• anxiolytic
  • It has antiemetic effects as with other 5-HT3 antagonists, and also has anxiolytic effects significantly stronger than other related drugs, and with less side effects than benzodiazepine anxiolytics. (wikipedia.org)
  • chemoreceptor
  • Works as antiemetic by blocking dopamine receptors in chemoreceptor trigger zone of CNS. (medscape.com)
  • Receptors on the floor of the fourth ventricle of the brain represent a chemoreceptor trigger zone , known as the area postrema , stimulation of which can lead to vomiting. (wikipedia.org)
  • Receptors on the floor of the fourth ventricle of the brain represent the chemoreceptor trigger zone. (wikipedia.org)
  • The presence of these chemicals in the blood activate 5-HT3 receptors in the chemoreceptor trigger zone, in turn releasing substance P, which activates NK1 receptors to cause an emetic response (vomiting). (wikipedia.org)
  • NMDA
  • Ketamine, an NMDA receptor antagonist, is used primarily for its analgesic effects and in an off-label capacity for its anti-depressant effects. (wikipedia.org)
  • Likewise, SP is known to bind to N-methyl-D-aspartate (NMDA) receptors by eliciting excitation with calcium ion influx, which further releases nitric oxide. (wikipedia.org)
  • tachykinin
  • This led to further research, resulting in the isolation of the genes that encoded the mammalian tachykinins and eventually the discovery of three different tachykinin receptors. (wikipedia.org)
  • In 1984, it was decided that the tachykinin receptors should be called tachykinin NK1 receptor, tachykinin NK2 receptor and tachykinin NK3 receptor. (wikipedia.org)
  • SP binds to all three of the tachykinin receptors, but it binds most strongly to the NK1 receptor. (wikipedia.org)
  • Tachykinin NK1 receptor, often referred to as NK1 receptor, is a member of family 1 (rhodopsin-like) of G protein-coupled receptors and binds to the Gαq protein. (wikipedia.org)
  • NK1 receptor, as well as the other tachykinin receptors, is made of seven hydrophobic transmembrane (TM) domains with three extracellular and three intracellular loops, an amino-terminus and a cytoplasmic carboxy-terminus. (wikipedia.org)
  • Tachykinin NK1 receptor consists of 407 amino acid residues, and it has a molecular weight of 58.000. (wikipedia.org)
  • subunit
  • This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. (wikipedia.org)
  • genes
  • To this end, the investigators will collect DNA samples and take advantage of the unique opportunity to investigate the effects of variation in candidate receptor genes in the context of the three treatment interventions for PDNV. (clinicaltrials.gov)
  • effects
  • In addition to antiemetic effects, it has the advantage of augmenting hypoxic ventilatory response, acting as a respiratory stimulant at high altitude. (medscape.com)
  • Below are several key targets of general anesthetics that likely mediate their effects: GABAA receptors are chloride channels that hyperpolarize neurons and function as inhibitory CNS receptors. (wikipedia.org)
  • treatment
  • Antiemetics, though previously thought to cause birth defects, have been proven safe for use by pregnant women in the treatment of morning sickness and the more serious hyperemesis gravidarum. (wikipedia.org)