AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and Processes
ApomorphineDopamine AgonistsReceptors, DopamineHaloperidolPiribedilEmeticsPenile ErectionPimozideStereotyped BehaviorDopamine AntagonistsStartle ReactionLevodopaAntiparkinson AgentsDopamineReceptors, Dopamine D2CatalepsyTranquilizing AgentsCarbidopaSensory GatingHydroxydopaminesYawningQuinpiroleParkinson DiseaseAdministration, SublingualDopamine AgentsParkinson Disease, SecondaryDomperidone2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepineReceptors, Dopamine D1OxidopamineErgolinesBis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfideAmphetamineMotor ActivityHarmineSubstantia NigraCorpus StriatumBehavior, AnimalPenisReceptors, Dopamine D3Infusion PumpsBenzazepinesDyskinesia, Drug-InducedSulpirideSpiperoneErectile DysfunctionLisurideInjections, SubcutaneousFlupenthixolDose-Response Relationship, DrugRats, Sprague-Dawley
Agonist apomorphineBehavioralBehaviorDopamine receptor agonistSprague-DawleyUnilateralSubstantiaIpsilateralStriatumHaloperidolCorticalLesionsNeuronsWistarDosesBromocriptineParkinson'sMedial prefroResponsesBehaviourForebrainStereotypyPerfusionChronicInhibitionTreatmentPathwayStimulationVivoGABAergicNeuronDopaminergic systemModelInjectionsSignificantlySelectiveAdult ratExplorationDrugsEffectMethodsBrainEffects
Agonist apomorphine2
  • The DA agonist apomorphine (100 μg/kg) produced decreased basal extracellular levels of DA, DOPAC and HVA in medial prefrontal cortex of both chronic clozapine-treated and chronic vehicle-treated rats. (elsevierpure.com)
  • These animals displayed a progressive emergence of hyper-locomotion and dysregulated response to the dopaminergic agonist apomorphine. (lu.se)
Behavioral6
  • In the present study, we examined the effect of a complex rearing environment during adolescence on attention and behavioral inhibition in adult male rats. (frontiersin.org)
  • We therefore set out to examine the effect of a complex environment during adolescence -whether primed by early life adversity or not- on behavioral inhibition and impulsivity in male rats. (frontiersin.org)
  • Differences in the behavioral profile of circling under amphetamine and apomorphine in rats with unilateral lesions of the substantia nigra. (mcmaster.ca)
  • Using behavioral tests, grip strength and numbers of apomorphine-induced contralateral rotation were declined in the ceftriaxone-treated group. (edu.hk)
  • Subsequent behavioral testing involved beam walking task, rotarod, visual discrimination task and apomorphine rotation. (johnshopkins.edu)
  • Behavioral and neurochemical effects of neurotensin microinjection into the ventral tegmental area of the rat. (shengsci.com)
Behavior5
  • Differential effects of dopaminergic drugs on open-field behavior of spontaneously hypertensive rats and normotensive Wistar-Kyoto rats. (aspetjournals.org)
  • To measure impulsive action and inhibition of behavior in rats, we used the 5-choice serial reaction time task (5-CSRTT) ( Robbins, 2002 ). (frontiersin.org)
  • Iloperidone has also been shown to reduce the effects of apomorphine induced climbing behavior in mice as well as the effects of head twitching induced by 5-HT in rats. (bionity.com)
  • Apomorphine facilitates male sexual behavior of Rhesus Monkeys Pomerantz SM. (baillement.com)
  • Furthermore, IP-LGF decreases apomorphine-induced rotational behavior and boosts engine peformace in these pets. (antiviralbiologic.com)
Dopamine receptor agonist1
  • Apomorphine, a dopamine receptor agonist, decreases the magnitude of neglect in rats with cortical lesions. (nih.gov)
Sprague-Dawley2
  • MAO activity was determined in whole brain or corpus striatum of female Sprague-Dawley rats (i40-200 g) by radio assay using 14C-5XT, 3H-dopamine (DA) or 14C-phenylethylamine (Pt) as substrate. (erowid.org)
  • Fifty male Sprague-Dawley rats were treated with streptozotocin to induce the DM model. (bvsalud.org)
Unilateral3
  • Method The rotational responses of male SPF rats with unilateral damage to their nigro-striatal system (induced by the injection of 10 mcg 5,6 dihydroxytryptamine (5,6-HT) or 3.5 mcg 6-hydroxydopamine (6-OH - dopamine) into the right medial forebrain bundle) to 1-5 mg/kg of (+)-methamphetamine, 0.05-3 mg/kg apomorphine or 100,200 or 1,500 mcg LSD/kg i.p. were determined. (erowid.org)
  • A well characterized animal model of Parkinson's disease is the unilateral destruction of the dopaminergic pathway in rats by administration of 6-hydroxydopamine (6-OHDA) ( Ungerstedt and Arbuthnott, 1970 ). (jneurosci.org)
  • Effects of unilateral dorsal and ventral striatal dopamine depletion on visual neglect in the rat: a neural and behavioural analysis. (shengsci.com)
Substantia4
  • All EAs block AC activity even at low concentration (DHergotoxin, 5 x 10 M). An age-related decrease in the sensitivity to DA stimulation of AC in striatum, substantia nigra and DAergic areas of rats has been shown. (erowid.org)
  • In the present work, we describe the effects of dopamine depletion after the administration of 6-hidroxidopamine (6-OHDA) into the substantia nigra pars compacta of male rats submitted to the pilocarpine model of epilepsy. (scielo.br)
  • We induced dopaminergic neuronal loss by infusing lipopolysaccharide (LPS) directly into the substantia nigra (SN) in rats and administered the VAP-1 inhibitor, PXS-4681A, daily. (biomedcentral.com)
  • The present results provide evidence that direct infusion of MPP+ into the medial forebrain bundle of the rat can lead to a complete loss of dopamine neurons in the pars compacta of the substantia nigra with ensuing behavioural, neurochemical and biochemical changes characteristic of the lesion. (unboundmedicine.com)
Ipsilateral3
  • Methamphetamine produced ipsilateral and apomorphine contralateral circling in rats pretreated with either of the neurotoxics. (erowid.org)
  • Rats that had received grafts ipsilateral to the lesioned striatum showed a 75% decrease in amphetamine-induced circling, but no significant change in apomorphine-induced circling. (shengsci.com)
  • After 3-5 weeks, MPP+-infused animals showed dose-related ipsilateral and contralateral circling in response to methamphetamine (1-5 mg/kg i.p.) and apomorphine (0.05-0.25 mg/kg s.c.) respectively. (unboundmedicine.com)
Striatum6
  • The grafts were implanted either in normal rats or in rats whose striatum had been lesioned with ibotenic acid. (shengsci.com)
  • Rats that had received intrathalamic grafts contralateral to the lesioned striatum (i.e. contralateral to the lesion-induced turning direction) showed a significant reduction of circling both after amphetamine (78% reduction) or apomorphine (77% reduction) injection. (shengsci.com)
  • Amphetamine and apomorphine responses in the rat following 6-OHDA lesions of the nucleus accumbens septi and corpus striatum. (research.com)
  • A guide cannula was implanted stereotaxically such that a microdialysis probe (Carnegie Medicin, Stockholm, Sweden) inserted 2 days later in the awake rat would be situated in the striatum (see Stahle and Ungerstedt). (baillement.com)
  • Hence, the intracerebral infusion of LGF stimulates the sprouting of DA terminals in the striatum of unilaterally 6-hydroxydopamine (6-OHDA)-lesioned rats [10], and promotes the extension of neural precursors as well as the era of brand-new neurons within this experimental style of PD [11]. (antiviralbiologic.com)
  • Right here we survey that IP-LGF boosts DA amounts and stimulates the outgrowth of DA terminals in the striatum of unilaterally 6-hydroxydopamine (6-OHDA)-lesioned rats and shields DA neurons from 6-OHDA neurotoxicity. (antiviralbiologic.com)
Haloperidol4
  • The rotational responses to LS13 were significantly decreased by 1 mg haloperidol/kg injected i.p. 10 min after the 200 mcg/kg dose of LSD, both in 6-OH-dopamine and 5,6-HT pretreated rats. (erowid.org)
  • However, when neuronal sampling was performed in unanesthetized rats, the single administration of haloperidol, (-)-sulpiride, or SCH 23390 (0.5, 25, and 0.3 mg/kg respectively 2-3 hr beforehand) increased the number of spontaneously active A9 and A10 DA neurons and their firing rate, whereas the chronic administration of these drugs (daily for 21- 28 d) failed to reduce the number of spontaneously active A9 and A10 DA neurons. (jneurosci.org)
  • The inhibitory effect of apomorphine on the firing rate of A9 and A10 DA neurons was prevented 3-4 hr after the acute or last injection of chronic haloperidol or (-)-sulpiride. (jneurosci.org)
  • The effect of lithium on chronic haloperidol enhanced apomorphine aggression in rats. (sakuhuvikeskus.ee)
Cortical1
  • This study provides a novel rat model of progressive cortical synucleinopathy, showing for the first time that cholinergic interneurons are vulnerable to α-synuclein over-expression. (lu.se)
Lesions1
  • Septal transplants restore maze learning in rats with fornix-fimbria lesions. (research.com)
Neurons4
  • In the 6-hydroxydopamine model of Parkinson's disease in the rat, there is a significant reduction in the number of dendritic spines on the principal projection neurons in the neostriatum, presumably attributable to loss of the nigrostriatal dopamine input. (jneurosci.org)
  • A widely accepted theory postulates that, in rats, chronic treatment with neuroleptics causes the depolarization inactivation of the majority of midbrain dopamine (DA) neurons. (jneurosci.org)
  • In the present study, efficacy of ceftriaxone in neuroprotection of dopaminergic neurons and amelioration of motor deficits in a rat model of Parkinson's disease were investigated. (edu.hk)
  • 7. Lindvall, O., Björklund, A.: Organization of catecholamine neurons in the rat central nervous system. (lu.se)
Wistar2
  • In general, basal levels of ambulation were similar in SHRs and their controls, the Wistar-Kyoto rats (WKY). (aspetjournals.org)
  • The fresh aerial parts, crushed (0.6 g), were applied to 10% of the total surface (12 cm 2 ) of the skin, for 24 hours, in Wistar rats (5 males and 5 females per group), in the general acute topically-induced toxicity model. (tramil.net)
Doses3
  • Growth hormone responses to graded doses of apomorphine HCl in schizophrenia. (mcmaster.ca)
  • NGF peptide levels retained in the crushed nerves of rats 5 days after surgery and in the culture medium of IMS32 cells, a mouse Schwann cell line, incubated for 24 h with high or low doses of MS-818, were measured by enzyme immunoassay. (iospress.com)
  • Despite aripiprazole's reported lack of effect on serotonin transporters, long-term treatment with aripiprazole or WS-50030 reversed olfactory bulbectomy-induced hyperactivity at doses that did not reduce activity in sham-operated rats, indicating antidepressant-like activity for both compounds. (montclair.edu)
Bromocriptine1
  • Bromocriptine (B) increases rat striatal cAMP in vivo but blocks in vitro activation of AC by DA. (erowid.org)
Parkinson's1
  • Continuous infusion of levodopa or apomorphine provide constant dopaminergic stimulations are good alternatives to deep brain stimulation to control motor fluctuations in patients with advanced Parkinson's disease (PD). (e-jmd.org)
Medial prefro1
  • Acute clozapine challenge (5-40 mg/kg i.p) produced dose-dependent increased extracellular levels of DA and its metabolites, 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA), in the medial prefrontal cortex of awake, free-moving rats as measured by in vivo brain microdialysis. (elsevierpure.com)
Responses2
  • Control rats showed no such rotational responses to amphetamine or apomorphine. (erowid.org)
  • No rotational responses were induced by up to 20 mg (+)-2-bromo - lysergic acid diethylamide bitartrate (BOL-148)- in the 5,6-HT - or the 6-OH-dopamine-treated rats. (erowid.org)
Behaviour5
  • Influence of the lesion of amygdaloid complex on behaviour and on effects of antidepressants in rats. (sakuhuvikeskus.ee)
  • The action of chronic lithium treatment on aggressive behaviour in morphine dependent rats and in rats chronically treated with dopaminomimetics. (sakuhuvikeskus.ee)
  • In the present work, cell suspension grafts from embryonic day 14-15 rat striatal primordia were implanted close to the ventromedial thalamic nucleus to investigate whether they can develop and survive in this ectopic location, and whether they induce changes in the circling behaviour of the host. (shengsci.com)
  • Four to eight months after transplantation, circling behaviour after amphetamine or apomorphine injection was evaluated. (shengsci.com)
  • Six months after lesion, animals infused with MPP+ continue to exhibit robust rotational behaviour in response to methamphetamine and apomorphine. (unboundmedicine.com)
Forebrain4
  • Novel AAV-Based Rat Model of Forebrain Synucleinopathy Shows Extensive Pathologies and Progressive Loss of Cholinergic Interneurons. (lu.se)
  • The aim of this study was to develop a first rat model of widespread progressive synucleinopathy throughout the forebrain using adeno-associated viral (AAV) vector mediated gene delivery. (lu.se)
  • Through bilateral injection of an AAV6 vector expressing human wild-type α-synuclein into the forebrain of neonatal rats, we were able to achieve widespread, robust α-synuclein expression with preferential expression in the frontal cortex. (lu.se)
  • 1-Methyl-4-phenylpyridinium ion (MPP+), the active metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, has been chronically infused (10 micrograms/24 h for 7 days) via osmotic minipumps into the left median forebrain bundle of the rat in order to determine whether it can induce permanent damage to the nigrostriatal dopamine system. (unboundmedicine.com)
Stereotypy1
  • Blockage of amphetamine induced motor stimulation and stereotypy in the adult rat following neonatal treatment with 6-hydroxydopamine. (research.com)
Perfusion1
  • The intrathalamic grafts of rats which had received a low dose of apomorphine (0.25 mg/kg) 2 h before perfusion showed clusters of intensely Fos-immunoreactive nuclei throughout the transplant, indicating that these cells had developed dopamine receptors and supersensitivity to dopamine agonists. (shengsci.com)
Chronic2
  • Non-Status Epilepticus female rats show seizure-like behaviors in the chronic phase of Pilocarpine experimental model. (scielo.br)
  • Zarkovsky, A. Analysis of dopamine receptor supersensitivity after chronic neuroleptic treatment APS Valge Lightning Fat Burner rats. (sakuhuvikeskus.ee)
Inhibition2
  • Iloperidone performed well against a prepulse inhibition (PPI) experiment, which was designed to gauge the extent of psychotic disorders in rats. (bionity.com)
  • Inhibition of transforming growth factor beta-activated kinase 1 confers neuroprotection after traumatic brain injury in rats. (shengsci.com)
Treatment3
  • Male rats were injected with 3H-dopa after drug treatment and the brains removed 30 min later and 3H-DA and 3H-3-methoxy-tryramine (3H-MT) isolated and determined. (erowid.org)
  • Furthermore, the inhibited activation of the CaSR/PLC/PKC pathway was observed in DMED rats with LCG treatment. (bvsalud.org)
  • Materials and Strategies LGF Purification LGF was purified from serum of 5-week bile duct-ligated rats carrying out a previously reported treatment [6]. (antiviralbiologic.com)
Pathway1
  • Collectively, LCG significantly ameliorated erectile function of DMED rats via increased NO generation, inhibiting endothelial cells apoptosis and penile fibrosis, which might benefit from the suppression of CaSR/PLC/PKC pathway in DMED rats. (bvsalud.org)
Stimulation2
  • Ergotamine (E) and dihydroE block DA induced stimulation of striatal adenylate cyclase (AC) less than apomorphine (A)-induced stimulation. (erowid.org)
  • However, this procedure is more invasive than apomorphine as it requires a percutaneous endoscopic gastrostomy Clinical experience with infusions shows that continuous dopaminergic stimulation of dopaminergic medications reduces dyskinesia and widens the therapeutic window in advanced PD. (e-jmd.org)
Vivo1
  • El extracto fluido 70% del follage no mostró efecto genotóxico en el ensayo in vivo de inducción de micronúcleos en médula ósea de ratón, ni mutagenicidad (hasta 5 mg/placa) en la prueba in vitro de reversión bacteriana Salmonella /microsoma (Ames) 26 . (tramil.net)
GABAergic1
  • Central-type benzodiazepine receptors mediate the antidopaminergic effect of clonazepam and melatonin in 6-hydroxydopamine lesioned rats: involvement of a GABAergic mechanism. (mcmaster.ca)
Neuron1
  • 2. Lindvall, O., Björklund, A.: The organization of the ascending catecholamine neuron systems in the rat brain as revealed by the glyoxylic acid fluorescence method. (lu.se)
Dopaminergic system1
  • The neurochemical effects of N,N-dimethyltryptamine (DMT) on the dopaminergic system of the rat brain, were investigated. (erowid.org)
Model1
  • In a rat model predictive of antipsychotic-like activity, WS-50030 and aripiprazole reduced conditioned avoidance responding by 42 and 55% at 10 mg/kg, respectively. (montclair.edu)
Injections1
  • Additionally, some rats received intrastriatal grafts, and lesioned but non-grafted rats and lesioned rats that had received injections of saline or of cell suspensions from fetal spinal cord in the thalamus were used as control. (shengsci.com)
Significantly1
  • Following an in-depth chemical and immunological study, they shown that LGF is an albuminCbilirubin complex, the focus which is normally undetectable in sera from healthful human beings or rats almost, but CHIR-99021 tyrosianse inhibitor significantly boosts in the current presence of hepatobiliary liver organ or disorders damage [3], [4]. (antiviralbiologic.com)
Selective1
  • 10. Lindvall, O., Björklund, A., Skagerberg, G.: Selective histochemical demonstration of dopamine terminal systems in rat di- and telencephalon: new evidence for dopaminergic innervation of hypothalamic neurosecretory nuclei. (lu.se)
Adult rat1
  • The lesion was induced by stereotactic injection of ouabain into adult rat brains. (johnshopkins.edu)
Exploration1
  • The effect of drugs acting on CCK receptors and rat free exploration in the exploration box. (sakuhuvikeskus.ee)
Drugs1
  • The use of rats exposed to antipsychotic drugs for consecutive weeks has been proposed with variations since the early 70's. (biomedcentral.com)
Effect1
  • Apomorphine inhibited ambulatory activity in WKY but had virtually no effect in SHRs. (aspetjournals.org)
Methods1
  • Methods: MS-818 at 1.0 or 10 mg/kg or the vehicle was intraperitoneally injected into rats daity. (iospress.com)
Brain2
  • Brain catecholamines may play a role in the development of hypertension in the spontaneously hypertensive rat (SHR). (aspetjournals.org)
  • The ventral tegmental area of the rat brain has been shown to possess high densities of neurotensin- and dopamine-containing neuronal perikarya. (shengsci.com)
Effects1
  • Purpose: We evaluated the effects of the drug MS-818 (2-piperadino-6-methyl-5-oxo-5,6-dihydro-(7H) pyrrolo-[3,4-d] pyrimidine maleate), a synthesized pyrimidine compound, on regeneration in crush-injured sciatic nerves of rats. (iospress.com)