• Vivo
  • In vivo effect of cabergoline, a dopamine agonist, on estrogen-induced rat pituitary tumors. (abcam.com)
  • In vivo intracellular recordings revealed that striatal projection neurons from rats with chronic nigrostriatal lesions had a more depolarized membrane potential during both the down and up states and an increased firing probability during the up events. (jneurosci.org)
  • PMID 15913873 Natesan S, Svensson KA, Reckless GE, Nobrega JN, Barlow KB, Johansson AM, Kapur S. The dopamine stabilizers (S)-(−)-(3-methanesulfonyl-phenyl)-1-propyl-piperidine [(−)-OSUand 4-(3-methanesulfonylphenyl)-1-propyl-piperidine (ACR16) show high in vivo D2 receptor occupancy, antipsychotic-like efficacy, and low potential for motor side effects in the rat. (wikipedia.org)
  • Striatal Neurons
  • Aged F344 Rats Exhibit an Increased Proportion of Dopamine Agonist-excited Striatal Neurons Neurobiology of Aging. (jove.com)
  • For both the D-AMPH and APO series, the percentage of striatal neurons that increased firing rates as a result of the DA agonists was 19% higher in the old animals than in the young animals. (jove.com)
  • basal ganglia
  • In striatal projection neurons, which receive the bulk of DA innervation within the basal ganglia, postsynaptic effects of DA are conferred to a 32 kDa dopamine- and cAMP-regulated phosphoprotein (DARPP-32). (jneurosci.org)
  • This disorder is caused by a deficiency of dopamine in the basal ganglia circuit leading to motor deficits. (wikipedia.org)
  • Parkinson's
  • Functional alterations in striatal projection neurons play a critical role in the development of motor symptoms in Parkinson's disease (PD), but their molecular adaptation to dopamine depletion remains poorly understood. (jneurosci.org)
  • PNU-96391A (OSU6162) antagonizes the development of behavioral sensitization induced by dopamine agonists in a rat model for Parkinson's disease. (wikipedia.org)
  • Unlike most D1-selective agonists, it shows efficacy in animal models of Parkinson's disease. (wikipedia.org)
  • Doxanthrine has been shown to be orally active in producing contralateral rotation in the 6-hydroxy-dopamine rat model of Parkinson's disease. (wikipedia.org)
  • Norepinephrine
  • The bulk of the literature in these fields focuses on norepinephrine (NE), dopamine (DA), serotonin (5-HT) and acetylcholine (ACh), all of which are involved in neuroendocrine regulation and in a variety of behaviors other than mating. (springer.com)
  • selectivity
  • This profile is shared with several related drugs such as 6-Br-APB and SKF-82,958, but not with certain other D1 full agonists such as A-77,636, reflecting functional selectivity of D1 activation. (wikipedia.org)
  • Neurons
  • Furthermore, lesioned rats had significantly fewer silent neurons than control rats. (jneurosci.org)
  • Simultaneous recordings of the frontal electrocorticogram and membrane potential of striatal projection neurons revealed that the signals were oscillating synchronously in the frequency range 0.4-2 Hz, both in control rats and rats with chronic nigrostriatal lesions. (jneurosci.org)
  • Spreading of the slow cortical rhythm is limited by the very low firing probability of control rat neurons, but a slow oscillation is well reflected in spike trains of ∼60% of lesioned rat neurons. (jneurosci.org)
  • Within the dopamine- and cAMP-regulated phosphoprotein of 32 kDa (DARPP-32) cascade of enzymes that plays a central role in signal integration of dopaminoceptive neurons multiple catalytic and regulatory subunits change their mRNA expression levels. (jneurosci.org)
  • In an attempt to obtain a more complete picture of the molecular adaptations to DA depletion, we conducted microarray based transcriptome analyses in striatonigral and striatopallidal neurons in the rat 6-hydroxydopamine (6-OHDA) model of PD. (jneurosci.org)
  • PMID
  • PMID 15795789 Rung JP, Carlsson A, Markinhuhta KR, Carlsson ML. The dopaminergic stabilizers (−)-OSU6162 and ACR16 reverse (+)-MK-801-induced social withdrawal in rats. (wikipedia.org)
  • PMID 17612788 Rung JP, Rung E, Helgeson L, Johansson AM, Svensson K, Carlsson A, Carlsson ML. Effects of (−)-OSU6162 and ACR16 on motor activity in rats, indicating a unique mechanism of dopaminergic stabilization. (wikipedia.org)
  • PMID 19269794 Dyhring T, Nielsen EØ, Sonesson C, Pettersson F, Karlsson J, Svensson P, Christophersen P, Waters N. The dopaminergic stabilizers pridopidine (ACR16) and (−)-OSU6162 display dopamine D(2) receptor antagonism and fast receptor dissociation properties. (wikipedia.org)
  • cabergoline
  • Cabergoline, a dopamine receptor agonist, has an antidepressant-like property and enhances brain-derived neurotrophic factor signaling. (abcam.com)
  • Rat studies show cabergoline has a direct inhibitory effect on pituitary lactotroph (prolactin) cells. (wikipedia.org)
  • Also, a study on rats found that cabergoline reduces voluntary alcohol consumption, possibly by increasing GDNF expression in the ventral tegmental area. (wikipedia.org)
  • Lactation: In rats cabergoline was found in the maternal milk. (wikipedia.org)
  • substantia
  • The D1 agonist SKF 38393 (5 mg/kg, i.v.) increased glucose utilization markedly in entopeduncular nucleus and substantia nigra pars reticulata ipsilateral to the lesion, while the D2 agonist quinpirole (1 mg/kg, i.v.) had no effect in these striatal output regions. (semanticscholar.org)
  • study on rats
  • A similar place preference, which was blocked by naloxone and by SCH 23390 and by raclopride, has been seen in a study on rats with drinking water. (wikipedia.org)