• Quinoline itself has few applications, but many of its derivatives are useful in diverse applications. (wikipedia.org)
  • Like other nitrogen heterocyclic compounds, such as pyridine derivatives, quinoline is often reported as an environmental contaminant associated with facilities processing oil shale or coal, and has also been found at legacy wood treatment sites. (wikipedia.org)
  • A metal-free cascade reaction was developed for the synthesis of indolo[1,2- a ]quinoline derivatives from arylsulfonyl hydrazides and 1-(2-(arylethynyl)phenyl)indoles in the presence of TBAI/TBHP. (rsc.org)
  • Studies suggest the potential clinical use of these quinolines and of their derivatives to inhibit tau aggregation and possible therapeutic routes for AD. (unboundmedicine.com)
  • Melanoma affine radiopharmaceuticals I. A comparative study of 131I-labeled quinoline and tyrosine derivatives. (curehunter.com)
  • Quinoline is metabolized through different pathways: one leading to the 5,6 -dihydrodiol derivatives which is a desactivation way, another one produces quinoline -N oxide and the third one, which is the activation pathway, involves an epoxidation in position 2 -3. (europa.eu)
  • Doebner reaction using anilines with an aldehyde and pyruvic acid to form quinoline-4-carboxylic acids Doebner-Miller reaction using anilines and α,β-unsaturated carbonyl compounds. (wikipedia.org)
  • Since 2011, several quinoline compounds have shown Epidermal Growth Factor Receptor (EGFR) inhibition 22 . (nature.com)
  • Going clockwise from top these are: Combes quinoline synthesis using anilines and β-diketones. (wikipedia.org)
  • Quinoline is used as a solvent and reagent in organic synthesis. (wikipedia.org)
  • In the present study the synthesis, antitubercular, antifungal, and antibacterial activities and structure activity relationship of aryloxypropanolamine substituted 8-hydroxy quinolines are reported. (nepjol.info)
  • Application of Modern Green Chemistry Methods in the Synthesis of Quinolines, Quinazolines and Quinazolinones, Advances in Organic Synthesis (2022) 16: 63. (eurekaselect.com)
  • Iron Single Atom Catalyzed Quinoline Synthesis. (bvsalud.org)
  • The carbon -based SACs exhibit excellent activity and selectivity (≈68%) for the synthesis of substituted quinolines by a three-component oxidative cyclization , affording a wide assortment of quinolines (23 examples) from anilines and acetophenones feedstock in an efficient, atom-economical manner. (bvsalud.org)
  • We have synthesized a new quinoline (4,7-dichloroquinoline) derivative which showed significant larvicidal and pupicidal properties against a malarial and a dengue vector and a lethal toxicity ranging from 4.408 µM/mL (first instar larvae) to 7.958 µM/mL (pupal populations) for Anopheles stephensi and 5.016 µM/mL (larva 1) to 10.669 µM/mL (pupae) for Aedes aegypti . (nature.com)
  • Compound 9 was the first halogenate quinoline derivative isolated from the genus of Trichoderma . (nih.gov)
  • It is a beta-diketone and an aromatic ketone in addition to being a derivative of quinoline, having E number E104. (macsenlab.com)
  • Quinolines are used in the manufacture of dyes and the preparation of hydroxyquinoline sulfate and niacin. (wikipedia.org)
  • Quinoline is an industrial chemical used to manufacture other products, including dyes. (ewg.org)
  • Quinoline Yellow belongs to the class of quinophthalone dyes. (macsenlab.com)
  • A high production volume chemical, quinoline is used to produce a variety of drugs and dyes. (cdc.gov)
  • Quinoline is used to produce various drugs and dyes. (who.int)
  • Quinoline Yellow has not been linked to any significant kind of long-term toxicity, it is not genotoxic or carcinogenic, and there is no indication that it has any negative impact on reproduction or development. (macsenlab.com)
  • [2] Studies show that Quinoline Yellow is not genotoxic or carcinogenic. (yunbangpharm.com)
  • Some evidences show that the pathway that lead to the mutagenic/carcinogenic properties of quinoline involves an epoxide in 2-3 position. (europa.eu)
  • The critical position for the mutagenic / carcinogenic property was confirmed to be in position 2 -3, by a screening carcinogenicity test, mutagenicity test and also by preventing the epoxide formation by substitution (fluoro-, chloro-) of quinoline. (europa.eu)
  • The other epoxide formed on the position 5,6 of the benzene moiety, is not mutagenic and substitution with fluorine for instance, showed that this epoxide is not involved in the mutagenic/carcinogenic properties of quinoline. (europa.eu)
  • The Working Group classified quinoline as "possibly carcinogenic to humans", Group 2B, based on sufficient evidence of carcinogenicity in experimental animals. (cdc.gov)
  • Kairine) Several anti-malarial drugs contain quinoline substituents. (wikipedia.org)
  • Quinoline provided the first anti-malarial medicine. (nature.com)
  • In view of the potential nature of these moieties it was considered worthwhile to study the effects of two pharmacophoric moieties such as quinoline and propanolamines/amino ethane in a single molecule. (nepjol.info)
  • Long-term exposure to 2-amino-3-methylimidazo[4,5-f]quinoline can trigger a potential risk of Parkinson's disease. (physiciansweekly.com)
  • Here, we studied the neurotoxicity of the HCA 2-amino-3-methylimidazole[4,5-f]quinoline (IQ) in vivo by utilizing a zebrafish model. (physiciansweekly.com)
  • Featuring a tetradentate ligand consisting of one amino quinoline and two methyl pyridine moieties, the resulting Cu(II)-complex is effective under visible light irradiation to add sulfonyl chlorides to alkenes and alkynes, including unactivated aliphatic olefins. (uni-regensburg.de)
  • In March, 2018, a Working Group of 23 scientists from 12 countries met at the International Agency for Research on Cancer (IARC) in Lyon, France, to finalise their evaluation of the carcinogenicity of quinoline, styrene , and styrene -7,8-oxide. (cdc.gov)
  • The International Agency for Research on Cancer (IARC) is pleased to announce that the IARC Monographs volume on styrene, styrene-7,8-oxide, and quinoline is now available online. (who.int)
  • This volume provides evaluations of the carcinogenicity of styrene, styrene-7,8-oxide, and quinoline. (who.int)
  • Quinoline and styrene are present in air pollution and in tobacco smoke. (who.int)
  • Quinoline and styrene are high production volume chemicals. (who.int)
  • Owing to its relatively high solubility in water quinoline has significant potential for mobility in the environment, which may promote water contamination. (wikipedia.org)
  • Enriched with vast domain knowledge, we are gaining tremendous success as a manufacturer, supplier and exporter of Lake Quinoline Yellow . (foodcoloursindia.com)
  • In order to maintain the quality of Lake Quinoline Yellow , it is packed in moisture free and chemically inert packaging material. (foodcoloursindia.com)
  • An ISO 9001-2008 certified organization, we are successfully meeting the requirements of Drugs, Food and Cosmetics Industry by providing a exquisite array of Lake Quinoline Yellow. (foodcoloursindia.com)
  • Known for purity levels, accurate pH value, non toxic nature and longer shelf life, these Lake Quinoline Yellow are used in Ices, scotch eggs and smoked haddock. (foodcoloursindia.com)
  • These Lake Quinoline Yellow are offered with superior quality packaging at competitive rates. (foodcoloursindia.com)
  • Quinoline Yellow is a bright greenish yellow, water soluble dye, which is known as food additive that is developed using sulfonating 2-(2-quinolyl) Indan-1, 3-dione. (syntheticfoodcolors.com)
  • Quinoline Yellow is the only dye in this group of importance for use in food coloration. (syntheticfoodcolors.com)
  • What is Quinoline Yellow? (macsenlab.com)
  • Macsen Laboratories is the leading manufacturer and supplier of Quinoline Yellow with ISO certification. (macsenlab.com)
  • In certain countries like the EU and Australia, Quinoline Yellow is used as a greenish yellow food additive in foods, like sauces, decorations, and coatings. (macsenlab.com)
  • Q. What is Quinoline Yellow Aluminium Lake? (macsenlab.com)
  • Quinoline Yellow has the potential to be transformed into it's equivalent aluminium lake , a pseudo-pigment form, by precipitating it with aluminium hydroxide in the form of an aluminium salt. (macsenlab.com)
  • Q. What is the difference between Quinoline Yellow SS and Quinoline Yellow WS? (macsenlab.com)
  • Quinoline Yellow SS is the "spirit-soluble" form of the dye and Quinoline Yellow WS is the "water-soluble" form of the dye. (macsenlab.com)
  • Q. Is Quinoline Yellow toxic? (macsenlab.com)
  • Q. Why was Quinoline Yellow banned? (macsenlab.com)
  • A study commissioned by the UK's Food Standards Agency found that when Quinoline Yellow used in a mixture of other preservatives (as in case of beverages), increased levels of hyperactivity in children, ADHD -like behavior, were observed. (macsenlab.com)
  • Buy high purity Quinoline Yellow from the leading manufacturer with ISO certification. (macsenlab.com)
  • QUINOLINE YELLOW 70% E104-C is a water soluble dye in compliance with EU, Japanese and Chinese cosmetic regulations. (sensient-beauty.com)
  • Quinoline Yellow is anionic in nature and is used to dye wool and silk. (yunbangpharm.com)
  • There was strong evidence that quinoline is genotoxic in experimental systems, inducing mutations and chromosomal damage in rodents and in vitro (upon metabolic activation), but no human data on cancer mechanisms were available. (cdc.gov)
  • Quinoline is considered as harmful by oral and dermal route according to the Dangerous Substance Directive criteria. (europa.eu)
  • According to effect acute toxic effects of quinoline, dermal absorption is possible but the extent is about 5-fold less important than by the oral route on the basis of the LD50 values. (europa.eu)
  • Exposure to quinoline may harm the liver, and it is classified as a possible human carcinogen. (ewg.org)
  • No data were available on cancer in humans, or on exposure, absorption, or distribution of quinoline in humans. (cdc.gov)
  • In both sexes of Crj:BDF1 mice, drinking water exposure to quinoline increased the incidences of liver histiocytic sarcoma, and in various organs, haemangioma and haemangiosarcoma. (cdc.gov)
  • Quinolines are often synthesized from simple anilines using a number of named reactions. (wikipedia.org)
  • Quinoline is a heterocyclic aromatic organic compound with the chemical formula C9H7N. (wikipedia.org)
  • The quinoline compound showed significant activity against the viral pathogen serotype 2 (DENV-2). (nature.com)
  • Quinoline is the synthetic heteroaromatic compound that conforms to the formula: C 9 H 7 N. (productingredients.com)
  • 2,4-Di(pyrrolidin-1-yl)quinoline is a useful chemical compound with a variety of research applications. (georganics.sk)
  • In vitro conditions and the purified quinoline exhibited insignificant toxicity on the host system up to 100 µM/mL. (nature.com)
  • A standard acute oral toxicity method has been performed with quinoline on rat. (europa.eu)
  • Quinoline is an azaarene that is present in tobacco smoke and air pollution. (cdc.gov)
  • The absorption/excretion of quinoline has been studied in rabbit. (europa.eu)
  • As quinoline is a weak base with a pKa around 5, the absorption is likely to take place in the small intestine rather than in the stomach. (europa.eu)
  • Quinoline is mainly used as in the production of other specialty chemicals. (wikipedia.org)
  • Quinolines are non-mescaline chemicals found in certain psychoactive cacti. (technoccult.net)
  • Moreover, these quinolines exhibit physical chemical properties similar to drugs able to penetrate the human brain blood barrier. (unboundmedicine.com)
  • A chemical class of colorants characterized by the quinoline structure derived from quinaldine. (sensientfoodcolors.com)
  • The presence of H 2 S dramatically reduced the hydrogenation of 1,2,3,4-tetrahydroquinoline to decahydroquinoline, altering unfavorably the reaction pathways involved in the HDN of quinoline. (psu.edu)
  • Quinolines" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ucdenver.edu)
  • In three feeding studies, quinoline increased the incidence of liver haemangiosarcoma in male rats of various strains. (cdc.gov)
  • The strategy is also applicable to the deuteration of quinolines at the fourth position, which is challenging by conventional methods . (bvsalud.org)
  • Quinoline is absorbed through the gastro-intestinal tract and metabolites are found in urine. (europa.eu)
  • 2 -OH quinoline has also been found. (europa.eu)
  • Quinoline occurs in petroleum and shale oil processing, and is found in groundwater and soil at coal tar and creosote-contaminated sites. (cdc.gov)
  • In vitro studies indicated a significantly lower inhibitory effect of amyloid-β42 on the aggregation, suggesting that tau aggregates are specific targets for quinoline interactions. (unboundmedicine.com)
  • Docking studies based on tau modeling, as a structural approach to the analysis of the interaction of tau-binding ligands, indicated that a C-terminal tau moiety, involved in the formation of PHFs, seems to be a site for binding of quinolines. (unboundmedicine.com)
  • Quinoline is only slightly soluble in cold water but dissolves readily in hot water and most organic solvents. (wikipedia.org)
  • In male and female F344/DuCrj rats, drinking water containing quinoline increased the incidences of haemangiosarcoma (in various organs), and hepatocellular adenoma and carcinoma. (cdc.gov)
  • XRD patterns of both high-performance phosphide catalysts revealed that the active phase was Ni 2 P. It is indicated that the HDN of quinoline on the MCM-41-supported nickel phosphides exclusively proceeds via a pathway, which involves fully saturated intermediates. (psu.edu)
  • We are pleased to offer high quality 2,4-Di(pyrrolidin-1-yl)quinoline in various sizes (for research, pilot-scale, or production applications) from milligrams to multi-kilogram batches, making it easy for you to choose the right amount to suit your needs. (georganics.sk)
  • We show that molecules from a family of quinolines interact specifically with oligomeric forms of tau, inhibiting their assembly into AD filaments. (unboundmedicine.com)
  • FAPIs based on a quinoline structure were synthesized and characterized with respect to binding, internalization, and efflux in cells expressing human and murine FAP as well as CD26. (snmjournals.org)
  • Quinolines are present in small amounts in crude oil within the virgin diesel fraction. (wikipedia.org)
  • 5 animals per sex per group were treated by quinoline doses from 0.10 to 0.40 mL/kg bw. (europa.eu)
  • We value your input so if you have suggestions regarding new applications for 8-(Bromomethyl)Quinoline email us and we will include your contribution on the website. (discofinechem.com)
  • No standard toxicokinetics study has been identified for quinoline. (europa.eu)
  • The next step of this way is the production of 3 -OH quinoline. (europa.eu)
  • The formation of 3 -OH quinoline is caused by CYP2E1, and the production of this metabolite is higher in rat than in human microsomes. (europa.eu)