• membranes
  • A mechanism is discussed for generation and function of peroxidative radicals as well as of active oxygen forms in lipid peroxidation, induced by organic hydroperoxides in liver microsomal membranes. (msk.ru)
  • For example, the melting temperature of di-oleoyl-phosphatidylethanolamine is -16 °C while the melting temperature of di-oleoyl-phosphatidylcholine is -20 °C. If the lipids had two palmitoyl chains, phosphatidylethanolamine would melt at 63°C while phosphatidylcholine would melt already at 41 °C. Lower melting temperatures correspond, in a simplistic view, to more fluid membranes. (wikipedia.org)
  • These radicals may induce lipid peroxidation of organelles like lysosomes, mitochondria, and sarcoplasmic membranes. (wikipedia.org)
  • Health and Dis
  • C. Benedetto and T.F. Slater, Electron spin resonance studies on human endometrium and cervix, in "Recent Studies on lipid Peroxidation in Health and Disease", T. F. Slater, ed., in press, (1980). (springer.com)
  • Das is the editor-in-chief of Lipids in Health and Disease, a journal published by BioMed Central and Current Nutrition & Food Science, published by Bentham Science. (wikipedia.org)
  • Antioxidants
  • In vitro studies have shown that antioxidants quench free radicals and ameliorate certain aspects of biomolecular damage caused by CS. (aacrjournals.org)
  • To investigate whether supplemental antioxidants reduce CS-related lipid peroxidation in vivo and whether they are more effective in combination, we conducted an intervention study in smokers. (aacrjournals.org)
  • In addition to regular exercise, nutritional antioxidants may combat free radical formation-as has been reported for GPLC. (wikipedia.org)
  • protein
  • In support of the above, previous work involving the individual components of GPLC has noted decreased protein and lipid peroxidation following glycine use, with potent antioxidant properties noted for propionyl-L-carnitine. (wikipedia.org)
  • liver
  • R. L. Willson, Free radical and tissue damage: mechanistic evidence from radiation Studies, in "Biochemical Mechanisms of Liver Injury" pp. 123-224, T. F. Slater, ed. (springer.com)
  • Biochem
  • A. Ingall, K. A. K. Lott, T. F. Slater, S. Finch and A. Stier, Metabolic activation of CC14 to a free-radical product: studies using a spin trap, Biochem. (springer.com)
  • E. K. Lai, P. B. McCay, T. Noguchi and K-L. Fong, In vivo spin trapping of trichloromethyl radicals formed from CC1 4 , Biochem. (springer.com)
  • T. F. Slater, Free radical mechanisms in tissue injury, Biochem. (springer.com)
  • S. W. Edwards, M. B. Hallet and A. K. Campbell, Oxygen radical production may be limited by oxygen concentration, Biochem. (springer.com)
  • vivo
  • 4-Hydroxy-2-nonenal (4-HNE), among them, is believed to be largely responsible for cytopathological effects observed during oxidative stress in vivo and has achieved the status of one of the best recognized and most studied of the cytotoxic products of lipid peroxidation. (hindawi.com)
  • electron
  • The ability of the catalyst to produce hydroxyl radicals ( · OH) was evaluated by electron paramagnetic resonance measurements using 5,5-dimethyl- 1-pyrroline- N -oxide (DMPO) as spin trap. (springer.com)
  • A free radical is any atom or molecule that has a single unpaired electron in an outer shell. (wikipedia.org)
  • Free radicals, which contain only a single electron in any orbital, are usually unstable toward losing or picking up an extra electron, so that all electrons in the atom or molecule will be paired. (wikipedia.org)
  • Note that the unpaired electron does not imply charge - free radicals can be positively charged, negatively charged, or neutral. (wikipedia.org)
  • Damage occurs when the free radical encounters another molecule and seeks to find another electron to pair its unpaired electron. (wikipedia.org)
  • The free radical often pulls an electron off a neighboring molecule, causing the affected molecule to become a free radical itself. (wikipedia.org)
  • The new free radical can then pull an electron off the next molecule, and a chemical chain reaction of radical production occurs. (wikipedia.org)
  • damage
  • Aluminium toxicity causes an increase in lipid peroxidation, with most damage occurring in the brain. (wikipedia.org)
  • The results showed support for pinoline's ability to reduce damage from lipid peroxidation. (wikipedia.org)
  • The free radical theory of aging (FRTA) states that organisms age because cells accumulate free radical damage over time. (wikipedia.org)
  • Noting that radiation causes "mutation, cancer and aging", Harman argued that oxygen free radicals produced during normal respiration would cause cumulative damage which would eventually lead to organismal loss of functionality, and ultimately death. (wikipedia.org)
  • Free radical damage within cells has been linked to a range of disorders including cancer, arthritis, atherosclerosis, Alzheimer's disease, and diabetes. (wikipedia.org)
  • This damage then causes mutations which lead to an increase of ROS production and greatly enhance the accumulation of free radicals within cells. (wikipedia.org)
  • Biology
  • in 1991, and since then the amount of research involving this chemical has been steadily increasing, with entire issues of relatively high-impact journals such as Molecular Aspects of Medicine and Free Radical Biology and Medicine devoting volumes to 4-HNE-centered publications. (wikipedia.org)
  • formation
  • K. Hasegawa and L. K. Patterson, Pulse r.adiolysis studies in model lipid systems: formation and behaviour of peroxyradicals in fatty acids, Photochem. (springer.com)
  • Candeias LP, Stratford MRL, Wardman P: Formation of hydroxyl radicals on reaction of hypochlorous acid with ferrocyanide, a model iron(II) complex. (springer.com)
  • Formation of novel nitrogen-containing oxidized lipid derivatives. (springer.com)
  • radiation
  • Two sources inspired Harman: 1) the rate of living theory, which holds that lifespan is an inverse function of metabolic rate which in turn is proportional to oxygen consumption, and 2) Rebbeca Gershman's observation that hyperbaric oxygen toxicity and radiation toxicity could be explained by the same underlying phenomenon: oxygen free radicals. (wikipedia.org)
  • cells
  • It has been shown that cells sustain progressive lipid peroxidation following an apoptotic signal, and it has been suggested that oxidative stress is a common mediator of apoptosis [ 5 - 7 ]. (hindawi.com)
  • 4-Hydroxynonenal, or 4-hydroxy-2-nonenal or 4-HNE or HNE, (C9H16O2), is an α,β-unsaturated hydroxyalkenal that is produced by lipid peroxidation in cells. (wikipedia.org)
  • activity
  • D. Rowley, J. M. C. Gutteridge, D. R. Blake and B. Halliwell, Lipid peroxidation in rheumatoid arthritis: TBA activity and catalytic iron salts in synovial fluid from RA. (springer.com)
  • The biological activity of this molecule is of interest as a potential free radical scavenger, also known as an antioxidant, and as a monoamine oxidase A inhibitor. (wikipedia.org)
  • increase
  • It is found throughout animal tissues, and in higher quantities during oxidative stress due to the increase in the lipid peroxidation chain reaction, due to the increase in stress events. (wikipedia.org)
  • There has been some evidence to suggest that free radicals and some reactive nitrogen species trigger and increase cell death mechanisms within the body such as apoptosis and in extreme cases necrosis. (wikipedia.org)
  • Injury
  • However, the 'tan' produced by erythrulose/DHA only has an SPF of up to 3, and enhances the free radical injury from UV (compared to untreated skin) for the 24 hours after self-tanner is applied, according to a 2007 study led by Katinka Jung of the Gematria Test Lab in Berlin. (wikipedia.org)