Reactivity amines. Medical search. Frequent questions

Aromatic amines have the nitrogen atom connected to an aromatic ring as in anilines . (newworldencyclopedia.org)
One organic reaction involving aromatic amines is the Goldberg reaction. (newworldencyclopedia.org)
The aromatic amines, such as aniline , have their lone pair electrons conjugated into the benzene ring, thus their tendency to engage in hydrogen bonding is diminished. (newworldencyclopedia.org)
The ligands were synthesized from 1-tetralone and different aromatic amines in refluxing toluene. (chemistryviews.org)
The desired products were formed in excellent yields from aromatic amines as well as thiophene- or furan-based amines. (chemistryviews.org)
Aromatic amines on treating with nitrous acid at low temperatures to form diazonium salts which are used in the synthesis of a variety of aromatic compounds. (topperlearning.com)
So direct oxidation of aromatic amines is not useful since it gives tarry oxidation products along with some nitro derivatives. (topperlearning.com)

Therefore, for laboratory purposes, N-alkylation is often limited to the synthesis of tertiary amines. (wikipedia.org)
N-alkylation is a general and useful route to quaternary ammonium salts from tertiary amines, because overalkylation is not possible. (wikipedia.org)
Secondary amines have two organic substituents bound to N together with one H. In tertiary amines all three hydrogen atoms are replaced by organic substituents. (newworldencyclopedia.org)
Secondary and tertiary amines do not show this reaction. (topperlearning.com)
Secondary and tertiary amines react with nitrous acid in a different manner. (topperlearning.com)
Tertiary amines do not react with benzenesulphonyl chloride. (topperlearning.com)
The reaction of amines with benzenesulphonyl chloride in a different manner is used for the distinction of primary, secondary and tertiary amines. (topperlearning.com)
The radical generation occurs via hydrogen abstraction by the action of a co-initiator such as tertiary amines. (igmresins.com)

SIV infections were initially identifi ed on the basis functionalized fl uorescent polystyrene beads (Luminex of cross-reactivity with HIV antigens ( 8 ), but to increase Inc.) by using the Bio-Plex Amine Coupling Kit (Bio- sensitivity, SIV lineage-specifi c ELISAs have been Rad Laboratories, Marnes-la-Coquette, France) according developed. (cdc.gov)
Species cross-reactivity must be investigated individually for each product. (medchemexpress.com)
This review explores evolving knowledge of the immunopathogenic mechanisms, pharmacogenomic associations, in vivo and ex vivo diagnostics for causality assessment, and medication cross-reactivity data related to SCAR syndromes. (medscape.com)
[ 4 ] The aim of this article is to provide a complementary review of emerging immunopathogenic mechanisms, established pharmacogenomic associations, in vivo and ex vivo causality assessment tools and medication cross-reactivity data related to SCAR syndromes. (medscape.com)

Most aliphatic amines display some solubility in water, reflecting their ability to form hydrogen bonds. (newworldencyclopedia.org)
Aliphatic amines display significant solubility in organic solvents , especially polar organic solvents. (newworldencyclopedia.org)
Aliphatic amines showed a lower reactivity and required a higher reaction temperature and a longer reaction time. (chemistryviews.org)
The diastereomers derived from some aliphatic amines were resolved by a reversed-phase chromatography with water-acetonitrile or normal-phase chromatography with n-hexane-ethyl acetate as the eluent. (unboundmedicine.com)
Primary aliphatic amines react with nitrous acid to form aliphatic diazonium salts. (topperlearning.com)

The reactions are complicated by the tendency of the product (a primary amine or a secondary amine) to react with the alkylating agent. (wikipedia.org)
Among others they react with amines giving amidines as the products. (springer.com)
Primary amines react with ketones such as acetone , and most amines are incompatible with chloroform and carbon tetrachloride. (newworldencyclopedia.org)
These NHS esters react with primary and secondary amine to form a stable amide linkage. (creativepegworks.com)
Chiral tagging reagents, 4-(N,N-dimethylaminosulphonyl)-7-(2-chloroformylpyrrolidin-1 -yl)-2,1,3- benzoxadiazole (R(+)-DBD-Pro-COCl and S(-)-DBD-Pro-COCl), react with mirror image enantiomers of amines to produce corresponding diastereomers in the presence of pyridine as a catalyst. (unboundmedicine.com)

A team has used neutron crystallography to image all of the atoms in a radical intermediate of a copper amine oxidase enzyme. (sciencedaily.com)
Now, in a study recently published in ACS Catalysis , a team led by researchers at Osaka Medical and Pharmaceutical University and Osaka University has used neutron crystallography to image the atom-by-atom structure of a copper amine oxidase enzyme. (sciencedaily.com)
Some copper amine oxidase enzymes exhibit unusual biochemistry, such as quantum tunneling, which enables otherwise inexplicably fast reaction rates. (sciencedaily.com)
This work has provided previously undisclosed structural details in a copper amine oxidase enzyme that has many functions in biochemical metabolism. (sciencedaily.com)

An exception is the amination of alpha-halo carboxylic acids that do permit synthesis of primary amines with ammonia. (wikipedia.org)
A summary of the catalytic synthesis and reactivity of N-silylated amines is presented. (ubc.ca)
The dual-catalyst approach also provides an expansive substrate scope and can address a broad range of alcohol and amine synthesis. (chemicalprocessing.com)
Morken now is capitalizing on the reactivity of the 1,2-diboron intermediate to participate in other transition metal-catalyzed processes, and has had some success in cross-coupling other electrophiles that are of use in target-oriented synthesis. (chemicalprocessing.com)
Her research focuses on new methodologies for preparing stereochemically complex, densely functionalized amines, catalyst-controlled, tunable chemo- and site-selective C-H functionalizations, uncovering new reactivities catalyzed by first-row transition metals, total synthesis of bioactive natural and unnatural products, and development of new bioorthogonal labeling reagents. (rsc.org)

While nitrogen, phosphorus and sulfur-based functional groups (FGs) are widely employed as effective directing groups (DGs) to control the site-selectivity of C-H activation, the use of common FGs ( e.g. ketone, alcohol and amine) as DGs has been continuously pursued. (rsc.org)

Many other industrially significant alkyl amines are produced, again on a large scale, from the alcohols. (wikipedia.org)
Thus the boiling point of amines is higher than those for the corresponding phosphines, but generally lower than the corresponding alcohols . (newworldencyclopedia.org)
Alcohols, or alkanols, resemble amines but feature an -OH group in place of NR 2 . (newworldencyclopedia.org)
Therefore, efficient catalytic processes for the direct oxidation of amines or the coupling of amines and alcohols are desirable. (chemistryviews.org)
Cross-coupling of benzylic alcohols and aromatic or benzylic amines also gave the desired products in high yields, with only small amounts of homocoupling byproducts. (chemistryviews.org)

The pre-weighed packaging prevents the loss of reagent reactivity and contamination over time by eliminating the repetitive opening and closing of the vial. (thermofisher.com)

2. Don't confuse thermodynamic stability with chemical reactivity. (chemicalforums.com)
Avoid incompatible materials (see Section Stability and reactivity). (europa.eu)
Table: Comparison of PEG NHS ester reactivity and stability. (creativepegworks.com)
They are considered as bioisosters of acrylamides, but their increased stability and unique reactivity can result in the development of new selective covalent binders. (enamine.net)

An important exception to this rule is that compounds of the type RC(O)NR 2 , where the C(O) refers to a carbonyl group, are called amides rather than amines. (newworldencyclopedia.org)
Imines are usually formed via condensations of carbonyl compounds and amines under acidic conditions. (chemistryviews.org)

Amine alkylation (amino-dehalogenation) is a type of organic reaction between an alkyl halide and ammonia or an amine. (wikipedia.org)
The reaction is called nucleophilic aliphatic substitution (of the halide), and the reaction product is a higher substituted amine. (wikipedia.org)
For example, reaction of 1-bromooctane with ammonia yields almost equal amounts of the primary amine and the secondary amine. (wikipedia.org)
For the arylation of amines with unactivated aryl halides, the Buchwald-Hartwig reaction is useful. (wikipedia.org)
Because of the relatively rapid reaction of HDI with hydroxyl radicals in the atmosphere and its high reactivity with water, significant environmental concentrations of HDI are not expected to occur except near emission sources. (cdc.gov)
The resultant N-silylamines serve as substrates in a variety of reactions, including C-N and C-C bond forming reactions, and are preferred in transformations because of the facile Si-N hydrolytic cleavage to reveal free amine products upon reaction completion. (ubc.ca)
To mitigate the competitive hydrolysis reaction, organic solvents such as amine-free, anhydrous DMF and DMSO may be used in combination with an aqueous buffer solution. (creativepegworks.com)
Performing the reaction in air provided sufficient oxygen for the homocoupling of primary amines, while the dehydrogenation of secondary amines required an oxygen atmosphere. (chemistryviews.org)
The reaction is carried out in the presence of a stronger base than the amine, such as pyridine, which removes HCl formed and shifts the equilibrium to the product side. (topperlearning.com)
This reaction is used as a test for primary amines. (topperlearning.com)
We disclose binding of a second molecule of high-affinity amine substrate during the enzymatic reaction, a previously unknown event in the enzyme active site," says Toshihide Okajima, senior author. (sciencedaily.com)

Hydrogen bonding significantly influences the properties of primary and secondary amines as well as the protonated derivatives of all amines. (newworldencyclopedia.org)
Hinsberg's reagent or benzenesulphonyl chloride (C 6 H 5 SO 2 Cl) reacts with primary amines and secondary amines to form sulphonamides. (topperlearning.com)
With secondary amine,N,N-diethyl-benzenesulphonamide is formed. (topperlearning.com)

Ketones are an especially attractive choice of DGs and substrates due to their prevalence in various molecules and versatile reactivity as synthetic intermediates. (rsc.org)

R4} _{{quaternay \atop ammonium} \atop cation}+\underbrace {X^{-}} _{halide \atop anion}} _{quaternay\ ammonium\ salt}}}} Amines and ammonia are generally sufficiently nucleophilic to undergo direct alkylation, often under mild conditions. (wikipedia.org)
Structurally amines resemble ammonia , wherein one or more hydrogen atoms are replaced by organic substituents such as alkyl and aryl groups. (newworldencyclopedia.org)
As displayed in the images below, primary amines arise when one of three hydrogen atoms in ammonia is replaced by an organic substituent. (newworldencyclopedia.org)
Gaseous amines possess a characteristic ammonia smell, liquid amines have a distinctive "fishy" smell. (newworldencyclopedia.org)

The chemical reactivity of 2-pyrrolidinones and 3-pyrrolin-2-ones was evaluated in reactions of addition, nucleophilic substitution, elimination, and reduction as well as the protection of the lactamic nitrogen. (hindawi.com)
In connection with our studies on the syntheses of potentially bioactive 2-pyrrolidinones and 3-pyrrolin-2-ones [ 1 ], we describe in this paper the results of the performed study on the chemical reactivity of these structural moieties in reactions of addition, nucleophilic substitution, elimination, and reduction as well as the protection of the lactamic nitrogen. (hindawi.com)
This enhancement of reactivity of the alpha hydrogens, in basic conditions, would be useful in posterior reactions. (hindawi.com)

Pyridoxylamine reactivity kinetics as an amine based nucleophile for screening electrophilic dermal sensitizers. (cdc.gov)

palladium or platinum and also on reduction with metals in acidic medium give amines. (topperlearning.com)

Carbimidates are compounds of great reactivity. (springer.com)
10 minutes) in water and moist soil or sediment to form an amine (i.e., 1,6-hexamethylene diamine) and polyurea compounds. (cdc.gov)
Amines are organic compounds and a type of functional group that contain nitrogen as the key atom. (newworldencyclopedia.org)
Keep away from reducing agents (e.g. amines), acids, alkalies and heavy metal compounds (e.g. accelerators, driers, metal soaps). (europa.eu)
Physical properties and chemical reactivity of alternant hydrocarbons and related compounds. (cas.cz)

NHS-PEG12-Biotin is a very long (56.0Å), pegylated, water-soluble, NHS-ester biotinylation reagent to label amines and maximize solubility of antibodies and other proteins. (thermofisher.com)

The reactivities of both enantiomers of DBD-Pro-COCl to chiral amines were almost comparable, whereas a slight difference of fluorescence intensity was observed with S(-)-DBD-Pro-COCl. (unboundmedicine.com)

In this method, primary amines are prepared by treating an amide with bromine in an aqueous or ethanolic solution of NaOH. (topperlearning.com)
The amine formed has one carbon atom less than the starting amide. (topperlearning.com)
Primary amine reacts with benzenesulphonyl chloride to form N-ethylbenzenesulphonyl amide. (topperlearning.com)

On heating aliphatic and aromatic primary amines with chloroform and ethanolic KOH they form isocyanides or carbylamines which have foul odour. (topperlearning.com)
Esacure TZT is particularly indicated for the photo polymerisation of UV curable systems when high reactivity, low curing odour and low yellowing are required. (igmresins.com)

Thermo Scientific EZ-Link NHS-PEG12-Biotin enables simple and efficient biotin labeling of antibodies, proteins, and any other primary amine-containing macromolecule. (thermofisher.com)
Proteins (e.g., antibodies) typically have several primary amines that are available as targets for labeling, including the side chain of lysine (K) residues and the N-terminus of each polypeptide. (thermofisher.com)

Dehydrocoupling of amines with silanes, hydrosilylation of imines and dealkenylative coupling of amines with vinylsilanes are three ways to achieve their catalytic syntheses. (ubc.ca)
Nitriles on reducing with LiAlH4 or catalytic hydrogenation produce primary amines. (topperlearning.com)

In his study, the reactivity of bicyclo[1.1.0]butyl aryl sulfones was similar to that of acrylamides in GSH-assay. (enamine.net)

supplied as an NHS ester for coupling to primary amine groups. (tocris.com)

Alkaloids are plant metabolites that have a nitrogen-containing chemical ring structure, alkali-like chemical reactivity, and pharmacologic activity. (medscape.com)

These molecules are easy to synthesize from BCB-carboxylic acid and diverse amines. (enamine.net)
This note deals primarily with the basic principles to understand the structure and reactivity of organic molecules. (freebookcentre.net)

The "self"-protein albumin in mouse airway fluid was uniquely modified by GSH-MDI at position 414K, a preferred site of MDI reactivity on human albumin. (cdc.gov)

Pthalimide on reacting with ethanolic solution of KOH forms potassium salt of pthalimide which on heating with alkyl halide followed by alkaline hydrolysis yields the corresponding primary amine. (topperlearning.com)

This method is used for preparing amines containing one carbon atom more than the starting amine. (topperlearning.com)

The Rs values obtained from 1-cyclohexylethylamine (CEA) having aliphatic ring structure was larger than those of amines (1-(1-naphthyl)ethylamine (NEA) and 1-phenylethylamine (PEA)) having aromatic ring structures. (unboundmedicine.com)

high molecular weight amines are, of course, solids. (newworldencyclopedia.org)

Amides on reducing with LiAlH 4 yield amines. (topperlearning.com)

S-HyNic is an amine-reactive reagent that directly converts amino groups on biomolecules and surfaces to HyNic groups. (vectorlabs.com)
Higher amines have the prefix amino as a functional group. (newworldencyclopedia.org)

Unique acetylene containing reagent with PEG4 spacer and amine reactivity. (kerafast.com)

Such recruitment coincided with the greater ability of s-GO to interact in vivo with peritoneal macrophages and was associated with a greater surface reactivity in comparison to l-GO. (springer.com)

Identifying the exact positions of the smallest hydrogen atoms in these enzymes is challenging with commonly used technologies, but is critical to engineering improved enzymes that exhibit unusual yet useful biochemical reactivity. (sciencedaily.com)

When used in conjunction with MAS Epoxy Resin it provides high reactivity and an extended gel time which allows for controlled application periods. (noahsmarine.com)

This review highlights the distinct electronic properties of N-silyl amines, N-silyl imines and N-silyl enamines that result in complementary reactivity to that of parent non-silyl variants. (ubc.ca)

The single-crystal structures confirmed the presence of a primary amine group in the amidine moiety. (springer.com)
Amides and amines have different structures and properties, so the distinction is chemically important. (newworldencyclopedia.org)

A subgroup of the alkaloids is the alkaloid amines, which include three major pharmacologic groups: the hallucinogenic alkaloid amines, the stimulant alkaloid amines, and the tropane alkaloids (also called the belladonna alkaloids or bicyclic alkaloids). (medscape.com)

Anatomy15

Organisms13

Diseases6

Chemicals and Drugs135

Analytical, Diagnostic and Therapeutic Techniques and Equipment35

Psychiatry and Psychology7

Phenomena and Processes48

Disciplines and Occupations4

Technology, Industry, Agriculture2

Information Science3

Health Care3

Aromatic amines7

Tertiary8

Cross-reactivity4

Aliphatic amines5

React5

Copper Amine Oxidase4

Synthesis5

Alcohol and amine1

Alcohols5

Reagent reactivity1

Stability4

Carbonyl2

Reaction11

Secondary3

Ketones1

Ammonia4

Reactions3

Electrophilic1

Acidic1

Compounds5

Solubility1

Chiral1

Amide3

Odour2

Antibodies2

Catalytic2

Aryl1

Ester1

Alkali1

Molecules2

Protein1

Yields1

Atom1

Structure1

Molecular1

Yield1

Amino2

Spacer1

Vivo1

Hydrogen1

High1

VARIANTS1

Structures2

Groups1