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  • radioactive
  • Essential aspects of binding assays include, but are not limited to, the concentration level of reactants or products (see radioactive section), maintaining the equilibrium constant of reactants throughout the assay, and the reliability and validity of linked reactions. (wikipedia.org)
  • chemical
  • Alkaloid and terpenoid natural products display an extensive array of chemical frameworks and biological activities. (pnas.org)
  • In analogy to digital microelectronics, these basic instructions can be combined and reused within hierarchical design structures so that complex procedures (e.g. chemical synthesis or biological assays) can be built up step-by-step. (wikipedia.org)
  • protein
  • A diverse and large set of data ranging from chemistry leads to biological assays and protein sequencing will now be managed and analysed through the Dotmatics Platform. (thefreedictionary.com)
  • A thermal shift assay quantifies the change in thermal denaturation temperature of a protein under varying conditions. (wikipedia.org)
  • Each method has its strengths and weaknesses but they all struggle with intrinsically disordered proteins without any clearly defined tertiary structure as the essence of a thermal shift assay is measuring the temperature at which a protein goes from well-defined structure to disorder. (wikipedia.org)
  • The company exhibits a wide range of tools related to recombinant protein purification consisting of expression vectors, affinity purification and detection reagents based on its Strep-tag/Strep-Tactin system. (wikipedia.org)
  • tissue
  • In addition to the bovine and porcine tissue from which pharmaceutical-grade heparin is commonly extracted, it has also been extracted and characterised from: Turkey Whale Dromedary camel Mouse Humans Lobster Fresh water mussel Clam Shrimp Mangrove crab Sand dollar Atlantic salmon Zebra fish The biological activity of heparin within species 6-11 is unclear and further supports the idea that the main physiological role of heparin is not anticoagulation. (wikipedia.org)
  • concentration
  • A method for the quantitation of the effects on a biological system by its exposure to a substance, as well as the quantitation of the concentration of a substance by some observable effect on a biological system. (thefreedictionary.com)
  • In comparison to the previous over-coated plate-based methods, SPA has a number of advantages that makes it more popular: Assay flexibility - the concentration of the components in the assay can be adjusted to suit the user due to the higher surface area design of the SPA beads, hence providing the user flexibility in designing assay. (wikipedia.org)
  • development
  • Although biological assays have been the cornerstone of endocrinologic measurements, the development of the radioimmunoassay (RIA) completely changed the field of endocrinology (1). (thefreedictionary.com)
  • Through the development of RIA technology, researchers have been able to move beyond the use of radioactivity, and instead, use liquid- and solid-phase, competitive, and immunoradiometric assays. (wikipedia.org)
  • studies
  • The principal interest of his research group is in host-pathogen interactions which he studies using a range of biophysical and structural techniques. (leeds.ac.uk)
  • Studies are screened, and only those assays using standardized methods and resulting in significant effects are used for the determination of ERL/ERM guidelines. (wikipedia.org)
  • although
  • Although binding assays are simple, they fail to provide information on whether or not the compound being tested affects the target's function. (wikipedia.org)
  • provides
  • This report provides an update on BIO048B Biological Therapies for Cancer: Technologies and Global Markets. (bccresearch.com)
  • QIAGEN provides a range of assays to study metabolism and metabolic disorders. (qiagen.com)
  • In addition to serving as a biorepository and distributor, ATCC provides specialized services as a biological resource center. (wikipedia.org)
  • ATCC also provides biological repository management services to institutions, agencies and companies wishing to outsource the handling of their own culture collections. (wikipedia.org)
  • structural
  • A series of enyne and diyne substrates is assembled using a tert -butylsulfinamide lynchpin that affords asymmetric induction, a uniquely suited reactivity pattern, and an unusual structural motif for biological evaluation ( 14 ). (pnas.org)
  • methods
  • The thermofluor assay was the first high-throughput thermal shift assay and its utility and limitations has spurred the invention of a plethora of alternate methods. (wikipedia.org)
  • bind
  • Indeed, alkaloid and terpenoid cores are prevalent among privileged scaffolds able to bind multiple biological targets ( 6 ), and a variety of alkaloid- and terpenoid-based libraries have been reported ( 7 - 11 ). (pnas.org)
  • measure
  • Some newer types are called "mix-and-measure" assays because they do not require separation of bound ligands. (wikipedia.org)
  • modern
  • The volumetric dynamic ranges involved in modern biological assays can also flummox human operators: no technician's eyesight is sufficiently acute to determine the dispensing accuracy of a two-microliter aliquot. (labmanager.com)
  • pharmaceutical
  • Pharmaceutical assay limits are often broader ( 98-101% ) than analytical grades ( 99.5-100 %) - because the range of tests are intended to identify typical undesirable impurities expected from the approved production processes. (yarchive.net)
  • A confounding factor is that many specifications are national, eg the US pharmaceutical grade of a drug may establish different assay and impurity limits than the British, European, or Japanese. (yarchive.net)
  • effects
  • Assays to quantitate the effects of an exposure model the effect of a substance in the real world. (thefreedictionary.com)
  • In the past, biological assays of acid rain's effects on lakes have focused largely on sport fish. (thefreedictionary.com)
  • Areas with small habitat fragments exhibit especially pronounced edge effects that may extend throughout the range. (wikipedia.org)
  • Infusion of epinephrine well within the physiological range suppresses human airway hyper-reactivity sufficiently to antagonize the constrictor effects of inhaled histamine. (wikipedia.org)
  • Component
  • Convenient - the key component of the SPA assay, the beads, do not depend on a particular plate type or supplier, hence its wide availability. (wikipedia.org)
  • optical
  • The metal particle can allow the binding to be visualized in an assay by optical or electronic means, including, for example, visual or spectrophotometric observation of color imparted by the size, composition and shape of the metalparticle. (patentgenius.com)
  • drugs
  • Specifically, despite the human body's endogenous receptors, hormones, and other neurotransmitters, pharmacologists utilize assays in order to create drugs that are selective, or mimic, the endogenously found cellular components. (wikipedia.org)
  • plasma
  • Early REA plasma assays indicated that epinephrine and total catecholamines rise late in exercise, mostly when anaerobic metabolism commences. (wikipedia.org)
  • enough
  • Compound Cloud enables customers to have control over the content and format of their compound library to fit their needs - eliminating wastage and reducing storage space by offering 'just in time' global delivery of pre-plated sets containing just enough compound for an assay. (ukspa.org.uk)
  • material
  • This includes the 18,000 sq ft (1,700 m2) biological material repository which contains 200 freezers to store biomaterials, including vapor-phase liquid nitrogen freezers, mechanical freezers, and cold rooms for storage at 4°C. Electricity at the repository is backed up by on-site generators. (wikipedia.org)