When administered intravenously, urodilatin induces strong diuresis and natriuresis with tolerable hemodynamic side effects. (wikipedia.org)
A message for the preprohormone is transcribed in the heart and kidneys from the gene of NP type A, resulting in a cGMP-dependent signal transduction, which induces diuresis and natriuresis, differentially processed to a peptide of 32 amino acids from the same precursor as renal ANP, may not be identical to the circulating cardiac hormone ANP. (wikipedia.org)
the most common one is via an effect on diuresis/natriuresis, but the mechanisms involved in these impressive cardiac benefits are incompletely understood. (nature.com)
That's a great question because although we don't know all the mechanisms that probably lead to the chronic benefits, for acute efficacy, we looked at the benefits across diuresis, natriuresis, and diuretic response, looking for any additive benefit acutely for a diuretic decongestive outcome and then safety across all the other outcomes. (medscape.com)
This medication works by Inhibiting the reabsorption of sodium and chloride ions in the ascending Henle loop and early distal tubule, which promotes natriuresis (excretion of sodium in urine) and diuresis (increased urine excretion). (simplenursing.com)
Proposed mechanisms of cardiovascular benefit include the promotion of osmotic diuresis and natriuresis in reducing preload, vascular vasodilatory effects reducing afterload, and improvement in cardiac metabolism. (anesthesiaexperts.com)
The alleged mechanisms that lead to improve cardiovascular outcome, even though still incompletely understood, include an association between improvement in cardiac pre- and after-load, partially explained by osmotic diuresis and natriuresis, prevention of cardiac remodelling, direct cardiac effects with improved cardiac energetics and ion handling, antiinflammatory effects, and anti-fibrotic effects. (farmaciajournal.com)
This causes the opening of pores in the luminal membrane of the tubular cells and allows for reabsorption of water from the glomerular filtrate, resulting in a concentrated urine. (vin.com)
SGLT2 inhibitors lead to a reduction in plasma glucose by inhibiting renal tubular glucose reabsorption, with resultant glucosuria. (ccs.ca)
In response to acute volume expansion patients exhibited exaggerated increases in ANP (5.3 pmol/l versus 3.0 pmol/l, P less than 0.05), exaggerated natriuresis, and an abnormal decrease in fractional proximal and distal tubular sodium reabsorption (PFRNa and DFRNa, respectively). (nih.gov)
Fractional reabsorption in the proximal convoluted tubule in glibenclamide-infused rats did not differ significantly from that in control animals, although the late proximal tubular fluid to plasma concentration ratio for potassium was reduced. (aspetjournals.org)
Cyclothiazide affects the distal renal tubular mechanism of electrolyte reabsorption. (drugbank.com)
Diuretic drugs, which inhibit active sodium reabsorption, reduce tubular oxygen consumption. (uni-regensburg.de)
The diuretics act primarily by inhibiting tubular reabsorption: just 1% decrease in tubular reabsorption would more than double urine output. (pharmacy180.com)
For simplification, tubular reabsorption can be divided into four sites (Fig. IX.1). (pharmacy180.com)
d) The disproportionately large HCO 3 ¯, acetate, PO 4 3 ¯, amino acid and other anion reabsorption create passive driving forces for Cl¯ to diffuse through the paracellular pathway (in between tubular cells), particularly in the later PT. (pharmacy180.com)
For this function regular and nephrotic rats had been put through extracellular fluid quantity expansion as well as the influence from the PDE5 inhibitor zaprinast only or in conjunction with the D1R antagonist Sch-23390 on natriuresis urinary cGMP excretion and immunolocalization of D1R in renal tubular cells was examined. (bioxorio.com)
The inability of mineralocorticoid receptor (MR) blockade to reduce hypertension associated with high angiotensin (Ang) II suggests direct actions of Ang II to regulate tubular sodium reabsorption via the epithelial Na+ channel (ENaC) in the aldosterone-sensitive distal nephron. (elsevierpure.com)
Sodium-glucose cotransporter 2 inhibitors (SGLT2is) are a new class of antidiabetic drug that inhibits renal tubular sodium-glucose reabsorption without stimulating insulin release in patients with type 2 DM (T2DM) [ 5 ]. (biomedcentral.com)
Pressure natriuresis3
Using the transporter profiling approach, Dr. McDonough and her colleagues have defined how stimuli such as dietary salts, Ang II, kidney injury, and immune cytokines increase renal sodium transport in a region specific manner along the nephron and how resultant hypertension provokes intrarenal responses to decrease sodium reabsorption (via pressurenatriuresis), a response that defines the blood pressure set point in the kidney. (usc.edu)
a process known as pressurenatriuresis, and influences the activity of various vasoactive systems such as the renin-angiotensin-aldosterone (RAS) system [9]. (onteenstoday.com)
Glucose6
Sodium-glucose cotransporter 2 (SGLT2) inhibitors are a unique class of oral antidiabetic medications that reduce glucose reabsorption in the renal proximal tubules, thereby enhancing urinary glucose excretion 1 . (nature.com)
By inhibiting sodium and glucose reabsorption from the proximal tubules, the improvement in insulin resistance and natriuresis improved the cardiovascular mortality in diabetes mellitus (DM) patients. (tmu.edu.tw)
SGLT2i are a new class of oral hypoglycemics initially used to help lower blood sugar in patients with type 2 diabetes by reducing the reabsorption of sodium and glucose at the proximal renal tubules. (anesthesiaexperts.com)
Transport of Na+ and K+ coupled to active reabsorption of glucose, amino acids, other organic anions and PO3 4 ¯ through specific symporters. (pharmacy180.com)
Only the glucose coupled Na+ reabsorption is electrogenic. (pharmacy180.com)
Sodium-glucose cotransporter-2 inhibitors (SGLT2i) are a newer class of anti-hyperglycaemic drugs that act by partially inhibiting glucose reabsorption from the renal filtrate and inducing glycosuria. (farmaciajournal.com)
Tubules8
It inhibits Na + /Cl - reabsorption from the distal convoluted tubules in the kidneys. (drugbank.com)
It inhibits Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. (ncats.io)
It reduces electrolyte reabsorption from the renal tubules. (medicscientist.com)
Although urine is finally modified in subsequent tubules, the proximal tubule is the main site for both NaCl and NaHCO 3 reabsorption. (cellphysiolbiochem.com)
The essential pathophysiologic mechanisms involved with CSWS certainly are a decrease in sympathetic anxious program outflow during intracranial disease, resulting in decreased sodium reabsorption in the proximal tubules, inhibition from the renin-angiotensin-aldosterone program, and launch of many natriuretic elements, such as for example ANP, mind natriuretic peptide (BNP) and additional natriuretic protein [24]. (bio-biz-navi.com)
The locating in PAN-NS rats how the upsurge in Na+ K+-ATPase activity in renal proximal tubules was associated with blunted natriuresis during D1R agonist fenoldopam infusion in regular in addition to volume expanded circumstances [13] suggested a decreased option of SB 743921 D1R in renal proximal tubules of PAN-NS might donate to sodium retention in this example. (bioxorio.com)
Angiotensin II also stimulates the production of aldosterone from the adrenal cortex, which causes the tubules of the kidneys to increase reabsorption of sodium, with water following, thereby increasing plasma volume, and thus also blood pressure. (standardofcare.com)
Urine2
In hyponatremic sufferers, SIADH diagnosis is dependant on the current presence of regular or decreased urine result, inappropriately focused urine, natriuresis, low-serum osmolality, and a standard or slightly elevated intravascular quantity in the lack of any renal, adrenal or thyroid complications. (bio-biz-navi.com)
The kidneys are excretory organs that perform three main functions to produce urine, filtration, reabsorption and secretion. (onteenstoday.com)
Excretion of sodium1
As a diuretic, cyclothiazide inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and water. (drugbank.com)
Inhibit2
We therefore investigated the effects of acetazolamide, furosemide, hydrochlorothiazide, and amiloride, known to preferentially inhibit sodium reabsorption at different segments of the nephron, on hypoxia-induced EPO formation in mice. (uni-regensburg.de)
It exerts its diuretic effect on the distal renal tubule to inhibit the reabsorption of sodium in exchange for potassium and hydrogen. (alpiedelamuralla.org)
Diuretic2
Hydrochlorothiazide, a thiazide diuretic, inhibits water reabsorption in the nephron by inhibiting the sodium-chloride symporter (SLC12A3) in the distal convoluted tubule, which is responsible for 5% of total sodium reabsorption. (drugbank.com)
By blocking the sodium-chloride symporter, hydrochlorothiazide effectively reduces the osmotic gradient and water reabsorption throughout the nephron.Hydrochlorothiazide, a thiazide diuretic, inhibits water reabsorption in the nephron by inhibiting the sodium-chloride symporter (SLC12A3) in the distal convoluted tubule, which is responsible for 5% of total sodium reabsorption. (drugbank.com)
Urinary1
Collectively, our study reveals a novel mechanism of UT-A3 regulation by ST6GalI-mediated sialylation modification that may play an important role in kidneyurea reabsorption and the urinary concentrating mechanism. (emory.edu)
Loss of potassium and bicarbonate1
Natriuresis may be accompanied by some loss of potassium and bicarbonate. (drugbank.com)
The dissociated HCO 3 ¯ in the cell is transported to cortical e.c.f. by basolateral membrane Na+HCO¯ symporter resulting in net reabsorption of NaHCO 3 . (pharmacy180.com)
Blockade1
These results are consistent with the hypothesis that the natriuresis resulting from glibenclamide administration is a consequence of blockade of potassium channels in the apical membrane of the thick ascending limb of Henle's loop. (aspetjournals.org)
Once sodium has entered the cell, it is transported out into the basolateral interstitium via the sodium-potassium ATPase, causing an increase in the osmolarity of the interstitium, thereby establishing an osmotic gradient for water reabsorption. (drugbank.com)
Acute1
It is concluded that in essential hypertension ANP is increased under basal conditions and the increase in natriuresis and ANP is exaggerated during acute volume expansion. (nih.gov)
Water3
secretion is the basis for a paracrine system regulating water and sodium reabsorption. (wikipedia.org)
ADM reduced water reabsorption through a PLC-pathway involving PKC. (emory.edu)
ADM-attenuated water reabsorption may be related to decreased trafficking of AQP2 to the plasma membrane. (emory.edu)
Peptide1
The natriuretic peptide system provides counter balance to the RAAS, enhancing natriuresis and vasodilation while decreasing fibrosis and apoptosis. (standardofcare.com)
Mechanism1
This new regulatory mechanism of channel function is critical for the maintenance of normal Na reabsorption in the kidney and of Na+ balance and blood pressure. (nih.gov)
Diuretics1
Loop diuretics work by inhibiting the reabsorption of sodium and chloride ions in the thick ascending limb of Henle's loop. (simplenursing.com)
They work by altering electrolytes' reabsorption, excretion, and fluid volume. (simplenursing.com)
Activity1
Simultaneous inhibition of MR and Ang II type 1 receptors ameliorated the enhanced ENaC activity caused by low dietary salt intake and produced significantly greater natriuresis than either inhibitor alone. (elsevierpure.com)