Percutaneous coronary intStent thrombosisAtherosclerosisArteriesMyocardial infarctionPrevent thrombosisDeep vein thromCardiacProtease-activateAcute coronaryAngiotensin-ConvertingAntagonistsDiseaseClopidogrelHuman coronary arteryAntiplateletCABGPlateletsPreventionAbstractRevascularizationLesionsInhibitsP2Y12Endothelial cellsAssaysHemorrhageKinaseInhibitorGraftPatientsUlcerationInhibitorsSignal transductionDrugsAbciximabSevereFormationFetalCongestive heart fTransportersMyeloidSaphenousHeart
Percutaneous coronary int13
- Both studies excluded patients on any other migraine preventative treatment, patients with medication overuse headache, patients with electrocardiogram abnormalities compatible with an acute cardiovascular event and patients with a history of stroke, myocardial infarction, unstable angina, percutaneous coronary intervention, coronary artery bypass grafting, deep vein thrombosis or pulmonary embolism within 6 months of screening. (pharmacytimes.com)
- The main goals of emergency department medical therapy are rapid intravenous thrombolysis and/or rapid referral for percutaneous coronary intervention (PCI), optimization of oxygenation, reduction of cardiac workload, and pain control. (medscape.com)
- It is indicated for reduction of thrombotic cardiovascular events (including stent thrombosis) in patients with acute coronary syndrome (ACS) managed by means of percutaneous coronary intervention (PCI) who have either (a) unstable angina or non-ST-elevation MI (NSTEMI) or (b) ST-elevation MI (STEMI) when managed with primary or delayed PCI. (medscape.com)
- Translational platelet function investigations performed in the percutaneous coronary intervention (PCI)-treated population receiving clopidogrel have identified high platelet reactivity to ADP (HPR) as a major risk factor for both acute as well as long-term ischaemic event occurrence, including stent thrombosis. (lu.se)
- article{583d315e-97a9-42ca-afc7-d0a569800561, abstract = {{Translational platelet function investigations performed in the percutaneous coronary intervention (PCI)-treated population receiving clopidogrel have identified high platelet reactivity to ADP (HPR) as a major risk factor for both acute as well as long-term ischaemic event occurrence, including stent thrombosis. (lu.se)
- Evaluation of Potential Racial Disparities in CYP2C19-Guided P2Y(12) Inhibitor Prescribing After Percutaneous Coronary Intervention. (iu.edu)
- Social deprivation index and ischemic events after percutaneous coronary intervention in patients with diabetes mellitus. (iu.edu)
- Genotype-Guided Antiplatelet Therapy After Percutaneous Coronary Intervention in Diverse Clinical Settings. (iu.edu)
- Impact of the CYP2C19*17 Allele on Outcomes in Patients Receiving Genotype-Guided Antiplatelet Therapy After Percutaneous Coronary Intervention. (iu.edu)
- The UK's drug guidance body has endorsed the use of prasugrel (Efient) in patients with acute coronary syndromes who are undergoing percutaneous coronary intervention. (mims.co.uk)
- [ 53 ] The risk for MI was reduced after percutaneous coronary intervention and noncardiac surgical procedures, but not for coronary artery bypass grafting (CABG). (medscape.com)
- However, endothelium that has regenerated after percutaneous coronary intervention is incompetent in terms of its integrity and function, with poorly formed cell junctions, reduced expression of antithrombotic molecules, and decreased nitric oxide production. (nature.com)
- Eptifibatide is a Platelet Aggregation Inhibitor that is FDA approved for the treatment of acute coronary syndrome ( ACS ), percutaneous coronary intervention ( PCI ). (wikidoc.org)
Stent thrombosis6
- They are used in the management of peripheral artery disease, as well as the prevention of coronary stent thrombosis and strokes. (wikipedia.org)
- Ticagrelor also reduces the rate of stent thrombosis in patients who have undergone stent placement for treatment of ACS, and it is indicated in patients with a history of MI more than 1 year previously. (medscape.com)
- People with CHD who continue to smoke cigarettes after revascularization may have adverse clinical outcomes, including stent thrombosis. (cdc.gov)
- Delayed arterial healing, characterized by poor endothelialization, is the primary cause of late (1 month-1 year postimplantation) and very late stent thrombosis following implantation of drug-eluting stents. (nature.com)
- The incompetent endothelium leads to late stent thrombosis and the development of in-stent neoatherosclerosis. (nature.com)
- Procedure-related elements The level of coronary artery disease (one vessel disease or even more), severe stent thrombosis, located area of the culprit lesion on coronary angiography, and valvular pathologies. (isme-la2019.org)
Atherosclerosis6
- A healthy endothelium provides for an antiadhesive/antithrombogenic surface, which can prevent the development of atherosclerosis and thrombosis. (hindawi.com)
- Coronary heart disease is mainly caused by atherosclerosis in coronary artery. (hizy.net)
- After coronary atherosclerosis, the surface of blood vessels becomes rough, and platelets in blood are easy to gather in rough places to form thrombosis and cause myocardial infarction. (hizy.net)
- The treatment goals for patients with coronary artery atherosclerosis are to relieve symptoms of coronary artery disease (CAD) and to prevent future cardiac events, such as unstable angina, AMI, and death. (medscape.com)
- Large, multicenter randomized trials of various pharmacologic modalities have recently achieved great success in the treatment of patients with coronary artery atherosclerosis. (medscape.com)
- Pathogenic drivers of SVG disease include early thrombosis, neointima formation (NF) and accelerated atherosclerosis. (gla.ac.uk)
Arteries9
- Men with more repeats within the regulatory region of the gene on both alleles had a significantly greater number of severely narrowed coronary arteries ( P = 0.009), larger areas of complicated lesions ( P = 0.008), and more calcifications of the coronary arteries ( P = 0.01) than men who had fewer repeats. (the-scientist.com)
- Since then, techniques for thrombolysis have branched in several directions with the treatment of thrombus and/or thrombosis in the coronary arteries, peripheral vascular and visceral arteries, dialysis grafts, veins, and IV catheters. (medscape.com)
- Increased platelet deposition on atherosclerotic coronary arteries. (thieme-connect.com)
- Overview of Coronary Artery Disease Coronary artery disease (CAD) involves impairment of blood flow through the coronary arteries, most commonly by atheromas. (msdmanuals.com)
- However, these medications may not be the best the coronary arteries. (ameli-perm.ru)
- You may be at greater risk for SCAD cross Coronary angioplasty is used to restore blood flow to the heart when the coronary arteries. (ameli-perm.ru)
- Impairment of vasorelaxation in nonstented proximal and distal segments of stented coronary arteries is more severe with drug-eluting stents than bare-metal stents, and stent-induced flow disturbances resulting in complex spatiotemporal shear stress can also contribute to increased thrombogenicity and inflammation. (nature.com)
- Coronary artery bypass grafting (CABG) is a surgical technique utilised to bypass one or more stenosed coronary arteries to re-establish blood supply to cardiac tissue. (gla.ac.uk)
- In peripheral tissues cocaine creates a sympathomimetic response by inhibiting the reuptake of serotonin (5-HT) and catecholamine resulting in a transient bradycardia accompanied by tachycardia hypertension and severe thrombosis in coronary arteries. (healthy-nutrition-plan.com)
Myocardial infarction6
- Acute Myocardial Infarction (MI) Acute myocardial infarction is myocardial necrosis resulting from acute obstruction of a coronary artery. (msdmanuals.com)
- Unstable Angina Unstable angina results from acute obstruction of a coronary artery without myocardial infarction. (msdmanuals.com)
- Adverse cardiovascular events (composite of cardiovascular death, nonfatal myocardial infarction, resuscitated cardiac arrest, coronary revascularization, hospitalization for angina pectoris, hospitalization for congestive heart failure, fatal or nonfatal stroke or transient ischemic attack, and any new diagnosis of peripheral vascular disease) for the comparison of amlodipine vs. placebo. (acc.org)
- Aspirin, as a common drug taken by patients with coronary heart disease, can prevent platelet aggregation, prevent thrombosis and reduce the risk of myocardial infarction. (hizy.net)
- Generally speaking, the blood pressure of patients with coronary heart disease should be controlled below 130/85 mmHg, which can reduce the occurrence of angina pectoris and myocardial infarction. (hizy.net)
- This can not only enhance their physique, but also is an important measure to reduce the recurrence of myocardial infarction of coronary heart disease. (hizy.net)
Prevent thrombosis2
- Drugs acting on the cardiovascular/respiratory systems: Antihypertensive drugs, antidysrhythmic drugs, drugs used to treat angina, acute coronary syndromes and cardiac failure, lipid lowering drugs, drug used to treat and prevent thrombosis, stroke and "brain killers", drugs used to treat asthma. (manchester.ac.uk)
- Aspirin can inhibit platelet aggregation and prevent thrombosis. (hizy.net)
Deep vein throm1
- Stay hydrated, wear loose-fitting clothing, and walk and stretch at regular intervals during long-distance travel (see Sec. 8, Ch. 3, Deep Vein Thrombosis & Pulmonary Embolism ). (cdc.gov)
Cardiac5
- This drug can help control blood pressure, control heart rate, dilate coronary vessels, improve cardiac ischemia in many ways, and effectively prevent angina pectoris attacks. (hizy.net)
- The past 4 decades have witnessed tremendous progress in the areas of acute cardiac care, coronary care unit expansion, thrombolytic usage, and PCI. (medscape.com)
- Endothelial cell-specific blockade of Nod1 signaling suppressed FK565-induced expression of these chemokines, accumulation of cardiac CD11c + macrophages, and subsequent coronary arteritis development. (elsevierpure.com)
- Conclusions - These results suggest that Ly6C hi monocytes are recruited to FK565-activated endothelial cells to generate cardiac CD11c + macrophages, which play a pivotal role in the pathogenesis of acute coronary arteritis. (elsevierpure.com)
- Genetic Variations Within METTL16 and Susceptibility to Sudden Cardiac Death in Chinese Populations With Coronary Artery Disease. (cdc.gov)
Protease-activate3
- Vorapaxar reversibly inhibits protease-activated receptor 1 (PAR-1) which is expressed on platelets, but its long half-life makes it effectively irreversible. (medscape.com)
- E5555 is a potent protease-activated receptor (PAR-1) antagonist targeting the G-coupled receptor and modulating thrombin-platelet-endothelial interactions. (uea.ac.uk)
- Human platelets express 2 thrombin receptors: protease-activated receptor (PAR)-1 and PAR4. (ashpublications.org)
Acute coronary3
- Another member of the class, rivaroxaban (Xarelto), has been launched for the prevention of post-surgical thromboembolism in Canada and Britain, but as with apixaban, the high stakes are riding on Phase III trials in acute coronary syndrome. (pharmexec.com)
- This agent is indicated to reduce the rate of thrombotic cardiovascular events in patients with acute coronary syndrome (ACS)-that is, unstable angina, non-ST elevation MI (NSTEMI), or ST-elevation MI (STEMI). (medscape.com)
- Three separate papers published online in Neurology on March 30 describe eight cases of acute acalculous cholecystitis (AAC), two cases of hemophagocytic lymphohistiocytosis (HLH), and one occurrence of acute coronary syndrome (ACS), all linked to the drug. (medscape.com)
Angiotensin-Converting1
- Use or nonuse of angiotensin-converting enzyme inhibitors or angiotensin receptor blockers in patients hospitalized for acute heart failure. (escardio.org)
Antagonists2
- Thrombolytic agents have been used alone or with anticoagulants (eg, heparin), platelet-receptor antagonists (eg, abciximab), and plasminogen or thrombin inhibitors (eg, argatroban). (medscape.com)
- Dostinex is in a group of drugs called dopamine receptor antagonists. (my-family-world7.pw)
Disease33
- NEW YORK, July 31 (Praxis Press) Accumulating evidence suggests that oestrogen protects against cardiovascular disease, and oestrogen receptors have been localized to several cell types implicated in the pathogenesis of this disease. (the-scientist.com)
- Previous reports from the Framingham Heart Study suggested a strong positive relationship between coronary heart disease and elevated levels of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels, in addition to an inverse relationship between the disease and high-density lipoprotein cholesterol (HDL-C) levels [ 5 - 8 ]. (cdc.gov)
- CAMELOT was a multicenter, double-blinded, placebo-controlled randomized trial that sought to study the effects of amlodipine or enalapril compared to placebo in normotensive patients with coronary artery disease. (acc.org)
- In this multicenter, randomized clinical trial of amlodipine, enalapril, or placebo among patients with coronary artery disease and relatively normal blood pressures, treatment with amlodipine was associated with a reduction in the composite endpoint of cardiovascular events compared to placebo, largely driven by a reduction in coronary revascularization and hospitalization from angina. (acc.org)
- Translational platelet research in patients with coronary artery disease: hat are the rnalor knowledge gaps? (lu.se)
- However, there is no information regarding the utility of platelet function testing to predict outcomes in patients with stable coronary artery disease and in medically managed patients with acute coronary syndromes. (lu.se)
- Therefore, futher studies are needed to delineate the role of platelet function testing across the spectrum of symptomatic coronary artery disease. (lu.se)
- His research interests include personalized medicine, pharmacogenetics, thrombosis, and therapies for coronary artery disease. (iu.edu)
- I am interested in the effects of genomic or epigenetic variations on coronary thrombosis phenotypes, and use of ex-vivo thrombosis assays in risk stratification of patients with coronary artery disease. (iu.edu)
- MicroRNA sequencing in patients with coronary artery disease - considerations for use as biomarker for thrombotic risk. (iu.edu)
- Reduces the risk of coronary heart disease, with risk falling sharply 1 to 2 years after cessation and then declining more slowly over the longer term. (cdc.gov)
- The drug is currently being tested in phase II trials in patients with coronary artery disease (CAD) and has potential antithrombotic and anti-inflammatory benefits. (uea.ac.uk)
- When there are coronary heart disease, hypertension and other diseases, the heart structure is easy to change and affect the heart function. (hizy.net)
- This drug can reduce the deformation of the heart and prolong the life of patients with coronary heart disease. (hizy.net)
- The importance of controlling hypertension to the prevention and treatment of coronary heart disease is well known. (hizy.net)
- High cholesterol is an important risk factor for coronary heart disease. (hizy.net)
- On the basis of healthy diet, patients with coronary heart disease should also take lipid-lowering drugs. (hizy.net)
- Under the same conditions, the prevalence rate of coronary heart disease in diabetic patients is 2-5 times higher than that in normal blood sugar patients. (hizy.net)
- Thus, how important it is to control diabetes for coronary heart disease patients. (hizy.net)
- Under the guidance of doctors, patients with coronary heart disease can take part in physical exercise appropriately according to their own conditions. (hizy.net)
- Results of the Clopidogrel After Surgery for Coronary Artery Disease (CASCADE) trial confirmed that this practice independently associated with improved graft patency, as demonstrated by coronary angiography and saphenous vein graft intravascular ultrasonography. (medscape.com)
- Management of SIHD includes both non Coronary artery or coronary death each year in the U. A coronary artery is a condition where the disease, infection or injury. (ameli-perm.ru)
- Taking estrogen-containing hormonal contraceptives combined with disorders in the F2 and F5 thrombophilia genes can lead to very dangerous health risks for you: thrombosis, bleeding, cardiovascular disease. (treegene.kz)
- If you or your relatives have had thrombosis, cardiovascular disease, heart attacks, strokes, this test is necessary for YOU to know your risks and be able to minimize them! (treegene.kz)
- We previously reported that a synthetic Nod1 ligand, FK565, induced acute coronary arteritis in mice similar to that of Kawasaki disease. (elsevierpure.com)
- The aim of this study was to examine changes in RNA expression for growth factors, cytokines, and receptors in epidermal-dermal tissues of the bovine claw relative to hostage, claw segment, and disease state of the horn. (unl.edu)
- The results demonstrated changes in disease state and, to a lesser extent, claw segment and were accompanied by alterations in the RNA expression of several cytokines, growth factors, and receptors present in the normal claw. (unl.edu)
- Editorial: Emerging receptors as new targets in health and disease. (uliege.be)
- Genetic Polymorphism of NQO1 Influences Susceptibility to Coronary Heart Disease in a Chinese Population: A Cross-Sectional Study and Meta-Anaylsis. (cdc.gov)
- Polygenic risk score in comparison with C-reactive protein for predicting incident coronary heart disease. (cdc.gov)
- Replacing device-measured sedentary time with physical activity is associated with lower risk of coronary heart disease regardless of genetic risk. (cdc.gov)
- Mode of transport, genetic susceptibility, and incidence of coronary heart disease. (cdc.gov)
- Association of the L3MBTL3 rs1125970 and rs4897367 gene polymorphisms with coronary heart disease susceptibility in the Chinese population: a case-control study. (cdc.gov)
Clopidogrel1
- Clopidogrel selectively inhibits adenosine diphosphate (ADP) binding to platelet receptors and subsequent ADP-mediated activation of glycoprotein GPIIb/IIIa complex, thereby inhibiting platelet aggregation. (medscape.com)
Human coronary artery3
- To determine the effects of medications on SAA-stimulated human coronary artery endothelial cells (HCAEC). (hindawi.com)
- The first report in 2007, on SAA-stimulated human coronary artery endothelial cells (HCAEC), exhibited a substantial and significantly higher induction of released IL-6 protein and mRNA levels as compared to HUVEC [ 17 ], as well as increased responsiveness to IL-1 β [ 18 ]. (hindawi.com)
- The observation of in vivo SMC phenotype switching in pre-implantation SVGs prompted development and generation of a ligand-independent contractile differentiation protocol for primary HSVSMCs and primary human coronary artery (HCA) SMCs. (gla.ac.uk)
Antiplatelet1
- Selective blockade of platelet receptors suggests unique antiplatelet properties of E5555 as a potential addition to current antithrombotic regimens. (uea.ac.uk)
CABG2
- The dynamics of those receptors expression on monocyte surface of patients with uncomplicated SIRS course followed coronary artery bypass surgery (CABG) was studied. (hindawi.com)
- There is an increased risk of bleeding in cases of emergency coronary artery bypass graft (CABG). (medscape.com)
Platelets4
- Prasugrel (Efient) prevents clot formation by binding to the P2Y12 ADP receptor on the surface of platelets, thereby inhibiting platelet activation and aggregation. (mims.co.uk)
- Nonetheless it is normally unclear when the hyper-reactivity of platelets from catecholamine or different pathogenic roots differentially predisposes platelets to thrombosis. (healthy-nutrition-plan.com)
- Particularly DAT may be the principal focus on for cocaine4 5 6 In line with the similarities of the transporters NMS-1286937 and their receptors among platelets and central anxious program the inhibitory aftereffect of cocaine on platelet is normally expected to end up being strong more than enough and elevates their plasma amounts. (healthy-nutrition-plan.com)
- Notably the 5-HT focus in bloodstream plasma is within the reduced nanomolar range however the thick granules of relaxing platelets shop millimolar concentrations of 5-HT10 11 NMS-1286937 The activities of 5-HT are mediated by various kinds of receptors but terminated by way of a one transporter SERT12. (healthy-nutrition-plan.com)
Prevention1
- Dipyridamole medicine for treatment and prevention of thrombosis and thromboembolism, prevention of occlusion of stents and aortocoronary shunts. (my-family-world7.pw)
Abstract1
- abstract = "Objective - Nod1 is an intracellular pattern recognition receptor for bacterial peptidoglycan fragments. (elsevierpure.com)
Revascularization1
- Revascularization for Acute Coronary Syndromes Revascularization is the restoration of blood supply to ischemic myocardium in an effort to limit ongoing damage, reduce ventricular irritability, and improve short-term and long-term outcomes. (msdmanuals.com)
Lesions3
- 2 Badimon L, Vilahur G. Thrombosis formation on atherosclerotic lesions and plaque rupture. (thieme-connect.com)
- The earliest pathologic descriptions of atherosclerotic lesions focused on morphologies of fatty streaks to fibroatheromas (FAs) and advanced plaques complicated by hemorrhage, calcification, ulceration, and thrombosis. (medscape.com)
- A modified version of the AHA classification was developed by our laboratory to include important pathologic lesions responsible for luminal thrombosis other than plaque rupture, such as plaque erosion and calcified nodule. (medscape.com)
Inhibits1
- It is a cyclo-pentyltriazolo-pyrimidine that is distinct from the mechanism of the thienopyridines in that it reversibly (rather than irreversibly) inhibits the P2Y12 receptor. (wikipedia.org)
P2Y122
- Thienopyridines are a class of selective, irreversible ADP receptor/P2Y12 inhibitors used for their anti-platelet activity. (wikipedia.org)
- Ticagrelor and its major metabolite reversibly interact with the platelet P2Y12 ADP-receptor to prevent signal transduction and platelet activation. (medscape.com)
Endothelial cells2
- Vascular endothelial cells normally provide an efficient barrier against thrombosis, lipid uptake, and inflammation. (nature.com)
- Senescent endothelial cells exhibit reduced eNOS activity and NO production,20, 21 and NO has been shown to be protective against the improvement of senescence, an effect which is D4 Receptor Inhibitor Source abrogated by L-NAME treatment.22, 23 Even so, the function of NO and L-NAME in vascular senescence in vivo is uncertain. (adenosine-receptor.com)
Assays1
- In S. Martins & D. Prazeres, G Protein-Coupled Receptor Screening Assays - Methods in Molecular Biology (pp. 149-157). (uliege.be)
Hemorrhage1
- and type VI, complicated plaques with surface defects, and/or hematoma-hemorrhage, and/or thrombosis. (medscape.com)
Kinase2
- TNF-a evokes blood-brain barrier dysfunction through activation of Rho-kinase and neurokinin 1 receptor Immunobiology. (nottingham.ac.uk)
- Whereas TGF-b1 may signal via the activin receptor-like kinase (ALK)5 or ALK1 receptors, BMP-9 mainly signals via the ALK1 receptor. (gla.ac.uk)
Inhibitor1
- Counseling and medication are inhibitor with nicotine receptor antagonist properties. (cdc.gov)
Graft1
- The graft is connected to the blocked coronary. (ameli-perm.ru)
Patients1
- Les antécédents et les examens cliniques de 752 patients consultant dans un centre de recherche sur l'endocrinologie et le métabolisme ont été consignés et des analyses en laboratoire ont été réalisées. (who.int)
Ulceration1
- Epidermal-dermal tissues were collected from the coronary, wall, sole, and bulb segments of 8- to 9-mo-old Holstein fetuses, normal adult cows, and adult cows with sole ulceration. (unl.edu)
Inhibitors1
- ACE inhibitors, angiotensin receptor blockers, and calcium channel blockers were discontinued over a 2-6-week period and were prohibited during the study (with the exception of study medications). (acc.org)
Signal transduction1
- Integrins are heterodimeric, transmembrane receptors that function as mechanosensors, adhesion molecules and signal transduction platforms in a multitude of biological processes. (thno.org)
Drugs1
- Dopamine D2L receptor density influences the recruitment of β-arrestin2 and Gi1 induced by antiparkinsonian drugs. (uliege.be)
Abciximab2
- We investigated, whether GPVI-Fc added in vitro on top of acetylsalicylic acid (ASA), the P2Y 12 antagonist ticagrelor, and the fibrinogen receptor antagonist abciximab alone or in combination would increase inhibition of platelet activation by atherosclerotic plaque. (thieme-connect.com)
- GPVI-Fc added on top of abciximab, a clinically used anti-fibrinogen receptor antibody which blocks platelet aggregation, strongly inhibited total (81%) and stable (89%) platelet adhesion. (thieme-connect.com)
Severe1
- Also within the lack of systemic platelet activation endothelial dysfunction or CV problems cocaine is normally associated with severe thrombosis of coronary arteries1 2 3 nevertheless the system where cocaine predisposes to platelet-dependent thrombus development is normally poorly known. (healthy-nutrition-plan.com)
Formation1
- PECAM-I, GP IIb/IIIa antigen, and activity with PAC-1, GPIb, thrombospondin, vitronectin receptor expression, and formation of platelet-monocyte aggregates were also significantly reduced by E5555. (uea.ac.uk)
Fetal2
- In normal tissues, certain RNA expression levels were clearly affected by hostage: 290.0-, 610.0-, 53.4-, and 8.1-fold greater expression of granulocyte-macrophage colony-stimulating factor was observed in fetal coronary, wall, sole, and bulb segment relative to adult tissues, respectively. (unl.edu)
- A claw segment effect was also observed in that IL-1α expression was greater (1.59-fold) in the normal adult wall relative to the coronary segment, and IL- 18 expression was greater (16.2-fold) in the normal adult sole compared with the coronary segment and 2.88 greater in the fetal sole relative to the bulb segment. (unl.edu)
Congestive heart f1
- Micardis is an angiotensin II receptor blocker which is used to treat high blood pressure (hypertension), congestive heart failure and to protect the kidneys from damage due to diabetes. (my-health-world7.pw)
Transporters1
- Introduction to drug targets: Structure, function and cellular location of ligand-gated channels, voltage gated channels, enzymes, nuclear hormone receptors, transporters and pumps, G-protein coupled receptors. (manchester.ac.uk)
Myeloid1
- Simultaneous stimulation of toll-like receptors (TLRs) and triggering receptor expressed on myeloid cells (TREM-1) activating receptor on monocytes results in the amplification of the inflammatory signal and multiple increase in proinflammatory cytokine production. (hindawi.com)
Saphenous1
- Despite advances in surgical technique and optimised pharmacological treatment, approximately 50% of all saphenous vein grafts (SVGs) fail at 10 years following coronary implantation often requiring potentially life-threatening and costly re-interventions. (gla.ac.uk)