• gastric ulcers
  • Before giving cimetidine to patients with gastric ulcers the possibility of malignancy should be considered since cimetidine may mask symptoms and dely diagnosis. (worldbid.com)
  • In a crossover study involving patients with active or healed duodenal or gastric ulcers, either continuous I.V. infusion of cimetidine 37.5 mg/hour (900 mg/day) or intermittent injection of cimetidine 300 mg q6h (1200 mg/day) maintained gastric pH above 4.0 for more than 50% of the time under steady-state conditions. (drugs.com)
  • ulcers
  • Cimetidine is also used to prevent ulcers in certain circumstances and to treat certain conditions that are associated with oversecretion of acid by the stomach (i.e. (medbroadcast.com)
  • erythromycin
  • Like several other medications, the most obvious being erythromycin, cimetidine interferes with the body's metabolization of sildenafil, causing its strength and duration to increase (therefore also its side effects to be more likely and prominent). (wikipedia.org)
  • toxicity
  • Cimetidine can also interact with a number of psychoactive medications, including tricyclic antidepressants and selective serotonin reuptake inhibitors, causing increased blood levels of these drugs and the potential of subsequent toxicity. (wikipedia.org)
  • Cimetidine has a theoretical but unproven benefit in paracetamol toxicity. (wikipedia.org)
  • and cimetidine can increase its elimination half-life and toxicity. (wikipedia.org)
  • Only supportive measures, and not additional treatment, are recommended for management of overdose or toxicity as the reactions are self-limiting. (wikipedia.org)
  • metabolism
  • Examples of specific interactions include the following: Cimetidine affects the metabolism of methadone, sometimes resulting in higher blood levels and a higher incidence of side effects, and may interact with the antimalarial medication hydroxychloroquine. (wikipedia.org)
  • orally
  • Cimetidine 800 mg orally at bedtime reduces mean hourly H + activity by greater than 85% over an eight-hour period in duodenal ulcer patients, with no effect on daytime acid secretion. (drugs.com)
  • secretion
  • Cimetidine 400 mg b.i.d. and 300 mg q.i.d. decrease nocturnal acid secretion in a dose-related manner, i.e., 47% to 83% over a six- to eight-hour period and 54% over a nine-hour period, respectively. (drugs.com)
  • The effect of a 300 mg breakfast dose of cimetidine continued for at least four hours and there was partial suppression of the rise in gastric acid secretion following the luncheon meal in duodenal ulcer patients. (drugs.com)
  • urticaria
  • Dermatographic urticaria manifests as an allergic-like reaction, in general a warm red wheal (welt) to appear on the skin. (wikipedia.org)
  • include other adverse reactions Urticaria Rashes In December 2013 the FDA added warnings to the label for clobazam, that it can cause serious skin reactions, Stevens-Johnson syndrome and toxic epidermal necrolysis, especially in the first 8 weeks of treatment. (wikipedia.org)
  • Sensitivity reactions: Urticaria, rash, pruritus and eosinophilia in white blood cell counts Other locations/body as a whole: Lower back pain, myalgia, arthralgia, fever, sweating, various cardiac arrhythmias, and hypotension Animal studies have failed to reveal evidence of fetal harm. (wikipedia.org)
  • substrate
  • Substitution with alanine or aspartate reduced export of tetraethylammonium (TEA) and cimetidine, and several had altered substrate affinities. (wikipedia.org)
  • rarely
  • Because of its hormonal effects, cimetidine rarely may cause sexual dysfunction including loss of libido and erectile dysfunction and gynecomastia (0.1-0.2%) in males during long-term treatment. (wikipedia.org)
  • Current H2 receptor antagonists have been very rarely associated with idiosyncratic drug reactions leading to liver failure. (biomedcentral.com)
  • tertiary amines
  • A convenient method for the preparation of secondary amines which are not contaminated with primary or tertiary amines is the reaction of cyanamide with alkyl halides to N,N-dialkylcyanamides which can easily be hydrolyzed to dialkylamines and then decarboxylated. (wikipedia.org)
  • drug
  • Cimetidine was approved in the United Kingdom in 1976, and was approved in the United States by the Food and Drug Administration for prescriptions in 1979. (wikipedia.org)
  • The anti-ulcer drug cimetidine is generated using such reactivity. (wikipedia.org)
  • Additional demethylation reactions occur in tumor cells, releasing formaldehyde in situ before the drug is excreted in the urine. (wikipedia.org)
  • enzyme
  • This enzyme catalyzes the following chemical reaction: N,N,N-trimethylamine + NADPH + H+ + O2 ⇌ {\displaystyle \rightleftharpoons } N,N,N-trimethylamine N-oxide + NADP+ + H2O FMO3 is the main flavin-containing monooxygenase isoenzyme that is expressed in the liver of adult humans. (wikipedia.org)
  • fewer
  • 1 Low-osmolality agents are associated with less discomfort, and fewer cardiovascular and anaphylactic-type reactions. (aafp.org)
  • include
  • [ 1 ] Undesirable consequences of delayed-type hypersensitivity (DTH) reactions include illness such as contact dermatitis and allograft rejection. (medscape.com)
  • occur
  • If such reactions do occur, prompt recognition allows them to be treated immediately. (aafp.org)
  • These reactions are not "true" allergic reactions, because they can occur in patients who have not been exposed to contrast material previously. (aafp.org)
  • A guanidino group is introduced by reaction of cyanamide with sarcosine In the industrial synthesis of creatine: This synthesis route mostly avoids problematic impurities like chloroacetic acid, iminodiacetic acid or dihydrotriazine that occur in other routes. (wikipedia.org)
  • systemic
  • The dying parasites are dislodged from their site of action in the host organism and may enter systemic circulation or may be destroyed by host immune reaction (phagocytosis). (wikipedia.org)
  • cause
  • Contrast agents with higher osmolality are more likely to cause adverse reactions of all kinds. (aafp.org)
  • If the membrane that surrounds the mast cells is too weak it will easily and rapidly break down under physical pressure, which will therefore cause an allergic-like reaction. (wikipedia.org)
  • thus
  • Water, hydrogen sulfide, and hydrogen selenide react with cyanamide to give urea, thiourea, and selenourea, respectively: H2NCN + H2E → H2NC(E)NH2 (E = O, S, Se) In this way, cyanamide behaves as a dehydration agent and thus can induce condensation reactions. (wikipedia.org)
  • Thus, all of these glutamate residues are involved in binding and/or transport of TEA and cimetidine, but their roles are different. (wikipedia.org)
  • immune
  • Persons of any age can be affected, but infants may not have the fully-developed immune capability to elicit a reaction. (medscape.com)
  • Treatment
  • Some evidence suggests cimetidine could be effective in the treatment of common warts, but more rigorous double-blind clinical trials found it to be no more effective than a placebo. (wikipedia.org)