OrganismsChemicals and DrugsInformation Science
RauwolfiaReserpineEncyclopedias as TopicBiogenic MonoaminesMonoamine OxidaseNorepinephrineAntihypertensive AgentsIndole Alkaloids
SerpentinaAlkaloidHypertensionVomitoriaDeserpidineAlkaloids such as reserpineSerpentineSnakerootRootsSchizophrenia1955AntipsychoticSerotonin19520.25 mgCanescensSpeciesNorepinephrineDepressionDopaminePharmacologicalPeripheralInhibitsPatient'sCirculatoryNoradrenalineMetabolismDerivativesAdverse effectsAntihypertensive drugsPatientsFoundGenusSymptomsAllergicExtensivelyPlantTreatmentHerbNauseaHigh blood prDrugCommonlyTranquilizerDrugs
Serpentina21
  • The powdered whole root of the Indian shrub Rauwolfia serpentina historically had been used to treat snakebites, insomnia, hypertension (high blood pressure), and insanity. (britannica.com)
  • Some species of Rauwolfia, particularly Rauwolfia Serpentina, are known for their medicinal properties and are used in traditional medicine to treat a variety of conditions such as hypertension and mental disorders. (definitions.net)
  • RESERPINE is derived from R. serpentina. (definitions.net)
  • The influence of media composition on callus induction and subsequent regeneration of Rauwolfia serpentina L. Benth has been studied. (scialert.net)
  • An endangered woody shrub Rauwolfia serpentina L. Benth belongs to the Apocynaceae family holds the tremendous potentialities for massive propagation and isolation of indole alkaloids through in vitro culture. (scialert.net)
  • Reserpine is an alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. (immunoportal.com)
  • The story of Rauwolfia serpentina is an example of a block in medical communication that, in retrospect, seems hard to understand. (laskerfoundation.org)
  • Derived from Rauwolfia serpentina (a plant that for centuries has been used in India for the treatment of mental illness, insomnia, and snake bites), reserpine was introduced in the West as a treatment for schizophrenia. (medscape.com)
  • Rauwolfia (Rauwolfia serpentina), also spelled ravolphia , is a medicinal plant in the milkweed family. (drugbank.com)
  • Reserpine is derived from Rauwolfia serpentina, and was commonly used as an antihypertensive agent in the 1950s 12 . (drugbank.com)
  • Rauwolfia serpentina gives reserpine, a hypotensive agent. (howmed.net)
  • The substance was responsible for about 50% of the antihypertensive and tranquilizing action of the snakeroot plant (Rauwolfia serpentina) that had been in use for hundreds of years in various preparations by Ayurvedic practitioners in India (Bein 1970).In 1954, Delay et al. (inhn.org)
  • Sarpagandha, also known as Rauwolfia serpentina, is a medicinal plant native to India. (aarogyacbd.com)
  • Rauwolfia Serpentina roots are used for calming the central nervous system. (yourmedkart.com)
  • The main active constituent in Rauwolfia Serpentina is Reserpine, which is well-known for its antipsychotic and antihypertensive action. (yourmedkart.com)
  • Rauwolfia Serpentina is likely Unsafe during pregnancy because it can pass through the placental barrier and cause unwanted effects and birth defects. (yourmedkart.com)
  • Safety Concerns: Patients sensitive to rauwolfia alkaloids such as deserpidine, rauwolfia serpentina, or reserpine may also be sensitive to yohimbine. (primelot.net)
  • Rauwolfia other snake - Rauwolfia serpentina Benth. (medprep.info)
  • In view of the great need for reserpine and aymaline, R. serpentina Benth. (medprep.info)
  • For example, Reserpine ( Rauwolfia serpentina) which was extracted during the 20th century was initially thought of as an animal tranquilizer before discovering its application in the treatment of psychosis and hypertension. (aarogyakhabar.com)
  • At around the same time, an extract from the plant Rauwolfia serpentina was introduced into western psychiatry. (rjwhelan.co.nz)
Alkaloid7
  • The Rauwolfia alkaloid, reserpine, was soon found to be a powerful tranquilizing agent and was identified as a valuable addition to psychiatric therapy. (laskerfoundation.org)
  • Reserpine is an indole alkaloid extracted from Rauwolfia serpentine roots, an Indian climbing shrub. (swolverine.com)
  • Reserpine, an alkaloid in Rauwolfia reduces BP by decreasing the activity of central and peripheral noradrenergic neurons. (hempstreet.in)
  • An extract from the bark of the roots of the African tree, Rauwolfia vomitoria, containing the alkaloid, alstonine (also called BG-8). (rifedigital.net)
  • The anti-psychotic alkaloid, reserpine, also found in Rauwolfia species is removed from Rovol V during the extraction process. (rifedigital.net)
  • Pharmacological studies with deserpidine, a new alkaloid from Rauwolfia canescens. (nih.gov)
  • The alkaloids reserpine, aymaline and some total alkaloid products (for example, raunatin) are used. (medprep.info)
Hypertension13
  • Large clinical trials have shown that combined treatment with reserpine plus a thiazide diuretic reduces mortality of people with hypertension. (wikipedia.org)
  • Reserpine is recommended as an alternative drug for treating hypertension by the JNC 8. (wikipedia.org)
  • The reserpine - thiazide diuretic combination is one of the few drug treatments shown to reduce mortality in randomized controlled trials: The Hypertension Detection and Follow-up Program, the Veterans Administration Cooperative Study Group in Anti-hypertensive Agents, and the Systolic Hypertension in the Elderly Program. (wikipedia.org)
  • Reserpine is used to treat mild to moderate hypertension , schizophrenia , and some symptoms of poor circulation . (rxlist.com)
  • Reserpine is sometimes used in treating hypertension, though newer antihypertensive drugs with fewer central nervous system side effects are the preferred treatment . (britannica.com)
  • For studies on the use of reserpine in the treatment of hypertension. (laskerfoundation.org)
  • In a historical paper on the use of Rauwolfia in hypertension which appeared in the British Heart Journal in 1949, he summed up 10 years of careful conscientious work that he had carried out personally, added the opinions of some 50 other physicians who had worked with Rauwolfia in hypertension, and produced a document which brought this drug finally and decisively into Western medicine. (laskerfoundation.org)
  • Rauwolfia alkaloids are indicated in the treatment of hypertension 6 . (drugbank.com)
  • Reserpine is an adrenergic blocking agent used to treat mild to moderate hypertension via the disruption of norepinephrine vesicular storage. (drugbank.com)
  • Reserpine was used for hypertension treatment. (howmed.net)
  • Indications: Mild to moderate hypertension Key ingredients: Rauwolfia (Sarpagandha): is a pungent smelling herb, which is a potent anti-hypertensive. (kayawell.com)
  • Reserpine has had FDA approval since 1955 and is one of the first agents developed to treat hypertension in clinical practice. (swolverine.com)
  • Reserpine is a catecholamine -depleting sympatholytic that is FDA approved for the {{{indicationType}}} of mild essential hypertension . (wikidoc.org)
Vomitoria2
Deserpidine2
  • Reserpine, deserpidine, rescinnamine, syrosingopine all reduce brain 5-HT levels and a similar reduction is produced by tetrabenazine (Rol-9569) benzquinamide and RO-4 - 1284. (erowid.org)
  • The active ingredients in this drug are alkaloids and about 50 have been identified through various studies, although the primary psychoactive components appear to be reserpine, rescinnamine, and deserpidine 10 . (drugbank.com)
Alkaloids such as reserpine1
Serpentine1
  • With neuroleptic drugs, the most significant changes in 5-HT metabolism in the brain are produced by Rauwolfia serpentine alkaloids and benzoquinoline derivatives. (erowid.org)
Snakeroot4
  • One of the chemicals in Indian snakeroot is the same as a prescription drug called reserpine. (rxlist.com)
  • Indian snakeroot contains chemicals such as reserpine that decrease heart rate and blood pressure. (rxlist.com)
  • The amount of reserpine and other chemicals in Indian snakeroot can vary from plant to plant. (rxlist.com)
  • Since the reserpine and other chemicals in Indian snakeroot can be very toxic, the dose must be accurate and the side effects monitored by a trained healthcare professional. (rxlist.com)
Roots1
Schizophrenia1
  • A review found that in persons with schizophrenia, reserpine and chlorpromazine had similar rates of adverse effects, but that reserpine was less effective than chlorpromazine for improving a person's global state. (wikipedia.org)
19552
  • Although the use of reserpine as a solo drug has declined since it was first approved by the FDA in 1955, the combined use of reserpine and a thiazide diuretic or vasodilator is still recommended in patients who do not achieve adequate lowering of blood pressure with first-line drug treatment alone. (wikipedia.org)
  • In 1955 researchers at the National Institutes of Health reported that reserpine reduces the levels of serotonin in the brains of animals. (rjwhelan.co.nz)
Antipsychotic1
  • The use of reserpine as an antipsychotic drug had been nearly completely abandoned, but more recently it made a comeback as adjunctive treatment, in combination with other antipsychotics, so that more refractory patients get dopamine blockade from the other antipsychotic, and dopamine depletion from reserpine. (wikipedia.org)
Serotonin4
  • Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. (immunoportal.com)
  • Spoiler alert: Brodie's work showed that a new psychiatric drug known as reserpine was capable of fully depleting the brain's stores of serotonin and ― of greatest significance, as it turned out - mimicking the neuromuscular symptoms typical of Parkinson's disease. (medscape.com)
  • Yet another line of research indicated that reserpine may induce depression and deplete monoamines (serotonin and norepinephrine) in the brain. (inhn.org)
  • It was later established that all three of the major biogenic amines in the brain, norepinephrine, serotonin, and dopamine, were all decreased by reserpine (again, in animals). (rjwhelan.co.nz)
19522
  • Reserpine, isolated in 1952, was the first of many Rauwolfia alkaloids found in the crude drug. (britannica.com)
  • The second , reserpine , was isolated from the Rauwolfia root in 1952 by Műller, Schlittler and Bein in the laboratories of CIBA, a Swiss pharmaceutical company(Műller, Schlittler, Bein 1952). (inhn.org)
0.25 mg2
  • The daily dose of reserpine in antihypertensive treatment is as low as 0.05 to 0.25 mg. (wikipedia.org)
  • Mean maximum plasma levels of plasma concentrations after 0.5 mg of Reserpine, administered as two 0.25 mg tablets or as an aqueous solution, peaked after 2.5 hours. (drugbank.com)
Canescens1
Species1
  • In total, up to 150 species of the genus Rauwolfia have been identified in the world flora, found in the tropics and subtropics of Southeast Asia, Africa and South America, which are now all being studied. (medprep.info)
Norepinephrine1
Depression2
  • Reserpine depletes brain (depression) and peripheral (PPH) noradrenaline (NA) storage sites, guanethidine depleted NA storage via blockade of reuptake 14 . (drugbank.com)
  • Reserpine may cause mental depression . (wikidoc.org)
Dopamine1
  • Therapeutic options include dopamine-depleting agents (eg, reserpine, tetrabenazine) and dopamine-receptor antagonists (eg, neuroleptics). (medscape.com)
Pharmacological1
  • It was appreciably lower at room temperature and almost negligible at 2 degrees C. . Only those rauwolfia alkaloids which exert reserpine-like pharmacological properties caused the release of 5- hydroxytryptamine. (erowid.org)
Peripheral4
  • The antihypertensive actions of reserpine are largely due to its antinoradrenergic effects, which are a result of its ability to deplete catecholamines (among other monoamine neurotransmitters) from peripheral sympathetic nerve endings. (wikipedia.org)
  • B enzoquinolizine derivatives and reserpine interfere with the process of storage of biogenic amines in the presynaptic granules of the brain and peripheral neurons. (erowid.org)
  • It's mechanism on peripheral blood vessels, is similar to that of Reserpine. (swolverine.com)
  • Reserpine results in a rapid reduction in cardiac output, heart rate, and peripheral vascular resistance. (hempstreet.in)
Inhibits1
  • Reserpine inhibits formation of biofilms by Staphylococcus aureus and inhibits the metabolic activity of bacteria present in biofilms. (wikipedia.org)
Patient's1
  • It is important that the anesthesiologist be aware of the patient's drug intake and consider this in the overall management, since hypotension has occurred in patients receiving rauwolfia preparations. (wikidoc.org)
Circulatory2
  • Preoperative withdrawal of reserpine does not assure that circulatory instability will not occur. (wikidoc.org)
  • The influence of ritalin (methylphenidate) on the behavioral and circulatory effects of reserpine. (nih.gov)
Noradrenaline1
  • Reserpine present in Rauwolfia removes the store of noradrenaline from artery walls which relaxes the blood vessels which makes the blood flow more easily slowering the heart rate leading to reduction of blood pressure. (yourmedkart.com)
Metabolism1
  • Hepatic metabolism accounts for less than 50% of the elimination of reserpine, with the remainder being eliminated in the faeces, and some unmetabolized reserpine and metabolites being eliminated in the urine. (drugbank.com)
Derivatives1
Adverse effects2
  • At doses of less than 0.2 mg/day, reserpine has few adverse effects, the most common of which is nasal congestion. (wikipedia.org)
  • In the same year, Steck reported on the similarities in therapeutic and adverse effects of reserpine and CPZ (Steck1954). (inhn.org)
Antihypertensive drugs1
  • A 2016 Cochrane review found reserpine to be as effective as other first-line antihypertensive drugs for lowering of blood pressure. (wikipedia.org)
Patients4
  • Moreover, reserpine was included as a secondary antihypertensive option for patients who did not achieve blood pressure lowering targets in the ALLHAT study. (wikipedia.org)
  • There is limited information regarding Off-Label Guideline-Supported Use of Reserpine in adult patients. (wikidoc.org)
  • There is limited information regarding Off-Label Non-Guideline-Supported Use of Reserpine in adult patients. (wikidoc.org)
  • Since reserpine increases gastrointestinal motility and secretion, it should be used cautiously in patients with a history of peptic ulcer , ulcerative colitis , or gallstones ( biliary colic may be precipitated). (wikidoc.org)
Found2
  • High dose studies in rodents found reserpine to cause fibroadenoma of the breast and malignant tumors of the seminal vesicles among others. (wikipedia.org)
  • Reserpine, an active compound found in Rauwolfia, renders the herb its antihypertensive property. (kayawell.com)
Genus1
  • Rauwolfia is a genus of evergreen trees and shrubs originating primarily in tropical and sub-tropical regions. (definitions.net)
Symptoms2
  • Reserpine has also been used for relief of psychotic symptoms. (wikipedia.org)
  • Reserpine controls high blood pressure or symptoms of agitation, but does not cure them. (safemedication.com)
Allergic1
  • tell your doctor and pharmacist if you are allergic to reserpine, aspirin, any other medications, tartrazine (a yellow dye in some processed foods and medications), or any of the ingredients in reserpine tablets. (safemedication.com)
Extensively1
  • Reserpine is extensively bound (95%) to plasma proteins 15 . (drugbank.com)
Plant3
  • Interestingly, the hairy root component of this plant has shown a remarkable capacity to regenerate into complete Rauwolfia plants and shows survival and unaltered biosynthetic potential during storage at decreased temperatures. (drugbank.com)
  • Modern scientists have researched this plant and identified a master molecule named reserpine. (penguin.co.in)
  • Genetic variation in Rauwolfia is shown in terms of potency and concentration of the active chemical reserpine produced by the plant. (unseenpassage.com)
Treatment4
  • Reserpine is a drug that is used for the treatment of high blood pressure, usually in combination with a thiazide diuretic or vasodilator. (wikipedia.org)
  • If you are currently taking reserpine, you should call your doctor to discuss switching to another treatment. (safemedication.com)
  • It may be more effective than reserpine in the treatment of chorea and less likely to cause hypotension. (medscape.com)
  • uses of Rauwolfia (a) It is used for the treatment of generalized Hodgkin's disease and chorionepithelioma. (deepcrazyworld.com)
Herb1
  • In 1953 chemists at Ciba, a pharmaceutical company, isolated the active compound from this herb and called it reserpine. (rjwhelan.co.nz)
Nausea1
  • Reserpine can cause: nasal congestion, nausea, vomiting, weight gain, gastric intolerance, gastric ulceration (due to increased cholinergic activity in gastric tissue and impaired mucosal quality), stomach cramps and diarrhea. (wikipedia.org)
High blood pr2
Drug2
  • Reserpine is almost completely metabolized in the body, and only about 1% is excreted as unchanged drug in the urine 15 . (drugbank.com)
  • There is limited information regarding Clinical Trial Experience of Reserpine in the drug label. (wikidoc.org)
Commonly1
  • The reserpine-hydrochlorothiazide combo pill was the 17th most commonly prescribed of the 43 combination antihypertensive pills available In 2012. (wikipedia.org)
Tranquilizer1
  • Reserpine is used as a long-acting tranquilizer to subdue excitable or difficult horses and has been used illicitly for the sedation of show horses, for-sale horses, and in other circumstances where a "quieter" horse might be desired. (wikipedia.org)
Drugs1
  • Reserpine refers to drugs that calm the central nervous system - tranquilizers. (medprep.info)