Pyrazol-5-one derivative 2 was exploited as a key intermediate for the synthesis of hitherto unknown fused pyrazole. (biomedcentral.com)
External electrolyte-free electrochemical one-pot cascade synthesis of 4-thiocyanato-1 H -pyrazoles[J]. Chinese Chemical Letters , 2023, 34(2): 107640. (ccspublishing.org.cn)
Importantly, both a gram-scale synthesis of 4-thiocyanato-1 H -pyrazoles and five one-pot sequential transformations starting from hydrazine were successfully accomplished. (ccspublishing.org.cn)
Although numerous studies have been published on the synthesis of thiocyanatopyrazoles through thiocyanation of pyrazoles ( Scheme 1a ) [ 39 - 45 ], an efficient protocol for both the construction of pyrazole scaffold and the incorporation of thiocyanato group in a single-step reaction has not been reported. (ccspublishing.org.cn)
Multicomponent synthesis of 4-thiocyanato-1 H -pyrazoles. (ccspublishing.org.cn)
However, to the best of our knowledge, the electrochemical cascade synthesis of 4-thiocyanato-1 H -pyrazoles has not been reported. (ccspublishing.org.cn)
Standard approaches to the scaffold require multi-step synthesis of the ATP bioisostere followed by phosgene or triphosgene-mediated coupling with the substituted pyrazole group. (sagepub.com)
Imidazoles, Pyrroles, Pyrazoles, Pyrrolidines;Biochemistry;Reagents for Oligosaccharide Synthesis;Highly Purified Reagents;Other Categories;Zone Refined Products;Buffer;ACS Grade Buffers;ACS Grade;Biological Buffers;Buffers A to Z;Building Blocks;C3 to C8;Chemical Synthesis;Essential Chemicals;Heterocyclic Building Blocks;Imidazoles;Inorganic Salts;Research Essentials;Solutions and Reagents;Intermediate for Propafenone hydrochloride. (lookchem.com)
Pyridine2
Two series of new tetracyclic pyrazolo[3,4-b]pyridine-based coumarin chromophores were synthesized through a facile reaction between 3-aldehyde-7-diethylaminocoumarin (5) or 3-acetyl-7-diethylaminocoumarin (6) and 5-amino pyrazole derivatives (7) in a one-pot procedure. (idexlab.com)
Alkaline of imidazole is slightly stronger than pyrazole and pyridine. (lookchem.com)
Derivatives were synthesized2
In this study, 20 novel disazo dyes containing pyrazole derivatives were synthesized by a convenient method. (idexlab.com)
A new series of (E)-4-((4-substitutedphenyl)diazenyl)-1H-pyrazole-3,5-diamine derivatives were synthesized by using greener poly ethylene glycol-400 as a reaction solvent. (chemmethod.com)
Aqueous3
The dinuclear cation [(eta(6)-C6Me6)(2)Ru-2(mu(2)-H)(3)](+) (1) reacts in aqueous solution with pyrazole and 4-methylpyrazole to give the bispyrazolato complexes [(eta(6)-C6Me6)(2)Ru-2(mu(2)-H)(mu(2)-eta(1),eta(1)-N2C3H2R)(2)](+) (R = H: 2, R = Me: 3). (unine.ch)
Interesting protocol for the iron-catalyzed coupling of pyrazoles in aqueous medium. (galchimia.com)
The authors have developed a protocol to carry out the iron-catalyzed coupling of pyrazole with aryl iodides in aqueous medium, as a way to overcome the problems found with solventless conditions. (galchimia.com)
Diazenyl1
CH-223191 (1-Methyl-N-[2-methyl-4-[2-(2-methylphenyl) diazenyl] phenyl-1H-pyrazole-5-carboxamide) was from Tocris Bioscience (Minneapolis, MN). (cancerhugs.com)
Substrates2
Some nitrogen-containing heteroaryl iodides are also used as substrates, and the amine partners can be not only pyrazole, but indole, azaindole, or carbazole, among others. (galchimia.com)
then reacting with unsaturated substrates to generate the carboxylated organic radicals. (nso-journal.org)
Iodide3
By using three mol from the more active catalyst PEPPSI-iPent38 at 60 C, it was feasible to react a hugely functionalized iodide containing an a,b-unsaturated amide, offering the polyfunctional product 10j in 57 yield. (btkinhibitor.com)
In a typical reaction, aryl iodide and pyrazole are reacted with FeCl 3 ·6H 2 O (10 mol%), trans - N , N '-dimethyl-1,2-diaminocyclohexane (20 mol%), and K 3 PO 4 ·H 2 O in water at 135 °C. The scope of the reaction seems to be good, allowing different groups in the aryl iodide. (galchimia.com)
Pyrazole or isoxazole derivatives are prepared by a palladium-catalyzed four-component coupling of a terminal alkyne, hydrazine (hydroxylamine), carbon monoxide under ambient pressure, and an aryl iodide. (tracks-movie.com)
Aryl1
Chemical ScienceEdge Write-up was successfully performed with a selection of various functionalized aryl (14a4c), a 3-thienyl (14d) plus a benzoyl substituent (14e) in the 2-position from the 1H-imidazo[1,2-b]pyrazole scaffold. (btkinhibitor.com)
Compounds3
Since most of the pyrazole derivatives show anti-microbial activity, the synthesized compounds are also expected to show antimicrobial activity. (biomedcentral.com)
Different condensed products were obtained from compounds 5 and 6, and the potential reaction mechanism was studied using the reaction of 5 with 5-amino- 1-Phenyl pyrazole (7a). (idexlab.com)
Diazotized compounds of 2(a-e)and 3(a-e) reacted with ethylacetoacetate to give 4-arylazo-3-amino-1 H- pyrazole -5-ylazo-ethylacetoacetate 4(a-e) and 4-arylazo-3-amino- 1-Phenyl pyrazole -5-ylazo-ethylacetoacetate 7(ae). (idexlab.com)
Acetamide1
we have synthesized N -2-benzamido-phenyl-5-methyl-pyrazol-3-yl acetamide by reacting benzoyl chloride with N -2-amino-phenyl-5-methyl-pyrazol-3-yl acetamide. (iucr.org)
Biological2
Pyrazoles are important moieties as building blocks for many heterocyclic products and act as abinucleophile [ 2 ] with abroad spectrum of remarkable biological activities. (biomedcentral.com)
Among various functionalized pyrazoles, diverse biological and pharmacological activities of thiocyanatopyrazoles have driven organic chemists to make effects to synthesize such molecules. (ccspublishing.org.cn)
Reaction2
Subsequently, the product of the previous reaction was reacted with hydrazine derivatives (a-e) to give pyrazole derivatives (7a-e). (derpharmachemica.com)
A practical synthetic method for 4-thiocyanato-1 H -pyrazoles through the electrochemical cascade reaction of hydrazines, 1, 3-diones and NH 4 SCN under metal-, chemical oxidant- and external electrolyte-free conditions was established. (ccspublishing.org.cn)
Spectral1
These novel synthesized disazo pyrazole disperse dyes were characterized by elemental analysis and spectral methods . (idexlab.com)
Subsequently2
subsequently, the produced salt was reacted with chloroacetylchloride to produce 2-chloro-1-(2-(methylthio)-1H-benzo[d]imidazol-1-yl)ethanone as starting compound (2). (derpharmachemica.com)
Hence, our plan is to synthesize some substituted pyrazole derivatives and subsequently screen for their antimicrobial activity. (biomedcentral.com)
Give3
The electron-deficient cluster (mu(2)-H)Ru-3(CO)(9)[mu(3)-NS(O)MePh] (1) reacts with the terminal alkyne PhCH2C=CH to give the vinyl complex Ru-3(mu(2)-CO)(2)(CO)(6)[mu(3)-NS(O)MePh](mu(2)-eta(1),eta(2)-PhCH2C=CH2 ) (2). (unine.ch)
Diazotized aniline and some aniline derivatives were reacted with malononitrile to give 2-arylazomalononitrile derivatives 1(a-e). (idexlab.com)
Isoxazoles unsubstituted in the 3-position react with hydroxide or ethoxide ions to give β-keto nitriles 358 → 359. (tracks-movie.com)
Isoxazoles2
The carbon-aluminum bond is still able to react further with several electrophiles, without the need of transmetalation providing a straightforward access to 3,4,5-trisubstituted isoxazoles and 1,3,4,5-tetrasubstituted pyrazoles. (organic-chemistry.org)
5-amino-4-arylazo-3-methyl- 1-Phenyl pyrazole s (2a-k) were diazotised and coupled with 5-hydroxy-3-methyl-1H- pyrazole and 5-hydroxy-3-methyl- 1-Phenyl pyrazole to generate two series disazo pyrazole disperse dyes (3a-k and 4a-k). (idexlab.com)
Afford1
The synthesized 2-arylazomalononitrile derivatives were reacted with hydrazine and phenyl hydrazine to afford the corresponding 3,5-diamino-4-arylazo-1 H- pyrazole 2(a-e) and 3,5-diamino-4-arylazo- 1-Phenyl pyrazole 3(a-e). (idexlab.com)
Abstract1
[email protected] (M.G.) * Correspondence: [email protected] Abstract: Functionalized pyrazole-urea scaffolds are a common type II chemotype for the inhibition of protein kinases (PKs), binding simultaneously into the ATP-binding pocket with an ATP bioisostere and into a vicinal allosteric pocket with a pyrazole group. (sagepub.com)
Intermediate1
Midazo[1,2-b]pyrazoles of type 7.Therefore, the cyano-substituted 1H-imidazo[1,2-b]pyrazole 7b was magnesiated to produce the metalated intermediate 17, which was then effectively reacted having a range of electrophiles in 579 yield (10a0j). (btkinhibitor.com)
Absorption ability and tautomeric structure of synthesized disazo pyrazole disperse dyes substituted with electron-withdrawing and electron-donating groups at their o, m- and p-positions were also examined in detail. (idexlab.com)
This heterocyclic organometallic was then allylated with allyl bromide within the presence of 20 mol CuCN 2LiCl toSelective metalation with the 1H-imidazo[1,2-b]pyrazole 7b applying TMPMgCl LiCl (eight) followed by electrophile trapping top to 3substituted 1H-imidazo[1,2-b]pyrazoles of kind 10.Scheme2021 The Author(s). (btkinhibitor.com)
Human1
This download might n't react human to be. (cdmw.de)
Water1
The asymmetric unit of the title compound, C 19 H 18 N 4 O 2 ·H 2 O, comprises the U-shaped pyrazole derivative and a solvent water mol-ecule. (iucr.org)
Activity1
The pyrazole-3-carboxamide derivatives (which are formally considered as 4-deaza-analogues of ribavirin) have shown activity against T-cell lymphocytes and influenza viruses in vitro . (news-medical.net)