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  • membranes
  • For example, the melting temperature of di-oleoyl-phosphatidylethanolamine is -16 °C while the melting temperature of di-oleoyl-phosphatidylcholine is -20 °C. If the lipids had two palmitoyl chains, phosphatidylethanolamine would melt at 63°C while phosphatidylcholine would melt already at 41 °C. Lower melting temperatures correspond, in a simplistic view, to more fluid membranes. (wikipedia.org)
  • These radicals may induce lipid peroxidation of organelles like lysosomes, mitochondria, and sarcoplasmic membranes. (wikipedia.org)
  • hydroxyl radical
  • C-S. Lai, T. A. Grover and L. M. Piette, Hydroxyl-radical production in a purified NADPH-cytochrome C (P450) reductase system, Archs. (springer.com)
  • Since surgery, radio and chemotherapy are associated with oxidative stress we analyzed the growth of breast cancer CD44+CD24-/lowESA+ cell line SUM159 cultured on collagen matrix in vitro, using either native collagen or the one modified by hydroxyl radical. (edu.pl)
  • Health and Dis
  • C. Benedetto and T.F. Slater, Electron spin resonance studies on human endometrium and cervix, in "Recent Studies on lipid Peroxidation in Health and Disease", T. F. Slater, ed., in press, (1980). (springer.com)
  • Das is the editor-in-chief of Lipids in Health and Disease, a journal published by BioMed Central and Current Nutrition & Food Science, published by Bentham Science. (wikipedia.org)
  • cytotoxic
  • These preliminary findings indicate that beside direct cytotoxic effects of anticancer therapies consequential oxidative stress and lipid peroxidation modify the microenvironment of CSCs influencing oxidative homeostasis that could additionally act against cancer. (edu.pl)
  • 4-Hydroxy-2-nonenal (4-HNE), among them, is believed to be largely responsible for cytopathological effects observed during oxidative stress in vivo and has achieved the status of one of the best recognized and most studied of the cytotoxic products of lipid peroxidation. (hindawi.com)
  • compounds
  • When a single unpaired electron is present, the resultant compound has a number of novel chemical and biological properties: such compounds are called free radicals. (springer.com)
  • The resulting lipid peroxides may interact with other molecules to form cross links, and thus either cause these compounds to perform their functions poorly, or render them non-functional altogether. (wikipedia.org)
  • A recent study compared the effectiveness of melatonin and other similar compounds on the lipopolysaccharide induced lipid peroxidation. (wikipedia.org)
  • endogenously
  • There are increasing bodies of evidence indicating that aldehydic molecules generated endogenously during the process of lipid peroxidation are causally involved in most of the pathophysiological effects associated with oxidative stress in cells and tissues. (hindawi.com)
  • protein
  • In support of the above, previous work involving the individual components of GPLC has noted decreased protein and lipid peroxidation following glycine use, with potent antioxidant properties noted for propionyl-L-carnitine. (wikipedia.org)
  • biological
  • Finally, catalyst reactivity in biological matrices was evaluated by oxidative degradation of lipids, revealing that α-Fe 2 O 3 is a good oxidative stress inducer, representing a new application for materials based on iron oxides. (springer.com)
  • D. R. Blake, R. E. Allen and J. Lunec, Free radicals in biological systems -A review orientated to inflammatory processes. (springer.com)
  • The biological activity of this molecule is of interest as a potential free radical scavenger, also known as an antioxidant, and as a monoamine oxidase A inhibitor. (wikipedia.org)
  • The free radical theory of aging was conceived by Denham Harman in the 1950s, when prevailing scientific opinion held that free radicals were too unstable to exist in biological systems. (wikipedia.org)
  • Biochem
  • A. Ingall, K. A. K. Lott, T. F. Slater, S. Finch and A. Stier, Metabolic activation of CC14 to a free-radical product: studies using a spin trap, Biochem. (springer.com)
  • E. K. Lai, P. B. McCay, T. Noguchi and K-L. Fong, In vivo spin trapping of trichloromethyl radicals formed from CC1 4 , Biochem. (springer.com)
  • T. F. Slater, Free radical mechanisms in tissue injury, Biochem. (springer.com)
  • liver
  • R. L. Willson, Free radical and tissue damage: mechanistic evidence from radiation Studies, in "Biochemical Mechanisms of Liver Injury" pp. 123-224, T. F. Slater, ed. (springer.com)
  • formation
  • K. Hasegawa and L. K. Patterson, Pulse r.adiolysis studies in model lipid systems: formation and behaviour of peroxyradicals in fatty acids, Photochem. (springer.com)
  • Candeias LP, Stratford MRL, Wardman P: Formation of hydroxyl radicals on reaction of hypochlorous acid with ferrocyanide, a model iron(II) complex. (springer.com)
  • Formation of novel nitrogen-containing oxidized lipid derivatives. (springer.com)
  • Biology
  • in 1991, and since then the amount of research involving this chemical has been steadily increasing, with entire issues of relatively high-impact journals such as Molecular Aspects of Medicine and Free Radical Biology and Medicine devoting volumes to 4-HNE-centered publications. (wikipedia.org)
  • unstable
  • Free radicals, which contain only a single electron in any orbital, are usually unstable toward losing or picking up an extra electron, so that all electrons in the atom or molecule will be paired. (wikipedia.org)
  • reaction
  • J. J. M. C. De Groot, G. J. Garssen, J. F. G. Vliegenthart and J. Boldingh, The detection of linoleic acid radicals in the anaerobic reaction of lipoxygenase, Biochim. (springer.com)
  • The free radicals are due to the action of UV light on AGE (Advanced Glycation End-products) as a result of the reaction of DHA with the skin, and the intermediates, such as Amadori products (a type of AGE), that lead to them. (wikipedia.org)
  • It is found throughout animal tissues, and in higher quantities during oxidative stress due to the increase in the lipid peroxidation chain reaction, due to the increase in stress events. (wikipedia.org)
  • The new free radical can then pull an electron off the next molecule, and a chemical chain reaction of radical production occurs. (wikipedia.org)
  • The chain reaction caused by free radicals can lead to cross-linking of atomic structures. (wikipedia.org)
  • cells
  • It has been shown that cells sustain progressive lipid peroxidation following an apoptotic signal, and it has been suggested that oxidative stress is a common mediator of apoptosis [ 5 - 7 ]. (hindawi.com)
  • 4-Hydroxynonenal, or 4-hydroxy-2-nonenal or 4-HNE or HNE, (C9H16O2), is an α,β-unsaturated hydroxyalkenal that is produced by lipid peroxidation in cells. (wikipedia.org)
  • activity
  • D. Rowley, J. M. C. Gutteridge, D. R. Blake and B. Halliwell, Lipid peroxidation in rheumatoid arthritis: TBA activity and catalytic iron salts in synovial fluid from RA. (springer.com)
  • increase
  • There has been some evidence to suggest that free radicals and some reactive nitrogen species trigger and increase cell death mechanisms within the body such as apoptosis and in extreme cases necrosis. (wikipedia.org)
  • Injury
  • However, the 'tan' produced by erythrulose/DHA only has an SPF of up to 3, and enhances the free radical injury from UV (compared to untreated skin) for the 24 hours after self-tanner is applied, according to a 2007 study led by Katinka Jung of the Gematria Test Lab in Berlin. (wikipedia.org)