Receptor adrenergic beta agonists. Medical search. Frequent questions

Atectura Breezhaler is indicated as a maintenance treatment of asthma in adults and adolescents 12 years of age and older not adequately controlled with inhaled corticosteroids and inhaled short-acting beta 2 -agonists. (medicines.org.uk)
Cough treatments proposed include corticosteroids, beta 2-adrenergic agonists, pertussis-specific immunoglobulin, antihistamines and possibly leukotriene receptor antagonists (LTRAs). (ox.ac.uk)
Treatment involves controlling triggering factors and drug therapy, most commonly with inhaled beta-2 agonists and inhaled corticosteroids. (msdmanuals.com)

Terbutaline sulfate injection, USP is a beta-adrenergic agonist bronchodilator available as a sterile, nonpyrogenic, aqueous solution in vials, for subcutaneous administration. (rxlist.com)
Conclusion Identification of the receptor mediating PGE 2 -induced relaxation represents a key step in developing a novel bronchodilator therapy. (bmj.com)
These data explain the lack of bronchodilator activity observed with selective EP 2 receptor agonists in clinical studies. (bmj.com)
New bronchodilator therapies are needed, given that currently approved bronchodilators such as long-acting β 2 adrenoceptor agonists often fail to relieve symptoms of COPD and severe asthma and safety concerns have been raised over long-term use. (bmj.com)
If the symptoms persist, this is an indication of poorly controlled asthma, and allergist / immunologist should be consulted to adjust prescription for the long acting bronchodilator since they are suitable for constant regulation and control of asthma symptoms ("Short-Acting Beta2-Agonists for Quick Relief of Asthma Symptoms", 2015). (essaywriter.org)
The paper is geared at the compressive analysis of three short acting adrenergic bronchodilator agents namely Metaproterenol, Albuterol, and Levalbuterol. (essaywriter.org)
A selective ADRENERGIC BETA-2 RECEPTOR agonist that functions as a BRONCHODILATOR when administered by inhalation. (umassmed.edu)
Betaxolol: Beta-Blockers (Beta1 Selective) like betaxolol may diminish the bronchodilator effect of Beta2-Agonists like orciprenaline . (pediatriconcall.com)

Beta-adrenergic receptor agonists delay while antagonists acce. (mysciencework.com)
Beta-adrenergic receptor agonists delay while antagonists accelerate epithelial wound healing: evidence of an endogenous adrenergic network within the corneal epithelium. (mysciencework.com)
Conversely, beta-adrenergic receptor antagonists accelerate CEC migration, enhance electric field-mediated directional migration, and promote corneal wound repair. (mysciencework.com)
Methods Using an extensive range of pharmacological tools, the relaxant potential of PGE 2 and selective agonists for the EP 1-4 receptors in the presence and absence of selective antagonists in guinea pig, murine, monkey, rat and human isolated airways was investigated. (bmj.com)
One class of these other drugs are leukotriene receptor antagonists. (medic8.com)
Examples of leukotriene receptor antagonists are montelukast and zafirlukast. (medic8.com)

We propose that the mechanism for the pro-motogenic effect of the beta-adrenergic antagonist is blockade of the beta2-adrenergic receptor preventing autocrine catecholamine binding. (mysciencework.com)
In this model, Beta2-Adrenergic Receptor (B2AR) - T4 Lysozyme fusion was developed to allow for structure solution. (proteopedia.org)

They are a class of sympathomimetic agents, each acting upon the beta adrenoceptors. (wikipedia.org)
Other short-acting sympathomimetic aerosol bronchodilators and adrenergic drugs: May potentiate effect. (nih.gov)
Blocks beta1- and beta2-receptors and has mild intrinsic sympathomimetic effects. (medscape.com)

Antihistamines work by acting against histamine receptors and thus stopping histamine giving you symptoms. (medic8.com)

Almost 62% of the women were dispensed at least one prescription for short-acting β2-agonist (SABA), 63% at least one inhaled corticosteroid (IC), 42% a fixed-combination of an IC and a long-acting β2-agonist (LABA) and 8% a LABA. (nih.gov)

In the current study, rats were exposed to dexamethasone or terbutaline during late gestation and the development of beta-receptor binding capabilities and adenylate cyclase activity evaluated in membrane preparations from kidney and lung. (rti.org)
Although dexamethasone and terbutaline also caused significant changes in development of beta-receptor binding capabilities, in neither tissue could these effects account for the direction or magnitude of the changes in adenylate cyclase reactivity. (rti.org)
Selected examples are: Arformoterol Buphenine Clenbuterol Dopexamine (β1 and β2) Epinephrine (non-selective) Fenoterol Formoterol Isoetarine Isoprenaline (INN), isoproterenol (USAN) (β1 and β2) Levosalbutamol (INN), levalbuterol (USAN) Orciprenaline (INN), metaproterenol (USAN) Pirbuterol Procaterol Ritodrine Salbutamol (INN), albuterol (USAN) Salmeterol Terbutaline These agents are also listed as agonists by MeSH. (wikipedia.org)
Terbutaline Sulfate Injection is a beta-adrenergic receptor agonist used for the prevention and reversal of bronchospasm in patients 12 years of age and older with asthma and reversible bronchospasm associated with bronchitis and emphysema . (rxlist.com)
Terbutaline Sulfate may interact with antidepressants , beta-blockers, and diuretics (water pills). (rxlist.com)
Scholars@Duke publication: Fetal terbutaline exposure causes selective postnatal increases in cerebellar alpha-adrenergic receptor binding. (duke.edu)
In the current study, pregnant rats were given 10 mg/kg of terbutaline on gestational days 17, 18 and 19 and adrenergic receptor binding capabilities examined in brain regions of the offspring. (duke.edu)
This is likely to contain terbutaline or salbutamol, which are beta-2 adrenergic agonists. (medic8.com)

The Metaproterenol should not be used with other beta adrenergic aerosol bronchodilators as it can result in additive effects. (essaywriter.org)

Second-generation histamine H1-receptor antagonist. (medscape.com)

Adrenergic+beta-Agonists at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Delbruck, Max. (wikipedia.org)

The dopamine D2 receptor is expressed and sensitizes adenylyl cyclase activity in airway smooth muscle. (ndriresource.org)

The effectiveness of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blocker AT-1 (ARBs) in reducing the systemic hypertension (SH) is widely known. (intechopen.com)

At dosages greater than required for beta-blockade, propranolol also exerts a quinidine-like or anesthetic-like membrane action, which affects the cardiac action potential. (nih.gov)
The net physiologic effect of beta-adrenergic blockade is usually advantageous and is manifested during exercise by delayed onset of pain and increased work capacity. (nih.gov)
Propranolol exerts its antiarrhythmic effects in concentrations associated with beta-adrenergic blockade, and this appears to be its principal antiarrhythmic mechanism of action. (nih.gov)

Indications of administration for β agonists include: Bradycardia (slow heart rate) Asthma Chronic obstructive pulmonary disease (COPD) Heart failure Allergic reactions Hyperkalemia Beta blocker poisoning Premature labor (this is an off-label use and could be detrimental) Although minor compared to those of epinephrine, beta agonists usually have mild to moderate adverse effects, which include anxiety, hypertension, increased heart rate, and insomnia. (wikipedia.org)
Patients with asthma should not normally be treated with beta-blockers. (nih.gov)
Currently approved bronchodilators such as long-acting β 2 adrenoceptor agonists are the mainstay treatments but often fail to relieve symptoms of chronic obstructive pulmonary disease and severe asthma and safety concerns have been raised over long-term use. (bmj.com)
A number of clinical studies have reported beneficial effects of inhaled PGE 2 on airway calibre in normal subjects and patients with asthma and COPD, and we have identified a role for the EP 4 receptor in these relaxant responses. (bmj.com)
New York, NY, December 2, 2009 - Commonly prescribed beta 2 adrenergic agonist drugs for the treatment of asthma in pregnant women as well as pre-term labor may increase the incidence of autism-spectrum disorders, psychiatric pathology, cognitive problems and poor school performance in their children, according to a new study published in the December 2009 issue of the American Journal of Obstetrics & Gynecology . (scienceblog.com)
beta-Adrenergic agonists used in therapy of premature labor and asthma cross the placenta and can affect development of the fetal nervous system. (duke.edu)

A role for beta-adrenergic receptor kinase. (jci.org)
The proposed mechanisms of such rapid receptor desensitization include receptor phosphorylation by either cAMP-dependent protein kinase or the specific beta-adrenergic receptor kinase (BARK), leading to functional uncoupling from adenylyl cyclase and sequestration of the receptors away from the cell surface. (jci.org)

Beta 2 adrenergic agonist drugs as a class are widely used in obstetrics as tocolytics to inhibit or slow down labor and bronchodilators, but may act as functional and behavioral teratogens when given continuously in the mid to late second or early third trimesters. (scienceblog.com)

In this case, positive inotropes (dobutamine 1-5 mcg/kg/min IV - an agonist of beta-adrenergic receptors) and diuretics are administered depending on the cardiomyopathy. (vin.com)
Diuretics , ACE inhibitors , and beta-blockers are cornerstones of HF treatment, but are associated with exacerbation of LUTS. (empr.com)

The regional and subtype selectivity are compatible with primary deficits in the development of noradrenergic projections to the cerebellum identified in previous studies and provide further evidence that therapeutic use of beta-adrenergic agonists may produce neurobehavioral teratology. (duke.edu)

beta-2-Adrenergic Receptor Agonists Modulate Human Airway Smooth Muscle Cell Migration via Vasodilator-Stimulated Phosphoprotein. (ndriresource.org)

Treatment with β 2 -adrenergic agonists results in skeletal muscle hypertrophy ( 11 - 14 ), while they cause a reduction in the body fat content ( 15 , 16 ). (spandidos-publications.com)
Metaproterenol is a moderately selective beta(2)-adrenergic agonist that stimulates receptors of the smooth muscle in the lungs, uterus, and vasculature supplying skeletal muscle, with minimal or no effect on alpha-adrenergic receptors. (pediatriconcall.com)

Selective alpha 2-receptor that reduces aqueous humor formation and increases uveoscleral outflow. (medscape.com)
Nonselective beta-adrenergic blocking agent that lowers IOP by reducing aqueous humor production. (medscape.com)

The aim of the study was to identify the receptor involved in prostaglandin E 2 (PGE 2 )-induced relaxation in guinea pig, murine, monkey, rat and human airways in vitro . (bmj.com)

Propranolol is a nonselective beta-adrenergic receptor blocking agent possessing no other autonomic nervous system activity. (nih.gov)

Many agents are available for lowering of IOP, including topical beta-blockers, adrenergic agents, and topical and systemic carbonic anhydrase inhibitors. (medscape.com)

Beta-blockers: May block bronchodilatory effects of beta-agonists and produce severe bronchospasm. (nih.gov)
Some studies have suggested that beta-blockers may increase bladder contractility and provoke symptoms of urinary urgency. (empr.com)
We had tried with angiotensin receptor blockers (ARBs) and failed. (medscape.com)

Exposure of beta-adrenergic receptors (BAR) to agonists often leads to a rapid loss of receptor responsiveness. (jci.org)
Animal studies support the concept that in humans prenatal exposure to continuous high doses of beta 2 adrenergic agonists can permanently dysregulate signaling from the beta 2 adrenergic receptor. (scienceblog.com)
Researchers show how sympathetic overactivity and disease are correlated, citing studies that show the association between in utero exposure to beta 2 adrenergic agonists in humans and later development of these conditions. (scienceblog.com)
The article is "In Utero Beta 2 Adrenergic Agonist Exposure and Adverse Neurophysiologic and Behavioral Outcomes" by Frank R. Witter, MD, Andrew W. Zimmerman, MD, James P. Reichmann, MBA, and Susan L. Connors, MD. It appears in American Journal of Obstetrics & Gynecology , Volume 201, Issue 6 (December 2009) published by Elsevier. (scienceblog.com)

Mirabegron , a selective beta 3-adrenoceptor agonist, is approved for treatment of OAB but may stimulate beta 3-adrenoreceptors in the heart, raising concerns about the cardiac safety of mirabegron in patients with HF. (empr.com)

We demonstrate that CECs express key enzymes required for epinephrine (beta-adrenergic receptor agonist) synthesis in the cytoplasm and can detect epinephrine in cell extracts. (mysciencework.com)
Epinephrine belongs to a class of drugs called alpha-adrenergic and beta-adrenergic receptor agonists. (medicalnewstoday.com)

Scholars@Duke publication: A mutation of the beta 2-adrenergic receptor impairs agonist activation of adenylyl cyclase without affecting high affinity agonist binding. (duke.edu)
Activation of guanyl nucleotide regulatory proteins (G proteins) by hormones and neurotransmitters appears to require the formation of high affinity agonist-receptor-G protein ternary complexes. (duke.edu)
Nevertheless, D267-273 exhibited high affinity agonist binding identical to that of the wild-type receptor. (duke.edu)
These findings indicate that the formation of high affinity agonist-receptor-Gs complexes is not sufficient to fully activate Gs. (duke.edu)
Time-dependent changes in the affinity of the receptor for agonists. (aspetjournals.org)
They also found that 1-fluoroestradiol and estradiol share similar bond lengths and intramolecular distances between key oxygens that are known to affect biological binding affinity to estrogen receptors. (cam.ac.uk)

In addition, agonist-induced sequestration of the receptor, a property not mediated by Gs, was also normal. (duke.edu)

Furthermore, our data indicate that in addition to its suggested role as a rapid modulator of adrenergic receptor function at synapse, rapid BARK-mediated receptor regulation may have functional relevance in other tissues in response to high circulating or local levels of agonists. (jci.org)

When the bladder becomes full, the stretch receptors of the detrusor muscle send a signal to the pons, which in turn notifies the brain. (medscape.com)
Antimuscarinic agents , the "mainstay of treatment" for patients with OAB, block muscarinic (M2 and M3) receptors in the bladder detrusor muscle, thereby reducing frequency and urgency. (empr.com)
Beta 3-adrenoceptor agonists enhance the action of the beta 3-adrenoceptor subtype, which is dominant in the detrusor muscle. (empr.com)

It specifically competes with beta-adrenergic receptor agonist agents for available receptor sites. (nih.gov)

For example, patients with low heart rate are given beta agonist treatments that are more "cardio-selective" such as dobutamine, which increases the force of contraction of the heart muscle. (wikipedia.org)
Higenamine is a beta receptor agonist similar to Synephrine that increases production of noradrenaline which in turn stimulates the "fight or flight" response that leads to enhanced focus and concentration. (a1supplements.com)
Hordenine is a popular nootropic that's derived from Bitter Orange and acts as a beta-2 adrenergic agonist similarly to Higenamine, which means that it increases energy and focus. (a1supplements.com)
In the smooth muscle, it causes relaxation by acting on intracellular adenyl cyclase beta-2 adrenergic receptors that cause increases in cyclic AMP through the conversation of ATP ("Metaproterenol: Indications, Side Effects, Warnings - Drugs.com", 2017). (essaywriter.org)
Despite the absence of body or brain growth impairment, selective increases were seen postnatally in cerebellar alpha 1- and alpha 2-receptor subtypes, whereas the same receptor populations were decreased by small amounts in cerebral cortex and midbrain + brainstem. (duke.edu)

Glucorticoids and adrenergic stimulation are both thought to control the development of beta-adrenergic receptors/responses. (rti.org)
When access to beta-receptor sites is blocked by propranolol, the chronotropic, inotropic, and vasodilator responses to beta-adrenergic stimulation are decreased proportionately. (nih.gov)
In contrast to previous publications, a role for the EP 4 receptor in relaxant responses in human airways in vitro was found. (bmj.com)

Intracellularly, the actions of orciprenaline are mediated by cAMP, the production of which is augmented by beta stimulation. (pediatriconcall.com)

Carazolol occupies a similar position as the rhodopsin inverse agonist, retinal. (proteopedia.org)

Activation of β1 receptors induces positive inotropic, chronotropic output of the cardiac muscle, leading to increased heart rate and blood pressure, secretion of ghrelin from the stomach, and renin release from the kidneys. (wikipedia.org)
Activation of β2 receptors induces smooth muscle relaxation in the lungs, gastrointestinal tract, uterus, and various blood vessels. (wikipedia.org)
Activation of the β3 receptors induces the metabolism of lipids. (wikipedia.org)
Administration of the β2-agonist formoterol (0.3 mg/kg for 7 days) in rats bearing Yoshida AH-130 ascites hepatoma tumors, a model which induces a strong loss of both body and muscle weight, resulted in a significant reversal of the muscle wasting process, as reflected by individual muscle weights. (spandidos-publications.com)

Salivary seromucous glands are regulated predominantly by parasympathetic activation of muscarinic receptors, resulting in exocrine secretion of mucins and macroglobulin responsible by lubrication and protection of oral mucosa 3-4 . (bvsalud.org)

One of the most relevant characteristics of cachexia is that of asthenia, which reflects significant muscle wasting noted in cachectic cancer patients The aim of the present study was to assess whether the β2-adrenergic agonist formoterol is associated with an improvement in physiological parameters such as grip force and total physical activity in cachetic rats. (spandidos-publications.com)
In light of these findings, the aim of the present investigation was to determine the influence of the cachectic state on the physical performance of rats, and to assess whether the β 2 -adrenergic agonist formoterol is associated with an improvement in physiological parameters such as grip force and total physical activity. (spandidos-publications.com)

Results In agreement with previous studies, it was found that the EP 2 receptor mediates PGE 2 -induced relaxation of guinea pig, murine and monkey trachea and that the EP 4 receptor mediates PGE 2 -induced relaxation of the rat trachea. (bmj.com)

It is a partial agonist at beta adrenergic receptors and acts as a coronary vasodilator and cardiotonic agent. (bvsalud.org)

β3 agonists are currently under clinical research and are thought to increase the breakdown of lipids in obese patients. (wikipedia.org)
Relaxant activity of AH13205 (EP 2 agonist) was also demonstrated in guinea pig but not human airway tissue, which may explain its failure in clinical studies. (bmj.com)
Formoterol, one of these compounds, is a highly potent β 2 -adrenoceptor-selective agonist which combines the clinical advantages of rapid onset of action with duration of action. (spandidos-publications.com)

Amisulpride is a neuroleptic that works by blocking dopamine D 2 /D 3 receptors ( ref ). (cam.ac.uk)

These agents act by competitive inhibition of histamine at the H1 receptor. (medscape.com)
4 Two medication classes are typically prescribed for this condition: antimuscarinic agents, and beta 3-adrenergic agonists. (empr.com)

Should you still require medication, your doctor may decide to add a long-acting beta-2 adrenergic agonist to your plan. (medic8.com)

citation needed] In 2013, zilpaterol, a β agonist sold by Merck, was temporarily withdrawn due to signs of sickness in some cattle that were fed the drug. (wikipedia.org)

Metaproterenol acts like any other beta adrenergic agonist through beta-2 adrenergic receptors which are predominant in bronchial smooth muscles. (essaywriter.org)

The FDA approved Fluoroestradiol F-18 in 2020 as a molecular imaging agent for positron emission tomography (PET) for detecting estrogen receptor-positive lesions as a supplement to biopsy in patients with recurrent or metastatic breast cancer. (cam.ac.uk)
The Beta-Agonist Lung injury TrIal-2 (BALTI-2) was initiated to evaluate the effects of this intervention on mortality in patients with ARDS. (birmingham.ac.uk)
Further trials of β-agonists in patients with ARDS are unlikely to be conducted. (birmingham.ac.uk)

Arbutamine Befunolol Bromoacetylalprenololmenthane Broxaterol Cimaterol Cirazoline Etilefrine Hexoprenaline Higenamine Isoxsuprine Mabuterol Methoxyphenamine Oxyfedrine Ractopamine Reproterol Rimiterol Tretoquinol Tulobuterol Zilpaterol Zinterol Alpha-adrenergic agonist "WHAT ARE BETA-AGONISTS? (wikipedia.org)
Selective alpha-adrenergic agonist (alpha2) without significant local anesthetic activity. (medscape.com)
There is strong evidence that obesity leads to increased sympathetic modulation and a decreased vagal tone leading to a lack of autonomic control (characterized by reduction of heart rate variability) that can bring about changes in the renin-angiotensin-aldosterone system in alpha agonists and central alpha 2-1 and beta-adrenergic receptors. (bvsalud.org)

Thus, glucocorticoids and beta-agonists can participate in the programming of development of postsynaptic reactivity by exerting actions upon post-receptor coupling mechanisms. (rti.org)

Beta-adrenergic receptor agonists delay CEC migration via a protein phosphatase 2A-mediated mechanism and decrease both electric field-directed migration and corneal wound healing. (mysciencework.com)
In the case of the beta 2-adrenergic receptor, multiple regions of the molecule have been implicated in coupling to the stimulatory G protein Gs. (duke.edu)
This finding raises the possibility that discrete regions of the receptor mediate ternary complex formation, whereas different loci may be involved in other aspects of G protein activation. (duke.edu)
Beta-2 Adrenergic Receptor s (B2ARs) are a type of G Protein-Coupled Receptor (GPCR) . (proteopedia.org)

These data have been confirmed in murine airways from EP 2 receptor-deficient mice ( Ptger2 ). (bmj.com)
In mice, activation of brown fats thermogenesis with a beta-3-adrenergic receptor agonist inhibits meals consumption. (aabioetica.org)

Nuclear magnetic resonance studies on the interaction of avoparcin with model receptors of bacterial cell walls. (aspetjournals.org)

In particular, the drug belongs to beta-adrenergic agonist class which is a group of medications which work the same way and treats the similar medical problem. (essaywriter.org)

Anatomy12

Organisms11

Diseases3

Chemicals and Drugs178

Analytical, Diagnostic and Therapeutic Techniques and Equipment21

Psychiatry and Psychology1

Phenomena and Processes29

Disciplines and Occupations2

Information Science3

Health Care2

Corticosteroids3

Bronchodilator8

Antagonists6

Beta2-adrenergic receptor2

Sympathomimetic3

Antihistamines1

Corticosteroid1

Terbutaline8

Aerosol bronchodilators1

Antagonist1

Subject Headings1

Adenylyl cyclase activity1

Angiotensin II recep1

Blockade3

Asthma6

Kinase2

Bronchodilators1

Diuretics2

Therapeutic1

Airway smooth muscle1

Skeletal muscle2

Aqueous2

Prostaglandin1

Nonselective1

Systemic1

Blockers3

Exposure4

Selective beta1

Epinephrine2

Affinity6

Sequestration1

Regulation1

Detrusor muscle3

Competes1

Increases5

Responses3

Stimulation1

Rhodopsin1

Induces4

Muscarinic1

Rats2

Mediates1

Vasodilator1

Clinical3

Dopamine1

Agents2

Medication1

Merck1

Bronchial1

Patients3

Alpha3

Mechanisms1

Protein4

Mice2

Interaction1

Class1