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AldehydesLipid PeroxidationLipidsLipid PeroxidesMalondialdehydeThiobarbituric Acid Reactive SubstancesAntioxidantsLipid MetabolismOxidative StressThiobarbituratesVitamin ELipid AGlutathionePeroxidesFree RadicalsGlutathione PeroxidaseEthaneSuperoxide DismutaseCatalaseAscorbic AcidLipid BilayersOxidation-ReductionFree Radical ScavengersF2-IsoprostanesLiverPregnatrienesIsoprostanesRats, WistarReactive Oxygen SpeciesPlant ExtractsFerrous CompoundsPhospholipidsHydroxyl RadicalHydrogen PeroxideGlutathione ReductaseMicrosomes, LiverButylated Hydroxytoluenetert-Butylhydroperoxidealpha-TocopherolFatty Acids, UnsaturatedProtein CarbonylationIronAcroleinDeferoxamineVitamin E DeficiencyFatty AcidsOxidantsCholesterolDinoprostBromobenzenesLipoproteins, LDLLinoleic AcidsRats, Sprague-DawleyCarbon TetrachloridePicratesFerric CompoundsLiposomesAmidinesProbucolHydroxidesRats, Inbred StrainsPhosphatidylcholinesPentanesLinoleic AcidCarbon Tetrachloride PoisoningBromotrichloromethaneProtective AgentsXanthine OxidaseMembrane FluidityGlutathione TransferaseErythrocytesCopperLipoxygenasePhenylenediaminesTriglyceridesOxygenDitiocarbNitrilotriacetic AcidChromatography, High Pressure LiquidDiquatDose-Response Relationship, DrugPhenolsNADPSuperoxidesTime FactorsL-Lactate DehydrogenaseMembrane Lipids
SpeciesOxidativeTBARSDegree of lipid peroxidationMalondialdehydeThiobarbituric Acid ReactGlutathione PeroxidaseMembranePathogenesisEnzymaticPolyunsaturated fattyUltravioletAccumulationEthanolRadicalSpermLungDamageVivoLiverAdductsProteinVascularMarkersConclusionsCellNucleophilicFreeProductsActivityIncreasesAdditionBlood
Species22
  • In addition, oxygen-derived reactive oxygen species including hydrogen peroxide and nitrogen free radicals, such as superoxide, hydroxyl radical and nitric oxide radical, undergo a complicated sequence of electron transfer reactions with other biomolecules, which lead to their modified physiological functions and diverse biological and pathophysiological consequences (e.g. oxidative stress). (nih.gov)
  • The effect of reactive oxygen species on equine sperm motility, viability, acrosomal integrity, mitochondrial membrane potential, and membrane lipid peroxidation. (aber.ac.uk)
  • Dive into the research topics of 'The effect of reactive oxygen species on equine sperm motility, viability, acrosomal integrity, mitochondrial membrane potential, and membrane lipid peroxidation. (aber.ac.uk)
  • Reactive oxygen species degrade polyunsaturated lipids, forming malondialdehyde. (wikipedia.org)
  • This compound is a reactive aldehyde and is one of the many reactive electrophile species that cause toxic stress in cells and form covalent protein adducts referred to as advanced lipoxidation end-products (ALE), in analogy to advanced glycation end-products (AGE). (wikipedia.org)
  • Sperm cells are highly sensitive to reactive oxygen species (ROS), which are produced during cellular oxidation. (mdpi.com)
  • Caffeine and its metabolites have antioxidant activity, scavenging reactive oxygen species. (karger.com)
  • NewsTarget) Oxidative stress represents an imbalance between the production of reactive oxygen species (free radicals) and the body's ability to detoxify the reactive intermediates and repair the resulting damage. (naturalnews.com)
  • Oxygen is required to support life, but its metabolites such as Reactive Oxygen Species (ROS) can modify cell functions, endanger cell survival, or both. (scialert.net)
  • The excessive generation of oxygen free radicals in the form of reactive oxygen species by abnormal spermatozoa and by contaminating leukocytes has been identified as one of the few defined etiologies for male infertility. (scialert.net)
  • Lipid peroxidation may be initiated by lipoxygenases or by reactive oxygen species. (uni-wuerzburg.de)
  • These spermatozoa also experienced increased mitochondrial generation of reactive oxygen species after 1 week of exposure, with elevated DNA oxidation and fragmentation across all exposure periods. (nature.com)
  • Lipid peroxidation generates reactive carbonyl species, including 4-hydroxy-2-nonenal (HNE), acrolein (ACR), 4-hydroxy-2-hexenal (HHE) and malondialdehyde (MDA). (usp.br)
  • OH radicals and protects against brain mtDNA damage, seizures, and lipid peroxidation induced by reactive oxygen species producers. (matreya.com)
  • Reactive oxygen species (ROS) have been proposed to contribute to such damage. (diabetesjournals.org)
  • Reactive oxygen species (ROS), such as the superoxide radical, the hydroxyl radical, and H 2 O 2 , are continuously produced in most cells under physiological conditions, and their levels are regulated by a number of enzymes and physiological antioxidants such as superoxide dismutase, glutathione peroxidase, and catalase as well as by other nonenzymatic antioxidants. (diabetesjournals.org)
  • Increased lipid peroxidation due to reactive oxygen species (ROS)-induced oxidative stress has been demonstrated in the neoplastic mammary tissue of dogs with malignant mammary tumors. (tubitak.gov.tr)
  • In lung tissue, lipid peroxidation, reactive oxygen species, superoxide dismutase activity and reduced glutathione were all increased by WPS exposure. (who.int)
  • Differences between reactive oxygen species and antioxidant defense system unbalance the redox status. (bvsalud.org)
  • 2011). Larger quantities of free radicals (reactive disease, diabetes, chronic respiratory diseases, and oxygen species [ROS]) present in the cigarette cancer (WHO, 2012). (bvsalud.org)
  • There is probably no single one chemical exposure responsible for these illnesses, but more likely a mixed exposure of chemical classes such as particulate matter and oxygenated organic species (oxidized volatile organic compounds that are likely biologically reactive and potentially cause cell damage and increase susceptibility to disease). (cdc.gov)
  • The basis of hapten- molecular mechanisms of the sensitization pro- protein binding work is the hypothesis that upon cess will result in novel opportunities for the skin absorption, only protein-reactive chemicals development of alternative methods for assessing (or those that can be metabolically or chemically skin sensitization hazard and relative potency of converted to protein-reactive species) are able to chemicals. (cdc.gov)
Oxidative3
  • In-stent stenosis is associated with significant increase in lipid peroxidation and attenuated glutathione-linked detoxification enzymes, consistent with oxidative stress. (vitality101.com)
  • The studies demonstrate that D. salina exhibits potent protective effects on UVB radiation-induced corneal oxidative damage in mice, likely due to both the increase of antioxidant enzyme activity and the inhibition of lipid peroxidation. (molvis.org)
  • The increased lipid peroxidation due to oxidative stress induction (increased TBARS and decreased \alpha-tocopherol concentration) found in neoplastic compared to normal mammary tissue of dogs with mammary cancer was similar in both groups of dogs fed with a different kind of diet, commercial or homemade. (tubitak.gov.tr)
TBARS5
  • Malondialdehyde and other thiobarbituric reactive substances (TBARS) condense with two equivalents of thiobarbituric acid to give a fluorescent red derivative that can be assayed spectrophotometrically. (wikipedia.org)
  • We therefore aimed to investigate peroxidation, measured as thiobarbituric the correlation between hypercholesterol- acid-reactive substance (TBARS). (who.int)
  • The purpose of this preliminary study was to compare the extent of lipid peroxidation, as evidenced by thiobarbituric acid-reactive substances (TBARS) and \alpha-tocopherol concentration in the neoplastic mammary tissue, among dogs with mammary cancer fed with different kinds of diet (commercial or homemade). (tubitak.gov.tr)
  • GSK690693 Overall liver lipid peroxidation was assessed by a thiobarbituric acid reactive substrate (TBARS) assay as explained by Ohkawa et al. (eprf.ca)
  • The lipid peroxidation (TBARS) and the enzymatic activity of catalase (CAT) were measured in the cardiac muscle. (bvsalud.org)
Degree of lipid peroxidation3
Malondialdehyde5
Thiobarbituric Acid React4
Glutathione Peroxidase2
Membrane1
  • Gangliosides 1 are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system. (matreya.com)
Pathogenesis3
  • This review provides an insight into different reactive aldehyde adducts and their role in the pathogenesis of lung disease. (cdc.gov)
  • If lipid peroxidation contributes to the pathogenesis of retinopathy of prematurity and chronic lung disease, these results suggest an explanatory mechanism. (bmj.com)
  • These results suggest that lipid peroxidation and alterations in the oxidant-antioxidant enzymatic system may play a role in the pathogenesis of IBS. (medscimonit.com)
Enzymatic1
  • Although phospholipid peroxidation has been associated with almost all known cell death programs, we chose to discuss enzymatic pathways activated during apoptosis and ferroptosis and leading to peroxidation of two phospholipid classes, cardiolipins (CLs) and phosphatidylethanolamines (PEs). (cdc.gov)
Polyunsaturated fatty2
Ultraviolet1
Accumulation1
  • Its unique signature that distinguishes it from other forms of cell death is the formation and accumulation of lipid hydroperoxides, particularly oxidized forms of polyunsaturated phosphatidylethanolamines (PEs), which drives cell death. (cdc.gov)
Ethanol3
  • The present study had evaluated the protective effect of hydroalcoholic (50-50: v/v) and aqueous extracts of L. kerstingii and M. oleifera against lipid peroxidation induced in vivo and in vitro by either cadmium or ethanol. (scialert.net)
  • Similar results were found in the kidney even though lipid peroxidation is slightly increased by ethanol in this organ. (scialert.net)
  • Cadmium a very toxic and ubiquitous metal and ethanol (95%) are known to induce lipid peroxidation (Traore et al . (scialert.net)
Radical2
  • The reactive hydroxy radical causes lipid peroxidation and therefore cell injury. (bmj.com)
  • The hydroxyl free radical is highly reactive and is produced in abundant amounts when the body is under stress. (naturalnews.com)
Sperm1
  • However, spermatozoa's lipids are the main substrates for peroxidation, which may provoke severe functional disorder of sperm. (scialert.net)
Lung1
  • Drinking alcohol and smoking cigarettes results in the formation of reactive aldehydes in the lung, which are capable of forming adducts with several proteins and DNA. (cdc.gov)
Damage4
  • Another set of animals were intracardially perfused with a fixative solution and their brains were subjected to immunofluorescence with lectins to determine the microvasculature profile, and anti-GFAP, anti-NeuN, anti-MBP and anti-Iba1 to study reactive astrocytes, neuronal damage, myelin dysarrangements and microglial state respectively. (biomedcentral.com)
  • This adduction may disturb cellular functions as well as damage proteins, nucleic acids and lipids. (cdc.gov)
  • This produces highly reactive cross-linking agents such as MDA that further damage cellular components leading to accelerated aging. (naturalnews.com)
  • Free reactive oxygen radicals cause damage of mammalian cells by oxidizing fatty acids, protein and DNA. (bvsalud.org)
Vivo1
  • It is impossible to measure free radicals directly in vivo, and it is necessary to rely on the quantification of their reaction products such as protein carbonyls, modified DNA, and lipid peroxidation products. (bmj.com)
Liver1
  • These findings demonstrate the central role lipid peroxidation plays in mediating progression of alcohol-induced necroinflammatory liver injury, stellate cell activation, matrix remodeling, and fibrosis. (eprf.ca)
Adducts2
  • These aldehydes react with nucleophilic targets in cells such as DNA, lipids and proteins to form both stable and unstable adducts. (cdc.gov)
  • These derivatives are highly reactive soft electrophiles that preferentially form adducts with soft nucleophilic sulfhydryl thiolates on cysteine residues. (jneurosci.org)
Protein2
  • C reactive protein (CRP), an important serum marker of atherosclerotic vascular disease, has recently been reported to be active inside human atherosclerotic plaques. (bmj.com)
  • 3 Moreover, inflammatory markers, such as C reactive protein (CRP), are strong independent predictors of future cardiovascular risk. (bmj.com)
Vascular2
  • Systemic sublethal administration of Shiga toxin 2 produced a deterioration of the cells that integrate the vascular unit displaying astrocytic and microglial reactive profiles, while edema and lipid peroxidation were also observed. (biomedcentral.com)
  • This group was retested to confirm important role in the pathophysiology of their blood lipid status before participating several vascular diseases, including athero- in the study. (who.int)
Markers1
Conclusions1
Cell3
Nucleophilic1
  • Further, using a model peptide we demonstrate adduct formation with Cys as the preferred nucleophilic residue and PE(26:2) +2 oxygens, as one of the most reactive truncated PE-electrophiles produced. (cdc.gov)
Free1
  • Free radicals are responsible for lipid peroxidation and have received much attention recently in connection with a variety of pathologies such as cancer (Zhu et al . (scialert.net)
Products1
  • This is based on the available LC-MS identification and quantitative information on the respective peroxidation products of CLs and PEs. (cdc.gov)
Activity1
Increases1
  • The hypothesis for this study was that lipid peroxidation, as evidenced by urinary MDA concentration, increases following blood transfusion. (bmj.com)
Addition1
  • 5] In addition, soy lipids, lecithins, and phytosterols are believed to restore barrier function and replenish moisture. (jcadonline.com)
Blood1
  • The advantage of urine analysis for MDA is that it is less invasive than blood sampling, and urinary MDA may give a more accurate picture of whole body lipid peroxidation. (bmj.com)