• There can, however, be few similarities between the two, as the bone marrow is a common site of metastasis of solid tumors too [6]. (fortunejournals.com)
  • In cancers, tumor cell-derived exosomal circRNAs can act on target cells or organs through the transport of exosomes, and then participate in the regulation of tumor development and metastasis. (ijbs.com)
  • CD62E may also play a role in the metastasis of certain tumor cells. (bdbiosciences.com)
  • However, the impact of M6P/IGF2R on tumour invasion and metastasis is so far only poorly understood. (boku.ac.at)
  • Future studies will aim at the identification of these anti-invasive M6P-modified protein(s) followed by a comprehensive assessment of their involvement in tumour invasion and metastasis. (boku.ac.at)
  • sis in primary breast cancer patients, toms of metastasis or recurrence and Tumour markers assays with elevated levels reflecting adverse with no other malignant disorders. (who.int)
  • No staging system exists for cancers of unknown primary origin-more precisely, histologically proven metastatic malignant tumors for which the primary site cannot be identified during pretreatment evaluation. (medscape.com)
  • Through the successful modulation of the TME by controlling pH, this has the potential to restore the proper functions of the immune response at tumour sites while decreasing its metastatic potential and sensitizing the tumour to available therapies. (wesparkhealth.com)
  • In addition, patients with cancer of unknown primary origin are defined as patients with histologically proven metastatic malignant tumors in which the primary site cannot be identified during pretreatment evaluation. (medscape.com)
  • After resection of an intracranial tumor, pathology studies suggested metastatic lung adenocarcinoma. (hho-bulgaria.com)
  • The results from this prevali- the field of cancer biomarkers (11-13), and that approach was dation study showed that patients could be classified into high- adopted here to define predictive serum biomarkers associated versus low-risk groups for developing metastatic breast cancer with tumor relapse in breast cancer patients. (lu.se)
  • A technical limitation of CAR-T technology is that it is challenging for CAR T-cells to target solid tumors. (tufts.edu)
  • At the moment, the therapy is most effective against hematological (blood) cancers but not solid tumors. (tufts.edu)
  • To solve this problem, the biopharmaceutical Celyad is developing a CAR-T that expresses Natural Killer Receptors (NKR) that can bind ligands of solid tumors. (tufts.edu)
  • The complexity of the human bone marrow, with context to haematological malignancies, is more difficult to elucidate with the present strategies compared to the niche of solid tumors. (fortunejournals.com)
  • Relevant information has now been established on solid tumors and their micro-environments, which include immune, endothelial and mesenchymal cells. (fortunejournals.com)
  • Other malignancies have occurred, including skin cancers and other solid tumors. (drugs.com)
  • There are multiple therapies being developed to address this challenge, including chimeric antigen receptor (CAR)-T-cell therapy, anticancer vaccines, and therapeutic antibodies. (wesparkhealth.com)
  • Arlen M, Arlen P, Tsang A, Wang X, Gupta R. The Therapeutic Value of Monoclonal Antibodies Directed Against Immunogenic Tumor Glycoproteins. (jcancer.org)
  • Monoclonal antibodies developed against immunogenic proteins (Tumor Specific Antigens/TSA's) that are expressed in human cancers, display a unique behavioral pattern. (jcancer.org)
  • It is required by FDA that the potential effects of tumor control and toxicity be defined using the naked antibodies produced under GMP conditions, In those situations where patients with recurrent malignancies are to be studied we have come to realize that a number of factors can influence the response to monoclonal therapy. (jcancer.org)
  • Some ANTIBODIES and carbohydrate-metabolizing proteins (ENZYMES) also bind to carbohydrates , however they are not considered lectins . (lookformedical.com)
  • The antigen is extracted from the cell in an appropriate lysis buffer, and antibodies are added to the lysate to allow formation of the immune complex. (neuromantics.net)
  • Monoclonal antibodies (mAbs) is usually a promising diagnostic software for antigenic illnesses corresponding to virus an infection, as they provide a excessive specificity towards a particular viral antigen. (kashbiotech.com)
  • Antibodies in opposition to the pink meat-derived carbohydrate N-glycolylneuraminic acid (Neu5Gc) exacerbate most cancers in "human-like" mice. (kashbiotech.com)
  • Transmembrane or otherwise tumor-associated polypeptides specifically expressed on the surface of cancer cells as compared to normal, non-cancerous cell(s) have been identified as cellular targets for cancer diagnosis and therapy with antibodies. (justia.com)
  • Some cytotoxic drugs tend to be inactive or less active when conjugated to large antibodies or protein receptor ligands. (justia.com)
  • The CAR-T receptor of the transgenic T-cell contains three domains: (1) a target-binding domain externally exposed to the extracellular environment, (2) a transmembrane domain, and (3) an activation domain that is intracellularly contained. (tufts.edu)
  • The transmembrane and activation domains of the CAR-T receptor are responsible for activating and triggering T-cell proliferation when the receptor binds to its target antigen. (tufts.edu)
  • This gene encodes a member of the calcium dependent lectin superfamily of type II transmembrane receptors. (unige.ch)
  • Nasal insufflation of IL-11 causes AHR in wild-type mice while lung inflammation induced by antigen sensitization and challenge, which mimics features of atopic asthma in humans, is attenuated in mice genetically deficient in IL-11 receptor subunit alpha-1 (IL-11R1-deficient mice), a transmembrane receptor that is required conjointly with glycoprotein 130 to transduce IL-11 signaling. (cdc.gov)
  • What is very challenging about any sort of immunotherapy, and in particular the checkpoint inhibitors, is that you need to get the treating product or the immune cells into the tumor microenvironment, which in the case of prostate cancer, happens to be the bone. (urologytimes.com)
  • A preparative regimen is needed to remove any inhibitory immune cells, ie, regulatory T cells (Tregs) that may contribute to a hostile tumor microenvironment, thereby providing an intratumoral milieu that blocks immune cell penetration. (urologytimes.com)
  • In accordance, attempts have been made to establish a link between the immune system and the tumor microenvironment, to comprehend tumor progression and achieve effective therapeutic approaches. (fortunejournals.com)
  • These therapies have only achieved limited success, with a major issue being the low (acidic) pH of the tumour microenvironment (TME), which is highly detrimental to immune cells, including T-cells, rendering them less effective. (wesparkhealth.com)
  • Interestingly, preliminary data from the Evans and Engle labs suggest that elevated levels of carbohydrate antigen (CA) 19-9 glycosylation directly cause pancreatitis and stimulate remodeling of the pancreatic microenvironment. (themarkfoundation.org)
  • We will also deliver in vivo data on the fate of SMAPs in the tumour microenvironment. (supramolecular-attack-particles.eu)
  • These changes are thought to lead to tumor-microenvironment interactions via factors secreted by stromal or epithelial cells in response to lymphoma cell-produced cytokines ( 7 ). (spandidos-publications.com)
  • Previous studies have established CA125 as a tumor-microenvironment factor that can be detected and found elevated (above normal 35 U/ml levels) in the serum of up to 40% of FL patients and other NHL patients. (spandidos-publications.com)
  • Persistent DDR induces a permanent proliferation arrest known as replicative senescence, which is thought to function as a tumor suppressor [ 6 - 8 ]. (oncotarget.com)
  • The mannose 6-phosphate/insulin-like growth factor II receptor (M6P/IGF2R) is a multifunctional tumour suppressor which binds a variety of factors that impinge on the proliferation, migration and invasiveness of cancer cells. (boku.ac.at)
  • These studies have revealed that the interaction between M6P/IGF2R and M6P-modified ligands is more important for tumour suppression than its capacity to limit the bioavailability of IGF2. (boku.ac.at)
  • The affinity matured starting antibody has a higher binding specificity and affinity than the target antigen. (patentpc.com)
  • Monoclonals developed from these tumor antigens are in the initial phases of investigation with regard to their specificity and antitumor activity. (jcancer.org)
  • CAR-T treatment involves the infusion of transgenic T-cells that express a Chimeric Antigen Receptor (CAR) on their cell membrane into the patient. (tufts.edu)
  • We are seeing a tremendous amount of interest in using chimeric antigen receptor T [CAR T] cells as an immune approach in prostate cancer. (urologytimes.com)
  • So, among the challenges that everybody's looked at, with regard to chimeric antigen receptor T cells, or armored CAR T cells, which we like to call them sometimes, is that they need to be stable. (urologytimes.com)
  • Molecular cloning, expression, and chromosomal localization of the human earliest lymphocyte activation antigen AIM/CD69, a new member of the C-type animal lectin superfamily of signal-transmitting receptors. (unige.ch)
  • In Sweden, there has been a steady prostate-specific antigen (PSA) velocity for the diagnosis of pros- decrease in age-standardized breast cancer mortality in women up tate cancer (15). (lu.se)
  • The method identifies a similar antibody or portion of an antibody that has a lower activity against the target antigen than its corresponding form. (patentpc.com)
  • Structure of the gene coding for the human early lymphocyte activation antigen CD69: a C-type lectin receptor evolutionarily related with the gene families of natural killer cell-specific receptors. (unige.ch)
  • The C-type lectin receptor CLEC9A mediates antigen uptake and (cross-)presentation by human blood BDCA3+ myeloid dendritic cells. (nih.gov)
  • Molecular characterization of the early activation antigen CD69: a type II membrane glycoprotein related to a family of natural killer cell activation antigens. (unige.ch)
  • Expression cloning of the early activation antigen CD69, a type II integral membrane protein with a C-type lectin domain. (unige.ch)
  • CD 69 antigen of human lymphocytes is a calcium-dependent carbohydrate-binding protein. (unige.ch)
  • Nuclear Receptors the nuclear receptor family consists of two types of receptors that have similar protein structure. (spiritsong.org)
  • Intramolecular carbohydrate-protein interactions. (musicastorrent.com)
  • The protein moiety is the predominant group with the carbohydrate making up only a small percentage of the total weight. (lookformedical.com)
  • Conjugated protein-carbohydrate compounds including mucins , mucoid, and amyloid glycoproteins . (lookformedical.com)
  • In our search for potentially tumour-suppressive M6P/IGF2R interaction partners, we identified an essentially uncharacterized M6P-modified protein previously named Cellular Repressor of E1A-stimulated Genes (CREG). (boku.ac.at)
  • These results establish that CREG is a lysosomal protein that undergoes proteolytic maturation in the course of its biosynthesis, carries the M6P recognition marker and depends on the interaction with M6P receptors for efficient delivery to lysosomes. (boku.ac.at)
  • In this respect, in contrast to predictors based for each serum protein was determined by comparing the samples upon tumor characteristics at the time of surgery, serum is a par- collected at the primary operation and then 3-6 mo later. (lu.se)
  • Gastric cancer (GC) is a common malignant tumor originating from gastric mucosa epithelial cells, and its onset is relatively insidious. (frontiersin.org)
  • We have previously demonstrated that the C-type lectin macrophage galactose-type lectin (MGL), expressed by human antigen presenting cells, can distinguish healthy tissue from CRC through its specific recognition of Tn antigen. (oncotarget.com)
  • SMAPs in human antigen specific CTL killing strategies. (supramolecular-attack-particles.eu)
  • At present, I am maintaining a small but steadily growing collection of carbohydrate antigens to support glycan array development, such as early diagnosis of infectious diseases and cancers. (sinica.edu.tw)
  • Glycan-based DC-SIGN targeting vaccines to enhance antigen cross-presentation. (dc4u-technologies.nl)
  • DC-SIGN mediated antigen-targeting using glycan-modified liposomes: Formulation considerations. (dc4u-technologies.nl)
  • Singh, SK, Streng-Ouwehand I, Litjens M, Kalay H, Saeland E and VAN KOOYK Y. Tumour -associated glycan modifications of antigen enhance MGL2 dependent uptake and MHC class I restricted CD8 T cell responses. (dc4u-technologies.nl)
  • Glycan modificatio of the tumor antigen gp100 targets DC-SIGN to enhance dendritic cell induced antigen presentation to T cells. (dc4u-technologies.nl)
  • Glycolipids are important for cell recognition, and are important for modulating the function of membrane proteins that act as receptors. (wikipedia.org)
  • Additionally, they can serve as receptors for cellular recognition and cell signaling. (wikipedia.org)
  • Lectins, or proteins that bind carbohydrates, can recognize specific oligosaccharides and provide useful information for cell recognition based on oligosaccharide binding. (wikipedia.org)
  • In innate immunity, immune cells are activated by their pattern recognition receptors (PRRs), which bind to pattern molecules of invading pathogens. (fortunejournals.com)
  • This includes the early recognition of these immunogenic membrane proteins that can serve as diagnostic markers, and the targeting of such markers for the destruction of the tumor, primarily thru ADCC. (jcancer.org)
  • However, a variety of lectins occur in animal species where they serve diverse array of functions through specific carbohydrate recognition. (lookformedical.com)
  • ELAM-1 mediates cell adhesion by recognition of a carbohydrate ligand, sialyl-Lex. (bdbiosciences.com)
  • Aarnoudse CA, Vallejo JJ, Saeland E and VAN KOOYK, Y. Recognition of tumor glycans by antigen-presenting cells. (dc4u-technologies.nl)
  • Compared with traditional histological biopsy, the liquid biopsy technique developed in recent years to detect circulating tumor markers in body fluids has attracted increasing attention in early diagnosis of tumors and detection of therapeutic effects. (ijbs.com)
  • ABSTRACT The value of serum tumour markers in the prognosis of patients with breast cancer is controversial. (who.int)
  • This prospective study in Yazd, Islamic Republic of Iran, assessed the value of the tumour markers carcinoembryonic antigen (CEA) and cancer antigen (CA) 15-3 in 159 patients with primary breast cancer. (who.int)
  • 90%) than has previously been achieved with either conventional tumour markers or a micro RNA panel," Dr Lerch and colleagues say. (medscape.com)
  • Galectins are a family of proteins that bind to carbohydrates on the surface of cells, regulating the amount of leukocytes through of apoptotic and non-apoptotic mechanisms being galectin-3 the most well studied of these lectins. (fapesp.br)
  • PLANT LECTINS are carbohydrate-binding proteins that have been primarily identified by their hemagglutinating activity (HEMAGGLUTININS). (lookformedical.com)
  • Bevilacqua MP, Stengelin S, Gimbrone MA Jr, Seed B. Endothelial leukocyte adhesion molecule 1: an inducible receptor for neutrophils related to complement regulatory proteins and lectins. (bdbiosciences.com)
  • This includes the amount of shed antigen in the serum at the time of treatment that could initiate immune complex formation as well as the shedding of inhibitory material into the serum possibly effecting an immune response. (jcancer.org)
  • Recent clinical evidence suggests that high serum levels of the tumor‑produced mucin 16 (MUC16) and cancer antigen 125 (CA125) have a negative impact on the effectiveness of RTX clinical activity in up to 40% of patients with follicular lymphoma. (spandidos-publications.com)
  • High serum level of CA125 is used as an indicator of tumor abdominal involvement, advanced staging, relapse rates and survival in NHL patients ( 8 - 12 ). (spandidos-publications.com)
  • The adhesion between endothelial CD62E molecules and a carbohydrate ligand on neutrophils is inhibited by the mAb 68-5H11. (bdbiosciences.com)
  • As a step towards their identification, we have recently established the individual importance of the different ligand-binding sites of the receptor for its anti-invasive properties. (boku.ac.at)
  • Here we demonstrate that by using glycopeptides with high affinity for the major histocompatibility complex and glycosylated in a position corresponding to a critical T cell receptor (TcR) contact, it is possible to induce anti-TACA CTL in vivo. (silverchair.com)
  • Monoclonals that we were able to develop from tumor specific proteins derived from colon and pancreas cancer were found capable of targeting those tumors to induce apoptosis. (jcancer.org)
  • Significantly, the co-administration of Freund's adjuvants with vaccine 1 was suggested to cause splenomegaly, containing increased variety of myeloid cells, which can include immature MDSCs or monocytes, to suppress expansion/differentiation into effector T cells and B cells (Fig. TACAs used in scientific trials are little T cell-independent antigens, they display poor immunogenicity and cannot induce immunoglobulin (Ig) course switching. (lavoixdesrroms.org)
  • The TLR family members is split into generally two groups, that have intracellular and extracellular receptors.13,21C23 Especially, TLR-1, TLR-6 and TLR-2, which are from the former TLRs, have a tendency to induce humoral immune system replies, whereas intracellular TLRs improve Th1 and cellular immune system responses. (lavoixdesrroms.org)
  • Molecular Biology of the Channel Catfish Gonadotropin Receptors: 2. (biolreprod.org)
  • Elucidating the cellular and molecular mechanisms though which bile acids impact tumor growth has the potential to reveal novel avenues for therapeutic intervention in not only PDA, but also other gastrointestinal malignancies. (themarkfoundation.org)
  • Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories. (lookformedical.com)
  • The present study demonstrated that CA125 could bind to RTX and reduce its tumor cell killing activity. (spandidos-publications.com)
  • Transcriptional regulation of the gene encoding the human C-type lectin leukocyte receptor AIM/CD69 and functional characterization of its tumor necrosis factor-alpha-responsive elements. (unige.ch)
  • Activated endothelial cells upregulate surface CD62E expression in response to various activators including inflammatory cytokines such as Interleukin-1 and Tumor Necrosis Factor. (bdbiosciences.com)
  • In biology, glycosylation is the process by which a carbohydrate is covalently attached to an organic molecule, creating structures such as glycoproteins and glycolipids. (wikipedia.org)
  • Saeland E, Belo A.I., Mongera S., van Die I, Meijer GA and VAN KOOYK Y. Differential glycosylation of MUC1 and CEACAM5 between normal mucosa and tumour tissue of colon cancer patients. (dc4u-technologies.nl)
  • however, despite its prevalence in FL and other cancers, the role of CA125 in tumor biology and immunity has been only recently elucidated. (spandidos-publications.com)
  • Latest findings: A number of ADCs with varied goal antigens have been investigated in ovarian, cervical, and endometrial most cancers. (kashbiotech.com)
  • Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. (cusabio.com)
  • The PD-1 and CTLA-4 are members of the CD28 receptor family. (fapesp.br)
  • before resection of the primary tumor and then postoperatively every 6-12 mo, resulting in three to five samples per patient. (lu.se)
  • No. 4,975,278) allows targeted delivery of the drug moiety to tumors, and intracellular accumulation therein, where systemic administration of these unconjugated drug agents may result in unacceptable levels of toxicity to normal cells as well as the tumor cells sought to be eliminated (Baldwin et al (1986) Lancet pp. (justia.com)
  • Due to the unobvious early symptoms and the influence of some adverse factors such as tumor heterogeneity and low immunogenicity, patients with advanced gastric cancer (AGC) cannot benefit significantly from treatments such as radical surgical resection, radiotherapy, chemotherapy, and targeted therapy. (frontiersin.org)
  • As such we plan to eventually employ the therapeutic mAbs in combination with chemotherapy as a means of enhancing the immunogenicity of the tumor system being treated and to possibly weaken the malignant growth for easier destruction by the mAb. (jcancer.org)
  • Sixty-eight patients (45 males, 23 females) were studied in order to assess the usefulness of mucosal tissue concentrations of both carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) in detecting patients at high risk for gastric cancer. (cnr.it)
  • Carcinoembryonic antigen (CEA) Sample and study design years of follow-up. (who.int)
  • Their response involves antigen capture, enhancing their MHC-II presentation receptors and production of chemokines and/or cytokines at the site of inflammation [9]. (fortunejournals.com)
  • Immunotherapy requires both overcoming the mechanisms by which cancer cells circumvent immune surveillance as well as re-sensitizing the tumour to inflammation, for example, training the immune system to recognize cancer-related antigens and making 'invisible' cells visible to the immune system. (wesparkhealth.com)
  • Self-adjuvanting vaccines, the conjugates of immunoenhancers and antigens, are anticipated to stimulate antigen-specific immune system responses without extreme inflammation.6C8 Furthermore, they possess well-defined structures and facilitate quality control of vaccine products hence. (lavoixdesrroms.org)
  • Elevated cell-surface expression of truncated carbohydrate structures such as Tn antigen (GalNAcα-Ser/Thr) is frequently observed during tumor progression. (oncotarget.com)
  • With the ability of the mAbs to demonstrate therapeutic antitumor activity in those patients with relatively advanced malignancies, the term tumor specific was introduced. (jcancer.org)
  • CD86 expression is modest in resting B cells, but it rises in response to BCR, CD40, IL-4R, LPS receptor, or 2-adrenergic receptor stimulation. (cusabio.com)
  • In most cases, histopathologic analysis will permit classification of these tumors into those with a favorable prognosis, which are mostly approached with locoregional treatment or systemic platinum-based chemotherapy, or an unfavorable prognosis, which are treated with empirical combination regimens involiving platinum or taxane. (medscape.com)
  • CA 19-9 primes pancreatic ductal cells for bile acid signaling that acts via the farnesoid X nuclear receptor (FXR). (themarkfoundation.org)
  • Glycoproteins are relevant as cell-surface receptors, cell-adhesion molecules, immunoglobulins, and tumor antigens. (wikipedia.org)
  • β-Agarase I digests agarose, releasing trapped DNA and producing carbohydrate molecules which. (neuromantics.net)
  • The molecule HLA-G is reported as a modulator of extracellular signaling by interacting with inhibitory receptors found on immune cells. (fapesp.br)
  • Soluble recombinant CD69 receptors optimized to have an exceptional physical and chemical stability display prolonged circulation and remain intact in the blood of mice. (unige.ch)
  • In mammals, transport of CREG to these compartments was shown to rely on the M6P receptor pathway as typical for soluble lysosomal proteins. (boku.ac.at)
  • Other challenges to this therapy include knowing the affinity of the CAR T cell for the antigen in question.Clearly, prostate-specific membrane antigen, or PSMA, has been a focal target for a variety of different approaches, including immunological approaches with vaccines and antibody-drug conjugates in addition to CAR T cells, and more recently, a theranostic approach with 177-lutetium PSMA-617. (urologytimes.com)
  • Provided herein are rational methods of affinity maturation to evolve an antibody's activity or a portion thereof based upon the structure/affinity/activity relationship of an antigen. (patentpc.com)
  • Key evidence showing that ADCC plays an important role in the clinical effect of RTX was provided by the analysis of Fc gamma RIIIa (CD16a) polymorphisms, where patients carrying CD16a 158V/V genotype (associated with high affinity Fc gamma receptor) showed significantly improved objective response rates compared with FL patients carrying at least one 158F allele (associated with low affinity Fc gamma receptor) ( 20 ). (spandidos-publications.com)
  • TACA-containing glycopeptides are appealing cytotoxic T cell (CTL)-based vaccines to prevent or treat cancer because the same sugar moieties are expressed in a variety of tumors, rendering a vaccination strategy applicable in a large population. (silverchair.com)
  • In the current study we show that designer glycopeptides containing the Thomsen-Freidenreich (TF) antigen (β-Gal-[1→3]-α-GalNAc- O -serine) are immunogenic in vivo and generate TF-specific CTL capable of recognizing a variety of tumor cells in vitro including a MUC1-expressing tumor. (silverchair.com)
  • Because of these encouraging results, we applied the same antigenic strategy to TACA-containing glycopeptides because induction of a degenerate T cell response against this class of tumor antigens may be of great advantage in cancer immunotherapy ( 10 - 12 ). (silverchair.com)
  • I also collaborate with researchers in the area of carbohydrate-based vaccine development and glycopeptides synthesis. (sinica.edu.tw)
  • A lot of what we've done has been predicated on various immunologic approaches that included carbohydrate, DNA, and naked DNA vaccines, as well as antibody drug conjugates directed against a variety of cell surface targets. (urologytimes.com)
  • These transgenic T-cells are then infused back into the patient to specifically target tumor cells. (tufts.edu)
  • When activated, the T-cells mediate killing of tumor cells by two mechanisms: (1) secretion of granzymes and (2) activation of death receptor signaling in the tumor cell. (tufts.edu)
  • These killing strategies are potentiated by additional signaling receptors on the T-cells that can improve T-cell proliferation and cytokine release. (tufts.edu)
  • Genes are inserted encoding a PSMA-targeted Centyrin CAR with an iCasp9-based safely switch and DHFR to purify CAR T Cells.These T stem cell memory cells have bone marrow homing capability that may be particularly relevant to bone tropic tumors, such as prostate cancer. (urologytimes.com)
  • Importantly, the benefit of this platform is that it will provide immunologic memory such that the CAR T cells will persist at the site of tumor, leading to more time for the cell to elicit an antitumor response. (urologytimes.com)
  • Because tumor-derived, cell-free DNA (cfDNA) is often released from cancer cells and circulates in the bloodstream, we hypothesized that breast cancer development is associated with changes in the amount of telomeric cfDNA that can be detected in the plasma. (oncotarget.com)
  • Regulatory T cells (Treg) from CD4+ CD25+, actively suppress the immune response against self antigens, alloantigens and tumor antigens, promoting tolerance antigen-specific suppression of activation and expansion of effectors cells, and the transcription factor Foxp3 marker as well characterization of this lineage. (fapesp.br)
  • We will further define the specific receptors interactions available to SMAPs and whether they target particular proteins, lipid, or carbohydrate components on the surface of tumour cells. (supramolecular-attack-particles.eu)
  • CD20 is a B-cell-specific antigen expressed on malignant FL cells. (spandidos-publications.com)
  • CLEC9A is a group V C-type lectin-like receptor (CTLR) that functions as an activation receptor and is expressed on myeloid lineage cells (Huysamen et al. (nih.gov)
  • Identification of such tumor-associated cell surface antigen polypeptides, i.e. tumor associated antigens (TAA), allows specific targeting of cancer cells for destruction via antibody-based therapies. (justia.com)
  • The use of antibody-drug conjugates (ADC), i.e. immunoconjugates, for the local delivery of cytotoxic or cytostatic agents, i.e. drugs to kill or inhibit tumor cells in the treatment of cancer (Lambert, J. (2005) Curr. (justia.com)
  • We have now demonstrated that reconstitution of functional M6P/IGF2R expression in receptor-deficient murine cancer cells severely compromises their invasive potential. (boku.ac.at)
  • Joshi MD, Unger WJ, Storm G, van Kooyk Y, Mastrobattista E. Targeting tumor antigens to dendritic cells using particulate carriers. (dc4u-technologies.nl)
  • Unger WWK and VAN KOOYK Y. 'Dressed for success' C-type lectin receptors for the delivery of glycovaccines to dendritic cells. (dc4u-technologies.nl)
  • van Vliet SJ, Gringhuis SI, Geijtenbeek TB and VAN KOOYK, Y. Regulation of effector T cells by antigen-presenting cells via interaction of the C-type lectin MGL with CD45. (dc4u-technologies.nl)
  • Therefore, a person with A blood type will have the A antigen and H antigen present on the glycolipids of the red blood cell plasma membrane. (wikipedia.org)
  • The target-binding domain is engineered to be structurally different than endogenous T-cell receptors because it recognizes antigens that are independent of major histocompatibility complex (MHC) antigens. (tufts.edu)
  • Instead, CAR-T recognizes antigens that are either proteins, carbohydrates, or gangliosides on the tumor cell surface. (tufts.edu)
  • The crystal structure of human and murine T cell receptors (TcRs) specific for immunodominant viral peptides presented to cytotoxic T cell (CTL) suggests that the central region of the peptide is critical for TcR contacts and that aromatic rings are accommodated in a small cavity determined by the variable CDR3 region of the TcR ( 7 , 8 ). (silverchair.com)
  • The retroviral vector transduced final CAR T cell product was often unstable, reaching the tumor-stromal interface, yet not moving beyond into the tumor. (urologytimes.com)
  • Crystal structure of the C-type lectin-like domain from the human hematopoietic cell receptor CD69. (unige.ch)
  • The SMAPs from the tumour cell point of view. (supramolecular-attack-particles.eu)
  • Biotinylated anti-CD3ε, anti-T-cell receptor (TCR)αβ, anti-Thy-1.2, and anti-Mac-1 (CD11b) were detected by streptavidin-Cy5 (Jackso. (neuromantics.net)
  • Leucocyte typing VI : white cell differentiation antigens : proceedings of the sixth international workshop and conference held in Kobe, Japan, 10-14 November 1996. (bdbiosciences.com)
  • Leucocyte typing V : white cell differentiation antigens : proceedings of the fifth international workshop and conference held in Boston, USA, 3-7 November, 1993. (bdbiosciences.com)
  • Conjugation with Th epitopes can stimulate T cell-dependent immune system responses, such as for example antigen-specific B cell IgG and activation class switching. (lavoixdesrroms.org)
  • Identification of DC-SIGN, a novel dendritic cell specific ICAM-3 receptor that supports primary immune responses. (dc4u-technologies.nl)
  • As of now, research teams have designed third-generation CAR-Ts that contain costimulatory receptors that ameliorate antitumor activity and proinflammatory cytokine secretion. (tufts.edu)
  • B7-2 homodimer interface mimotopes prevent superantigen lethality by blocking the superantigen-host costimulatory receptor interaction. (cusabio.com)
  • The monoclonals (mAbs) that we have developed against specific immunogenic tumor membrane proteins have been studied in detail. (jcancer.org)
  • Using a cohort of 386 colon cancer patients we demonstrate that high MGL binding to stage III tumors is associated with poor disease-free survival, independent of microsatellite instability or adjuvant chemotherapy. (oncotarget.com)
  • Through testing an enzymatically resistant, cancer-targeting, modulator based on carbohydrate imaging that restores physiological pH, this could potentiate other cancer therapies and resolve the issue around the pH of TME. (wesparkhealth.com)
  • However, there are still few mature biomarkers available to guide clinical practice, so it is urgent to investigate novel stable and reliable tumor biomarkers in cancer research. (ijbs.com)
  • At present, the detection of a specific circRNA in fluid exosomes of cancer patients provides new ideas and research methods for liquid biopsy of tumors [ 9 ]. (ijbs.com)
  • La présente étude prospective à Yazd (République islamique d'Iran) a évalué la valeur des marqueurs tumoraux tels que l'antigène carcino-embryonaire et l'antigène carbohydrate 15-3 chez 159 patientes ayant reçu un premier diagnostic de cancer du sein. (who.int)
  • The biomarker signature includes 9 metabolites as well as the carbohydrate antigen 19-9 (CA19-9), which is currently the only blood-based biomarker in clinical use for pancreatic cancer. (medscape.com)
  • Interleukin-11 receptor subunit alpha-1 is required for maximal airway responsiveness to methacholine following acute exposure to ozone. (cdc.gov)
  • Proteins which contain carbohydrate groups attached covalently to the polypeptide chain. (lookformedical.com)
  • CC is the second commonest primary liver tumour worldwide, after hepatocellular carcinoma (HCC). (bmj.com)