• Cinnamic_acid = 42 reactions were found. (brenda-enzymes.org)
  • The first step in phenylpropanoid biosynthesis is the deamination of L-phenylalanine to trans -cinnamic acid, catalyzed by phenylalanine ammonia lyase (PAL) (EC 4.3.1.5). (biomedcentral.com)
  • Cinnamic acid is hydroxylated by cinnamate-4-hydroxylase (C4H) (EC 1.14.13.11) to make 4-coumaric acid, which is then activated by 4-coumaroyl:CoA ligase (4CL) (EC 6.2.1.12) to make 4-coumaroyl-CoA. (biomedcentral.com)
  • A pathway for stilbene biosynthesis was constructed in Escherichia coli with 4-coumaroyl CoA ligase 1 4CL1) from Arabidopsis thaliana and stilbene synthase (STS) cloned from Arachis hypogaea . (biomedcentral.com)
  • In enzymology, a trans-cinnamate 4-monooxygenase (EC 1.14.14.91) is an enzyme that catalyzes the chemical reaction trans-cinnamate + NADPH + H+ + O2 ⇌ {\displaystyle \rightleftharpoons } 4-hydroxycinnamate + NADP+ + H2O The 4 substrates of this enzyme are trans-cinnamate, NADPH, H+, and O2, whereas its 3 products are 4-hydroxycinnamate, NADP+, and H2O. (wikipedia.org)
  • The systematic name of this enzyme class is trans-cinnamate,NADPH:oxygen oxidoreductase (4-hydroxylating). (wikipedia.org)
  • Substitution of 4CL1 with a homologous enzyme, 4CL4, with a preference for ferulic acid over 4-coumaric acid, had no effect on the conversion of ferulic acid. (biomedcentral.com)
  • Enzyme Nomenclature, 1992) EC 4. (lookformedical.com)
  • Phenylpropionic acids, such as 4-coumaric acid and caffeic acid, can be efficiently converted to stilbene compounds by recombinant E. coli cells expressing plant biosynthetic genes. (biomedcentral.com)
  • Phenylalanine ammonialyase (PAL), cinnamic acid 4-hydroxylase (C4H) and 4- coumarate: CoA ligase (4CL) are key enzymes in this pathway [6]. (scirp.org)
  • 2001). The common steps of phenylpropanoid pathway are catalyzed by phenylalanine ammonia- lyase (PAL), cinnamate 4-hydroxylase (C4H) and 4-coumarate:CoA ligase (4CL). (scielo.br)
  • In enzymology, a trans-cinnamate 4-monooxygenase (EC 1.14.14.91) is an enzyme that catalyzes the chemical reaction trans-cinnamate + NADPH + H+ + O2 ⇌ {\displaystyle \rightleftharpoons } 4-hydroxycinnamate + NADP+ + H2O The 4 substrates of this enzyme are trans-cinnamate, NADPH, H+, and O2, whereas its 3 products are 4-hydroxycinnamate, NADP+, and H2O. (wikipedia.org)
  • A family of enzymes that catalyze the stereoselective, regioselective, or chemoselective syn-dehydrogenation reactions. (nih.gov)
  • The second step in the phenylpropanoid pathway is the hydroxylation of trans cinnamic acid to 4-coumaric acid, which is catalyzed by C4H, a cytochrome P450 monooxygenase [8,9]. (scirp.org)
  • Phenylpropanoid biosynthesis comprises reactions through which metabolic channeling may occur. (scirp.org)
  • The systematic name of this enzyme class is trans-cinnamate,NADPH:oxygen oxidoreductase (4-hydroxylating). (wikipedia.org)
  • 4- coumaroyl CoA is funneled into branched pathways leading to a wide array of phenolic metabolites, including lignin, 﫿avonoids [5]. (scirp.org)
  • Sgp130Fc administration also reduced immune cell infiltration and oxidative stress in the mouse atrium and abrogated IL-6 trans-signaling activation-mediated connexin dysregulation and reactive oxygen species production in atrial myocytes. (bvsalud.org)
  • 1997), to the production of 4-coumaroyl CoA (or a respective thiol ester in the presence of other 4-hydroxycinnamate). (scielo.br)
  • RESULTS: In patients, the elevation of IL-6 trans-signaling level was positively associated with AF occurrence. (bvsalud.org)
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