• Assessing outcomes objectively is challenging, but the evolution of injury severity scoring systems with sufficient precision and reproducibility now permits trauma centers to compare their processes and outcomes, facilitating identification of best practices that form the foundations of quality improvement programs. (medscape.com)
  • Blast injury emerged as a primary source of morbidity among US military personnel during the recent conflicts in Iraq and Afghanistan, and led to an array of adverse health outcomes. (biomedcentral.com)
  • Secondary brain insults after traumatic brain injury such as electrolyte dysfunctions are associated with poor outcomes. (annalsofafricansurgery.com)
  • These bad outcomes may be associated with secondary brain insults such as electrolyte abnormalities that arise from inflammatory and biochemical cascades initiated by the primary injury insult to the brain (9, 17, 18). (annalsofafricansurgery.com)
  • Together, these studies provide potential strategies of quantifying and improving the outcomes of individuals who engage in severe aggressive outbursts. (abainternational.org)
  • Standardized trauma scoring systems allow for appropriate triage and classification of trauma patients as well as prediction of patient outcomes and risk adjustment when evaluating patient outcomes and hospital performance. (bmj.com)
  • Dr. Staudenmayer was promoted to Associate Professor of Surgery in 2016, and continues her research, policy and advocacy work to improve the care and outcomes for patients with traumatic injuries and critical surgical illnesses. (stanford.edu)
  • Dichotomized Glasgow Outcome Score at 6 months showed 70% with good outcomes and 30% with moderate to severe disability. (cellvation.com)
  • Ongoing projects are focused on understanding how inflammatory responses are regulated after a stroke and how they affect short-term brain injury and long term outcomes like dementia and depression. (stanford.edu)
  • or = 160 mg/dl within the first 24 h of admission following TBI is associated with poor outcomes irrespective of the severity of injury [ 4 ] . (researchsquare.com)
  • Both severity of injury and statin were significant predictors of reduced motor recovery ( p = 0.001, and p = 0.04, respectively). (nature.com)
  • However, trauma mortality prediction in individual patients by any scoring system is limited and is in general no better than good clinical judgment. (medscape.com)
  • The ability to predict outcome from trauma (ie, mortality) is perhaps the most fundamental use of injury severity scoring, a use that arises from the patient's and the family's desires to know the prognosis. (medscape.com)
  • Traumatic brain injury (TBI), also known as acquired brain injury, head injury, or brain injury, causes substantial disability and mortality. (medscape.com)
  • Background post-injury acquired immunodepression (AID) is frequently assessed by the diminished expression of Human Leukocyte Antigen-D Related on circulating monocytes (mHLA-DR). The relation with mortality and the occurrence of ICU-acquired infections (IAI) requires confirmation in large cohorts of patients. (medrxiv.org)
  • The other collected parameters were: the SAPS II and SOFA scores, sex, age, comorbidity, mortality and ICU-acquired infections. (medrxiv.org)
  • Interpretation the association between the early mHLA-DR expression and ICU mortality does not improve the prediction given by the severity scores. (medrxiv.org)
  • Background: Traumatic brain injury (TBI) is a serious hazard to human health and is characterized by high rates of disability and mortality. (aging-us.com)
  • Injury severity was ascertained by applying the Trauma Mortality Prediction Model, and patient comorbidities were quantified using the Charlson Comorbidity Index. (aku.edu)
  • Diffuse axonal injury (DAI), an important pathoanatomical subgroup of traumatic brain injury (TBI), refers to intracranial injury caused by rapid and sustained deceleration or acceleration of the brain, leading to higher mortality and functional impairment. (researchsquare.com)
  • Much of the morbidity and mortality is a result of preventable communicable diseases, malnutrition, complications associated with pregnancy and delivery as well as war-related injuries. (who.int)
  • Special regard in the examination was given to Glasgow coma scale, a precise anatomical description of injuries, results of investigations and treatment were recorded. (bmj.com)
  • Each dimension is scored on a scale of 1 (less intense) to 5 (more intense) in which each score is defined based what is clinically relevant for the individual patient. (abainternational.org)
  • Next, we tested the therapeutical potential of AstroRx cells in a lipopolysaccharide (LPS)-based ARDS mouse model by injecting AstroRx intravenously (i.v). We determined the degree of lung injury by using a severity scoring scale of 0-2, based on the American Thoracic Society. (tau.ac.il)
  • Parents (N = 263) completed a self-administered questionnaire with scale items based on 4 constructs of the Protection Motivation Theory: perceived vulnerability, perceived severity, response efficacy, and self-efficacy. (cdc.gov)
  • Our perceived risk scale was informed by the Protection Motivation Theory (PMT) ( 15 ), a theory on how persons make decisions to adopt health-related behavior ( 16 ) and its 4 constructs: perceived severity and perceived vulnerability to a health threat, and response efficacy and self-efficacy to respond to the threat. (cdc.gov)
  • The clinical assessment of head injury severity is commonly based on what is known as the Glasgow Coma Scale (GCS) according to doctors. (braininjurylawyer24-7blog.com)
  • The primary measure was the Pediatric Intensity Level of Therapy (PILOT) scale used to quantify treatment of elevated intracranial pressure. (cellvation.com)
  • Alcohol related falls are more often associated with severe craniofacial injury. (bmj.com)
  • A prospective cross-sectional study of one hundred and seventeen patients with severe head injury. (annalsofafricansurgery.com)
  • All consecutive patients presenting with severe head injury defined by GCS ≤ 8 and whose next of kin had given informed consent were recruited into the study. (annalsofafricansurgery.com)
  • Bednar and Hausman examined the effectiveness of an individualized outburst severity score that quantified several unique dimensions of severe behavior (e.g., frequency of problem behavior, duration, number of staff required, staff rating of severity, and staff/patient injury). (abainternational.org)
  • Dr. Kolodenker treats a variety of common and rare conditions of the foot and ankle, including injuries (minor as well as severe trauma), general foot pain, heel pain, hammertoes, bunions, flat feet, plantar fasciitis, and neuromas. (insighthack.com)
  • Lung injury (LI) is commonly involved in 15%~60% of severe AP, and severe LI is likely to trigger acute respiratory distress syndrome (ARDS) and respiratory failure (RF). (hindawi.com)
  • A score of 3-8 means severe injury, 9-12 is a moderate brain injury, while 13-15 is mild head injury, based upon examination six hours after injury. (braininjurylawyer24-7blog.com)
  • Acute systemic inflammation characterizes the vast majority of the patients admitted in intensive care (ICU) related to various acute injuries such as sepsis 1 , major surgical procedure 2 , severe polytrauma 3 and medical diseases 4 . (medrxiv.org)
  • CEVA101 is currently being developed for the treatment of severe traumatic brain (closed head) injury in adults and children. (cellvation.com)
  • Study results showed that CEVA101 therapy was associated with a reduction in treatment intensity required to manage ICP associated severity of organ injury and duration of ICP monitoring following severe TBI, as compared to the matched control group. (cellvation.com)
  • The alcohol group had a higher incidence of head injuries (46 (48%) versus 22 (9%)) with a lower incidence of limb injuries (39 (39%) versus 183 (76%)) than the no alcohol group. (bmj.com)
  • This is the first study to report the effectiveness of a single PRP injection in ankle syndesmosis injuries for Rugby Union players, who appear to have a high incidence of this injury. (bmj.com)
  • Several studies 1-3 have suggested that these injuries have a higher incidence than once thought, and are probably underdiagnosed. (bmj.com)
  • Traumatic brain injury (TBI) is one of the main factors of death and disability in adults with a high incidence worldwide. (medsci.org)
  • An increased incidence of PTSD is associated with physical problems and chronic health conditions after combat-related injury. (health.mil)
  • Annual and monthly incidence of paediatric injury-related ED presentations from 2010 to 2019 were used to fit autoregressive integrated moving average models, from which forecast estimates with 95% prediction intervals were derived and compared against corresponding observed values to obtain estimates of absolute and relative forecast errors. (mdpi.com)
  • The state of inflammation was further assessed by quantifying the immune-cell infiltration to the bronchoalveolar lavage fluid (BALF) and by the presence of proinflammatory cytokines and chemokines in the BALF and serum. (tau.ac.il)
  • Of note, recent study identified that miR-127 expression was aberrant in the inflammation-related pulmonary disorders [ 36 ] and further revealed that enhanced expression of miR-127 could promote the development of inflammatory macrophages and contribute to the exaggerated lung inflammation and injury [ 37 ]. (hindawi.com)
  • Collectively, we demonstrated that hyperglycemia was involved in mediating secondary injury after DAI by disrupting BBB integrity by inducing inflammation through the PPARγ/caveolin-1/TLR4 pathway. (researchsquare.com)
  • Conclusions More than half of the subjects who randomly enter a community pharmacy had ages that make it impossible to calculate the CV risk by SCORE. (bvsalud.org)
  • Conclusions This pilot study shows that, following ankle syndesmosis injury, a single autologous PRP injection may accelerate safe and successful return to Rugby Union, with improved functional capacity and reduced fear avoidance. (bmj.com)
  • Characterization of injury severity is crucial to the scientific study of trauma, yet the actual measurement of injury severity began only 50 years ago. (medscape.com)
  • Our objective was to establish the prevalence of cholesterol-lowering agent use following spinal cord injury (SCI) and to determine the impact on recovery of motor function. (nature.com)
  • This report describes the prevalence of screening positive for PTSD and the association with injury severity and time since injury among U.S. military personnel injured during combat operations. (health.mil)
  • The prediction of the prognosis based on the level of severity scores APACHE 2, SAPS II or SOFA appears difficult to improve by the addition of biomarkers, despite an impressive list of reported biomarkers. (medrxiv.org)
  • Defining the role of host biomarkers in the diagnosis and prognosis of the severity of childhood pneumonia: a prospective cohort study. (ox.ac.uk)
  • We evaluated the differential contribution of LqSOFA and host biomarkers to the diagnosis and prognosis of pneumonia severity. (ox.ac.uk)
  • Nervous system injury, as the most common and serious secondary injury after TBI, determines the prognosis of TBI patients. (medsci.org)
  • We completed retrospective analysis of statin use in individuals with neurologically significant spinal cord injury in a historical cohort study. (nature.com)
  • Using beach volleyball data, a "traditional" cohort study approach using a time-loss injury definition suggested that injury risk was very low. (bmj.com)
  • Risk factors are typically also examined in cohort studies, where the characteristics of injured athletes can be compared with athletes without injury. (bmj.com)
  • BackgroundThe relationship between acute combat-related traumatic injury (CRTI) to coronary flow reserve (CFR) and subclinical cardiovascular risk have not been examined and was the primary aim of this study.Methods and resultsUK combat veterans from the ADVANCE cohort study (UK-Afghanistan War 2003-14) with traumatic limb amputations were compared to injured non-amputees and to a group of uninjured veterans from the same conflict. (imperial.ac.uk)
  • This retrospective cohort designed study compared pediatric subjects treated with CEVA101 (treatment group) in the initial Phase 1 trial with a control group of age- and severity-matched children. (cellvation.com)
  • The Saudi cohort was younger, the median age being 36 years compared with 50 years, with 51% of injuries caused by road traffic incidents. (bmj.com)
  • This retrospective cohort study included children aged ≤15 years who presented to the ED at the Children's Hospital at Westmead, Sydney, New South Wales, Australia, with a principal diagnosis of injury during 1 January 2010 to 31 December 2021. (mdpi.com)
  • 2 The final step in the injury prevention sequence is to introduce measures that are likely to reduce the future risk and/or severity of sports injuries and document whether they are effective. (bmj.com)
  • This testing certifies each of these products achieve the criteria for G-Max (shock) in addition to the Head Injury Criterion score, which measures the impact severity quantifying the risk of head trauma. (tigerturf.com)
  • Secondary measures included Pediatric Logistic Organ Dysfunction score and days of intracranial pressure (ICP) monitoring as a surrogate for length of neurointensive care. (cellvation.com)
  • See Pediatric Concussion and Other Traumatic Brain Injuries , a Critical Images slideshow, to help identify the signs and symptoms of TBI, determine the type and severity of injury, and initiate appropriate treatment. (medscape.com)
  • The ability to predict survival after trauma is perhaps the most fundamental use of injury severity scoring, Furthermore, injury severity scoring can provide objective correlations with resource utiliziation such as length of stay and costs of treatment, as well as inform clinical decisions regarding management of injuries of specific severity. (medscape.com)
  • Injury severity scoring is indispensable in stratifying patients into comparable groups for prospective clinical trials. (medscape.com)
  • A total of 1972 US military personnel who sustained a blast-related injury during military operations in Iraq and Afghanistan were identified from clinical records. (biomedcentral.com)
  • The purpose of the current study is to define and quantify relevant dimensions of problem behavior that occur in episodic outbursts to determine an effective clinical outcome measure. (abainternational.org)
  • Results suggest a composite severity score could be an effective measure of clinical outcome. (abainternational.org)
  • CEVA101 is intravenously infused within 48 hours of injury, by slow IV push at doses to be defined by ongoing Phase 2 clinical trials. (cellvation.com)
  • The objective of this study is to assess whether the estimation of arterial stiffness can improve CV risk stratification compared to SCORE in patients at community pharmacies. (bvsalud.org)
  • Methods Observational prospective epidemiological study in which consecutive individuals entering a participating Community Pharmacy are offered a voluntary measurement of blood pressure and estimation of pulse wave velocity by oscillometry (AGEDIO, IEM®) to stratify their CV risk according to SCORE compared to the use of arterial stiffness. (bvsalud.org)
  • 16/122 (13.1%) patients under 40 years and 72/364 (19.8%) over 65 years of age presented pathological stiffness and could be classified as high-risk, even though being out of the age-range of SCORE. (bvsalud.org)
  • Among them, according to SCORE, only 6 (2.1%) fell into the high-risk category. (bvsalud.org)
  • The second step is to map the causes of injuries, to identify their risk factors and mechanisms. (bmj.com)
  • SGW's top seven TigerTurf products have received IPEMA certification and exceed the necessary G-Max and Head Injury Criterion scores, which determine the severity of impact and quantify the risk of head trauma. (sgwarizona.com)
  • 0.0001) were independently associated with lower SEVR after adjusting for age, rank, ethnicity and time from injury.ConclusionCRTI, traumatic amputation and its worsening physical deficit are associated with lower coronary flow reserve and heightened subclinical cardiovascular risk. (imperial.ac.uk)
  • The State of US Health, 1990-2016: Burden of Diseases, Injuries, and Risk Factors Among US States. (rochester.edu)
  • 1 Asymmetric warfare dominated the battlefield, commonly in the form of improvised explosive devices and other blast weaponry, which placed infantry and combat support personnel at risk of injury. (health.mil)
  • Performance could be further improved by using summary risk prediction scores such as the EUROSCORE II for coronary artery bypass graft surgery or the GRACE risk score for acute coronary syndrome. (who.int)
  • The following descriptors were used: coronavirus infection, acute kidney injury and risk factors in five databases, namely PudMed, Scopus, Embase, Virtual Health Library and Web of Science. (bvsalud.org)
  • Coronavirus infection, acute kidney injury, risk factors. (bvsalud.org)
  • The majoritary findings concluded that Acute Kidney Injury (AKI) was the main renal finding in patients contaminated by SARS-coV-2, follow by the risk factors identified for developing renal worsening in patients with COVID-19, like the extremes of age, race, sex, pre-existing diseases and disease evolution. (bvsalud.org)
  • While under physiologic conditions the blood-brain barrier renders the CNS impermeable to cholesterol [ 4 ], following insult (such as spinal cord injury (SCI)) the loss of barrier integrity renders the brain sensitive to peripheral cholesterol levels [ 5 ], and opens a temporary window for transport of both peripheral cholesterol and pharmaceutical agents. (nature.com)
  • Although, decisions for individual patients should never be based solely on a statistically derived injury severity score, scoring systems can nonetheless serve to estimate quantitatively the level of acuity of injured patients that are applied to adjustments in hospital outcome assessments. (medscape.com)
  • Therefore, decisions for individual patients should never be based solely on a statistically derived injury severity score. (medscape.com)
  • However, assessment years after injury made it impossible to determine whether dyslipidemia in individuals with SCI was a cause or consequence of reduced motor function. (nature.com)
  • In 2006, following informal discussions during the 1st World Congress on Sports Injury Prevention in Oslo in June 2005, the Fédération Internationale de Football Association Medical Assessment and Research Centre (F-MARC) hosted an Injury Consensus Group comprising a range of experts involved in the study of football injuries. (bmj.com)
  • We investigated the value added by biomarkers of the host infection response to the performance of the Liverpool quick Sequential Organ Failure Assessment score (LqSOFA), for triage of children presenting with pneumonia to a primary care clinic in a refugee camp on the Thailand-Myanmar border. (ox.ac.uk)
  • It enables assessment of the evolution of injury over time, as well as brain growth and maturation. (nature.com)
  • 7,8 Moreover, assessment of PTSD following combat-related injury is essential for planning appropriate treatment protocols and improving long-term well-being. (health.mil)
  • Review of the literature demonstrated a Finnish study by Honkanen 1 and an American study by Hingson 2 investigating alcohol related falls although there has been more research on the effect of alcohol on general brain injury. (bmj.com)
  • This study compares the pattern and severity of injury in those that have taken alcohol with those who have not. (bmj.com)
  • The study compares pattern and severity of injury with blood alcohol concentration within the alcohol group. (bmj.com)
  • The present study described blast-related injury profiles with varying QOL levels that may indicate the need for integrated health services. (biomedcentral.com)
  • To address these questions, we initiated a retrospective chart-review study of adults with traumatic SCI to assess (1) frequency of statin use in the acute/subacute period post injury, and (2) whether statin use was associated with different rates of recovery. (nature.com)
  • Results from the FIVB Volleyball Injury Study were used to compare two different recording methods. (bmj.com)
  • However, regardless of the study design used, the ability to record and report the magnitude of injuries reliably is a critical factor across all stages of injury prevention research. (bmj.com)
  • The following study sought to examine if teaching ED staff basic strategies on how to prevent, identify, manage and de-escalate crisis behaviors can improve the quality of services provided to patients who are in behavior health care crisis, increase staff buy in, decrease the use of restraint, and decrease staff injuries. (abainternational.org)
  • The aim of this study was to determine the expression of microRNA-127 (miR-127) in both rat models and patients of acute pancreatitis (AP) with lung injury (LI). (hindawi.com)
  • To our best knowledge, it is the first study that integrated miR-127 and the inflammatory injuries of the pancreas and the lung. (hindawi.com)
  • A recent nationwide cross-sectional study conducted between 2009 and 2017 discovered an annual average of 34,538 emergency department visits for fatal firearm injuries (Kaufman et al. (biomedcentral.com)
  • A second study was conducted to evaluate whether pediatric TBI patients receiving CEVA101 within 48 hours of injury experienced a reduction in therapeutic intensity directed toward managing elevated intracranial pressure relative to matched controls. (cellvation.com)
  • Methods This was an observational study using records with injury dates in 2018 from the registries at both hospitals. (bmj.com)
  • This study aimed to quantify changes in paediatric injury-related Emergency Department (ED) presentations at a large metropolitan paediatric hospital during the first two years of the COVID-19 pandemic (i.e., 2020 and 2021). (mdpi.com)
  • However, negative findings have also been reported, including for response inhibition tests [ 18 , 19 ] and by a study quantifying multiple executive functions [ 20 ]. (hindawi.com)
  • This study demonstrates how digital technology can quantify some of the factors that trigger asthma," Len Horovitz, MD, a pulmonary specialist at Lenox Hill Hospital in New York City, who was not involved with the study, told Medscape Medical News . (medscape.com)
  • The AIS is the basis for the Injury Severity Score (ISS), which is the most widely used measure of injury severity in patients with trauma. (medscape.com)
  • To discover if there is a significant difference in the pattern and severity of injury sustained during falls in patients who have consumed alcohol and those who have not. (bmj.com)
  • Of the 437 (47.3%) patients who were susceptible to calculating SCORE, 42/437 patients (9.6%) presented pathological arterial stiffness. (bvsalud.org)
  • However, scoring systems can serve to estimate quantitatively the level of acuity of injured patients that are applied to adjustments in hospital outcome assessments. (medscape.com)
  • Patients with the same GCS score may well have completely different causes for it, which means completely different treatment is necessary. (braininjurylawyer24-7blog.com)
  • Fatalities may even occur in patients who are not treated properly, even those with GCS scores above 9. (braininjurylawyer24-7blog.com)
  • From 2006 to 2014, the annual cost of initial hospitalizations for firearm-related injuries was $734.6 million, with Medicaid covering one-third and self-pay patients covering one-quarter of the financial burden (Spitzer et al. (biomedcentral.com)
  • while reading the studies, it was concluded that Acute Kidney Injury was the main renal finding in patients contaminated by SARS-CoV-2. (bvsalud.org)
  • The technical committee undertakes a formal process to investigate, evaluate and quantify blunt impact threats, and then research and develop test methods and criteria to determine compliance of given systems with respect to the essential impact protection for users. (wikipedia.org)
  • Additional investigation is needed to address potential impact of statin-therapy in the context of CNS injury and repair. (nature.com)
  • Often, the severity of a head impact is overestimated, but it's much more common for the reverse to be true. (braininjurylawyer24-7blog.com)
  • Brain injury often results in various physical and mental sequelae, such as epilepsy, chronic encephalopathy, and depression [ 2 ], which cause great harm to sufferers and have a tremendous economic impact on families and the social health system. (aging-us.com)
  • Field trauma scoring also is used to facilitate rational prehospital triage decisions, thereby minimizing the time from injury occurrence to definitive management. (medscape.com)
  • Taken together, these findings demonstrate that, at the appropriate dose, the nitrated fatty acid CXA-10 exhibits anti-inflammatory and antifibrotic effects in the kidney and limits renal injury in a model of CKD. (aspetjournals.org)
  • Background: An acute respiratory distress syndrome (ARDS) is caused by the increased amounts of pro-inflammatory cytokines and neutrophil-mediated tissue injury. (tau.ac.il)
  • Especially, pulmonary administration of PSLipos-L-NAC could significantly reduce the inflammatory response of M1-like macrophages in lung tissue and promote lung injury repair in a bleomycin-induced acute lung injury (ALI) mouse model, providing a potential therapeutic approach for ALI. (biomedcentral.com)
  • Our previous work showed that lower Young's modulus (E) of PS-containing deformable nano-liposomes would greatly affect PS-receptor-mediated macrophage responses, including cellular internalization, anti-inflammatory and pro-healing cytokine production, but the synergistic effects of drug-loaded PS-containing deformable nano-liposomes on macrophage-based therapy for inflammatory injuries remain much less understood [ 13 ]. (biomedcentral.com)
  • Hyperglycemia treatment aggravated neurological impairment and axonal injury, increased cell apoptosis and glial activation, and promoted the release of inflammatory factors, including TNF-α, IL-1β, and IL-6. (researchsquare.com)
  • The first step in the sequence of sports injury prevention research, as outlined by van Mechelen et al in 1992, 1 is to describe the magnitude of the problem in terms of the frequency and severity of injuries. (bmj.com)
  • Serum sodium abnormalities are common in traumatic brain injury (TBI), and are usually associated with the primary brain injury or interventions such as hyperosmolar therapies used in the management of raised intracranial pressure (1, 2). (annalsofafricansurgery.com)
  • Trauma scoring is a cornerstone of trauma care improvement interventions. (bmj.com)
  • Pain severity should be assessed before and after potentially painful interventions. (msdmanuals.com)
  • This symposium will present the results of two studies that examined methods of quantifying and decreasing intense bursts of aggressive behavior. (abainternational.org)
  • The severity of both limb and head injury is greater and correlates directly with blood alcohol concentration. (bmj.com)
  • This article reviews the conceptual and statistical background necessary to understand injury severity scoring, presents the most common scoring systems, and addresses new ideas and trends in trauma scoring. (medscape.com)
  • Trauma scoring also is used for quality assurance by allowing evaluation of trauma care both within and between trauma centers, a contentious and controversial area that is likely to only increase in importance. (medscape.com)
  • Perhaps the most important role for injury severity scoring is in trauma care research. (medscape.com)
  • Blunt trauma personal protective equipment (PPE) protects the wearer against injuries caused by blunt impacts. (wikipedia.org)
  • To quantify the levels of protection of a Blunt Trauma PPE, users and industry rely on technical standards. (wikipedia.org)
  • Trauma scoring is a cornerstone of trauma quality improvement (QI) efforts, and is key to organizing and evaluating trauma services. (bmj.com)
  • The objective of this review was to assess the appropriateness, feasibility, and QI applicability of traditional trauma scoring systems in LMIC settings. (bmj.com)
  • Materials and methods This systematic review searched PubMed, Scopus, CINAHL, and trauma-focused journals for articles describing the use of a standardized trauma scoring system to characterize holistic health status. (bmj.com)
  • Traumatic brain injury (TBI), as the most common cause of death in trauma centers, is also one of the major causes of death and disability in adults worldwide [ 1 , 2 ]. (medsci.org)
  • Hyperglycemia aggravates brain damage after diffuse axonal injury (DAI), but the underlying mechanisms are not fully defined. (researchsquare.com)
  • physical therapy can relieve muscle spasms and contractions in mild TBI [ 10 ], but their effects on secondary injuries are limited [ 11 ]. (medsci.org)
  • In vivo, AstroRx cells were able to lower the degree of lung injury in LPS-treated animals compared with the sham injected animals (P = 0.039). (tau.ac.il)
  • Is MicroRNA-127 a Novel Biomarker for Acute Pancreatitis with Lung Injury? (hindawi.com)
  • In the consensus document, an injury was defined as "any physical complaint sustained by a player that results from a football match or football training, irrespective of the need for medical attention or time loss from football activities. (bmj.com)
  • Results Groups were comparable in anthropometrics, playing position and MRI injury severity. (bmj.com)
  • Prolonged exposure to temperatures that induce chill coma result in a time- and temperature-dependent accumulation of damage (chilling injury), which ultimately results in death. (silverchair.com)
  • Results: About 23.5% of respondents scored >3 using the GHQ-12 questionnaire, signifying a likehood of psychiatric morbidity. (bvsalud.org)
  • Background About 5.8 million people die each year as a result of injuries, and nearly 90% of these deaths occur in low and middle-income countries (LMIC). (bmj.com)
  • An increasing number of evidence suggests that miRNAs may act as potential biomarkers for pancreatic injury [ 19 - 23 ]. (hindawi.com)
  • All subjects underwent Technetium-99 m sestamibi single-photon emission computed tomographic imaging for the estimation of myocardial ischemia, expressed as Summed Stress Score (SSS). (springer.com)
  • In the alcohol group severity and pattern correlated with alcohol concentration at the time of injury. (bmj.com)
  • 4) severity should be measured based on functional level and not time loss from sports. (bmj.com)
  • Aims To determine whether a single ultrasound-guided platelet-rich plasma (PRP) injection into the anterior inferior tibiofibular ligament (AITFL) reduces the time for rugby athletes to return to function and match play following MRI confirmed ankle syndesmosis injury. (bmj.com)
  • Similarly, this technique can be used retrospectively to identify and control for differences in baseline injury severity between patient populations. (medscape.com)
  • No significant differences were observed in severity of injury or demographic composition between groups. (nature.com)
  • An accurate method for quantitatively summarizing injury severity has many potential applications. (medscape.com)
  • Neonatal brain magnetic resonance imaging (MRI) has been shown to be more sensitive than cranial ultrasound (CUS) for the detection of non-cystic WMI, and is therefore considered the gold-standard neuroimaging method to identify and quantify diffuse WMI of prematurity. (nature.com)
  • The aim of this paper was to provide recommendations on how standardised methodology can be developed to quantify overuse injuries in surveillance studies. (bmj.com)
  • In conclusion, new approaches are needed to develop more appropriate methodology to quantify overuse injuries in studies. (bmj.com)
  • This resulted in a consensus statement published in 2006 aiming to establish definitions and methodology, implementation and reporting standards for studies of injuries in football and to provide the basis for studies of injuries in other team sports. (bmj.com)
  • Studies conducted in high-income countries (HIC) or describing scores for isolated anatomic locations were excluded. (bmj.com)
  • Appendix Table A9, available at https://links.lww.com/OPX/A572 , reports the median and IQR of metrics found to be significantly different between concussed individuals and uninjured individuals in prior studies (BOX score, left.distLeft, right.distRight, conj.varXtopbotRatio, left.varYtop) for each group of participants. (lww.com)
  • Researchers use multiple independent variables (eg, age, injury severity) to predict the dependent variable (or outcome). (medscape.com)
  • An individualized outburst severity score was used as a more appropriate outcome measure of treatment for these individuals. (abainternational.org)
  • White matter injury (WMI) is the most frequent type of brain lesion in preterm infants and may be present to some degree in up to 50% of very low birth weight infants. (nature.com)
  • 1 month after resolution of an acute tissue injury, or accompanies a nonhealing lesion. (msdmanuals.com)
  • The score is obtained by observing the patient's impairment in speech, motor function, and eye movement. (braininjurylawyer24-7blog.com)
  • Zhu X, Cheng J, Yu J, Liu R, Ma H, Zhao Y. Nicotinamide mononucleotides alleviated neurological impairment via anti-neuroinflammation in traumatic brain injury. (medsci.org)
  • Taken together, our data showed that NMN alleviated neurological impairment via anti-neuroinflammation in traumatic brain injury and the mechanisms may involve TLR2/4-NF-κB signaling. (medsci.org)
  • 1-year post injury, and individuals without documented neurological deficits, resulting in 83 participants for subsequent analysis. (nature.com)
  • The control group was treated in an identical fashion, per standard of care, guided by the CMHH traumatic brain injury management protocol, derived from American Association of Neurological Surgeons guidelines. (cellvation.com)
  • More recently, physicians suggested that injury severity scoring can provide objective information for end-of-life decision-making and resource allocation. (medscape.com)
  • To determine how pattern and severity of injury correlates with blood alcohol concentration. (bmj.com)
  • Implications exist for current multidisciplinary care of wounded active duty and veteran service members, and future research should determine whether multimorbidity denotes distinct post-blast injury syndromes. (biomedcentral.com)
  • To determine the cause of this loss of function, we measured the effects of cold exposure on ion and water homeostasis in muscle tissue, hemolymph and the alimentary canal of the fall field cricket, Gryllus pennsylvanicus , during an exposure to 0°C that caused chilling injury and death. (silverchair.com)
  • 10 Rugby Union players were recruited during the 2014 season, and consented to receive a single autologous PRP injection into the AITFL within 14 days of MRI confirmed ankle syndesmosis injury. (bmj.com)
  • PRP injections may accelerate safe return to play for Rugby Union players with non-surgical ankle syndesmosis injuries, when combined with appropriate rehabilitation. (bmj.com)
  • Ankle syndesmosis injury (ASI) appears to be an increasingly common injury among the sporting population. (bmj.com)
  • 145 mmol/L, can result from a primary brain injury resulting in central diabetes insipidus or as a result of hyperosmolar therapies such as the use of hypertonic saline (3, 4). (annalsofafricansurgery.com)
  • White matter injury (WMI) is the most frequent form of preterm brain injury. (nature.com)
  • Huang L , Kang J , Chen G , Ye W , Meng X , Du Q , Feng Z , . Low-intensity focused ultrasound attenuates early traumatic brain injury by OX-A/NF-κB/NLRP3 signaling pathway. (aging-us.com)
  • Traumatic brain injury (TBI) remains a major global public health problem [ 1 ]. (aging-us.com)
  • Ongoing projects focus on glial cells (astrocytes and microglia) and how they coordinate with immune cells from the blood to affect bystander brain injury in the days after stroke. (stanford.edu)
  • therefore, multiple alternative scoring systems have been proposed, each with its own problems and limitations. (medscape.com)
  • 5 hypothesized multiple etiologies for the relationship between combat-related injury and PTSD, including increased levels of perceived threat to life and peritraumatic dissociation (i.e., feeling emotionally numb or separated from a traumatic event) among injured relative to non-injured personnel. (health.mil)
  • Introduction The burden of injury in the Kingdom of Saudi Arabia (KSA) has increased in recent years, but the country has lacked a consistent methodology for collecting injury data. (bmj.com)
  • Advances in combat casualty care, medical transport, and personal protective equipment led to a greater survivability from wounds, and the US Military Health System subsequently faced a growing number of service members and veterans with injury-related sequelae [ 3 ]. (biomedcentral.com)