• Antibodies
  • The agent-polymer-peptide complex may be delivered to target cells by, for example, a pre-targeting technique utilizing bispecific or multispecific antibodies or fragments, having at least one binding arm that recognizes the hapten and at least a second binding arm that binds specifically to a disease or pathogen associated antigen, such as a tumor associated antigen. (freepatentsonline.com)
  • For the production of antibodies against defined cell surface antigens such as these, the best approach has been described to include chemical conjugation of the antigen to a highly immunogenic carrier protein plus the use of a potent immunologic adjuvant. (aacrjournals.org)
  • Additionally, C3b molecules can attach to the Fc regions of antigen-bound antibodies leading to phagocytosis or movement to the liver, where the C3b-tagged immune complex is then destroyed. (wikipedia.org)
  • For instance, an antibody deficiency can be diagnosed in the presence of low immunoglobulins, recurrent infections and failure of the development of antibodies on exposure to antigens. (wikipedia.org)
  • These receptors, which we now call "antibodies," were called by Ehrlich "amboceptors" to emphasise their bifunctional binding capacity: They recognise and bind to a specific antigen, but they also recognise and bind to the heat-labile antimicrobial component of fresh serum. (wikipedia.org)
  • The mannose-binding lectin pathway can be activated by C3 hydrolysis or antigens without the presence of antibodies (non-specific immune response). (wikipedia.org)
  • gene
  • This unit describes quantitation of functional interactions between HIV envelope glcoprotein and target cell receptors, using assay of cell fusion‐dependent reporter gene activation. (currentprotocols.com)
  • GeneReviews/NCBI/NIH/UW entry on Atypical Hemolytic-Uremic Syndrome OMIM entries on Atypical Hemolytic-Uremic Syndrome CD46 antigen at the US National Library of Medicine Medical Subject Headings (MeSH) Human CD46 genome location and CD46 gene details page in the UCSC Genome Browser. (wikipedia.org)
  • CD9 antigen is a protein that in humans is encoded by the CD9 gene. (wikipedia.org)
  • binds
  • Each fiber monomer is comprised of an amino-terminus that is noncovalently anchored to the penton base, a carboxy-terminus globular domain that binds to the cell surface receptor, and a rod-like shaft that varies in length according to the Ad serotype. (pubmedcentralcanada.ca)
  • Furthermore, host cells express p33 (globular C1q receptor) on the surface, which binds C1q, and prevents it from initiating complement activation. (wikipedia.org)
  • vaccine
  • To characterize the safety and immunogenicity of a heptavalent antigen-keyhole limpet hemocyanin (KLH) plus QS21 vaccine construct in patients with epithelial ovarian, fallopian tube, or peritoneal cancer in second or greater complete clinical remission. (aacrjournals.org)
  • Such a vaccine has already been tested in a number of trials involving other tumor types which have a high expression of CD46, including one type of adult brain tumor. (wikipedia.org)
  • tumor
  • Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. (wikipedia.org)
  • Their tumor specificity is due to abundant expression of the MV receptor CD46 in glioma cells. (grantome.com)
  • Established medulloblastoma (a malignant brain tumor common in childhood) specimens express CD46, and that medulloblastoma specimens removed from patients had a high level of CD46 expression. (wikipedia.org)
  • repeats
  • The extracellular region of CD46 contains four short consensus repeats (SCR) of about 60 amino acids that fold into a compact beta-barrel domain surrounded by flexible loops. (wikipedia.org)
  • human
  • Here, we investigated the interaction of different stable gonoccocal LOS phenotypes with human dendritic cells and demonstrate that each variant targets a different set of receptors on the dendritic cell, including the C-type lectins MGL and DC-SIGN. (biomedsearch.com)
  • interaction
  • While their precise interaction has not yet been determined, the second and third SCR domains have been demonstrated to be required for HHV-6 receptor binding and cellular entry. (wikipedia.org)
  • inflammation
  • Marie JC, Astier AL, Rivailler P, Rabourdin-Combe C, Wild TF, Horvat B: Linking innate and acquired immunity: divergent role of CD46 cytoplasmic domains in T cell induced inflammation. (sysmex-flowcytometry.com)
  • cells
  • CD46), which is ubiquitously expressed and plays a critical role in protecting host cells from damage by the C3b. (wikipedia.org)
  • T-/B+ SCID (T cells predominantly absent): γc deficiency, JAK3 deficiency, interleukin 7 receptor chain α deficiency, CD45 deficiency, CD3δ/CD3ε deficiency. (wikipedia.org)
  • The plasma membranes of cells contain combinations of glycosphingolipids and protein receptors organised in glycolipoprotein microdomains termed lipid rafts. (wikipedia.org)
  • Upon immunisation with an antigen, more of these receptors are formed, and they are then shed from the cells to circulate in the blood. (wikipedia.org)
  • primary
  • The initial attachment of Ad to its primary receptor, which differs among Ad subgroups ( Table 1 ), is considered as one of the primary determinants to Ad tropism. (pubmedcentralcanada.ca)
  • AIDS
  • Dalgleish AC, Beverley PCL, Clapham PR, Crawford DH, Greaves MF, Weiss RA (1984) The CD4(T4) antigen is an essential component of the receptor for the AIDS retrovirus. (springer.com)