• 2000
  • Because of inadequate reporting, conclusions cannot be drawn from the results of a fourth experiment in which some liver tumours were observed in rats fed up to 2000 ppm in the diet (equivalent to about 100 mg/kg bw/day). (inchem.org)
  • pituitary
  • Genotypes at these loci, termed Esta1, 2, and 3, do not have a significant impact on the ability of DES to induce pituitary tumorigenesis or inhibit growth of these F2 rats. (deepdyve.com)
  • sensitivity
  • The sensitivity of the BN rat to DES-induced thymic atrophy appears to segregate as an incompletely dominant trait in crosses between the BN and ACI strains. (deepdyve.com)
  • In a (BN × ACI)F2 population, we find strong evidence for three major genetic determinants of sensitivity to DES-induced thymic atrophy on rat Chromosome (RNO) 10 and RNO2. (deepdyve.com)
  • environmental
  • When Skinner and his colleagues exposed gestating rats to methoxychlor at a range typical of high environmental exposures, they saw increases in the incidence of kidney disease, ovary disease and obesity in offspring spanning three generations. (sciencecodex.com)
  • However
  • However MTX and LNAME did not modify any other parameter studied with the exception of relative pulse amplitude in MTX treated rats. (jcircadianrhythms.com)
  • However, the values of DA in the MBH in MTX plus L-NAME treated animals were statistically decreased as compared to LNAME treated rats. (jcircadianrhythms.com)
  • development
  • Role of transforming growth factor-α and the epidermal growth factor receptor in embryonic rat testis development. (epa.gov)
  • While one study has linked methoxychlor to the development of leukemia in humans, most studies in animals and humans have been negative, thus the EPA has determined that it is not classifiable as a carcinogen. (wikipedia.org)
  • oral
  • The F1 females were dosed with corn oil (0 mg/kg), or the test articles: Ethinyl Estradiol (0.0025 and 0.0050 mg/kg/day), Methoxychlor (12.5, 25, and 50 mg/kg/day), or Phenobarbital (25, 50 and 100 mg/kg/day), once daily via oral gavage from PND 22-42/43. (nih.gov)
  • Methoxychlor was tested by the oral route only in the rat. (inchem.org)
  • The oral LD 50 in rats is 39 mg/kg, and the dermal LD 50 in rabbits is 65 mg/kg. (merckvetmanual.com)
  • Effect
  • The lowest observable effect level (LOEL) for an endocrine effect was 25 mg/kg/day for Flutamide, 10 mg/kg/day for Vinclozolin, 100 mg/kg/day for Phenobarbital, 12.5 mg/kg/day for Methoxychlor, and 0.005 mg/kg/day for Ethinyl Estradiol. (nih.gov)
  • formation
  • Role of neurotropins in rat embryonic testis morphogenesis (cord formation). (epa.gov)