field of endocytic trafficking in the function of G-protein-coupled receptors, where I investigated the role of Ubiquitin in endosomal trafficking. (abdn.ac.uk)
Internalization from the cell membrane and endosomal trafficking of receptor tyrosine kinases (RTK) are important regulators of signaling in normal cells that can frequently be disrupted in cancer. (stanford.edu)
The adrenal tumour pheochromocytoma (PCC) can be caused by activating mutations of the RET receptor tyrosine kinase, or inactivation of TMEM127, a transmembrane tumour suppressor implicated in trafficking of endosomal cargos. (stanford.edu)

The mannose 6-phosphate receptor carries ligands from the Golgi destined for the lysosome by a similar mechanism. (wikipedia.org)
Transportation of LAPTM5 from Golgi to lysosome could be inhibited by deficiency of Nedd4, a key member of E3 ubiquitin ligase family overexpressing in invasive BCa and promoting its progression. (spandidos-publications.com)
In the trans-Golgi network (TGN), phosphorylated lysosomal enzymes bind to M-6-P receptors, which direct the enzymes into clathrin-coated vesicles. (biomedcentral.com)

Antibodies to the transferrin receptor (TfR) are used to transport therapeutic molecules across the blood-brain barrier. (rupress.org)
High-affinity transferrin receptor (TfR) bispecific antibodies facilitate trafficking of TfR to lysosomes and induce TfR degradation to decrease the ability of TfR to mediate BBB transcytosis. (rupress.org)

demonstrate that high-affinity antibodies to TfR trigger internalization and lysosomal degradation of the receptor, impairing the passage of molecules into the brain. (rupress.org)

On the other hand, epidermal growth factor (EGF) and the EGF receptor have a pH-resistant bond that persists until it is delivered to lysosomes for their degradation. (wikipedia.org)
BACKGROUND: Antibody drug conjugates (ADCs) targeting the epidermal growth factor receptor (EGFR), such as depatuxizumab mafodotin (Depatux-M), is a promising therapeutic strategy for glioblastoma (GBM) but recent clinical trials did not demonstrate a survival benefit. (stanford.edu)

LYTACs that engage the asialoglycoprotein receptor for targeted protein degradation. (stanford.edu)
Selective protein degradation platforms have afforded new development opportunities for therapeutics and tools for biological inquiry. (stanford.edu)

The receptor tyrosine kinases ErbB2 and EGFR, which are often overexpressed in breast cancer, are examples of cell surface receptors used for evaluating nanoparticle-based targeted drug delivery systems. (dtic.mil)
Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2 (By similarity). (anticorps-enligne.fr)

Clathrin and cargo molecules are assembled into clathrin-coated pits on the plasma membrane together with an adaptor complex called AP-2 that links clathrin with transmembrane receptors, concluding in the formation of mature clathrin-coated vesicles (CCVs). (wormbook.org)
Effective drug-release requires trafficking of the endocytosed receptor-bound cargo into the lysosomes for efficient disintegration. (dtic.mil)

Molecules or ligands internalized from the plasma membrane can follow this pathway all the way to lysosomes for degradation or can be recycled back to the cell membrane in the endocytic cycle. (wikipedia.org)
In Washington, Almeida addressed how Aβ might influence cell surface receptors and proposed that it does so by impinging on the multivesicular body sorting pathway. (alzforum.org)
The endocytic trafficking pathway is the site of action for receptor-targeted drug-delivery strategies, including Antibody-Drug- Conjugates ADCs and nanoparticle drug-delivery systems. (dtic.mil)
Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. (anticorps-enligne.fr)

Lysosomes are membrane-bound compartments that degrade macromolecules and clear damaged organelles to enable cellular adaptation to various metabolic states. (stanford.edu)
By developing novel tools and harnessing the power of metabolomics, proteomics and functional genomics, our lab will define 1) how the lysosome communicates with other cellular compartments to fulfill the metabolic demands of the cell under various metabolic states, 2) and how its dysfunction leads to rare and common human diseases. (stanford.edu)

Mechanistically, we demonstrated that WSG induced degradation of TGFβ and EGF receptors via proteasome and lysosome, respectively. (greenmedinfo.com)
indeed, activity-dependent turnover of many neurotransmitter receptors in dendritic spines is thought to occur through the proteasome ( Ehlers, 2003 ). (alzforum.org)
Other groups also reported hints that Aβ, perhaps its oligomers, impairs proteasome function, potentially slowing down the turnover of receptors and other synapse components. (alzforum.org)

Anti-apoptotic signaling of the insulin-like growth factor-I receptor through mitochondrial translocation of c-Raf and Nedd4. (anticorps-enligne.fr)

One area of particular interest is the role of ubiquitination in directing receptor translocation to intralumenal vesicles and its requirement or otherwise for trafficking to the lysosome. (abdn.ac.uk)

At specific time points related to the doubling time of the cancer cells, we found that accumulation of HER2-HApt-AuNS complexes in lysosomes, lysosomal activity, and lysosomal degradation of HER2 were positively correlated. (northwestern.edu)
Loss of TMEM127 altered normal cell membrane organization and recruitment and stabilization of membrane protein complexes, impaired assembly, and maturation of clathrin coated pits, and reduced internalization and degradation of cell surface RET. (stanford.edu)
This fusion is regulated by HOPS (homotypic fusion and protein sorting) and SNARE (Snap receptor) complexes. (mtak.hu)

SNX1, SNX2, and SNX4 associate predominantly with membranes and bind transmembrane receptors such as those for EGF, PDGF, and insulin. (bdbiosciences.com)

Ces molécules contrôlent ce processus en favorisant l'internalisation du récepteur de l'antigène des cellules B et la sélection vers les lysosomes pour la dégradation par ubiquitination de l'Ig, un composant du complexe BCR. (umontreal.ca)
TMEM127 suppresses tumor development by promoting RET ubiquitination, positioning, and degradation. (stanford.edu)
Mechanistically, TMEM127 binds to RET and recruits the NEDD4 E3 ubiquitin ligase for RET ubiquitination and degradation via TMEM127 C-terminal PxxY motifs. (stanford.edu)
Mechanistically, SUSD6 forms a trimolecular complex with TMEM127 and MHC-I, which recruits WWP2 for MHC-I ubiquitination and lysosomal degradation. (stanford.edu)

This work shows how a perceived disadvantage of nanoparticle-based therapeutics - the inability of nanoconstructs to escape from vesicles and thus induce a biological response - can be overcome by both targeting lysosomes and exploiting lysosomal degradation of the biomarkers. (northwestern.edu)
Rab11 often links vesicles to molecular motors, and this study finds that loss of the microtubule motor dynein also leads to defective Neuroglian and Ppk26 degradation. (sdbonline.org)

For example, low-density lipoprotein (LDL) is taken into the cell by binding to the LDL receptor at the cell surface. (wikipedia.org)
The first is low-density lipoprotein receptor-related protein (LRP) and the second is the major ( RHL -1 ) subunit of the asialoglycoprotein receptor. (diff.org)

This signalling fidelity of GPCRs is maintained by an elegant series of interactions that firstly prevent signalling and is followed by a regulated trafficking process involving the removal of desensitised receptors from the surface of the cell (internalisation) followed by either recycling to the plasma membrane for repeated signalling (resensitisation) or targeting to the lysosome for destruction and downregulation (Figure 1). (abdn.ac.uk)

Lysosomes are involved in cellular digestion. (wikipedia.org)
TMEM127 contributes to RET cellular positioning, trafficking, and lysosome-mediated degradation. (stanford.edu)
NLRP3/cryopyrin is a member of the NOD-like receptor (NLR) protein family that plays a pivotal role in the inflammatory response against pathogens and cellular damage. (nature.com)
Src plays a critical role in regulating cellular responses induced by protease-activated receptor 1 (PAR1). (tmu.edu.tw)
Thus, lysosomes play important roles in cellular activity. (biomedcentral.com)
Ferritin is an acute-phase reactant that coordinates cellular defense against oxidative stress and inflammation along with transferrin and its receptor. (medscape.com)

Markers include RAB7, RAB9, and mannose 6-phosphate receptors. (wikipedia.org)

The endosome is directed to lysosomes and the iron is transferred to the transit pool or endogenous ferritin. (diff.org)
There are several possible fates for endocytosed ferritin including catabolism of the protein in lysosomes, excretion in the bile or inclusion in the endogenous ferritin pool. (diff.org)

They bind tightly to the ASIALOGLYCOPROTEIN RECEPTOR which is located on hepatocyte plasma membranes. (harvard.edu)

Diferric transferrin binds to its specific receptor and is endocytosed. (diff.org)
The haem-haemopexin complex binds to its specific receptor CD91 and is endocytosed. (diff.org)
The haemoglobin-haptoglobin complex binds to a specific receptor. (diff.org)

Here, we show that loss of TMEM127 causes wildtype RET protein accumulation on the cell surface, where increased receptor density facilitates constitutive ligand-independent activity and downstream signaling, driving cell proliferation. (stanford.edu)
Our finding provides a new paradigm for how an irreversibly activated receptor regulates its downstream signalling. (tmu.edu.tw)

In addition, previous studies have shown that lysosomes may play important roles in cancer development and progression through the abovementioned biological processes and that the functional status and spatial distribution of lysosomes are closely related to cancer cell proliferation, energy metabolism, invasion and metastasis, immune escape and tumor-associated angiogenesis. (biomedcentral.com)

We study the role of the lysosome in metabolic adaptation using subcellular omics approaches, functional genomics and innovative biochemical tools. (stanford.edu)
Lysosomes are subcellular organelles responsible for the physiologic turnover of cell constituents. (medscape.com)

Within the target organelle, lysosomes, HER2 was degraded by enzymes at low pH, which resulted in apoptosis. (northwestern.edu)
The findings suggest that any trauma that causes apoptosis may also attenuate BACE degradation and ultimately lead to increased Aβ production. (alzforum.org)

Identification of a family of sorting nexin molecules and characterization of their association with receptors. (bdbiosciences.com)

Ferritin in lysosomes is converted into hemosiderin upon partial degradation of its protein shell by lysosomal enzymes. (medscape.com)
Koorts AM, Viljoen M. Ferritin and ferritin isoforms I: Structure-function relationships, synthesis, degradation and secretion. (medscape.com)

To address these questions, our lab uses a multidisciplinary approach to study the biochemical functions of the lysosome in vitro and in vivo. (stanford.edu)

Increased HER2 degradation by HApt-AuNS triggered cell death and cell cycle arrest in the G0/G1 phase inhibition of cell proliferation. (northwestern.edu)
G-protein coupled receptors (GPCRs), represent the largest family of cell surface receptors and are the prime regulators of many physiological systems. (abdn.ac.uk)
Too few receptors and the signal is missed, too many and the signal overwhelms the cell. (abdn.ac.uk)
Moreover, some studies demonstrated that LAPTM5 was highly expressed in malignant B lymphomas and involved in B cell malignancies ( 10 ), involving in negative regulation of cell surface T and B cell receptor by promoting lysosome degradation ( 6 ). (spandidos-publications.com)
Reduced expression of bone morphogenetic protein receptor 2 subverts a stress granule response, heightens GM-CSF mRNA translation, and increases inflammatory cell recruitment to exacerbate pulmonary arterial hypertension. (rupress.org)
Dendrite pruning requires the developmentally regulated degradation of the cell adhesion molecule Neuroglian , and loss of Rab11 causes defects in the developmental degradation of Neuroglian and another target, the ion channel Ppk26 . (sdbonline.org)
However, cancer-cell specific alterations that lead to receptor recycling, instead of lysosomal-degradation, can dampen the efficiency of drug delivery. (dtic.mil)
Studies have demonstrated that food allergens are transported in large quantities across the epithelium by binding to cell surface IgE/CD23, which opens a gate for intact dietary allergens to transcytose across the epithelial cells that protect the antigenic protein from lysosomal degradation in enterocytes. (medscape.com)

Therefore, identifying the factors and mechanisms that regulate the functional status and spatial distribution of lysosomes and elucidating the relationship between lysosomes and the development and progression of cancer can provide important information for cancer diagnosis and prognosis prediction and may yield new therapeutic targets. (biomedcentral.com)

Lactoferrin binds to LRP or RHL -1 and is endocytosed and targeted to the lysosomes for degradation. (diff.org)

Levels of the phosphorylated, endocytosed EGF receptor stayed up in transgenic cells for much longer than in wild-type. (alzforum.org)
Here, we report that, at single-nucleus resolution, TMEM127-mutant tumors share precursor cells and transcription regulatory elements with pheochromocytomas carrying mutations of the tyrosine kinase receptor RET. (stanford.edu)
Therefore, researchers called lysosomes the "garbage disposals" of cells [ 1 ]. (biomedcentral.com)
6) Lysosomes are the pools of metabolites in cells, including amino acids, sugars, lipids and nucleotides. (biomedcentral.com)

Anatomy34

Organisms11

Diseases5

Chemicals and Drugs115

Analytical, Diagnostic and Therapeutic Techniques and Equipment22

Phenomena and Processes48

Disciplines and Occupations1

Information Science3

Health Care2

Endosomes22

Autophagy12

Proteins15

ENDOCYTOSIS12

Fuse5

Intracellular10

Endosomal5

Golgi3

Transferrin receptor2

Internalization and lysosomal1

Epidermal growth2

Protein degradation2

EGFR2

Cargo2

Pathway4

Compartments2

Proteasome3

Mitochondrial1

Translocation1

Complexes3

Transmembrane1

Ubiquitination4

Vesicles2

Lipoprotein2

Plasma membrane1

Cellular6

Mannose1

Endogenous2

Asialoglycoprotein1

Specific receptor3

Downstream2

Metabolism1

Subcellular2

Apoptosis2

Molecules1

Ferritin2

Vitro1

Cell8

Regulate1

Binds1

Cells4