Receptor cyclic amp dependent protein kinases. Medical search. Frequent questions

It is possible that M2 and M2 come from dif-ferent modification of receptor proteins, such as phosphorylation, methylation, association with other protein or polymerization. (nii.ac.jp)
Publications] Y. Watanabe: 'Effect of phosphorylation of inhibitory GTP-binding protein by cyclic AMP-dependent protein kinase on its ADP-ribosylation by pertussis toxin, islet-activating protein. (nii.ac.jp)
Small-molecule, ligand-activated G protein-coupled receptors are generally thought to be rapidly desensitized within a period of minutes through receptor phosphorylation and internalization after repeated or prolonged stimulation. (johnshopkins.edu)
A group of enzymes that are dependent on CYCLIC AMP and catalyze the phosphorylation of SERINE or THREONINE residues on proteins. (rush.edu)
Bovo E, Huke S, Blatter LA, Zima AV. The effect of PKA-mediated phosphorylation of ryanodine receptor on SR Ca2+ leak in ventricular myocytes. (rush.edu)
Increased intracellular cyclic AMP increases the activity of cAMP-dependent protein kinase A, which inhibits the phosphorylation of myosin and lowers intracellular calcium concentrations. (pharmfair.com)
T739 phosphorylation is normally governed by CaMKII and possibly kinase assay where we incubated GSTCNL-1 (outrageous type or T739A), GSTCNL-2, GSTCNL-3 and GSTCNL-4 c-tail fusion protein with CaMKII and ATP. (findadig.com)
We solved the protein by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE), Bismuth Subcitrate Potassium and immunoblotting uncovered which the phosphorylation stateCspecific antibody particularly recognized just the NL-1 c-tail that's phosphorylated at T739 (Fig. 2a). (findadig.com)
Consistent with the interpretation that cAMP/PKA signaling becomes impaired in c-SANC, acute β-adrenergic receptor stimulation increases phospholamban and RyR2 phosphorylation, enhances RGS2-labeling density, and accelerates the AP firing rate to the similar maximum in c- and f-SANC. (johnshopkins.edu)
Adv-RGS2 infection, or pertussis toxin treatment to disable G i -signaling, each partially rescues the c-SANC spontaneous AP firing rate.Thus, a G i -dependent reduction in PKA-dependent protein phosphorylation, including that of Ca 2+ cycling proteins, reduces the spontaneous AP firing rate of c-SANC, and can be reversed by genetic or pharmacologic manipulation of PKA signaling. (johnshopkins.edu)
We measured this using an improved fluorescent reporter and by phosphorylation of endogenous cAMP-response-element binding protein (CREB). (nature.com)
Egan, J. J., Greenberg, A. S., Chang, M. K. & Londos, C. Control of endogenous phosphorylation of the major cAMP-dependent protein kinase substrate in adipocytes by insulin and beta-adrenergic stimulation. (nature.com)
Here DARPP-32 phosphorylation by protein kinase A (PKA), DARPP-32 into a powerful protein phosphatase 1 (PP1) inhibitor. (pp1a.com)
DARPP-32 can itself inhibit the following PKA DARPP-32 phosphorylation by cyclin-dependent kinase 5 (Cdk5). (pp1a.com)
Mechanistic investigations revealed reduce GR-Ser211 phosphorylation following PP1α silencing and provide the first indication of the involvement of glycogen synthase kinase 3 (GSK-3). (pp1a.com)

Here we report that extinction is triggered by two hippocampal signaling pathways underlying retrieval (the cAMP-dependent protein kinase and the mitogen-activated protein kinase pathways) and two other mechanisms that become activated at the same time and are not necessary for retrieval (N-methyl-D-aspartate glutamatergic receptors and the calcium/calmodulin-dependent protein kinase II signaling pathway). (unboundmedicine.com)
The kinases of this family that have been suggested to play a role in apoptosis are the mitogen-activated protein kinase (MAPK) family, specifically p42/44 ERK, p38 MAPK and c-Jun N-terminal kinase (JNK), cyclic AMP-dependent protein kinase (PKA), protein kinase B (PKB), or Akt and protein kinase C (PKC). (inamericawithgrace.com)

The effects of histamine were reversed by a protein kinase A (PKA) inhibitor, N-[2-(4-bromocinnamylamino) ethyl]-5-isoquinoline (H89), and mimicked by a dibutyryl cAMP and an adenylate cyclase activator, forskolin. (elsevierpure.com)
Functionally active targeting domain of the beta-adrenergic receptor kinase: an inhibitor of G beta gamma-mediated stimulation of type II adenylyl cyclase. (musc.edu)
Significantly, the actions of both GLP-1 and forskolin were abolished by the selective Ca 2+ /calmodulin-dependent phosphatase 2B (calcineurin) inhibitor, FK506, as well as by the chelation of intracellular Ca 2+ by BAPTA (bis(2-aminophenoxy)ethane- N,N,N ′ ,N ′-tetraacetate). (diabetesjournals.org)

2018 ) Dorsal BNST α-adrenergic receptors produce HCN-dependent excitatory actions that initiate anxiogenic behaviors. (neurotree.org)
It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. (pharmfair.com)
Salbutamol is a beta(2)-adrenergic agonist and thus it stimulates beta(2)-adrenergic receptors. (pharmfair.com)
Here we show that in adipocytes, chronically high insulin levels inhibit β-adrenergic receptors (but not other cAMP-elevating stimuli) from activating PKA. (nature.com)
Chronically high insulin levels may disrupt the close apposition of β-adrenergic receptors and PKA, identifying a new mechanism for crosstalk between heterologous signal transduction pathways. (nature.com)
Neurotransmitters released from cardiac sympathetic nerves bind to alpha- and beta-adrenergic receptors, eliciting a cascade of intracellular responses. (medscape.com)

Phosphodiesterases (PDEs) regulate the local concentration of 3',5' cyclic adenosine monophosphate (cAMP) within cells. (nih.gov)
Considerably higher resistance against cyclic nucleotide phosphodiesterases compared to dibutyryl or 8-Br-cAMP, no metabolic side effects. (biolog.de)
Dr. Beavo is being recognized for his research on the identification, regulation and functions of cyclic nucleotide phosphodiesterases, work on cyclic nucleotides, and for his strong commitment to mentoring. (aspet.org)
In 1977, Dr. Beavo joined the department of pharmacology at the University of Washington, where his research revealed 11 diverse families of cyclic-nucleotide phosphodiesterases with different substrate specificity and regulation. (aspet.org)

We demonstrate here that PDE4 inhibitors enhance the anti-inflammatory cytokine interleukin-1 receptor antagonist (IL-1Ra) secretion in LPS-activated mouse peritoneal macrophages, and this response was regulated at the transcriptional level rather than an increased IL-1Ra mRNA stability. (ox.ac.uk)
The response to GLP-1 was mimicked by forskolin and largely inhibited by the protein kinase A (PKA) inhibitors, H89 and myristoylated PKI(14-22) amide, indicating partial mediation via a cAMP/PKA pathway. (diabetesjournals.org)

Included under this category are two cyclic-AMP-dependent protein kinase subtypes, each of which is defined by its subunit composition. (rush.edu)
1. Gamm, D. M., Baude, E. J. and Uhler, M. D. (1996) 'The Major Catalytic Subunit Isoforms of cAMP-dependent Protein Kinase Have Distinct Biochemical Properties in Vitro and in Vivo', Journal of Biological Chemistry, 271(26), pp. 15736-15742. (bomiprot.org)
Harris BA: Complete cDNA sequence of a human stimulatory GTP-binding protein alpha subunit. (smpdb.ca)
Somatic mutations of the catalytic subunit of cyclic AMP-dependent protein kinase (PRKACA) gene in Japanese patients with several adrenal adenomas secreting cortisol [Rapid Communication]. (cdc.gov)
Novel somatic mutations in the catalytic subunit of the protein kinase A as a cause of adrenal Cushing's syndrome: a European multicentric study. (cdc.gov)

Vasoconstrictors interact with their cognate G protein coupled receptors activating a variety of signalling pathways to promote smooth muscle proliferation. (bvsalud.org)
These data suggest that the synergistic action of glucose and GLP-1 to promote insulin gene transcription is mediated through NFAT via PKA- and calcineurin-dependent pathways in pancreatic β-cells. (diabetesjournals.org)
Dr. Martemyanov is being recognized for his research on how G protein signaling pathways are organized and regulated in the retina, heart and brain. (aspet.org)
An author of over 100 publications, his lab has made key contributions in elucidation of structure/functional organization of RGS protein complexes, their role in controlling ion channels and second messenger pathways and implications for physiology of the nervous and cardiovascular systems. (aspet.org)
Akt is a serine/threonine-specific protein kinase that plays a critical role in controlling the balance between survival and death pathways in cells. (inamericawithgrace.com)
Serine/threonine (S/T) protein kinases are crucial components of diverse signaling pathways in eukaryotes, including the model filamentous fungus Neurospora crassa. (inamericawithgrace.com)

The phosphodiesterase 4D3 (PDE4D3) was found in the cardiac ryanodine receptor (RyR2)/calcium-release-channel complex (required for excitation-contraction [EC] coupling in heart muscle). (nih.gov)
However, the β 1 AR-induced cAMP signal is counterbalanced and masked by the receptor-bound phosphodiesterase (PDE) 4D8-dependent cAMP hydrolysis. (johnshopkins.edu)
Phosphodiesterase 4B negatively regulates endotoxin-activated interleukin-1 receptor antagonist responses in macrophages. (ox.ac.uk)
cAMP decomposition into AMP is catalyzed by the enzyme phosphodiesterase . (wikipedia.org)

cAMP is a derivative of adenosine triphosphate (ATP) and used for intracellular signal transduction in many different organisms, conveying the cAMP-dependent pathway . (wikipedia.org)
Tilly JL, Aihara T, Nishimori K, Jia XC, Billig H, Kowalski KI, Perlas EA, Hsueh AJ: Expression of recombinant human follicle-stimulating hormone receptor: species-specific ligand binding, signal transduction, and identification of multiple ovarian messenger ribonucleic acid transcripts. (smpdb.ca)

Here we demonstrate that elevation of cyclic AMP (cAMP) levels in human umbilical vein endothelial cells (HUVECs) specifically attenuates ERK1,2 activation in response to either leptin or a soluble interleukin IL-6 receptor-α/IL-6 (sIL-6R-α/IL-6) trans-signalling complex but not protein kinase C activator phorbol 12-myristate 13-acetate. (gla.ac.uk)
Activator of protein kinase A (cyclic AMP agonist). (biolog.de)
8-Bromoadenosine 3′, 5′-cyclic monophosphate (8Bro) is an activator of cyclic AMP-dependent protein kinase, also known as protein kinase A (PKA), and was recently shown to support the differentiation of hiPSCs into ECs [ 20 ]. (biomedcentral.com)
Cyclic AMP receptor protein was originally identified as a catabolite gene activator protein. (bvsalud.org)

D1 receptors regulate the memory, learning, and the growth of neurons, also is used in the reward system and locomotor activity, mediating some behaviors and modulating dopamine receptor D2-mediated events. (wikipedia.org)
2020 ) Cyclic AMP-dependent protein kinase and D1 dopamine receptors regulate diacylglycerol lipase-α and synaptic 2-arachidonoyl glycerol signaling. (neurotree.org)
5-Hydroxytryptamine type 2A receptors regulate cyclic AMP accumulation in a neuronal cell line by protein kinase C-dependent and calcium/calmodulin-dependent mechanisms. (aspetjournals.org)
In both and Flo8 interacts with Efg1, a homolog of the Phd1/Sok2 and StuA proteins that regulate morphogenesis of and FoStuA, GcStuA and MoStu1 (Mstu1), have recently been recognized [29]C[31]. (bio2009.org)
The aryl hydrocarbon receptor (AhR), a member of the bHLH-Per-Arnt-Sim subfamily, is a ligand-activated transcription factor reported to regulate nervous system development in both invertebrates and vertebrates, but the functions that AhR signaling pathway may have for mammalian cerebral cortex development remains elusive. (waseda.jp)
Alpha-adrenergic receptor stimulation produces a cascade of second messenger systems that subsequently regulate calcium channels and in turn elicit increases in cytosolic calcium. (medscape.com)

The active subunits catalyze the transfer of phosphate from ATP to specific serine or threonine residues of protein substrates. (wikipedia.org)
V-Raf murine sarcoma viral oncogene homolog B1 ( B-RAF) is a gene that codes a protein B-Raf, which is a serine/ threonine-protein kinase. (inamericawithgrace.com)
Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis (PubMed:15528381, PubMed:1825810, PubMed:31548394). (inamericawithgrace.com)
Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. (inamericawithgrace.com)
STRAP (Serine/Threonine Kinase Receptor Associated Protein) is a Protein Coding gene. (inamericawithgrace.com)
A topological analysis predicted PknB, the serine/threonine protein kinase of S. The serine/threonine-specific protein kinase Akt (protein kinase B), when phosphorylated by phosphotidylinositol-3-kinase, is a key mediator of tolerance. (inamericawithgrace.com)
The great majority are serine/threonine kinases, which phosphorylate the hydroxyl groups of serines and threonines in their targets. (inamericawithgrace.com)
Regarded as constitutively active enzymes, known to participate in many, diverse biological processes, the intracellular regulation bestowed on the CK1 family of serine/threonine protein kinases is critically important, yet poorly understood. (inamericawithgrace.com)
The specificity of serine/threonine kinases is partly determined by interactions with a few residues near the phospho-acceptor residue, forming the so-called kinase-substrate motif. (inamericawithgrace.com)

Sensitivity of the N-methyl-D-aspartate receptor to polyamines is controlled by NR2 subunits. (aspetjournals.org)
Expression of mRNAs encoding subunits of the N-methyl-D-aspartate receptor in cultured cortical neurons. (aspetjournals.org)
They are tetrameric proteins that contain two catalytic subunits and two type II-specific regulatory subunits. (musc.edu)
Rgs1, a regulator of G-protein signaling, interacts with all the three G subunits and functions as a negative regulator of G-proteins in [52]. (bio2009.org)
Cyclic AMP binds to specific locations on the regulatory units of the protein kinase, and causes dissociation between the regulatory and catalytic subunits, thus enabling those catalytic units to phosphorylate substrate proteins. (wikipedia.org)
Cell surface cyclic AMP receptors are not included (CYCLIC AMP RECEPTORS), nor are the eukaryotic cytoplasmic cyclic AMP receptor proteins, which are the regulatory subunits of CYCLIC AMP-DEPENDENT PROTEIN KINASES. (bvsalud.org)
Codina J, Stengel D, Woo SL, Birnbaumer L: Beta-subunits of the human liver Gs/Gi signal-transducing proteins and those of bovine retinal rod cell transducin are identical. (smpdb.ca)

The D2S and D2L dopamine receptor isoforms are differentially regulated in Chinese hamster ovary cells. (aspetjournals.org)
Notably, the nonphosphorylatable mutant (T739A), aswell as the various other neuroligin isoforms that people put through the same kinase assay, demonstrated no immunoreactivity with pT739-Ab, highlighting the specificity of pT739-Ab for NL-1 phosphorylated at T739. (findadig.com)
The Akt kinase family comprises three highly homologous isoforms: Akt1 (PKBα), Akt2 (PKBβ), and Akt3 (PKBγ) [4,14]. (inamericawithgrace.com)

In 1998 a family of cAMP-sensitive proteins with guanine nucleotide exchange factor (GEF) activity was discovered. (wikipedia.org)

2018 ) Activated CaMKIIα binds to the mGlu5 metabotropic glutamate receptor and modulates calcium mobilization. (neurotree.org)
Vasodilation by the calcium-mobilizing messenger cyclic ADP-ribose. (ox.ac.uk)
We have previously identified NFAT (nuclear factor of activated T-cells) as a key regulator of insulin gene transcription in pancreatic β-cells that is activated by the calcium/calmodulin-dependent protein phosphatase 2B (calcineurin) in response to increased [Ca 2+ ] i ( 10 ). (diabetesjournals.org)
Glucose metabolism activates this pathway by means of increasing [Ca 2+ ] i via L-type voltage-dependent calcium channels (VDCCs) by affecting the electrical activity of the cell. (diabetesjournals.org)
Beta-adrenergic stimulation activates adenylate cyclase, which increases cyclic adenosine monophosphate (AMP) levels and causes increased calcium influx into myocardial cells. (medscape.com)

Although dihydrexidine has significant D2 properties, it is highly biased at D2 receptors and was used for the first demonstration of functional selectivity with dopamine receptors. (wikipedia.org)

Vasoconstrictor-driven G protein-coupled receptor (GPCR)/phospholipase C (PLC) signaling increases intracellular Ca2+ concentration to mediate arterial contraction. (bvsalud.org)
Protein kinase A can also phosphorylate specific proteins that bind to promoter regions of DNA, causing increases in transcription. (wikipedia.org)

The inhibitory effect of cAMP could not be reversed by inhibition of cAMP-dependent protein kinase (PKA) but was blocked by depletion of the alternative intracellular cAMP sensor exchange protein activated by cAMP 1 (Epac1), which is also required to observe SOCS-3 accumulation in response to cAMP. (gla.ac.uk)
Hormones mobilize intracellular second messengers and initiate signalling cascades involving protein kinases and phosphatases, which are often spatially compartmentalized by anchoring proteins to increase signalling specificity 1 . (nature.com)

Cyclic AMP is synthesized from ATP by adenylate cyclase located on the inner side of the plasma membrane and anchored at various locations in the interior of the cell. (wikipedia.org)
[1] Adenylate cyclase is activated by a range of signaling molecules through the activation of adenylate cyclase stimulatory G ( G s )-protein-coupled receptors. (wikipedia.org)
Adenylate cyclase is inhibited by agonists of adenylate cyclase inhibitory G ( G i )-protein-coupled receptors. (wikipedia.org)

Similarly, treatment of the cells with the membrane-permeable cAMP analog 8-(4-chlorophenylthio)-cAMP induced functional desensitization and down-regulation of the D 1 receptor, although it was not as great as that observed with agonist pretreatment. (aspetjournals.org)
Fenoldopam is a selective D1 receptor partial agonist that does not cross the blood-brain-barrier and is used intravenously in the treatment of hypertension. (wikipedia.org)
Dihydrexidine derivatives A-86929 - full agonist with 14-fold selectivity for D1-like receptors over D2 Dihydrexidine - full agonist with 10-fold selectivity for D1-like receptors over D2 that has been in Phase IIa clinical trials as a cognitive enhancer. (wikipedia.org)
SKF-89145 SKF-89626 7,8-Dihydroxy-5-phenyl-octahydrobenzo[h]isoquinoline: extremely potent, high-affinity full agonist Cabergoline - weak D1 agonism, highly selective for D2, and various serotonin receptors Pergolide - (similar to cabergoline) weak D1 agonism, highly selective for D2, and various serotonin receptors A photoswitchable agonist of D1-like receptors (azodopa) has been described that allows reversible control of dopaminergic transmission in wildtype animals. (wikipedia.org)
Inhibition of PDE4 activity recovers the receptor-induced cAMP signal and promotes contractile response in mouse hearts during extended periods of agonist stimulation. (johnshopkins.edu)
Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. (pharmfair.com)

The Ca(2+) signal is evoked via ryanodine receptors (RyRs) in sarcoplasmic reticulum proximal to the plasma membrane. (ox.ac.uk)

La proteína receptora del AMP cíclico se identificó originalmente como proteína activadora de genes catabólicos. (bvsalud.org)
In order to assess the importance of S/T kinases to Neurospora biology, we embarked on a global analysis of 86 S/T kinase genes in Neurospora. (inamericawithgrace.com)
Common genetic variants in the glucocorticoid receptor and the 11ß-hydroxysteroid dehydrogenase type 1 genes influence long-term cognitive impairments in patients with Cushing's syndrome in remission. (cdc.gov)

Four subtypes (M1-M4) in muscarinic receptors (mACh-R) were discovered by the method of gene technology. (nii.ac.jp)

Publications] X.M. Zhou: 'The SH-H subgroup of cardiac M_2 receptors (M_2 ) inhibits adenulate cyclase activity. (nii.ac.jp)
Specific PKA inhibition completely inhibits all β-adrenergic receptor effects. (johnshopkins.edu)

cAMP then activates protein kinase A (PKA) which phosphorylates downstream effectors that lead to a specific cellular response. (smpdb.ca)

The estrogenic diminution of cannabinoid-induced hyperphagia correlated with a rapid (within 15 min) attenuation of cannabinoid-mediated decreases in glutamatergic synaptic input onto arcuate neurons, which was completely blocked by inhibition of protein kinase C (PKC) and attenuated by inhibition of protein kinase A (PKA). (elsevierpure.com)

Cardiac maCh-R (M2 subtype) are thought to consist of a single species of receptor protein. (nii.ac.jp)
The results showed that cardiac maCh-R consist of two subclasses, both regulated by GTP binding proteins. (nii.ac.jp)
Publications] A. Mizushima: 'The H-L subgroup of guinea-pig cardiac M_2 receptors (M_2 ) regulates formation of inositol phosphates. (nii.ac.jp)
Here, using live cell imaging of cAMP with a FRETbased biosensor and myocyte contraction assay, we show that the catecholamine-activated β 1 adrenergic receptor ( β 1 AR) continuously stimulates second messenger cAMP synthesis in primary cardiac myocytes and neurons, which lasts for more than 8 h (a decay t 1/2 of 3.9 h) in cardiac myocytes. (johnshopkins.edu)

It is a protein that in humans is encoded by the DRD1 gene. (wikipedia.org)
This study found an increase in excess GR transcriptional activity of protein phosphatase 1 alpha (PP1α) in HEK-293 cells and a decrease in the expression levels of GR-responsive gene knockdown following PP1α model A549 cells endogenously . (pp1a.com)

To investigate the role of the cAMP-dependent protein kinase (PKA) in the desensitization and down-regulation of the D 1 dopamine receptor, we stably expressed the rat cDNA for this receptor in mutant Chinese hamster ovary (CHO) cell lines deficient in PKA activity. (aspetjournals.org)
90% down-regulation of D 1 receptors in the parental cell line but only a 50 and 30% decrease in the 10260 and 10248 cells, respectively. (aspetjournals.org)
Our results suggest that PKA significantly contributes to the desensitization and down-regulation of D 1 receptors in CHO cells and that type II PKA may be the more relevant isoform with respect to regulating D 1 receptor function. (aspetjournals.org)
However, despite numerous studies indicating that ß2AR and A2BR can be substrates for GRK/arrestin proteins, currently little is known regarding GRK/arrestin regulation of these endogenous receptors in arterial smooth muscle. (bvsalud.org)
This study provides a first demonstration of how different complements of GRK and arrestin proteins contribute to the regulation of signalling and desensitization of these important receptors mediating vasodilator responses in arterial smooth muscle. (bvsalud.org)
cAMP is associated with kinases function in several biochemical processes, including the regulation of glycogen , sugar , and lipid metabolism . (wikipedia.org)
As its name suggests, the receptor is activated by follicle-stimulating hormone (FSH) and plays an important role in the regulation of reproduction. (smpdb.ca)

TY - JOUR T1 - The role of NMDA glutamate receptors, PKA, MAPK, and CAMKII in the hippocampus in extinction of conditioned fear. (unboundmedicine.com)

Ecopipam is a selective D1-like receptor antagonist that has been studied clinically in humans in the treatment of a variety of conditions, including schizophrenia, cocaine abuse, obesity, pathological gambling, and Tourette's syndrome, with efficacy in some of these conditions seen. (wikipedia.org)
The effects of histamine were antagonized by an H2 receptor antagonist, famotidine, and mimicked by H2/H4 receptor agonists dimaprit and 4-methylhistamine. (elsevierpure.com)
The cAMP-dependent protein kinase A antagonist N-(2-[p-bromocinnamylamino]ethyl)-5-isoquinolinesulfonamide hydrochloride (H89) blocked hyperpolarization by isoprenaline and cAMP, respectively, but not hyperpolarization by cADPR. (ox.ac.uk)

Furthermore, to detect whether PKC or PKA have the ability to phosphorylate NL-1 T739, we examined GSTCNL-1 after kinase reactions using liquid chromatography combined to tandem mass spectrometry (LC/MS/MS) and discovered that just CaMKII phosphorylates T739 (Fig. 1eCg). (findadig.com)

Woolson, H. D. , Thomson, V. S. , Rutherford, C. , Yarwood, S. J. and Palmer, T. M. (2009) Selective inhibition of cytokine-activated extracellular signal-regulated kinase by cyclic amp via Epac1-dependent induction of suppressor of cytokine signalling-3. (gla.ac.uk)
In addition, it reveals a novel Epac-dependent mechanism by which cAMP can specifically inhibit ERK in response to cytokine receptor activation. (gla.ac.uk)
These results as a whole indicated that histamine inhibited the AGE-2- and AGE-3-induced adhesion molecule expression and cytokine production via H2 receptors and the cAMP/PKA pathway. (elsevierpure.com)
This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion. (cusabio.com)

Mesodermal progenitor cells are further differentiated into ECs by utilizing a combination of human vascular endothelial growth factor A165 (VEGF), basic fibroblast growth factor (bFGF), 8-Bromoadenosine 3′,5′-cyclic monophosphate sodium salt monohydrate (8Bro) and melatonin (Mel) for 48 h. (biomedcentral.com)
Cyclic adenosine monophosphate ( cAMP , cyclic AMP , or 3',5'-cyclic adenosine monophosphate ) is a second messenger , or cellular signal occurring within cells, that is important in many biological processes. (wikipedia.org)
Earl Sutherland of Vanderbilt University won a Nobel Prize in Physiology or Medicine in 1971 "for his discoveries concerning the mechanisms of the action of hormones", especially epinephrine, via second messengers (such as cyclic adenosine monophosphate, cyclic AMP). (wikipedia.org)

and the level of type2 regulator of G-protein signaling (RGS2), that facilitates adenylyl cyclases/cAMP/protein kinase A (PKA) via G i inhibition, is substantially reduced. (johnshopkins.edu)

By acting as a ligand-dependent transcription factor of the glucocorticoid receptor (GR) mediates the action of glucocorticoids and regulates many physiological processes. (pp1a.com)
Association of glucocorticoid receptor haplotypes with body composition and metabolic parameters in HIV-infected patients from the FRAM study. (cdc.gov)

We conclude, therefore, that relaxation of arterial smooth muscle by adenylyl cyclase-coupled receptors results, in part, from a cAMP-dependent and protein kinase A-dependent increase in cADPR synthesis, and subsequent activation of sarcoplasmic reticulum Ca(2+) release via RyRs, which leads to activation of BK(Ca) channels and membrane hyperpolarization. (ox.ac.uk)

Together, these findings unveil a long lasting adrenergic signal in neurons and myocytes under prolonged stimulation and an underappreciated role of PDE that is essential in classic receptor signaling desensitization and in maintaining a long lasting cAMP equilibrium for ligand-induced physiological response. (johnshopkins.edu)

Here, endogenous GRK isoenzymes and arrestin proteins were selectively depleted using RNA-interference in rat arterial smooth muscle cells (RASM) and the consequences of this for ß2AR- and A2BR-mediated adenylyl cyclase (AC) signalling were determined by assessing cAMP accumulation. (bvsalud.org)
In artery smooth muscle, adenylyl cyclase-coupled receptors such as beta-adrenoceptors evoke Ca(2+) signals, which open Ca(2+)-activated potassium (BK(Ca)) channels in the plasma membrane. (ox.ac.uk)
The FSH receptor activates G(s) proteins which leads to the activation of adenylyl cyclase and produces the secondary messenger cAMP. (smpdb.ca)

The cyclic AMP-dependent protein kinase A signaling pathway plays a major role in regulating plant infection from the rice blast fungus and or are both necessary for development of spores and appressoria by and play roles in cell wall differentiation, regulating melanin pigmentation and cell surface hydrophobicity during spore formation. (bio2009.org)

Several D1 receptor agonists are used clinically. (wikipedia.org)
All of these drugs are preferentially D2-like receptor agonists. (wikipedia.org)
Dihydrexidine and adrogolide (ABT-431) (a prodrug of A-86929 with improved bioavailability) are the only selective, centrally active D1-like receptor agonists that have been studied clinically in humans. (wikipedia.org)

cAMP activates the cAMP-dependent protein kinase (PKA). (nih.gov)
Generation of cAMP through Gs-coupled G protein-coupled receptor (GPCR) [e.g. ß2-adrenoceptor (ß2AR), adenosine A2B receptor (A2BR)] activation, induces arterial smooth muscle relaxation, counteracting the actions of vasoconstrictors. (bvsalud.org)
which encodes a putative G-protein-coupled receptor may be involved in regulating Mac pc1 activities, because is required for surface acknowledgement and virulence and exogenous cAMP restores appressorium formation and pathogenicity in deletion mutants [55]. (bio2009.org)
Neither cyclic AMP (cAMP)-reliant proteins kinase A (PKA) Bismuth Subcitrate Potassium nor cAMP-dependent proteins kinase C (PKC) phosphorylated NL-1 as robustly as do CaMKII (Fig. 1b). (findadig.com)
In addition, cAMP binds to and regulates the function of ion channels such as the HCN channels and a few other cyclic nucleotide-binding proteins such as Epac1 and RAPGEF2 . (wikipedia.org)
In eukaryotes, cyclic AMP works by activating protein kinase A (PKA, or cAMP-dependent protein kinase ). (wikipedia.org)
Not all protein kinases respond to cAMP. (wikipedia.org)
Several classes of protein kinases , including protein kinase C, are not cAMP-dependent. (wikipedia.org)
Further effects mainly depend on cAMP-dependent protein kinase , which vary based on the type of cell. (wikipedia.org)
These are termed Exchange proteins activated by cAMP (Epac) and the family comprises Epac1 and Epac2 . (wikipedia.org)

To counteract vasoconstrictor-induced contraction, GPCR/PLC signaling can be desensitized by G protein-coupled receptor kinases (GRKs), with GRK2 playing a predominant role in isolated arterial smooth muscle cells. (bvsalud.org)

Neuronal microtubule-associated protein 2D is a dual A-kinase anchoring protein expressed in rat ovarian granulosa cells. (nature.com)

Cyclic AMP-Dependent Protein Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (rush.edu)

There are a number of ligands selective for the D1 receptors. (wikipedia.org)
As a result, none of the known orthosteric ligands is selective for the D1 vs. the D5 receptor, but the benzazepines generally are more selective for the D1 and D5 receptors versus the D2-like family. (wikipedia.org)

This transient G protein-coupled receptor activation remains at odds with many observed long-lasting cellular and physiological responses. (johnshopkins.edu)

A cyclic AMP-dependent protein kinase subtype primarily found in particulate subcellular fractions. (musc.edu)

Many typical and atypical antipsychotics are D1 receptor antagonists in addition to D2 receptor antagonists. (wikipedia.org)
No other D1 receptor antagonists have been approved for clinical use. (wikipedia.org)

Anatomy19

Organisms13

Chemicals and Drugs165

Analytical, Diagnostic and Therapeutic Techniques and Equipment12

Phenomena and Processes43

Information Science3

Phosphorylation15

Mitogen-activa2

Inhibitor3

Adrenergic Receptors6

Phosphodiesterases4

Inhibitors2

Subunit5

Pathways6

Phosphodiesterase4

Signal transduction2

Activator4

Regulate6

SERINE9

Subunits7

Isoforms3

Guanine nucleo1

Calcium5

Dopamine receptors1

Increases2

Intracellular2

Adenylate cyclase3

Agonist6

Ryanodine1

Genes3

Subtypes1

Inhibits2

Activates protein1

Attenuated by inhibition1

Cardiac4

Gene2

Regulation7

MAPK1

Antagonist3

Phosphorylate1

Cytokine4

Monophosphate3

Inhibition1

Glucocorticoid receptor2

Synthesis1

Stimulation1

Adenylyl3

Pathway1

Agonists3

CAMP10

Arterial smooth muscle1

Neuronal1

MeSH1

Selective2

Transient1

Subtype1

Antagonists2