Rats ovariectomy. Medical search. Frequent questions

This work was undertaken on female Wistar rats aged 12-14 months. (biomedcentral.com)
METHODS: Twenty-four female Wistar rats were divided into 2 groups and animals in each group were fed either a normal diet (ND) or a high-fat diet (HFD) for 24 weeks. (cmu.ac.th)
Methods: Female Wistar rats were divided into six groups: the sham, model, and Xian-Ling-Gu-Bao capsule (XLGB) groups, and the low-, medium-, and high-dose PTE groups. (researchgate.net)

Olive oil effectively mitigated ovariectomy-induced osteoporosis in rats, and is a promising candidate for the treatment of postmenopausal osteoporosis. (biomedcentral.com)
Thus, we investigated the effects of Pu-erh tea extract (PTE) on ovariectomy-induced osteoporosis in rats and on osteoclastogenesis in vitro. (researchgate.net)
Conclusion: PTE can ameliorate ovariectomy-induced osteoporosis in rats and suppress osteoclastogenesis in vitro. (researchgate.net)

This study evaluated the effects of the amount and ratio of dietary n-6 and n-3 polyunsaturated fatty acids (PUFAs) on bone mineral in 3-month-old sexually mature ovariectomized (OVX) Sprague-Dawley rats. (nih.gov)
METHODS The study was performed in 48 female 5 months old Sprague-Dawley rats. (dtu.dk)
Experiments in this study examined the effects of wheel running on intakes of chow and palatable diet e.g. high fat (HF) or high sucrose (HS) diet in male and female Sprague-Dawley rats. (johnshopkins.edu)

Local Changes in Immunoreactive Gonadotropin Releasing Hormone in the Rat Median Eminence during the Estrous Cycle. (karger.com)
Ketanserin and anxiety levels: Influence of gender, estrous cycle, ovariectomy and ovarian hormones in female rats. (bvsalud.org)

Female rats with intact ovaries and ovariectomized (OVX) females treated with 17β-estradiol, progesterone, or placebo were subjected to transient, unilateral middle cerebral artery occlusion followed by reperfusion (I/R). The maximum contractile response, measured my wire myography, in response to the endothelin B receptor agonist sarafotoxin 6c was increased in female arteries after I/R, but the maximum response was significantly lower in arteries from OVX females. (lu.se)

Heersche, Johan N.M. / Effects of ovariectomy on turnover of alveolar bone in the healed extraction socket in rat edentulous mandible . (elsevierpure.com)

Mammary tissue is extensive in both female and male rats and is found ventral, lateral and dorsal, running from the shoulder and chin area to the base of the tail. (ratguide.com)
The Sprague-Dawley male rats were divided randomly into four groups: normal group, diabetes mellitus group (DM group), DM with EA treatment group (EA group), and DM with sham EA treatment group (sham EA group). (hindawi.com)
Experiment 1 demonstrated that acute wheel running results in robust HF or HS diet avoidance in male rats. (johnshopkins.edu)
Experiment 2 demonstrated that male rats developed decreased HF diet preferences regardless of the order of diet and wheel running access presentation. (johnshopkins.edu)
Ovariectomy in females resulted in HF diet preference patterns that were similar to those in male rats during simultaneous exposure of HF and wheel running access but similar to intact females when running occurred before HF exposure. (johnshopkins.edu)

All the treatments significantly restored this depressed molecular profile revealed in OVX rats. (unime.it)
Genistein aglycone, 1mg/kg , also significantly increased the thickness of collagen and breaking strength of skin in the OVX rats. (unime.it)
Dual-energy X-ray absorptiometry measurements for femur and tibia bone mineral content (BMC) and bone mineral density showed that the DHA-rich diets (HP5 and LP5) resulted in a significantly lower bone loss among the OVX rats at 12 weeks. (nih.gov)
CTX decreased significantly compared to vehicle treatment over the five week treatment period in the S-M treated but not in the S-G treated rats. (dtu.dk)
The bladder weight, serum glucose, bladder wall thickness, volume threshold for micturition, and postvoid residual (PVR) volume in the diabetic rats were significantly higher than those in the control animals. (hindawi.com)
EA treatment significantly reduced the bladder weight, bladder wall thickness, volume threshold for micturition, and PVR volume in diabetic rats. (hindawi.com)
For the intact animals, ody weights in the three vitamin E supplemented groups respectively did not differ significantly from the normal rat chow group throughout the ten-month study period. (medicaljournal-ias.org)
Ovariectomy significantly increased body weights of the rats on the normal rat chow diet and the three vitamin E supplemented diets. (medicaljournal-ias.org)
However, ovariectomy failed to increase body weights of the total and partial vitamin E deficient diet groups, which did not differ significantly from their intact controls. (medicaljournal-ias.org)
Our results showed that ovariectomy significantly increased the activity of cytosolic creatine kinase, but did not alter the activity of creatine kinase in the mitochondrial fraction of hippocampus of female adult rats. (ufrgs.br)

Since osseointegration around implants requires formation and maintenance of new bone, knowledge of how ovariectomy (OVX) affects turnover of mandibular and maxillary bone is required. (elsevierpure.com)
In the present study, we investigated the effects of OVX on turnover of alveolar bone in the healed extraction socket of the rat left mandibular incisor. (elsevierpure.com)
Conclusions: Our results suggest that OVX increases the turnover of alveolar bone in the healed extraction socket of rat mandibular incisor, resulting in a decrease of cancellous bone volume with time. (elsevierpure.com)
Salgado MCM, Marchin AMP da S, Tera T de M, Rocha RF da, Marchini L. Effects of estrogen deficiency combined with chronic alcohol consumption on rat mandibular condyle. (unicamp.br)
Aim: To investigate the effects of estrogen deficiency associated with chronic alcohol consumption on the mandibular condyle in rats. (unicamp.br)

Methods: The molars and the incisor on left side in 6-month-old Sprague-Dawley female rats (n = 38) were extracted and left to heal for 4 months. (elsevierpure.com)
Tumors can arise anywhere that mammary tissue type is present but is most often seen at the pit of the arm, abdomen, and groin of female rats. (ratguide.com)
AIM Ovariectomy of female rats induces significant bone-loss by depriving endogenous estrogen production. (dtu.dk)
The effects of vitamin E deficiency and supplementation on body weight in intact and ovariectomised female rats were studied. (medicaljournal-ias.org)
Diet was administered ad libitum to sham control (SHAM) and OVX female rats until the onset of glucose intolerance in OVX rats as determined by an intraperitoneal glucose tolerance test (IPGTT). (uoguelph.ca)
Methods: Fifty-four female rats were first divided equally into two groups: ovariectomized (Ovx) and simulated ovariectomy (Sham). (unicamp.br)
In this study, we evaluated the effects of ovariectomy, an animal model of hormonal depletion on some biochemical and behavioral parameters in female adult rats. (ufrgs.br)
Initially, we investigated the effect of ovariectomy on some parameters of energy metabolism (Na+,K+-ATPase, pyruvate kinase and respiratory chain enzymes) in striatum of female adult rats. (ufrgs.br)
We also tested the effect of ovariectomy on the creatine kinase activity in cytosolic and mitochondrial fractions prepared from hippocampus of female rats. (ufrgs.br)
Finally, we investigated the effect of ovariectomy on anxiety-like behavior in female adult rats. (ufrgs.br)
Reproductive Senescence and Ischemic Stroke Remodel the Gut Microbiome and Modulate the Effects of Estrogen Treatment in Female Rats. (tamu.edu)
10-12-month-old) Sprague-Dawley female rats, that are naturally estrogen-deficient, have worse stroke outcomes as compared to normally estrous-cycling adult (5-6-month-old) females. (tamu.edu)
These data provide the first evidence that microbial gut communities and metabolites are altered by reproductive senescence in female rats at baseline and after stroke, and suggest that estrogen may impact stroke recovery differently in adult and reproductive senescent females due to an age-specific effect on gut microbiota and metabolites. (tamu.edu)
Although female rats with running wheel access initially showed complete avoidance of the two palatable diets, the avoidance of the HS diet was transient. (johnshopkins.edu)
In female rats, simultaneous presentation of the HF diet and running access resulted in transient complete HF diet avoidance whereas running experience prior to HF diet access did not affect the high preference for the HF diet. (johnshopkins.edu)

This study was conducted to evaluate the protective effects of olive oil supplementation against osteoporosis in ovariectomized (OVX) rats. (biomedcentral.com)
These changes were attenuated by olive oil supplementation in the Olive-OVX rats. (biomedcentral.com)
In light of the aforementioned data, we undertook this study to evaluate the efficacy of olive oil supplementation in preventing menopause-induced osteoporosis using the ovariectomized rat model. (biomedcentral.com)
Under such background, we have supplemented Ovariectomized (OVX) - rats with olive oil four weeks before ovariectomy with an aim to evaluate the efficacy of olive oil supplementation starting before menopause. (biomedcentral.com)
The Effects of Estrogen, Grape Pomace, and Resveratrol Supplementation on Glucose Tolerance and Insulin Signaling in Ovariectomized Rats. (uoguelph.ca)

Our hypothesis was that estrogen deficiency aggravates skeletal muscle dysfunction in obese-insulin resistant rats, via increased muscle oxidative stress and mitochondrial dysfunction. (cmu.ac.th)
CONCLUSIONS: These findings suggest that skeletal muscle dysfunction may occur due to increased muscle oxidative stress and mitochondrial dysfunction as a result of ovariectomy and obese-insulin resistance. (cmu.ac.th)
In addition, EA repaired the damaged bladder detrusor muscle of diabetic rats by reducing mitochondrial damage of the SMCs and fibroblasts. (hindawi.com)

Application of PBM to the recipient site before and after fat transfer improved outcomes in rats at 56 day after fat grafting by means of volume retention, increased neovascularization and adipocyte viability and reduced necrosis, fibrosis and inflammation. (google.com)
This study was conducted to determine whether the daily consumption for 84 days of tyrosol and hydroxytyrosol, the main olive oil phenolic compounds, and olive oil mill wastewater (OMWW), a byproduct of olive oil production, rich in micronutrients, may improve bone loss in ovariectomized rats (an experimental model of postmenopausal osteoporosis) and in ovariectomized rats with granulomatosis inflammation (a model set up for senile osteoporosis). (nih.gov)
As expected, an induced chronic inflammation provoked further bone loss at total, metaphyseal, and diaphyseal sites in ovariectomized rats. (nih.gov)

At week 13, rats in each group were subdivided into 2 subgroups: sham-operated or ovariectomized (n = 6/subgroup). (cmu.ac.th)
RESULTS: We found that an obese-insulin resistant condition was observed in sham-operated HFD-fed rats, ovariectomized ND-fed rats, and ovariectomized HFD-fed rats. (cmu.ac.th)

CONCLUSIONS AND IMPLICATIONS: Relatively long-term, systemic treatment with genistein aglycone shows comparable efficacy to oestrogen in reversing some molecular, histological and functional changes of the skin associated with ovariectomy in aged rats. (unime.it)

In the Olive-OVX rats these parameters were markedly improved as compared to the OVX group. (biomedcentral.com)
Results: Bone turnover was increased by ovariectomy (OVX) as reflected by increased static parameters of bone formation and resorption. (elsevierpure.com)

Rats fed the LP diets displayed the lowest overall serum concentrations of the bone resorption biomarkers pyridinoline (Pyd) and deoxypyridinoline, whereas the bone formation marker osteocalcin was lowest in the HP groups. (nih.gov)

Rats fed ad libitum (free-fed) have lower survival and a higher incidence of pancreatic, mammary, and pituitary tumors than rats fed a moderate dietary restriction of identical diets (Boorman & Everitt, 2006). (ratguide.com)

We investigated the effects of genistein aglycone and compared them with systemic raloxifene hydrochloride and 17-α-ethinyloestradiol on skin changes in aged, ovariectomized (OVX) rats. (unime.it)
This study aimed to evaluate the effects of TQ on spatial memory and hippocampal long-term potentiation (LTP) in rats with thioacetamide (TAA)-induced liver injury and hepatic encephalopathy. (magiran.com)
Therefore, we explored the effects and mechanisms of EA on DBD in streptozotocin-high-fat diet- (STZ-HFD-) induced diabetic rats. (hindawi.com)
Flores, C. & Stewart, J. (2000) Basic fibroblast growth factor as a mediator of the effects of glutamate in the development of sensitization to stimulant drugs: studies in the rat. (concordia.ca)
Sorge, R. E., & Stewart, J. (2006)The effects of chronic buprenorphine on intake of heroin and cocaine in rats and its effects on nucleus accumbens dopamine levels during self-administration. (concordia.ca)
Sorge, R. E., & Stewart, J. (2006)The effects of long-term chronic buprenorphine treatment on the locomotor and nucleus accumbens dopamine response to acute heroin and cocaine in rats. (concordia.ca)
Here we adopted a controlled, prospective design in a nonhuman primate model to test the effects of ovariectomy and estrogen replacement on normal cognitive aging. (jneurosci.org)
The present exploratory study in a rat model sought to investigate effects of differential expression of Ciita on bone structural integrity and strength. (lu.se)

For 12 weeks, the rats were fed either a high-PUFA (HP) or a low-PUFA (LP) diet with a ratio of n-6/n-3 PUFAs of 5:1 (HP5 and LP5) or 10:1 (HP10 and LP10). (nih.gov)
Germinated brown rice ameliorates obesity in high-fat diet induced obese rats. (greenmedinfo.com)
The control diet was normal rat chow. (medicaljournal-ias.org)

Our goal was to assess whether short term treatment with strontium in ovariectomized rats would affect biochemical markers of bone turnover as well as promote a bone strength. (dtu.dk)

EXPERIMENTAL APPROACH: Six months after ovariectomy, rats were randomly allocated to different groups and treated, daily, with genistein aglycone (1 and 10mg/kg s.c.), raloxifene hydrochloride (0.05 and 0.5mg/kg s.c.) or 17-α-ethinyloestradiol (0.003 and 0.03mg/kg s.c.) for 12 weeks. (unime.it)

The site-dependent variations in trabecular bone morphology were studied in the rat tibia by magnitude and phase difference three-dimensional nuclear magnetic resonance microscopy and image processing, and the implications of ovariectomy were evaluated. (elsevierpure.com)

Regardless of the dietary PUFA content, DHA in the 5:1 diets (HP5 and LP5) preserved rat femur BMC in the absence of estrogen. (nih.gov)
To induce vitamin E deficiency, the rats were fed vitamin E deficient and 50% vitamin E deficient diets. (medicaljournal-ias.org)

EA reduced the infiltration of inflammatory cells in the bladder mucosa layer of diabetic rats. (hindawi.com)

Light microscopic examination of the tibia of the OVX rats revealed a significant decrease in the cortical bone thickness (CBT) and the trabecular bone thickness (TBT). (biomedcentral.com)

We observed that the animal behavior in the elevated plus maze task and in light-dark box test was not affected by ovariectomy. (ufrgs.br)

KEY RESULTS: Skin samples of untreated OVX rats showed a decrease in TGF-β1, VEGF, MMP-2, MMP-9, tissue inhibitor of metalloproteinase (TIMP)-1 and TIMP-2 compared with sham OVX rats. (unime.it)
Estrogen plays a role in maintaining body weight, since ovariectomy in rats, resulting in hypoestrogenemia, also results in significant weight gain. (medicaljournal-ias.org)
Results showed that ovariectomy increases the activity of the enzymes Na+,K+-ATPase, succinate dehydrogenase and complex II. (ufrgs.br)
Results: In DA.VRA4 rats, BMD/BMC, cross-sectional area and biomechanical properties were lower. (lu.se)

To study the relative abundance and the changes of both estrogen receptor alpha (ERalpha) and ERbeta mRNA before and after ovariectomy in major organs important to the regulation of calcium homeostasis, we compared the degree of mRNA expression of ERalpha to that of ERbeta in rat tissues by performing competitive reverse transcription polymerase chain reaction (RT-PCR) with internal standards. (yonsei.ac.kr)
Mouse, rat, and human IL-17A can induce IL-6 secretion in mouse stromal cells, indicating that all homologs can recognize the mouse IL-17A receptor. (thermofisher.com)

However, as testosterone is released in the male rat fetus before mammary tissue development occurs the mammary glands are rudimentary, and they do not have nipples. (ratguide.com)

The OVX-rats showed a significant decrease in plasma calcium levels, and a significant increase in plasma ALP, MDA, and nitrates levels. (biomedcentral.com)

Ovariectomized (OVX) rats were used as an animal model of osteoporosis. (researchgate.net)
For this dissertation, I developed a rat model of hysterectomy to systematically evaluate the role of hysterectomy in the context of cognition. (fabbs.org)

No difference in phosphorylation of the insulin signaling protein, Akt, was found after insulin injection in any tissue between SHAM and OVX rats. (uoguelph.ca)

It is well known that caloric intake affects tumor incidence in rats. (ratguide.com)

These findings show that dietary DHA lowers the ratio of 18:2n-6 (linoleic acid)/n-3 in bone compartments and that this ratio in tissue correlates with reduced Pyd but higher bone alkaline phosphatase activity and BMC values that favor bone conservation in OVX rats. (nih.gov)

The mRNA expression of ERalpha in the bone marrow and renal cortex decreased abruptly after ovariectomy, which may partially explain why the effect of estrogen deficiency can be amplified and why trabecular bone loss is more predominant than cortical bone loss shortly after surgical or natural menopause. (yonsei.ac.kr)

The classical three-point bending and impact tests were carried out for three rat bone groups: control (SHO), the humerus of animals under the conditions of established osteopenia (OVX), and bones of rats receiving nesfatin-1 after ovariectomy (NES). (mdpi.com)
After 4 weeks, the 36 OVX rats were randomized into three groups and subjected to treatment by oral gavage with vehicle alone or vehicle + 533 mg/kg/day strontium glutamate (S-G) or 300 mg/kg/day strontium malonate (S-M)(both doses correspond to 137 mg ionic strontium/kg/day). (dtu.dk)

4 weeks before ovariectomy and 8 weeks after. (biomedcentral.com)
After 4 weeks acclimatization, 12 rats were subjected to sham operation and the remaining 36 were ovariectomized (OVX). (dtu.dk)

In this paper, the influence of nesfatin-1 administration on rat humerus mechanical properties was analyzed. (mdpi.com)

At the end of the experimental period the contraction of the gastrocnemius muscles was tested before the rats were sacrificed. (cmu.ac.th)

Delayed E2 replacement, RESV and GP were not effective in restoring normal glucose tolerance in OVX rats. (uoguelph.ca)

This study indicates that the dietary ratio of n-6/n-3 PUFAs (LP5 and HP5) and bone tissue concentration of total long-chain n-3 PUFAs (DHA) minimize femur bone loss as evidenced by a higher BMC in OVX rats. (nih.gov)

Description: The eBio17B7 antibody reacts with mouse and rat IL-17A with no recognition of IL-17F. (thermofisher.com)

Examination of the liver specimens revealed mononuclear cellular infiltration in the portal areas in the OVX-rats which was not detected in the Olive-OVX rats. (biomedcentral.com)
Research was administered on rats and it had been found that garlic inhibited the synthesis of cholesterol within the rat liver cells . (vedantu.com)

BACKGROUND AND PURPOSE: Ovariectomy accelerates age-related skin changes as adequate oestrogen levels are required to control structural integrity and functional capacity of skin. (unime.it)
Specimens excised from the proximal tibial metaphysis in ovariectomized (n = 7) and intact control (n = 4) rats were imaged at 9.4T with their anatomic axes parallel to the direction of the magnetic field. (elsevierpure.com)

In the present study, it was aimed to determine the effect of estradiol and progesterone on homocysteine levels in pinealectomized and ovariectomized rats. (nel.edu)

pQCT analysis of the distal femur revealed only a relatively modest effect of strontium treatment on BMD (693 and 703 mg/cm3 in S-M and S-G respectively compared to 671 mg/cm3 in vehicle treated OVX and 750 mg/cm3 SHAM rats). (dtu.dk)
Insulin tolerance was not worsened in OVX rats, and was unaffected with treatment. (uoguelph.ca)

Antihypertensive effect of giant embryo brown rice and pre-germinated giant embryo brown rice on spontaneously hypertensive rats. (greenmedinfo.com)
Cholesterol lowering and antioxidative effect of pregerminated brown rice in hypercholesterolemic rats. (greenmedinfo.com)
Effect of pinealectomy on homocysteine levels in ovariectomized rats. (nel.edu)

Loss of estrogen, however, did not aggravate these impairments in the muscle of rats with obese-insulin resistant condition. (cmu.ac.th)

Anatomy15

Organisms8

Diseases9

Chemicals and Drugs28

Analytical, Diagnostic and Therapeutic Techniques and Equipment11

Phenomena and Processes23

Information Science1

Health Care1

Wistar3

Osteoporosis in rats3

Sprague-dawley rats3

Estrous Cycle2

Middle Cerebr1

Mandible1

Male rats5

Significantly10

Mandibular5

Female15

Supplementation5

Mitochondrial3

Inflammation3

Sham-operated2

Conclusions1

Parameters2

Bone formation1

Libitum1

Effects8

Diet3

Biochemical1

Randomly1

IMPLICATIONS1

Diets2

Diabetic1

Tibia1

Behavior1

Results4

Receptor2

Mammary glands1

Decrease1

Model2

Phosphorylation1

Affects1

Findings1

Estrogen deficiency1

Groups2

Weeks2

Influence1

Experimental1

Normal1

Dietary1

Recognition1

Liver2

Control2

Study1

Treatment2

Effect3

Insulin1