AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesHealth Care
2-AcetylaminofluoreneHydroxyacetylaminofluoreneAcetoxyacetylaminofluoreneFluorenesCarcinogensLiver Neoplasms, ExperimentalRats, Inbred F344Precancerous ConditionsDiethylnitrosamineDNA AdductsLiverMutagensgamma-GlutamyltransferaseBiotransformationBenzo(a)pyrenep-DimethylaminoazobenzeneBenzopyrene HydroxylaseDNAMethyldimethylaminoazobenzeneNitroanisole O-DemethylaseCell Transformation, NeoplasticCarcinogenesisLipotropic AgentsHepatectomyMicrosomes, LiverBenzopyrenesMethylnitrosoureaDeoxyguanosineRats, Inbred StrainsDNA Repair4-Hydroxyaminoquinoline-1-oxideMutagenicity TestsAminobiphenyl CompoundsLiver RegenerationAldrinNeoplasms, ExperimentalPolydeoxyribonucleotidesCocarcinogenesis9,10-Dimethyl-1,2-benzanthraceneDNA DamageHydroxylationSulfuric AcidsLiver NeoplasmsMethylcholanthreneUltraviolet RaysAminesDNA ReplicationAzoxymethanePhenobarbitalCytochrome P-450 Enzyme SystemHyperplasiaAnticarcinogenic AgentsGlutathione TransferasePapillomaNitrophenolsEpoxide HydrolasesGuanine
ToxicologyThyroidMiceCarcinogenicLiver
Toxicology2
  • Toxicology and Carcinogenesis Studies of 2,3-Dibromo-1-Propanol (CAS No. 96-13-9) in F344/N Rats and B6C3F1 Mice (Dermal Studies). (nih.gov)
  • Toxicology and Carcinogenesis Studies of 3,3'-Dimethoxybenzidine Dihydrochloride (CAS No. 20325-40-0) in F344/N Rats (Drinking Water Studies). (nih.gov)
Thyroid3
  • Wistar rats receiving a single injection of 2,2′-dihydroxy-N-nitrosodipropylamine (a tumor initiator) followed by 4,4′-methylenedianiline (MDA) in the diet for 19 weeks, developed thyroid follicular cell carcinomas and follicular cell and papillary adenomas. (cdc.gov)
  • Fischer 344/N rats and B6C3F l mice receiving MDA as 4,4′-methylenedianiline dihydrochloride ad libitum in drinking water for 2 years developed thyroid follicular cell carcinomas and adenomas, C-cell adenomas of the thyroid, hepatocellular carcinomas and adenomas, alveolar bronchiolar adenomas, malignant lymphomas, and benign tumors of the adrenal gland. (cdc.gov)
  • 1999 . Species Differences in Thyroid, Kidney and Urinary Bladder Carcinogenesis. (nih.gov)
Mice2
  • In accordance with the Cancer Policy of the Occupational Safety and Health Administration (OSHA) ("Identification, Classification, and Regulation of Potential Occupational Carcinogens," 29 CFR 1990), on the basis of findings of carcinogenic and tumorigenic responses in rats and mice, NIOSH recommends that MDA be regarded as a potential occupational carcinogen. (cdc.gov)
  • The observation of cancers and tumors in both rats and mice treated with MDA meets the criteria established in the Cancer Policy of the Occupational Safety and Health Administration for considering MDA a potential human carcinogen in the workplace. (cdc.gov)
Carcinogenic1
  • 1979 . Measurement of DNA-excision repair in suspensions of freshly isolated rat hepatocytes after exposure to some carcinogenic compounds: its possible use in carcinogenicity screening. (nih.gov)
Liver2
  • 1981 . The selective activation of cytochrome P-450 dependent microsomal hydroxylases in human and rat liver microsomes. (nih.gov)
  • Effect of repeated ether anesthesias on the monooxygenase system of rat liver S-9 fractions. (unibo.it)