• The Heterocyclic Compounds GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. (grc.org)
  • From a foundation of heterocyclic compounds, scientists forge solutions to benefit humans and to expand human knowledge. (grc.org)
  • As one of the longest-running Gordon Research Conferences, the 2023 Heterocyclic Compounds GRC will continue to provide a platform for disclosures of new strategies for the discovery, synthesis, incorporation, and application of powerful heterocycles. (grc.org)
  • The complex interactions leading to a wide range of biological activity can be probed, enhanced, and harnessed through heterocyclic compounds. (grc.org)
  • Phthalhydrazide is one of the useful starting material toward the synthesis of heterocyclic compounds, and considered as a valuable structural unit in organic synthesis due to its significant pharmacological and biological activities. (heterocycles.jp)
  • This method witnessed as a powerful tool for the construction of a diverse range of biological active quinoline scaffolds and other nitrogen containing heterocyclic compounds due to its operational modesty, high atom economy, regio- and stereoselectivity. (heterocycles.jp)
  • The composition of the conference covered a wide range of organic chemists working in the field of biologically active heterocyclic compounds. (cbcconf.com)
  • Heterocyclic compounds are cyclic compounds in which one or more ring atoms are not carbon (that is, hetero atoms). (medmuv.com)
  • Multicomponent synthesis of 3-thiazolines in the Asinger reaction. (wikipedia.org)
  • A carboxylic-acid-directed oxidative Heck reaction enables a direct synthesis of 4-aryl-3-butenoic acids in good yields. (organic-chemistry.org)
  • A new method of synthesis of 2-(1,2-diferrocenylvinyl)benz- and azabenzimidazoles (3a-f), (4a-f) and 1'H,3'H(Me)-spiro-[(aza)benzimidazoline-2',3-(1,2-diferrocenylcyclopropenes)] (5a-f) via reactions of diferrocenyl(methylsulfanyl)cyclopropenylium iodide (1) with aromatic o -diamines (2a-f) in the presence of Et 3 N (80 °C - 82 °C ) is described. (scirp.org)
  • Cycloaddition reactions of oxyallyl cations are widely studied and applied in the synthesis of various natural products. (unr.edu)
  • The synthesis of intervenolin by the author employs thiocyanate-isothiocyanate rearrangement and Suzuki-Miyaura cross coupling as key reactions, which was utilized in structure-activity relationship studies. (heterocycles.jp)
  • The present report focuses on the advancement of aza-Diels-Alder reaction for the synthesis of optically active and inactive quinoline derivatives. (heterocycles.jp)
  • The nitro-Mannich (aza-Henry) reaction, in which a nitroalkane and an imine react to form a β-nitroamine, is a versatile tool for target-oriented synthesis. (uitm.edu.my)
  • Although the first stereoselective reaction was developed only 20 years ago, and enantioselective and diastereoselective versions for the synthesis of non-racemic compounds soon after, there are nowadays a variety of reliable methods which can be used for the synthesis of APIs and other biologically active substances. (uitm.edu.my)
  • Synthesis of the reported structure of piperazirum using a nitro-Mannich reaction as the key stereochemical determining step by: James C. Anderson, et al. (uitm.edu.my)
  • In addition, the reaction of ketone 8 with several lithium acetylides allowed the stereoselective synthesis of new azasugars alkylated at C-3. (unifi.it)
  • Swindell CS, Tao M (1993) Chiral Auxiliary-Mediated Asymmetric Induction in a Thermal Inverse Electron Demand Hetero - Diels-Alder Reaction - Enantioselective Synthesis of the Taxol A-Ring Side Chain . (chempedia.info)
  • Pyrrolidine as an organocatalyst enables a general and efficient biomimetic method for the synthesis of aldimines from aldehydes and compounds bearing an amino group. (organic-chemistry.org)
  • To achieve these aims we are involved in the development of new reactions, new asymmetric processes and new strategies for synthesis. (ox.ac.uk)
  • Sulfondiimines are the di-aza analogues of sulfones and have potential value in medicinal chemistry owing to their attractive physicochemical properties, but there are limited ways for their synthesis. (ox.ac.uk)
  • New stereo- and chemoselective reactions involving cycloaddition and organocatalyst-mediated functionalization were developed for total synthesis of batrachotoxin and epoxyquinols, carnosic acid, etc. (keio.ac.jp)
  • New pathways for the synthesis of various carbohydrates were developed using inexpensive and abundantly available compounds as starting materials, and by the application of chemo-enzymatic reactions. (keio.ac.jp)
  • Diversity-oriented synthesis is a synthetic method for producing a large number of compounds with different molecular skeletons from a single starting material. (keio.ac.jp)
  • In particular, "diversity-enhanced extracts," which combine diversity-oriented synthesis with search for natural compounds, can yield a group of new compounds with structural diversity that exceeds that of natural compounds obtained from plants and microorganisms. (keio.ac.jp)
  • For example, we will perform chemical reactions directly on the extracts of medicinal plants used as crude drugs, as used in diversity-directed synthesis, to produce diversity-enhanced extracts. (keio.ac.jp)
  • Transition metal-mediated C-H bond activation/functionalization, Development of new synthetic methodologies, Design and synthesis of new ligands and catalytic systems for organic reactions, Organometallics, especially organo-boron and organo-silicon chemistry. (cbmr.res.in)
  • Organic compounds -- Synthesis. (edu.hk)
  • Y] D. S. TOROK, H. ZIFFER: "Synthesis and Reactions of 11-Azaartemisinin and Derivatives", TETRAHEDRON LETT. (epo.org)
  • The aza-Michael products have been targeted as truncated ritonavir analogues for investigation as potential HIV -1 protease inhibitors, and representative compounds have been subjected to enzyme inhibition assays to explore the extent and type of inhibition. (ru.ac.za)
  • In particular, PAHs are compounds containing only carbon and hydrogen atoms (i.e. unsubstituted PAHs and their alkyl-substituted derivatives), while the more general name of "polycyclic aromatic compounds" also includes functional derivatives (e.g. nitro-PAHs) and heterocyclic analogues (e.g. aza-areas). (umanaloggia.it)
  • Aza- and diazafulvenium methide derivatives bearing only one methyl group at C-7 are intercepted in sigmatropic hydrogen shifts to give functionalized pyrroles and pyrazoles, respectively. (eurekaselect.com)
  • The Baylis-Hillman products have been explored as substrates for aza-Michael reactions using various amino derivatives including protected amino acids in the presence of the tetrabutylammonium bromide (TBAB) and the ionic liquid, 3-butyl-1- methylimidazoleboranetetrafluoride (BmimBF₄), as catalysts. (ru.ac.za)
  • In this research, we explored the rhodium(III)-catalyzed cross-coupling reactions of organoboronic acids and hydroxylamines derivatives. (edu.hk)
  • This invention relates to the use of certain 11-aza derivatives of artemisinin in the treatment and/or prophylaxis of diseases caused by infection with a parasite, certain novel 11-aza derivatives of artemisinin, processes for their preparation and pharmaceutical compositions containing such 11-aza derivatives. (epo.org)
  • The reaction is investigated in the field of piperidine, piperazine, and tropane derivatives. (heterocycles.jp)
  • The electrochemical properties of compounds 3a, 3b, 3d and 5f a re investigated using cyclic square wave voltammetry. (scirp.org)
  • Following our groups' previous discovery, intramolecular aza-(4+3) cycloadditions of such transient intermediates generated by the dehydrohalogenation of corresponding α-halohydroxamates with furan and N-Boc pyrroles were developed. (unr.edu)
  • The solution is based on the identification by the present inventors that by employing novel in situ generated esters, such as 17ß-carboxy- imidazoryl-, succinimidyl- or triazolyl esters of formula (III), as intermediates, an increased threshold against competing hydrolysis reactions was achieved. (allindianpatents.com)
  • The increased stability of the intermediates (such as compounds of formula (III)) against competing hydrolysis reactions, removes the need to work under anhydrous conditions. (allindianpatents.com)
  • The imino halide products are intermediates in the preparation of antibiotic compounds. (gc.ca)
  • The reaction tolerates a wide range of substrates and a variety of functional groups. (organic-chemistry.org)
  • The mild reaction conditions (neutral pH, reaction temperatures ≤23 °C) are especially attractive for substrates containing sensitive functional groups. (caltech.edu)
  • Likewise, N,N-dialkylhydroxylamines and benzohydroxamic acids are effective substrates for the C-N coupling reactions with the corresponding tertiary amines and amides being formed in 47 - 97% yields. (edu.hk)
  • Getting inspired from the previous (3+2) cycloaddition reactions of indoles, we further expanded this reactivity in other carbonyl compounds. (unr.edu)
  • Tris(2,2,2-trifluoroethyl)borate [B(OCH 2 CF 3 ) 3 ] is a mild and general reagent for condensation of amides or amines with carbonyl compounds providing N -Sulfinyl, N -toluenesulfonyl, N -(dimethylamino)sulfamoyl, N -diphenylphosphinoyl, N -(α-methylbenzyl), and N -(4-methoxyphenyl) aldimines at room temperature. (organic-chemistry.org)
  • This reaction has a great scope of forming aza-stereocenters which can be tuned by different asymmetric catalysts. (beilstein-journals.org)
  • Therefore, harsh reaction conditions and the necessity of an external activator like catalysts are common prerequisites for processes involving C-H bond breaking. (beilstein-journals.org)
  • Baylis-Hillman reactions have been conducted on both series of chromone carbaldehydes using three different catalysts, viz. (ru.ac.za)
  • Imines are common in synthetic and naturally occurring compounds and they participate in many reactions. (wikipedia.org)
  • Furthermore, the hydroxylated products can readily be converted into vicinal tricarbonyl compounds, which are useful synthetic precursors. (organic-chemistry.org)
  • Investigations of the chemical transformations of such compounds are certainly of interest for theoretical, practical and synthetic organic chemistry, as well as for the search of compounds with favorable practical properties, such as thermal stability, electrical conductivity (even superconductivity), biological activity, nonlinear optical effects, etc. [ 39 ]. (degruyter.com)
  • This method provides easy access to 12-18 membered hydroxamate macrocycles.Hexahydropyrrolo[2,3-b]indole compounds are important targets in the synthetic community. (unr.edu)
  • This Conference continues the series of international meetings first held in 2001 on the Chemistry and Biological Activity of Synthetic and Natural Compounds. (cbcconf.com)
  • Boronic acids are some of the most versatile and widely used reagents available to synthetic chemists, particularly for cross-coupling reactions. (ox.ac.uk)
  • tosylimines react with α,β-unsaturated carbonyl compound to give allylic amines in the Aza-Baylis-Hillman reaction. (wikipedia.org)
  • A Chan-Lam coupling reaction of benzylic and allylic boronic esters with primary and secondary anilines provides valuable alkyl amine products. (organic-chemistry.org)
  • Our group's interest in generating electrophilic nitrogen species led us to generate aza-analog of such allylic cation intermediate to provide easy access to seven-membered lactams. (unr.edu)
  • Here we were able to demonstrate the extended scope of the intramolecular aza-(4+3) cycloaddition reactions of allylic cations to generate macrocyclic motifs. (unr.edu)
  • Allylic and propargylic diazenes and their rearrangement by [3,3]-sigmatropic elimination of dinitrogen (retro-enc reaction) have been invoked in numerous organic transformations. (caltech.edu)
  • The reaction is tolerant of a wide range of arylsilanes and various sensitive halide functional groups as well as a broad scope of amines. (organic-chemistry.org)
  • Amines are organic compounds and a type of functional group that contain nitrogen as the key atom. (newworldencyclopedia.org)
  • An important exception to this rule is that compounds of the type RC(O)NR 2 , where the C(O) refers to a carbonyl group, are called amides rather than amines. (newworldencyclopedia.org)
  • One organic reaction involving aromatic amines is the Goldberg reaction. (newworldencyclopedia.org)
  • Neat non-volatile amines react efficiently with various aromatic aldehydes in the absence of any catalyst or solvent, to give imines after a reaction time of eight minutes under microwave irradiation. (organic-chemistry.org)
  • Imines and secondary amines were synthesized selectively by a Pd-catalyzed one-pot reaction of benzyl alcohols with primary amines. (organic-chemistry.org)
  • The reactions did not require any additives and were effective for a wide range of alcohols and amines. (organic-chemistry.org)
  • Iron-catalyzed aerobic oxidative reactions of primary amines, secondary amines, benzylamines with anilines, and alcohols with amines in the presence of air as the economic and safe oxidant, provide several direct, practical, and greener approaches for the preparation of useful imines. (organic-chemistry.org)
  • In organic chemistry, an imine (/ɪˈmiːn/ or /ˈɪmɪn/) is a functional group or organic compound containing a carbon-nitrogen double bond (C=N). The nitrogen atom can be attached to a hydrogen or an organic group (R). The carbon atom has two additional single bonds. (wikipedia.org)
  • The aza-Diels-Alder reaction is a [4+2] cycloaddition, involving the insertion of nitrogen atom into dienes or dienophiles. (heterocycles.jp)
  • These compounds have a charged nitrogen center, and necessarily come with a negative counterion, so they are called quaternary ammonium salts. (newworldencyclopedia.org)
  • Since oxygen is more electronegative than nitrogen, RO- H is typically more acidic than the related R 2 N- H compound. (newworldencyclopedia.org)
  • Nitrogen-containing glycomimetics such as aza- or iminosugars are known to behave as PCs for lysosomal storage disorders (LSDs). (unifi.it)
  • A mild three-component reaction of aromatic aldehydes, alkyl bromides, and aqueous ammonia as the nitrogen source gives imines in very good yields. (organic-chemistry.org)
  • The aromatic heterocycles include such compounds as pyridine, where nitrogen replaces one of the СН groups in benzene, and pyrrole , in which the aromatic sextet is supplied by the four electrons of the two double bonds and the lone pair on nitrogen. (medmuv.com)
  • Preparation of α-aza-amino acid precursors and related compounds by no. (digar.ee)
  • The equilibrium in this reaction usually favors the carbonyl compound and amine, so that azeotropic distillation or use of a dehydrating agent, such as molecular sieves or magnesium sulfate, is required to favor of imine formation. (wikipedia.org)
  • The chief reaction of imines, often undesirable, is their hydrolysis back to the amine and the carbonyl precursor. (wikipedia.org)
  • The structural diversity of the products, ranging from simple heterocycles or azabicycles to complex alkaloids, iminosugars, amino acids or diamino acids and phosphonates, shows the versatility of the nitro-Mannich reaction and its potential for future developments. (uitm.edu.my)
  • In fact, many medicines have been developed from natural compounds produced by plants, fungi, bacteria, and other microorganisms. (keio.ac.jp)
  • Thus, natural compounds are the resources for drug discovery. (keio.ac.jp)
  • We conduct research to find natural product that can be used as resources for drug discovery, or to create them using natural compounds as motifs. (keio.ac.jp)
  • On the other hand, as a result of the vigorous search for natural compounds, new natural compounds are being depleted. (keio.ac.jp)
  • Therefore, it is not possible to conduct innovative drug discovery research by simply searching for natural compounds in the conventional way. (keio.ac.jp)
  • As a new drug discovery resource, we will focus on " unexploited organisms" which are different from conventionally used organisms, such as plants, fungi, and bacteria, for the search of natural compounds. (keio.ac.jp)
  • Condensation of carbon acids with nitroso compounds. (wikipedia.org)
  • The compound (5S,6S,11aS)-hexahydro-6-methyl-5- phenylspiro[l H,7 H-pyrrolo[2,l-e][l,3,6,2]dioxazasilonine- 3,1'-silacyclopentan]-7-one (1) results from the silicon-directed condensation of the prolinol-derived O-silacyclopentyl ketene N,O-acetal (2) with benzaldehyde. (caltech.edu)
  • The crystal structure of C 12 H 13 NOS, which was obtained in a base-catalysed condensation reaction of thiophene-3-carboxaldehyde with 1-aza-bicyclo[2.2.2]octan-3-one, is presented. (uky.edu)
  • This review assembles recent advances in asymmetric aza-Friedel-Crafts reactions mediated by organocatalysts. (beilstein-journals.org)
  • The title compound, (4S,5S,8R,10Z)-2,2,5,6,8,10- hexamethyl-4-phenyl-l,3-dioxa-6-aza-2-silacycloundec- 10-en-7-one, crystallizes with two virtually identical molecules in the asymmetric unit, each with the same absolute configuration. (caltech.edu)
  • In terms of mechanism, such reactions proceed via the nucleophilic addition giving a hemiaminal -C(OH)(NHR)- intermediate, followed by an elimination of water to yield the imine (see alkylimino-de-oxo-bisubstitution for a detailed mechanism). (wikipedia.org)
  • The tetrahedral intermediate can undergo two different reactions, the cleavage of the C2ÿN2 bond (the classical mechanism) and the cleavage of the C2-X6 bond (X=O, N). Both compounds present similar energy barriers for the classical fragmentation, and show considerably lower barriers for the alternative mechanism. (uib.es)
  • Goldberg and coworkers first demonstrated that the reaction of the isolated chromophore (1) with thiols in the presence of double-stranded DNA leads to DNA cleavage by a free-radical mechanism. (caltech.edu)
  • The following detailed mechanism emerges for the DNA cleavage reaction. (caltech.edu)
  • Cp*Rh(Ph)Cl(PPh₃)] was prepared to examine the mechanism of the C-N coupling reaction. (edu.hk)
  • Reactions of this type in the chemistry of cyclopropenylium cations have not yet been studied. (degruyter.com)
  • Sulfur(VI) based moieties, in particular, sulfonamide and sulfone-containing compounds have been widely used in medicinal chemistry, for a variety of disease targets. (ox.ac.uk)
  • In a preliminary experiment , the optically active a-chloronitroso compound in Eq. (15). (chempedia.info)
  • However, many disadvantages are associated with metal-mediated organic transformations including harsh reaction conditions (e.g., high temperature) and toxic solvents. (beilstein-journals.org)
  • Cycloaddition reactions are powerful transformations for the construction of various cyclic organic molecules. (unr.edu)
  • Displacement from planarity in π-extended systems usually requires harsh reaction conditions, which heterocycles rarely tolerate. (nature.com)
  • intramolecular hetero-Diels-Alder reaction. (osi.lv)
  • Key features of this sequence include the coupling of the enol triflate 11 and the arylboronic acid 10 (90%), the thermal deprotection/internal amidation of the coupling product 18 (84%), the use of 2-chloropyridine as an economical alternative to 2,6-di-tert-butylpyridine to promote the reaction of the quinolone 9 and triflic anhydride (85%), the highly stereoselective addition of the (Z)-enediyne 31 to the quinoline 61 (89%), intramolecular acetylide addition within the acetylenic ketone 66 (94%), and oxidation of the phenol 76 with iodosobenzene to afford the quinone imine precursor 77 in 89% yield. (caltech.edu)
  • NMR spectroscopy has been used to elucidate complex and competing mechanistic pathways involved in the Baylis-Hillman reactions of selected 2-nitrobenzaldehydes with MVK in the presence of DABCO - reactions which afford the normal BaylisHillman product, the MVK dimer and syn- and anti-Baylis-Hillman type diadducts. (ru.ac.za)
  • Aromatic aldehydes were found to be the best substrate, however, aliphatic aldehydes, ketones, esters, and amides also provided a good yield of desired cycloadducts.All the compounds were characterized using 1H-NMR, 13C-NMR, IR and high-resolution mass spectrometry. (unr.edu)
  • Diazo compounds having esters, phenylsulfone, cyano and phosphonate groups are good coupling partners, and their reactions with benzohydroxamic acids gave the corresponding oxisoindoles in up to 90% yields. (edu.hk)
  • The repolymerization reaction occurs mainly under conditions of oxygen deficiency and, consequently, the rate of formation of PAHs increases as the oxygen/fuel ratio decreases. (umanaloggia.it)
  • During each formation process, PAHs are always present as a class (never as individual compounds) in complex mixtures containing other substances and chemical classes. (umanaloggia.it)
  • The ease of a chemical transformation depends on the thermodynamic instability of a chemical bond owing to its fast cleavage under mild reaction conditions. (beilstein-journals.org)
  • This is determined by a peculiar chemical behavior of such compounds due to mutual influence of the metallocene and heterocyclic moieties. (degruyter.com)
  • remember that chemical compounds are not proper nouns, so lower case is indicated throughout. (newworldencyclopedia.org)
  • The nonaromatic compounds have physical and chemical properties that are typical of the particular hetero atom. (medmuv.com)
  • Any chemical species which acts as an electron-pair donor in a chemical bonding reaction with a LEWIS ACID. (bvsalud.org)
  • The reaction of the chromophore subunit (1) of the natural antitumor antibiotic neocarzinostatin with methyl thioglycolate produces an NMR-observable intermediate, assigned as 2, which decays with a half-life of ~2 h at -38 °C to form the putative biradical 3. (caltech.edu)
  • It was demonstrated that Lewis-acid catalysis of this reaction can lead to impressive accelerations, particularly in aqueous media . (chempedia.info)
  • The aza-oxyallyl cations generated by dehydrohalogenation form α-halohydroxamates underwent (3+2) cycloaddition reaction with substituted indoles. (unr.edu)
  • We aimed to expand the use of sulfinates in such reactions in a variant that allowed for simpler purification of the reagents, multistep elaboration and greater diversity of the nucleophilic coupling partners. (ox.ac.uk)
  • We showed that heterocyclic allyl sulfones can function as latent sulfinate reagents, undergoing deallylation to release the sulfinate functionality under the reaction conditions used for the cross-coupling. (ox.ac.uk)
  • Because of this reactivity, the compounds studied are expected to be beta-lactamase inhibitors. (uib.es)
  • Notably, alkyl diazoacetates with β-hydrogen atom were good partners for the cycloaddition reaction. (edu.hk)
  • This dinuclear arylrhodium(III) complex was catalytically inactive for the cycloaddition reaction. (edu.hk)
  • In this work, semicarbazones containing a tert-butyl carbazate moiety was examined for the rhodium(III)-catalyzed cycloaddition reaction with alkynes. (edu.hk)
  • However, the Rh(III)-catalyzed cycloaddition reaction between semicabazone 5a and diazomalonate (4a) is still under investigation. (edu.hk)
  • The interest in oxazoline compounds bearing ferrocenyl substituents in the molecules can be traced back to the discovery of ferrocene [ 37 ]. (degruyter.com)
  • Chiral substituents in dienophiles can be used to make Diels-Alder reactions enantioselective. (chempedia.info)
  • Kresze and co-workers have looked at the possibility of effecting nitroso Diels-Alder reactions enantioselectively. (chempedia.info)
  • The main advantages of organocatalyzed stereoselective reactions include mild reaction conditions and the use of a sole catalyst without the need of other chiral ligands [4,5] . (beilstein-journals.org)
  • In these reactions, stereoinduction in the products is achieved by the chiral environment present in the catalyst itself. (beilstein-journals.org)
  • In the catalytic reaction, Glu35 is thought to act as a general acid catalyst to protonate the glycosidic oxygen, while Asp52 acts as a conjugate base and stabilizes the carbonium ion intermediate that adopts a half-chair conformation with C1 carbon displaying sp 2 hybridization. (frontiersin.org)
  • As for the aza- Diels-Alder reaction , enantioselective reactions between imino dienophiles 60 and diene 61, using a chiral binaphtholzirco-nium catalyst 23, are known (Eq. 26) [27]. (chempedia.info)
  • Ligand effects on the kinetics of the Diels-Alder reaction can be separated into influences on the equilibrium constant for binding of the dienoplule to the catalyst (K ) as well as influences on the rate constant for reaction of the complex with cyclopentadiene (kc-ad (Scheme 3.5). (chempedia.info)
  • The use of photosensitive C 70 for the catalytic oxidation of benzylamines to the corresponding imines enables faster reaction rates, lower catalyst loadings, and clean reactions with simple workup without chromatography, compared to C 60 or other commonly used photosensitizers such as tetraphenylporphyrin (TPP). (organic-chemistry.org)
  • New and existing data pertaining to the potential role of DNA as a catalyst in the thiol activation reaction and to the potential participation of the carbohydrate amino group of 1 in that reaction is evaluated. (caltech.edu)
  • The kinetic data confirm the concomitant operation of two pathways and reveal that, in the initial stage of the reaction, the product distribution is kinetically controlled, whereas in the latter stage, thermodynamic control results in the consumption of the normal Baylis-Hillman product and predominance of the anti-diadduct. (ru.ac.za)
  • We anticipated that isoindoles could be prepared by the formal [4 + 1] cycloaddition of O-carboxylates oximes with diazo compounds. (edu.hk)
  • The compound crystallizes in the orthorhombic crystal structure of La3Co2Sn7 type with two Wyckoff sites for the U atoms. (ebsco.com)
  • α-Halohydroxamates with two reacting termini separated by tether chains of three to six atoms underwent cycloaddition reactions successfully to provide unique tricyclic and polycyclic lactams in good yields. (unr.edu)
  • A Mizoroki-Heck type reaction of boronic acids proceeds under a Pd(II)-mediated pathway using a catalytic amount of Pd(OAc) 2 in the presence of Cu(OAc) 2 as an oxidant. (organic-chemistry.org)
  • Furthermore, catalytic cycloaddition reactions of benzohydroxamic acids / semicarbazones with diazo compounds / alkynes were also accomplished. (edu.hk)
  • By reaction of alkenes with hydrazoic acid in the Schmidt reaction. (wikipedia.org)
  • Among these approaches, the dipole/HOMO-controlled reactions of electron-deficient alkenes are especially promising because a variety of combinations between chiral Lewis acids and electron-deficient alkenes have been well investigated in the study of catalyzed enantioselective Diels-Alder reactions. (chempedia.info)
  • Ubiquitous carboxylic acids can serve as starting materials for a photocatalytic decarboxylative C-O bond formation reaction that provides rapid and facile access to the corresponding acetoxylated products. (organic-chemistry.org)
  • Ketones undergo similar reactions, but less commonly than aldehydes. (wikipedia.org)
  • The reaction of aldehydes and aqueous ammonia with epoxides leads to imines bearing a vicinal hydroxyl group regioselectively. (organic-chemistry.org)
  • Mechanistic studies of the reaction of the (S)-prolinol-derived O-silyl ketene N,O-acetal 1 with aromatic aldehydes are reported. (caltech.edu)
  • It is determined that while there is evidence to support the hypothesis that the carbohydrate amino group of 1 participates in the thiol activation of 1 in organic solvents, no conclusions may be drawn at this time concerning its role in the corresponding reaction in water in the presence of DNA. (caltech.edu)
  • Method for preparing a steroidal carbothioic acid by reacting steroidal carboxylic acids or salts with carbodiimides alone or in conjunction with a coupling enhancer followed by reaction with a nucleophilic sulfur containing agent. (allindianpatents.com)
  • In particular, radical cross-coupling reactions exploiting SmI 2 -induced selective generation of aminoketyl radicals have emerged as concise and efficient methods for constructing 2-azabicycles, pyrrolidines and complex polycyclic barbiturates. (mdpi.com)
  • Those polycyclic lactams were further transformed into an array of functionalized molecules including polyhydroxylated azepane derivates.Macrocycles are an important class of compounds having conformational flexibility with potential bioactivity. (unr.edu)
  • On interaction of 16,16-dimethyl-8-aza-D-homogona-1,3,5(10),9(11),13-pentaene-12,17 a -dione with acetic anhydride acylotropic rearrangement occurs with the formation of a single product, viz. (osi.lv)
  • Although the first stereoselective reaction was developed only 20 years ago, and enantioselective and diastereoselective versions for the synth. (uitm.edu.my)
  • In the older literature, imine refers to the aza-analogue of an epoxide. (wikipedia.org)
  • When R = H, the compound is a primary imine, when R is hydrocarbyl, the compound is a secondary imine. (wikipedia.org)
  • Imine react with dienes in the Imine Diels-Alder reaction to a tetrahydropyridine. (wikipedia.org)
  • Both the quinone imine and isobenzofuran components of the final coupling reaction can be varied, thus providing an ideal route for the preparation of a wide variety of dynemicin analogs. (caltech.edu)
  • A direct metal-free α-hydroxylation of α-unsubstituted β-oxoesters and β-oxoamides using m -chloroperbenzoic acid as the oxidant enables straightforward metal-free access to important α-hydroxy-β-dicarbonyl moieties under mild reaction conditions. (organic-chemistry.org)
  • The observed inertness is attributed to the stability of the aza-rhodacyclic complex, which should be difficult to dissociate for diazo coordination. (edu.hk)
  • Usually imines refer to compounds with the general formula R2C=NR, as discussed below. (wikipedia.org)
  • Aromatic imines react with an enol ether to a quinoline in the Povarov reaction. (wikipedia.org)
  • The aza-Friedel-Crafts reaction allows an efficient coupling of electron-rich aromatic systems with imines for the facile incorporation of aminoalkyl groups into the aromatic ring. (beilstein-journals.org)
  • The title compound, which contains a double bond connecting an azabicyclic ring system to a thiophen-3-ylmethylene moiety, crystallizes from solution in methanol and has a thienyl ringflip disorder. (uky.edu)
  • There are many multicomponent reactions using phthalhydrazide under different conditions. (heterocycles.jp)
  • This review article aims to give an overview of recent applications of phthalhydrazide in the multicomponent reactions during the period of 2006 to 2021. (heterocycles.jp)
  • The structures of the resultant compounds are established using IR, 1 H and 13 C NMR spectroscopy, mass spectrometry and elemental analysis. (scirp.org)
  • The characterization of the new compounds was done by IR, 1 H- and 13 C-NMR spectroscopy, mass-spectrometry, elemental analysis and X-ray diffraction studies. (degruyter.com)
  • In the preparation of fluticasone propionate, the introduction of the CH2F-moiety has been accomplished by the reaction of the carbothioic metal salt with a dihalomethane derivative, preferably a fluorohalomethane. (allindianpatents.com)
  • The pericyclic reactions of 4,5-dimethoxycarbonyl-substituted aza- and diazafulvenium methides generated under microwave-induced thermolysis conditions have been described. (eurekaselect.com)
  • The reaction conditions are compatible with a range of functional groups. (organic-chemistry.org)
  • However, this reaction was unsuccessful in our initial trials due to relative instability of the N-O bond in the reaction conditions. (edu.hk)
  • Kinetics and mechanisms of the gas-phase reactions of the hydroxyl radical with organic compounds under atmospheric conditions. (cdc.gov)
  • eng] Different mechanisms for the alkaline hydrolysis of oxo and aza-g-lactam rings have been studied by ab initio calculations at the MP2/6-31¿G*//MP2/6-31¿G* and B3LYP/6-31¿G*//B3LYP/6-31¿G* levels. (uib.es)
  • Pharmacological chaperones (PCs) are small compounds able to rescue the activity of mutated lysosomal enzymes when used at subinhibitory concentrations. (unifi.it)
  • Aziridines are most commonly prepared by related cyclization reactions. (medmuv.com)
  • The calicheamicin-glutathione disulfide 6 is formed as the major product of the reaction, while the dihydrothiophene derivative 3, the thiosulfenic acid derivative 4, and the calicheamicin-glutathione trisulfide 5 are formed as comparatively minor products. (caltech.edu)