The aim of the present work was the preparation of novel derivatives of naphthalen-2-ol by a two-step synthesis, in the form of a racemic mixture (compounds I-XIII). (sciendo.com)
Compounds1
Ruoslati and co-workers {Current Opinion in Oncology, 1998, 10, 560-5) showed that RGD analogues that bind to the tumour endothelium, once conjugated to the cytotoxic agent doxorubicin, form compounds that are more efficient and less toxic than doxorubicin alone. (allindianpatents.com)
Synthesis2
An N-alkylation of the piperazine ring with 3-methylbenzylchloride completes the synthesis. (wikipedia.org)
To obtain the enantiomerically pure drug, stereoselective synthesis and splitting of racemic mixtures are the options. (sciendo.com)
Drug1
Drug forms contain the racemic dihydrochloride. (wikipedia.org)
Note1
Note that many TCAs , TeCAs, antipsychotics , ergolines , and some piperazines like buspirone , trazodone , nefazodone , etoperidone , and mepiprazole all antagonize α 1 -adrenergic receptors as well, which contributes to their side effects such as orthostatic hypotension . (en-academic.com)
Common1
The most common piperidines and piperazine are phencyclidine (PCP), ketamine, benzylpiperazine (BZP), and 3-trifluoromethylphenylpiperazine (TFMPP). (medscape.com)
Tablet1
[1] It is provided in the form of a capsule or tablet taken by mouth or orally disintegrating tablets taken on the tongue for Parkinson's disease and as a patch applied to skin for depression. (cloudfront.net)