• This chemotactic signaling pathway is relatively conserved across bacteria, whereas chemoeffectors and chemoreceptors vary among bacterial species/strains. (nature.com)
  • Advances in transcriptome sequencing allow for simultaneous interrogation of differentially expressed genes from multiple species originating from a single RNA sample, termed dual or multi-species transcriptomics. (biomedcentral.com)
  • We describe best practices for multi-species transcriptomics and differential gene expression. (biomedcentral.com)
  • We demonstrated that only 39 differentially expressed genes (DEGs) were present in all species. (frontiersin.org)
  • Proteins found in any species of algae. (lookformedical.com)
  • Several large species-specific families appear to result from multiple rounds of segmental duplications of tandem gene arrays, a novel mechanism not yet described in yeasts. (biomedcentral.com)
  • Please note that proteins can be included in multiple pathways, ie. (embl.de)
  • Therefore, the study of IBD must be faced exploiting an integrated and multilevel approach, ranging from genes, transcripts and proteins to pathways altered in affected tissues, and carefully considering their regulatory mechanisms, which may intervene in the pathology onset. (biomedcentral.com)
  • Protein components of different pathways for carbon and nitrogen source utilization were identified, which so far has remained unexplored in yeast, offering clues for further biotechnological developments. (biomedcentral.com)
  • Garlic contains various bioactive compounds whose metabolic pathways, plant-pathogen interactions, defensive genes, identify interaction networks, and functional genomics were not previously predicted in the garlic at the genomic level. (springeropen.com)
  • We compared the ortholog gene family of the A. sativum transcriptome to A. thaliana , O. sativa , and Z. mays and found that 12,077 orthologous gene families are specific to A. sativum L. Furthermore, we identified genes involved in plant defense mechanisms, their protein-protein interaction network, and plant-pathogen interaction pathways. (springeropen.com)
  • In garlic, the next-generation sequencing analysis based on RNA from renewal buds resulted in de novo assembly of 128,000 unigenes that were annotated and analyzed with respect to Gene Ontology (GO) and metabolic pathways [ 28 ]. (springeropen.com)
  • Fault tolerance in protein interaction networks: stable bipartite subgraphs and redundant pathways. (leibniz-fli.de)
  • Fundamentals of Receptor-ligand interactions. (entrance.net.in)
  • I want to have a network of the interactions between the proteins of these 100 genes. (stackexchange.com)
  • Overall, the high-resolution structure of photoactive yellow protein supports a mechanism whereby electrostatic interactions create an active site poised for photon-induced rearrangements and efficient protein-mediated signal transduction. (embl-heidelberg.de)
  • However, the task of predicting protein-protein interactions between a new virus and human cells is extremely challenging due to scarce data on virus-human interactions and fast mutation rates of most viruses. (biomedcentral.com)
  • Additionally, we employ an additional objective which aims to maximize the probability of observing human protein-protein interactions. (biomedcentral.com)
  • Virus infection involves several types of protein-protein interactions (PPIs) between the virus and its host. (biomedcentral.com)
  • In this work, we cast the problem of predicting virus-human protein interactions as a binary classification problem and focus specifically on emerging viruses that has limited experimentally verified interaction data. (biomedcentral.com)
  • This gene is widely expressed in tumoral tissues and seems to be involved in integrin-like cell interactions. (unige.ch)
  • Structural Characterization of N-Linked Glycans in the Receptor Binding Domain of the SARS-CoV-2 Spike Protein and their Interactions with Human Lectins. (unige.ch)
  • Additionally, 40 records on CHST genetic and biochemical properties were hand-picked from UniProt, GeneCards, InterPro, and neXtProt databases. (bvsalud.org)
  • retained genes for the last three steps of the pathway, allowing The most abundant group of heme proteins are cytochromes them to synthesize heme from their host-derived precursors (20). (medicinelakex1.com)
  • Our comparative analyses also suggest the Toll-like receptor pathway may be essential for tolerance/sensitivity to symbionts and pathogens. (biomedcentral.com)
  • Tools such as gene clustering coefficients, all-pairs shortest paths and pathway lengths calculation have been developed to provide data analysis support. (biomedcentral.com)
  • L. agilis BKN88 contains five putative chemoreceptor genes ( mcp1 - mcp5 ). (nature.com)
  • Sequence alignments suggested that the chloroplast infA gene encoding initiation factor 1 in the green alga Chlorella vulgaris has TTG as a putative initiation codon. (lookformedical.com)
  • The majority of the protein-coding genes (76.5%) were assigned with a putative function while the remaining ones were annotated as hypothetical proteins. (micrornamimic.com)
  • The protein contains 294 amino acids, the first 22 of which are characteristic of a bacterial signal sequence peptide. (wikipedia.org)
  • basic concepts of sequence alignment: local and global alignments, Needleman and Wunsch, Smith and Waterman algorithms for pairwise alignments, gap penalties, use of pairwise alignments for analysis of Nucleic acid and protein sequences and interpretation of results Multiple sequence alignments (MSA): the need for MSA, basic concepts of various approaches for MSA (e.g. progressive, hierarchical etc. (entrance.net.in)
  • From our results and the sequence homology, weconclude that PGRP is a ubiquitous protein involved in innate immunity,conserved from insects to humans. (embl-heidelberg.de)
  • Transformation of the diploid oomycete plant pathogen Phytophthora infestans with antisense, sense, and promoter-less constructs of the coding sequence of the elicitin gene inf1 resulted in transcriptional silencing of both the transgenes and the endogenous gene. (lookformedical.com)
  • The sequence encoded a novel protein rich in alanine (25%) and proline (20%), which contained regions similar to proteins of comparable amino acid composition such as extracellular matrix components or the membrane-cytoskeletal linker synapsin. (lookformedical.com)
  • lyrata (Lyre-leaved rock-cress) Triacylglycerol lipase 2 gene At5g1418 MUA22.18 MUA22.19 MYZUS PERSICAE-INDUCED LIPASE 1 , arath-Q8LPF5 Arabidopsis thaliana (Mouse-ear cress) Arabidopsis lyrata subsp. (inrae.fr)
  • lyrata (Lyre-leaved rock-cress) hypothetical protein (at5g25770) , arath-C7A10.830 Arabidopsis thaliana DNA chromosome 4,gene C7A10.830 No. 2 AT4G36530 , arath-F1N18.12 Arabidopsis thaliana (Mouse-ear cress) f1n18.12 AT1G29840 protein , arath-F1P2.110 Arabidopsis thaliana (Mouse-ear cress). (inrae.fr)
  • hypothetical protein f1p2.110 (at3g47560) , arath-F1P2.140 Arabidopsis thaliana (Mouse-ear cress). (inrae.fr)
  • This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. (embl.de)
  • Percentage points are related to the number of proteins with CADG domain which could be assigned to a KEGG orthologous group, and not all proteins containing CADG domain. (embl.de)
  • We used a transcriptomic approach to define the protease and antiprotease genes specifically expressed in the hen liver in relation to vitellogenesis by comparing sexually mature and pre-laying chickens showing different steroid milieu. (biomedcentral.com)
  • We found that "uncharacterized protein LOC419301/similar to porin" (GeneID:419301), an antiprotease and "cathepsin E-A-like/similar to nothepsin" (GeneID:417848), a protease, were the only over-expressed candidates (21-fold and 35-fold difference, respectively) that are present in the egg yolk. (biomedcentral.com)
  • Heme/iron-binding proteins, protease inhibitors, proteases, lipocalins and immune-related proteins were the categories most abundantly expressed in females, while glycolytic enzymes, protease inhibitors and lipocalins were the most abundantly expressed in males. (biomedcentral.com)
  • We find that the potato genome substantially expanded its repertoire of disease-resistance genes when compared with closely related seed-propagated solanaceous crops, indicative of the effect of tuber-based propagation strategies on the evolution of the potato genome. (nature.com)
  • metabolism of this heme-free eukaryote, we searched for heme- There are only a few examples of facultatively anaerobic or containing proteins in its de novo sequenced genome and exam-ined several cellular processes for which heme has so far been con- pathogenic bacteria that do not require heme (10-12), but no sidered indispensable. (medicinelakex1.com)
  • What are the publicly available databases of influenza virus gene/genome sequences? (stackexchange.com)
  • We sequenced the worm's ~ 688-Mb haploid genome with an overall completeness of ~ 95% and discovered that L. luymesi lacks many genes essential in amino acid biosynthesis, obligating them to products provided by symbionts. (biomedcentral.com)
  • Though the organism is reported to be non-motile, numerous genes associated with flagellar motility are present in the genome (see below). (micrornasynthesis.com)
  • Brief summaries describing the function of each gene's product are of great value to the research community, especially when interpreting genome-wide studies that reveal changes to hundreds of genes. (stanford.edu)
  • Network properties of complex human disease genes identified through genome-wide association studies. (leibniz-fli.de)
  • Hence, these proteins could be candidate antigen targets for the development of vaccines aimed at the control and prevention of O. erraticus infestations and the diseases this tick transmits. (biomedcentral.com)
  • Molecular characterization of prostate carcinoma tumor antigen-1, PCTA-1, a human galectin-8 related gene. (unige.ch)
  • Surface-epitope masking and expression cloning identifies the human prostate carcinoma tumor antigen gene PCTA-1 a member of the galectin gene family. (unige.ch)
  • Ornithodoros erraticus saliva contains bioactive proteins that play essential functions in tick feeding and host defence modulation, which may contribute to host infection by tick-borne pathogens. (biomedcentral.com)
  • A monoclonal antibody raised against purified flagellar basal apparatuses from the green flagellate Spermatozopsis similis reacted with a protein of 210 kDa (p210) in western blots. (lookformedical.com)
  • The protein was part of the Y-shaped fibrous linkers between the doublet microtubules and the flagellar membrane, as indicated by statistical analysis of post-labeled sections using anti-centrin and anti-tubulin as controls. (lookformedical.com)
  • Cadherin-homologous domains present in metazoan dystroglycans and alpha/epsilon sarcoglycans, yeast Axl2p and in a very large protein from magnetotactic bacteria. (embl.de)
  • In animals, cadherin domain-containing proteins are adhesion molecules that modulate a wide variety of processes including cell polarization and migration but they have also been identified in yeast and magnetotactic bacteria. (embl.de)
  • One bacteria-induced gene encodes a proteinthat, after expression in the baculovirus system, was shown to be apeptidoglycan recognition protein (PGRP). (embl-heidelberg.de)
  • Experimental results show that our proposed model works effectively for both virus-human and bacteria-human protein-protein interaction prediction tasks. (biomedcentral.com)
  • Our study contains an extensive sequencing and functional gene-annotation analysis of A. sativum L. The findings provide insights into the molecular basis of TFs, defensive genes, and a reference for future studies on the genetics and breeding of A. sativum L. (springeropen.com)
  • Additional gene prediction analysis and functional annotation was performed within the Integrated Microbial Genomes - Expert Review (IMG-ER) platform [37]. (micrornamimic.com)
  • Gene reduction analysis revealed that the gene deletion processes are under selective pressure, and many of the inactivations are probably related to the organism's interaction with its host environment. (asm.org)
  • Human genes altered in IBD have been collected from literature, paying particular interest for the immune system alterations prompted by the interaction with the gut microbiome. (biomedcentral.com)
  • Discovery and optimization of chromenotriazolopyrimidines as potent inhibitors of the mouse double minute 2-tumor protein 53 protein-protein interaction. (leibniz-fli.de)
  • PPI spider: a tool for the interpretation of proteomics data in the context of protein-protein interaction networks. (leibniz-fli.de)
  • Systematic characterization of the protein interaction network and protein complexes in Saccharomyces cerevisiae using tandem affinity purification and mass spectrometry. (leibniz-fli.de)
  • NASCENT: An automatic protein interaction network generation tool for non-model organisms. (leibniz-fli.de)
  • Constructing glucagon like peptide-1 receptor fused with derivatives of GFP for visualizing protein-protein interaction in living cells. (leibniz-fli.de)
  • Protein-protein interaction inhibition (2P2I): fewer and fewer undruggable targets. (leibniz-fli.de)
  • Small molecule protein-protein interaction inhibitors as CNS therapeutic agents: current progress and future hurdles. (leibniz-fli.de)
  • Understanding the interaction patterns between a particular virus and human proteins plays a crucial role in unveiling the underlying mechanism of viral infection and pathogenesis. (biomedcentral.com)
  • We developed a multitask transfer learning approach that exploits the information of around 24 million protein sequences and the interaction patterns from the human interactome to counter the problem of small training datasets. (biomedcentral.com)
  • This additional task objective acts as a regularizer and also allows to incorporate domain knowledge to inform the virus-human protein-protein interaction prediction model. (biomedcentral.com)
  • Molecular cloning and characterization of the mouse tag7 gene encoding anovel cytokine. (embl-heidelberg.de)
  • Chemotaxis is triggered by the binding of ligands (chemoeffectors) to chemoreceptors called methyl-accepting chemotaxis proteins (MCPs) and transducer-like proteins (Tlps). (nature.com)
  • I tried to get a kind of conversion table for all human genes. (stackexchange.com)
  • The resource provides a section devoted to human genes identified as altered in IBD, which can be queried at different biomolecular levels and visualised in gene-centred report pages. (biomedcentral.com)
  • The IBDsite is an attempt to group available information regarding human genes and microbial aspects related to IBD, by means of a multilevel mining tool. (biomedcentral.com)
  • Classification of nonenzymatic homologues of protein kinases. (leibniz-fli.de)
  • These include 37 proteases and antiproteases, which are likely to play a role in the formation of the yolk (vitellogenesis), as regulators of protein metabolism. (biomedcentral.com)
  • Parasitic ecule because it reversibly binds to certain proteins, such as kinetoplastid flagellates represent a rare example of organisms transcription factors and ion channels, and thus modulates their that depend on oxidative metabolism but are heme auxotrophs. (medicinelakex1.com)
  • Axl2p is predicted to be a type I transmembrane protein. (embl.de)
  • GXD's primary emphasis is on endogenous gene expression during development. (jax.org)
  • Mice homozygous for disruptions in this gene display immune system abnormalities involving development of both T and B cells and affecting susceptibility to both bacterial and viral infections as well as impaired thermogenic gene expression and energy expenditure. (jax.org)
  • Expression of C5a anaphylatoxin chemotactic receptor 1 (C5aR1), sulfated C5aR1 in, and binding of 6x-His-tagged Hemolysin C (HlgC) and Panton-Valentine leukocidin (PVL) slow-component to THP-1 cell lines was detected and analyzed via flow cytometry. (bvsalud.org)
  • Mutations of CHST3 gene cause skeletal dysplasia, chondrodysplasia, and autosomal recessive multiple joint dislocations while increased tissue expression of CHST11, CHST12 and CHST15 is an unfavourable prognostic factor in ovarian cancer, glioblastoma and pancreatic cancer, respectively. (bvsalud.org)
  • I downloaded gene expression data ( exp_seq ) from the ICGC file browser. (stackexchange.com)
  • However, gene expression-based signatures present some limitations because they do not consider metabolic role of the genes and are affected by genetic heterogeneity across patient cohorts. (tu-dortmund.de)
  • Genomic organization of the tag7gene and its promoter region remind those of the genes of the tumornecrosis factor locus, although the tag7 gene is not linked to this locus.The gene is located on chromosome 7 at the area that corresponds to band7A3, which has genetic linkage with lupus-like disease in mouse models.tag7 transcription is essential for lymphoid organs. (embl-heidelberg.de)
  • In soluble guanylyl cyclase, heme serves as a protein cofactor for fundamental cellular processes, such as as the nitric oxide sensor, and thus plays an important role in electron transport in the respiratory chain, oxidative stress re- signal transduction. (medicinelakex1.com)
  • 2). In aerobic organisms that produce energy mainly through Some kinetoplastids that parasitize insects obtain heme from their oxidative phosphorylation, most of the synthesized heme is used bacterial endosymbionts, which can be eliminated by antibiotic for the formation of the cytochromes functioning in the electron treatment, turning these protists into heme auxotrophs (17). (medicinelakex1.com)
  • Heme, flavin, and a 4-hydroxycinnamyl chromophore are used in different proteins. (embl-heidelberg.de)
  • Peptide bond, phi, psi and chi torsion angles, ramachandran map, anatomy of proteins - Hierarchical organization of protein structure - Primary. (entrance.net.in)
  • This gene encodes a member of the galectin family. (unige.ch)
  • This domain is found in a family of animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme [ ( PUBMED:9707603 ) ], and some bacterial homologues. (embl-heidelberg.de)
  • Mechanisms for sugar recognition have evolved independently in diverse protein structural frameworks, but share some key features. (embl.de)
  • However, the genetic mechanisms allowing organisms to maintain host-symbiont associations at the molecular level are still mostly unknown, and in the case of bacterial-animal associations, most genetic studies have focused on adaptations and mechanisms of the bacterial partner. (biomedcentral.com)
  • This list of 582 genes contains 12 proteases and 3 antiproteases. (biomedcentral.com)
  • These results raise the question of the biological significance of egg yolk proteases and antiproteases, and more generally of all minor proteins that have been identified in egg yolk. (biomedcentral.com)
  • Click on a disease name to see all genes associated with that disease. (jax.org)
  • Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains. (unige.ch)
  • Taxonomic distribution of proteins containing CLECT domain. (embl.de)
  • The complete taxonomic breakdown of all proteins with CLECT domain is also avaliable . (embl.de)
  • Click on the protein counts, or double click on taxonomic names to display all proteins containing CLECT domain in the selected taxonomic class. (embl.de)
  • Several PAS-domain proteins are known to detect their signal by way of an associated cofactor. (embl-heidelberg.de)
  • The alpha/beta fold, which differs from the original chain tracing, shows striking similarity to distinct parts of the signal transduction proteins profilin and the SH2 domain. (embl-heidelberg.de)
  • This entry represents the catalytic domain found in a number of serine/threonine- and tyrosine-protein kinases. (rcsb.org)
  • Lectins are a diverse group of proteins, both in terms of structure and activity. (embl.de)
  • When examined from the viewpoint of the bound sugar, the structural information accumulated so far on lectins and other proteins that are specific to galactose and glucose (or mannose), provides suggestive evidence for distinct ligand-dependent distribution of hydrogen-bond partners in the combining site. (embl.de)
  • Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene. (jax.org)
  • Serine/threonine-protein kinases, tyrosine-protein kinases, and dual specificity protein kinases (e.g. (rcsb.org)
  • Well, I'm trying to convert a list of Human Gene referenced by Ensembl Gene IDs to Entrez Gene IDs. (stackexchange.com)
  • Number of protein-coding transcribed from this gene as defined by Ensembl . (proteinatlas.org)
  • The transfer of the major egg yolk proteins such as Very Low Density Lipoproteins (VLDL) containing essentially apovitellenin and apolipoprotein-B, but also vitellogenins and some other plasma proteins from the blood such as serum albumin to the interstitial fluid of the thecae is possible due to the presence of broad discontinuities in the capillary endothelium. (biomedcentral.com)