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HypertrophyCardiomegalyMyocardiumHypertrophy, Left VentricularMyocytes, CardiacHeartMyocardial ContractionHeart VentriclesRats, Sprague-DawleyRats, WistarHypertrophy, Right VentricularOrgan SizeVentricular RemodelingEchocardiographyFibrosisBlood PressureDisease Models, AnimalPapillary MusclesCardiotonic AgentsAtrial Natriuretic FactorIsoproterenolHeart FailureVentricular Function, LeftHemodynamicsCalcineurinHypertensionMyocardial InfarctionTime FactorsAngiotensin IICardiomyopathy, HypertrophicMyocardial IschemiaMice, TransgenicPhenylephrineEndomyocardial FibrosisSarcomeresCells, CulturedRNA, MessengerRats, Inbred WKYCalciumMyocardial Reperfusion InjuryReceptors, Adrenergic, betaSignal TransductionCardiomyopathiesCardiac OutputArrhythmias, CardiacHeart RateMyosin Heavy ChainsCell SizeCell EnlargementAdrenergic beta-AgonistsElectrocardiographyMice, KnockoutCoronary CirculationRats, Inbred SHRVentricular PressureMice, Inbred C57BLBody WeightAnimals, NewbornCardiomegaly, Exercise-InducedRats, Inbred StrainsGene ExpressionMuscle ProteinsVentricular Dysfunction, LeftConstrictionCardiomyopathy, DilatedHeart DiseasesPressureMitochondria, HeartDeath, Sudden, CardiacDogsMyocardial StunningGene Expression RegulationCardiac Surgical ProceduresCardiac MyosinsPerfusionNFATC Transcription FactorsVentricular MyosinsGATA4 Transcription FactorEndothelin-1Ventricular Function, RightSarcoplasmic Reticulum Calcium-Transporting ATPasesSarcoplasmic ReticulumPhosphorylationDiastoleBlotting, WesternHeart AtriaDose-Response Relationship, DrugMyocardial ReperfusionReceptors, Adrenergic, alphaMuscle CellsMyosinsSystoleCardiac Output, LowPhysical Conditioning, AnimalVentricular FunctionNatriuretic Peptide, BrainAortaImmunohistochemistryHeart Function TestsStroke Volume
Right ventricularDysfunctionFibrosisOxidative stressEchocardiographyMyocytesInducesEjection fractionContractilityPathogenesis of cardiacAngiotensinCardiomyocyte hypertrophyCardiomyocytesFunctionCongestive Heart FVolume overload-inducedPressure overloadMiceSystolic performancePathologicalDiabeticHypertensionMechanismsIncrease in cardiacIncreasesAutocrine-paracrineTissueDilated cardiomyopathyTroponinFibroblastsLeft ventricleApoptosisProliferationSeptalDilationCharacterizeStimulationInhibitionRemodelingElectrophysiologyIschemicAdultMitralResident cardiacSkeletal muscleRegulationParacrineArrhythmiaInflammationCollagenReversalHeart failureGeneIncidence
Right ventricular2
Dysfunction15
  • A Disintegrin and Metalloprotease-17 Regulates Pressure Overload-Induced Myocardial Hypertrophy and Dysfunction Through Proteolytic Processing of Integrin β1. (kassirilab.com)
  • p38 mitogen-activated protein kinase (p38 MAPK) inhibition exerts beneficial effects on left ventricular (LV) remodeling and dysfunction. (aspetjournals.org)
  • In particular, diastolic dysfunction and impaired SR Ca2+ handling were improved in severe LV pressure overload hypertrophy and diabetic cardiomyopathy. (fu-berlin.de)
  • Heart failure with preserved ejection fraction (HFpEF) and right ventricular (RV) dysfunction are frequent complications of diabetic cardiomyopathy. (unideb.hu)
  • Thus, we examined if the interaction of prediabetes and salt-sensitive hypertension exacerbated myocardial dysfunction and accelerated the development of HFpEF in young GK rats. (edu.au)
  • Therefore, we aimed at comparing speckle-tracking echocardiography (STE)-derived parameters to the indices of left ventricular (LV) pressure-volume (PV) analysis to detect cardiac dysfunction in rat models of type-1 (T1DM) and type-2 (T2DM) diabetes mellitus. (biomedcentral.com)
  • Based upon that, in the current study we aimed at comparing STE with PV analysis for the detection of characteristic differences between T1DM- and T2DM-associated cardiac dysfunction in relevant rodent models. (biomedcentral.com)
  • Percutaneous transluminal renal angioplasty (PTRA) fails to fully improve cardiac injury and dysfunction in patients with renovascular hypertension (RVH). (biomedcentral.com)
  • In conclusion, the present study confirmed that CA resuscitation activated the renin‑Ang II‑AT1R signaling pathway, which may contribute to myocardial dysfunction in rats. (spandidos-publications.net)
  • The present study confirmed that EPO treatment is beneficial for protecting cardiac function post‑resuscitation, and the roles of EPO in alleviating post‑resuscitation myocardial dysfunction may potentially be associated with enhanced myocardial expression of AT2R. (spandidos-publications.net)
  • The mortality rate following cardiopulmonary resuscitation (CPR) in out-of-hospital cardiac arrest (CA) is ~75%, one-third of which is thought to be caused by myocardial dysfunction ( 1 ). (spandidos-publications.net)
  • 13]Peng H,Sarwar Z,Yang XP,et al.Profibrotic Role for Interleukin-4 in Cardiac Remodeling and Dysfunction[J].Hypertension,2015,66(3):582-589. (xml-journal.net)
  • At that time the evidence also suggested that diastolic dysfunction was due to myocellular hypertrophy and myocardial fibrosis, and at the cellular level there were defects in calcium transportation, myocardial contractile protein collagen formation, and fatty acid metabolism ( 2 ). (diabetesjournals.org)
  • Left ventricular diastolic dysfunction is characterized by impairment in early diastolic filling, prolongation of isovolumetric relaxation, and increased atrial filling, and these characteristics have even been documented in young type 1 diabetic patients ( 3 ). (diabetesjournals.org)
  • While these studies of diastolic dysfunction were performed in diabetic patients with a normal left ventricular mass, left ventricular hypertrophy is more prevalent in type 2 diabetic patients and contributes to ventricular dysfunction. (diabetesjournals.org)
Fibrosis12
  • In this study, we found that Wistar rats, exposed to tobacco cigarette smoke at doses of 5, 10, or 15 cigarettes for 30 min twice a day for 1 month, had a dose-dependently reduced heart weight to body weight ratio and enhanced interstitial fibrosis as identified by histopathologic analysis. (nih.gov)
  • In hypertensive heart disease, reactive myocardial fibrosis represents as an excessive accumulation of fibrillar collagen within the normal connective tissue structures of the myocardium. (springer.com)
  • Thus cardiac fibroblast function is modulated by either effector hormone of the RAAS, AngII and ALDO, via specific receptors that lead to progressive myocardial fibrosis in disease states where circulating or local RAAS is activated, i.e., in hypertensive heart disease. (springer.com)
  • Weber KT, Brilla CG (1991) Pathological hypertrophy and cardiac interstitium: fibrosis and reninangiotensin-aldosterone system. (springer.com)
  • Animals receiving RWJ 24 h after MI for 7 days showed similar improvements in fractional shortening, dP/dt max , LVEDP, including reduced fibrosis and hypertrophy. (aspetjournals.org)
  • In T1DM, SrS correlated with contractility, SrIVR with active relaxation, while in T2DM SrE was related to cardiac stiffness, cardiomyocyte diameter and fibrosis. (biomedcentral.com)
  • Pathologies, as atherosclerosis, cardiac fibrosis, and cardiomyopathy, are often linked to the failure of cardiovascular tissue cells to reenter the cell cycle, namely, senescence, due to endogenous or exogenous causes. (hindawi.com)
  • In summary, this present study would probe the influences of AREG on cardiac hypertrophy and fibrosis, and quest whether AREG regulates cardiac hypertrophy through affecting oxidative stress and apoptosis. (beds.ac.uk)
  • Chronic cardiac inflammation and fibrosis can progress into severe forms of cardiomyopathy. (spandidos-publications.com)
  • Sophora flavescens alkaloids (KuShen) have been previously reported to exert anti‑inflammatory effects, whereas Panax quinquefolium saponins (XiYangShen) has been shown to alleviate cardiac fibrosis. (spandidos-publications.com)
  • The second stage is characterized by chronic inflammation of the myocardium, which causes myocardial remodeling and fibrosis, ultimately progressing into dilated cardiomyopathy (DCM) ( 2 ). (spandidos-publications.com)
  • Unlike myocardial fibrosis, which is likely due to hyperglycemia, left ventricular hypertrophy is most likely related to the insulin resistance syndrome ( 12 ). (diabetesjournals.org)
Oxidative stress4
  • Using rats overexpressing human amylin in the pancreas (HIP rats) and control myocytes incubated with human amylin, we show that amylin aggregation at the sarcolemma induces oxidative stress and Ca(2+) dysregulation. (nih.gov)
  • Does oxidative stress modulate left ventricular diastolic function in asymptomatic subjects with hereditary hemochromatosis? (uc.edu)
  • Intra-renal MSC delivery during PTRA preserved stenotic-kidney function, reduced systemic oxidative stress and inflammation, and thereby improved cardiac function, oxygenation, and myocardial injury four weeks after revascularization, suggesting a therapeutic potential for adjunctive MSC delivery to preserve cardiac function and structure after reversal of experimental RVH. (biomedcentral.com)
  • This research aims to explore the effect of AREG on cardiac hypertrophy, and whether the oxidative stress and apoptosis was involved in the influence of AREG on cardiac hypertrophy. (beds.ac.uk)
Echocardiography4
  • Cardiac function was assessed by echocardiography and hemodynamic measurements. (aspetjournals.org)
  • Left ventricular volume with three-dimensional echocardiography: all vendors the same? (uc.edu)
  • The left ventricular end-diastolic volume (LVEDV) and LVEF were determined by echocardiography, and New York Heart Association (NYHA) functional class was estimated. (snmjournals.org)
  • Left ventricular structure and function were measured by echocardiography and two-dimensional speckle tracking imaging for analysis of left ventricular strain and strain rate. (xml-journal.net)
Myocytes4
  • Here, we investigated whether amylin aggregates interact directly with cardiac myocytes and whether controlling hyperamylinemia protects the heart.By Western blot, we found abundant amylin aggregates in lysates of cardiac myocytes from obese patients, but not in controls. (nih.gov)
  • Treatment doubled the blood concentration of eicosanoids, which drastically reduced incorporation of aggregated amylin in cardiac myocytes and blood cells, without affecting pancreatic amylin secretion. (nih.gov)
  • Pertinently, a pan-CYP26 inhibitor, talarozole, blunted the impact of phenylephrine on ATRA decline and hypertrophy in neonatal rat ventricular myocytes. (jci.org)
  • IP3-dependent increases in nucleoplasmic Ca²⁺ in adult cardiac myocytes. (icm-mhi.org)
Induces1
  • Initially, the increased workload that results from high blood pressure or loss of contractile tissue induces compensatory cardiomyocyte hypertrophy and thickening of the left ventricular wall, thereby enhancing contractility and maintaining cardiac function. (justia.com)
Ejection fraction3
  • The Valsartan in Heart Failure Trial (Val-HeFT) reported that the addition of valsartan significantly improves New York Heart Association (NYHA) functional class, left ventricular remodeling, left ventricular ejection fraction (LVEF), and signs and symptoms of heart failure ( 16 ). (snmjournals.org)
  • Publisher Correction to: Electrocardiogram-less, free-breathing myocardial extracellular volume fraction mapping in small animals at high heart rates using motion-resolved cardiovascular magnetic resonance multitasking: a feasibility study in a heart failure with preserved ejection fraction rat model. (ucla.edu)
  • Electrocardiogram-less, free-breathing myocardial extracellular volume fraction mapping in small animals at high heart rates using motion-resolved cardiovascular magnetic reesonance multitasking: a feasibility study in a heart failure with preserved ejection fraction rat model. (ucla.edu)
Contractility4
  • When normalized for cardiac mass, female hearts developed higher pressures than males, suggesting superior contractility in the face of hypertensive heart disease. (medscape.com)
  • The difference between mechanical in- crease in peripheral resistance and the added factor of a change in myocardial 'contractility' was demonstrated in the following experiment: clamping the aorta resulted in a go per cent increase in left ventricular pressure but sympathetic stimulation to the heart during aortic clamping produced an additional increase of 120 per cent with systolic pressures rising to above 300 mm Hg (6). (nih.gov)
  • Left ventricular contractility also can be increased by reducing the perfusion pressure within the carotid sinus (200). (nih.gov)
  • Likewise, LV contractility and maximal first derivative of left ventricular pressure (dP/dt max ) was improved (12.5 and 14.4%) and LV end diastolic pressure (LVEDP) was reduced (49.4 and 54.6%) with both treatments. (aspetjournals.org)
Pathogenesis of cardiac2
  • However, the molecular mechanism behind the pathogenesis of cardiac disease is unknown. (nih.gov)
  • Although considerable progress has been made in elucidating the molecular pathogenesis of cardiac hypertrophy, the precise mechanisms guiding the hypertrophic process remain unknown. (pharmaceuticalintelligence.com)
Angiotensin3
  • In order to elucidate the role of the RAAS effector hormones, angiotensin II (AngII) and aldosterone (ALDO), in the regulation of collagen synthesis or inhibition of MMP 1 production, adult human cardiac fibroblasts were cultured. (springer.com)
  • ACE inhibitors are believed to act principally by blocking the formation of angiotensin II (A-II), a potent vasoconstrictor and cardiovascular growth stimulator that may contribute to increased impedance to left ventricular ejection and cardiac remodeling ( 8 , 9 ). (snmjournals.org)
  • Angiotensin (Ang) II induced cardiac hypertrophy in mice and neonatal rat cardiomyocytes (NRCMs) or HL-1 cells in vitro. (beds.ac.uk)
Cardiomyocyte hypertrophy1
  • We speculate that a combination of cardiomyocyte hypertrophy and enhanced epicardial fibre function are the most likely mechanisms for the preserved global LV function in young GK rats. (edu.au)
Cardiomyocytes8
  • Cardiomyocyte passive tension (Fpassive) was higher in LV and RV cardiomyocytes of ZDF rats than in those receiving preventive vardenafil treatment. (unideb.hu)
  • Ca2+-sensitivity of isometric force production (pCa50) was significantly higher in LV (but not in RV) cardiomyocytes of ZDF rats than in their counterparts in the Lean or Lean + Vard groups. (unideb.hu)
  • In accordance, the phosphorylation levels of cardiac troponin I (cTnI) and myosin binding protein-C (cMyBP-C) were lower in LV (but not in RV) cardiomyocytes of ZDF animals than in their counterparts of the Lean or Lean + Vard groups. (unideb.hu)
  • Our data illustrate partially overlapping myofilament protein alterations for LV and RV cardiomyocytes in diabetic rat hearts upon long-term PDE-5A inhibition. (unideb.hu)
  • The ischemia and hypoxia caused by the sudden occlusion of the main coronary arteries lead to myocardial infarction, leading to hypertrophic growth of cardiomyocytes and left ventricular dilatation, which eventually develops into heart failure. (researchsquare.com)
  • Over time, however, the left ventricular chamber dilates, systolic pump function deteriorates, cardiomyocytes undergo apoptotic cell death, and myocardial function progressively deteriorates. (justia.com)
  • After AREG downregulation, the increases of Ang II induced cardiac weight and cardiomyocytes area were inhibited. (beds.ac.uk)
  • Transplantation of iPS-derived cardiomyocytes was found to "integrate into host myocardium and generate organized sarcomeric structures, while endothelial and smooth muscle cells contribute to the host vasculature," as reported in the review. (pulmonologyadvisor.com)
Function26
  • In a study using aortic banding to mimic pressure overload, male and female rats had similar increases in left ventricular wall thickness and mass after 6 weeks, with preserved systolic function. (medscape.com)
  • For example, women with aortic stenosis develop concentric hypertrophy, lower wall stress and better systolic function compared with men. (medscape.com)
  • [ 37 ] Another study in ovariectomized spontaneously hypertensive rats demonstrated that those who received the estrogen receptor α-specific agonist had smaller end systolic volumes and better left ventricular function compared with those treated with a nonspecific estrogen-receptor agonist or controls. (medscape.com)
  • found that 2 hr of exposure to SHS significantly destroyed cardiac autonomic function, as evidenced by decrements in heart rate variability in 16 adult nonsmokers. (nih.gov)
  • Collagen synthesis was determined by 3 H-proline incorporation, and MMP 1 activity by degradation of 14 C-collagen measured under serum-free conditions in confluent fibroblasts after 24 hour-incubation with either AngII or ALDO over a wide range of concentrations (10 -11 -10 -6 M). In addition, the effects of the mineralocorticoid, deoxycorticosterone (DOC), and prostaglandin E 2 (PGE 2 ) on cardiac fibroblast function were determined. (springer.com)
  • Timely and effective revascularization is extremely important for saving the infarcted myocardium and improving heart function. (researchsquare.com)
  • Interestingly, basal global cardiac function and β-adrenergic mediated positive inotropy was preserved in young GK rats. (edu.au)
  • In GK rats exposed to a HS diet, we observed subtle declines in basal global diastolic and systolic LV function. (edu.au)
  • Our results also indicate that impaired CB dynamics is a feature of early T2DM DCM, although global cardiac function is preserved. (edu.au)
  • Fascination with the role of Ca 2+ has proliferated into all aspects of our understanding of normal cardiac function and the progression of heart disease, including induction of cardiac hypertrophy, heart failure, and sudden death. (jci.org)
  • Mesenchymal stem cells (MSCs) restore renal function, but their potential for attenuating cardiac injury after reversal of RVH has not been explored. (biomedcentral.com)
  • We hypothesized that replenishment of MSCs during PTRA would improve cardiac function and oxygenation, and decrease myocardial injury in porcine RVH. (biomedcentral.com)
  • Cardiac structure, function (fast-computed tomography (CT)), and myocardial oxygenation (Blood-Oxygen-Level-Dependent- magnetic resonance imaging) were assessed in-vivo . (biomedcentral.com)
  • PTRA attenuated left ventricular remodeling, whereas myocardial oxygenation, subendocardial microvascular density, and diastolic function remained decreased in RVH + PTRA, but normalized in RVH + PTRA-MSC. (biomedcentral.com)
  • The addition of valsartan to an ACE inhibitor improves cardiac sympathetic nerve activity, left ventricular function, and symptoms in patients with CHF. (snmjournals.org)
  • This study was performed to determine whether valsartan can improve cardiac sympathetic nerve activity, left ventricular function, and symptoms in patients with CHF. (snmjournals.org)
  • AIM To evaluate the effects of diet and exercise intervention on left ventricular systolic function in obese rats. (xml-journal.net)
  • Increased diastolic function and decreased systolic function determine pathological hypertrophy, which usually causes heart failure and is related to increased cardiomyocyte death [ 12 ]. (beds.ac.uk)
  • Right ventricular (RV) function is well-established as 1 of the main prognostic risk factors in patients with pulmonary arterial hypertension (PAH). (pulmonologyadvisor.com)
  • 2 The authors proposed that "targeting angiogenesis in the RV myocardium appears to be a promising approach to improve its function…[and the] use of stem cells as therapeutic agents could, hence, represent a new treatment option for PAH . (pulmonologyadvisor.com)
  • This trilineage cell transplantation can significantly improve left ventricular function and angiogenesis, while reducing infarct size and cell apoptosis. (pulmonologyadvisor.com)
  • Beta-adrenergic stimulation maintains cardiac function in Serca2 knockout mice. (virtualrat.org)
  • There has been rapid development in functional cardiac tile function. (nih.gov)
  • MRI can be used to assess anatomy as a are known to decrease cardiac function by decreasing cal- function of cardiac cycle (1), regional blood flow using cium influx into the heart. (nih.gov)
  • 1 ated with changes in cardiac function (7). (nih.gov)
  • The heart is capable of maintaining contractile function despite a transient decrease in blood flow and increase in cardiac ATP demand during systole. (biomedcentral.com)
Congestive Heart F1
Volume overload-induced2
Pressure overload4
  • Treatment with 17β-estradiol (a nonspecific estrogen-receptor agonist and the major circulating estrogenic hormone) in ovariectomized rats with heart failure induced by aortic banding, led to an attenuation of hypertrophy in response to pressure overload. (medscape.com)
  • In severe left ventricular (LV) pressure overload and diabetic cardiomyopathy, decreased expression of the SERCA2 gene is thought to contribute to the development of heart failure. (fu-berlin.de)
  • To examine whether specific targeting SERCA2 gene expression in the myocardium can protect against development of heart failure in chronic pressure-overload and diabetic cardiomyopathy a comparative analysis of diastolic performance and SR Ca2+-transport was performed using transgenic rats (TGR) overexpressing SERCA2a under the control of a hCMV-enhancer/cß-actin promoter and wild-type (WT) animals with normal cardiac SERC2a expression. (fu-berlin.de)
  • Indeed, EGF receptor (EGFR) transactivation, triggered by shedding of HB-EGF from the cell surface, plays an important role in cardiac hypertrophy resulting from pressure overload in the aortic-banding model. (pharmaceuticalintelligence.com)
Mice3
  • Guidelines for measuring cardiac physiology in mice. (kassirilab.com)
  • The goal of this study is to investigate the reproducibility of strain parameters that were measured in mice using cardiac magnetic resonance (CMR) feature-tracking (CMR42, Canada). (researchgate.net)
  • In this model, autoimmune myocarditis can be induced by the subcutaneous inoculation of susceptible mice with cardiac myosin and complete Freund's adjuvant ( 6 ). (spandidos-publications.com)
Systolic performance1
  • Further, we were also able to demonstrate that global left ventricular (LV) systolic performance was significantly improved in diabetic rats treated with fasudil. (edu.au)
Pathological3
  • Both miR-182-3p inhibitor and overexpression of Myadm augmented the pathological progression in rats in response to MCT-induced PAH. (thno.org)
  • Hypertrophic cardiomyopathy (HCM) is a genetic heart disease that is associated with many pathological features, such as a reduction in global longitudinal strain (GLS), myofiber disarray and hypertrophy. (researchgate.net)
  • Pathological cardiac hypertrophy begins with an adaptive response to increased workload. (beds.ac.uk)
Diabetic6
  • Cardioprotection by controlling hyperamylinemia in a "humanized" diabetic rat model. (nih.gov)
  • Here we aimed to characterize RV and left ventricular (LV) remodeling and its prevention by vardenafil (a long-acting phosphodiesterase5A (PDE-5A) inhibitor) administration in a diabetic HFpEF model. (unideb.hu)
  • Rat models of T1DM (induced by 60 mg/kg streptozotocin, n = 8) and T2DM (32-week-old Zucker Diabetic Fatty rats, n = 7) and corresponding control animals (n = 5 and n = 8, respectively) were compared. (biomedcentral.com)
  • Exosomes-nano-sized, lipid vesicles released from cells-can protect the hearts of non-diabetic rats. (researchgate.net)
  • Since then we have learned that diabetic cardiomyopathy is not a rare condition but instead a very common one, and that its etiology is largely due to hyperglycemia with contributions from the insulin resistance syndrome that cause left ventricular hypertrophy. (diabetesjournals.org)
  • and in the Tayside Study, left ventricular hypertrophy was present in 32% of normotensive type 2 diabetic subjects who were not utilizing ACE inhibitors and had no known coronary artery disease ( 10 , 11 ). (diabetesjournals.org)
Hypertension8
Mechanisms5
  • There is a growing body of evidence to suggest that the female myocardium has distinct adaptive mechanisms when subjected to stress, which may, in part, account for the observed clinical differences. (medscape.com)
  • M-protein exhibits a different pattern of expression in cardiac and skeletal muscle, as well as fast- versus slow-skeletal muscle during development, suggesting different regulatory mechanisms for expression quantity and temporal appearance. (wikipedia.org)
  • However, so far the mechanisms behind cardiac disease in subjects exposed to SHS are poorly understood. (nih.gov)
  • Therefore, the aim of this thesis was to further explore mechanisms that could drive the development of DCM and HFpEF using rat models of early T1DM and T2DM. (edu.au)
  • In fact, the molecular mechanisms that protect the heart against stress are downregulated by aging, making the myocardium more susceptible to injury. (hindawi.com)
Increase in cardiac1
Increases1
  • The theoretical investigation demonstrates that elimination of myoglobin only slightly increases the predicted range of oscillation of cardiac oxygenation level during beat-to-beat transients in blood flow and ATP utilization. (biomedcentral.com)
Autocrine-paracrine1
  • 4. Evidence for an autocrine-paracrine role of adrenomedullin in the cultured rat adrenal zona glomerulosa cells. (nih.gov)
Tissue7
  • miRNAs play a variety of roles in atrial fibrillation, including regulation of electrical remodeling and modulation of structural remodeling of cardiac tissue. (hindawi.com)
  • The fact, that the myocardium of both ventricles is involved, irrespective of ventricular loading conditions, suggests that circulating factors, and not the hemodynamic load are primary responsible for this adverse response of the myocardial fibrous tissue. (springer.com)
  • Factor SM, Zhao MJ, Eng C, Robinson TF (1988) The effects of acutely increased ventricular cavity pressure on intrinsic myocardial connective tissue. (springer.com)
  • This Rat cTn-I ELISA Kit was designed for the quantitative measurement of Rat cTn-I protein in serum, plasma, tissue homogenates. (cusabio.com)
  • Growth differentiation factor 11 (GDF11) is a member of the transforming growth factor beta 1 (TGF-β1) superfamily that reverses age-related cardiac hypertrophy, improves muscle regeneration and angiogenesis, and maintains progenitor cells in injured tissue. (researchgate.net)
  • The impact of spatially localized microenvironments of signaling could be extensive heterogeneous tissue remodeling, which can be particularly important in an electrically coupled tissue like myocardium. (pharmaceuticalintelligence.com)
  • IPS cell transplantation in MCT-induced PAH rats led to significant reductions in RVSP, RVH, and lung tissue inflammation. (pulmonologyadvisor.com)
Dilated cardiomyopathy2
  • In addition, arrhythmogenic right ventricular cardiomyopathy, dilated cardiomyopathy, and hypertrophic cardiomyopathy were remarkably enriched signaling pathways of DEmRNAs in DEcircRNA-DEmiRNA-DEmRNA regulatory network. (hindawi.com)
  • Quantitation of the retinoids in ventricular myocardium by mass spectrometry revealed 32% and 39% ATRA decreases in guinea pig HF and in patients with idiopathic dilated cardiomyopathy (IDCM), respectively, despite ample reserves of cardiac vitamin A. ATRA (2 mg/kg/d) was sufficient to mitigate cardiac remodeling and prevent functional decline in guinea pig HF. (jci.org)
Troponin1
  • The levels of lactate dehydrogenase (LDH), creatine kinase‑myocardial band (CK‑MB), cardiac troponin I (cTn‑I), IL‑1β, IL‑6, TNF‑α, TGF‑β1, collagen type I (Col Ⅰ) and collagen type III (Col Ⅲ) were measured by ELISA in the mouse myocardial tissues or serum. (spandidos-publications.com)
Fibroblasts3
  • Cardiac collagen metabolism is regulated by cardiac fibroblasts which express mRNAs for types I and III collagens, the major fibrillar collagens in the heart, and for interstitial collagenase or matrix metalloproteinase (MMP) 1 which is the key enzyme for interstitial collagen degradation. (springer.com)
  • In contrast, collagen synthesis of cardiac fibroblasts was significantly decreased by PGE 2 treatment. (springer.com)
  • However, under the chronic stress state characterized by the continuous increase of AREG, the long-term activation of EGFR can enhance the activation, proliferation, myofibroblast differentiation, migration and collagen synthesis of cardiac fibroblasts [ 9 ]. (beds.ac.uk)
Left ventricle3
  • The only outlet from the left ventricle (LV) is a ventricular septal defect (VSD). (medscape.com)
  • The only outflow from the left ventricle (LV) is a ventricular septal defect (VSD), which diverts blood toward the RV. (medscape.com)
  • Computational modeling of Takotsubo cardiomyopathy: effect of spatially varying beta-adrenergic stimulation in the rat left ventricle. (virtualrat.org)
Apoptosis2
Proliferation1
Septal2
  • After 4 weeks, female rats had increased cardiac mass with notable septal hypertrophy, whereas males had diffuse wall hypertrophy. (medscape.com)
  • Here, using the whole-cell patch-clamp technique, we compared Kv and Kir current densities (I(Kv) and I(Kir)) in the left (LCSMCs), right (RCSMCs), and septal branches of coronary smooth muscle cells (SCSMCs) from control and monocrotaline (MCT)-induced PAH rats exhibiting RVH. (bvsalud.org)
Dilation2
  • female rats had continued increase in the left ventricular mass, without cavity dilation, indicative of continued remodeling. (medscape.com)
  • In time, HIP rats developed cardiac hypertrophy and left-ventricular dilation. (nih.gov)
Characterize1
  • A minority of persons with long-standing T cruzi infection develop the serious cardiac and gastrointestinal problems that characterize chronic symptomatic Chagas disease. (medscape.com)
Stimulation3
  • Despite great elevation of left intraventricular systolic pressure Anzola and Rush- mer (6) found a decrease rather than the expected increase in diastolic circum- ference and a decline in left ventricular diastolic pressure during stimulation of the sympathetic nerves to the heart. (nih.gov)
  • In vitro experiments confirmed a dose-dependent reduction in hypertrophy, with RWJ following tumor necrosis factor-α stimulation. (aspetjournals.org)
  • In isolated rat hearts, IPo stimulation reduced post-is- chaemic infarct size with associated elevations in Akt, eNOS, and p70S6K, while these beneficial effects of IPo were abolished by PI3K inhibition (either by LY294002 or wortmannin), indicating the involvement of PI3K-Akt in IPo. (researchgate.net)
Inhibition2
  • Taken together, we submit that low cardiac ATRA attenuates the expression of critical ATRA-dependent gene programs in HF and that strategies to normalize ATRA metabolism, like CYP26 inhibition, may have therapeutic potential. (jci.org)
  • In the first part of this thesis, we were able to demonstrate that chronic inhibition of the RhoA/Rho-kinase (ROCK) pathway with fasudil improved regionally impaired diastolic myosin head extension and depressed systolic mass transfer in the myocardium of rats with early T1DM. (edu.au)
Remodeling5
  • Physiologic differences between pre- and post-menopausal women add complexity to the adaptive response and call into question the role of estrogen in cardiac remodeling. (medscape.com)
  • The mRNA and activity of matrix metalloprotease-2 (MMP-2), representing the progress of cardiac remodeling, were also elevated in the heart. (nih.gov)
  • Continuous but not short-term p38 MAPK blockade attenuates post-MI remodeling, which is associated with functional benefits on the myocardium. (aspetjournals.org)
  • Post-ischemic left ventricular (LV) remodeling and its hypothetical prevention by repeated remote ischemic conditioning (rRIC) in male Sprague?Dawley rats were studied. (unideb.hu)
  • Moreover, cell surface engineering plausible for cardiac remodeling and the future prospective will be discussed at the end. (biomedcentral.com)
Electrophysiology3
  • The field of translational cardiac electrophysiology has flourished in the last two decades, leading to multiple new treatments and tools being translated into clinical practice. (isctr.org)
  • In this chapter, we will describe some of the most common and important translational research platforms currently used in the field of cardiac electrophysiology. (isctr.org)
  • The extracellular electrogram forms the basis of the majority of recordings in the clinical cardiac electrophysiology laboratory. (isctr.org)
Ischemic1
  • The resulting genetically modified MSCs showed enhanced target homing effect and greater retention rate in the ischemic myocardium after the intravenous delivery. (biomedcentral.com)
Adult1
  • M-protein is expressed in adult cardiac muscle and fast skeletal muscle, and functions to stabilize the three-dimensional arrangement of proteins comprising M-band structures in a sarcomere. (wikipedia.org)
Mitral2
  • Patients with DORV may also present with varying degrees of left ventricular hypoplasia and mitral valve anomalies such as stenosis or atresia. (medscape.com)
  • The geometrical details and biomechanical relationships of the mitral valve-left ventricular apparatus are very complex and have posed as an area of research interest for decades. (researchgate.net)
Resident cardiac1
  • Here, we showed that proteomic analyses of human and guinea pig heart failure (HF) were consistent with a decline in resident cardiac ATRA. (jci.org)
Skeletal muscle2
  • M-protein is expressed only in striated muscle, including fast skeletal muscle and cardiac muscle. (wikipedia.org)
  • Although the L-VDCC subunits are most abundant in fast skeletal transverse tubules, Ca 2+ influx is not required for contraction in skeletal muscle, unlike cardiac muscle, which requires Ca 2+ entry with each beat and triggers Ca 2+ release from the sarcoplasmic reticulum (SR) via Ca 2+ -release channels, e.g., ryanodine receptor 2 (RyR2). (jci.org)
Regulation4
  • With regard to the regulation of survival pathway, using dot blotting, we found cardiac insulin-like growth factor-1 (IGF-1) and IGF-1 receptor mRNA levels to be significantly increased, indicating that compensative effects of IGF-1 survival signaling could occur. (nih.gov)
  • The magnitude of the relative changes in stroke work and peripheral resistance suggests that the cardiac responses to baroreceptor stimula- tion play an important role in the reflex regulation of arterial pressure. (nih.gov)
  • Regulation of cardiac nitric oxide signalling by nuclear β-adrenergic and endothelin receptors. (icm-mhi.org)
  • However, whether AREG participated in the regulation of cardiac hypertrophy is still unclear. (beds.ac.uk)
Paracrine1
  • Thus, HB-EGF acts as an autocrine and local paracrine cardiac growth factor that leads to loss of gap junction proteins within a spatially confined microenvironment. (pharmaceuticalintelligence.com)
Arrhythmia2
  • However, vascular inflammation, thrombosis, and ventricular arrhythmia may be mediated more directly by excessive actions of n-6 eicosanoids than by blood lipoproteins. (nih.gov)
  • We will then provide an overview of cardiac optical mapping, a technique increasing in popularity that allows for the non-invasive recording of optical action potentials from tens of thousands of sites simultaneously, thereby allowing for detailed mapping of arrhythmia circuits. (isctr.org)
Inflammation1
  • Myocarditis is cardiac inflammation that can be caused by viruses, bacteria or autoimmune diseases ( 1 ). (spandidos-publications.com)
Collagen4
  • Furthermore, AngII significantly decreased MMP 1 activity while ALDO or DOC had no effect on cardiac fibroblast-mediated collagen degradation. (springer.com)
  • Weber KT (1989) Cardiac interstitium in health and disease: the fibrillar collagen network. (springer.com)
  • By routine and special staining, myocardial collagen fibrils, mast cell infiltration, and autophagy were observed in the myocardium. (xml-journal.net)
  • 12]Su Z,Yin J,Wang T,et al.Up-regulated HMGB1 in EAM directly led to collagen deposition by a PKCbeta/Erk1/2-dependent pathway: cardiac fibroblast/myofibroblast might be another source of HMGB1[J].J Cell Mol Med,2014,18(9):1740-1751. (xml-journal.net)
Reversal1
  • To our knowledge this is the first study to demonstrate topographical changes in ventricular ANP expression in response to the development and reversal of cardiac hypertrophy. (curehunter.com)
Heart failure2
  • Several reports have suggested that the treatment of heart failure can improve cardiac sympathetic nerve activity based on cardiac MIBG scintigraphy in patients with CHF ( 20 - 22 ). (snmjournals.org)
  • We have also translated these technologies to the clinic by developing patient-specific models of cardiac electromechanics [12-14] that have shown exciting potential to improve prediction of therapeutic outcomes in patients with dyssynchronous heart failure. (virtualrat.org)
Gene3
  • 8. Adrenomedullin peptide: gene expression of adrenomedullin, its receptors and receptor activity modifying proteins, and receptor binding in rat testis--actions on testosterone secretion. (nih.gov)
  • In contrast, miR-182-3p mimic and Myadm gene knockout attenuated the changes in the hemodynamics and structure of the cardio-pulmonary system in MCT-induced PAH in rats. (thno.org)
  • Because the neuron has physiological to perform an acute project of osteoporosis, dilatation working to the blood follows manifested in the 31-JUL-2003 and cardiac gene. (xtenddigital.com)
Incidence2
  • In conclusion, we found that the effects of SHS on cardiomyocyte are mediated by the Fas death-receptor-dependent apoptotic pathway and might be related to the epidemiologic incidence of cardiac disease of SHS-exposed non-smokers. (nih.gov)
  • Background Left ventricular assist device (LVAD) is associated with a high incidence of right ventricular (RV) failure, which is hypothesized to be caused by the occurring inter‐ventricular interactions when the LV is unloaded. (researchgate.net)