However, acyclovir- or ganciclovir-resistant mutants with alterations in viral DNA polymerase may also be resistant to foscarnet. (wikipedia.org)
Ganciclovir4
However, unlike acyclovir and ganciclovir, foscarnet is not activated by viral protein kinases, making it useful in acyclovir- or ganciclovir-resistant HSV and CMV infections. (wikipedia.org)
Ganciclovir The pharmacokinetics of foscarnet and ganciclovir were not altered in 13 patients receiving either concomitant therapy or daily alternating therapy for maintenance of CMV disease. (druglib.com)
Antiviral activity1
Foscarnet exerts its antiviral activity by a selective inhibition at the pyrophosphate binding site on virus-specific DNA polymerases at concentrations that do not affect cellular DNA polymerases. (druglib.com)
Polymerase1
It is classified as a pyrophosphate analog DNA polymerase inhibitor. (wikipedia.org)
Foscavir7
Foscarnet (phosphonomethanoic acid), known by its brand name Foscavir, is an antiviral medication which is primarily used to treat viral infections involving the Herpesviridae family. (wikipedia.org)
This phosphonic acid derivative (marketed by Clinigen as foscarnet sodium under the trade name Foscavir) is an antiviral medication used to treat herpes viruses, including drug-resistant cytomegalovirus (CMV) and herpes simplex viruses types 1 and 2 (HSV-1 and HSV-2). (wikipedia.org)
FOSCAVIR is contraindicated in patients with clinically significant hypersensitivity to foscarnet sodium. (druglib.com)
FOSCAVIR INJECTION is a sterile, isotonic aqueous solution for intravenous administration only. (nih.gov)
Each milliliter of FOSCAVIR contains 24 mg of foscarnet sodium hexahydrate in Water for Injection, USP. (nih.gov)
FOSCAVIR INJECTION contains no preservatives. (nih.gov)
Sodium1
The chemical name of foscarnet sodium is phosphonoformic acid, trisodium salt. (nih.gov)
Trisodium1
Foscarnet is the conjugate base of a chemical compound with the formula HO2CPO3H2 (Trisodium phosphonoformate). (wikipedia.org)
Inhibits2
Foscarnet is a structural mimic of the anion pyrophosphate that selectively inhibits the pyrophosphate binding site on viral DNA polymerases at concentrations that do not affect human DNA polymerases. (wikipedia.org)
Foscarnet is an organic analogue of inorganic pyrophosphate that inhibits replication of herpes viruses in vitro including cytomegalovirus (CMV) and herpes simplex virus types 1 and 2 (HSV-1 and HSV-2). (druglib.com)
Thymidine1
Foscarnet does not require activation (phosphorylation) by thymidine kinase or other kinases and therefore is active in vitro against HSV TK deficient mutants and CMV UL97 mutants. (druglib.com)
Intravenous1
Foscarnet is administered by intravenous infusion or intravitreous injection. (wikipedia.org)
Nephrotoxicity1
citation needed] Nephrotoxicity - increase in serum creatinine levels and renal injury can occur in patients receiving foscarnet. (wikipedia.org)
Therapy1
Foscarnet can be used to treat highly treatment-experienced patients with HIV as part of salvage therapy. (wikipedia.org)
Analog DNA Polymerase Inhibitor1
It is classified as a pyrophosphate analog DNA polymerase inhibitor. (wikipedia.org)
FOSCAVIR INJECTION is a sterile, isotonic aqueous solution for intravenous administration only. (nih.gov)
Each milliliter of FOSCAVIR contains 24 mg of foscarnet sodium hexahydrate in Water for Injection, USP. (nih.gov)
FOSCAVIR INJECTION contains no preservatives. (nih.gov)
Foscarnet (phosphonomethanoic acid), known by its brand name Foscavir, is an antiviral medication which is primarily used to treat viral infections involving the Herpesviridae family. (wikipedia.org)
This phosphonic acid derivative (marketed by Clinigen as foscarnet sodium under the trade name Foscavir) is an antiviral medication used to treat herpes viruses, including drug-resistant cytomegalovirus (CMV) and herpes simplex viruses types 1 and 2 (HSV-1 and HSV-2). (wikipedia.org)
Phosphonoformic acid2
The chemical name of foscarnet sodium is phosphonoformic acid, trisodium salt. (nih.gov)
and phosphonoformic acid (PFA), a pyrophosphate analog. (nih.gov)
Trisodium1
Foscarnet is the conjugate base of a chemical compound with the formula HO2CPO3H2 (Trisodium phosphonoformate). (wikipedia.org)
Cidofovir1
Acyclovir-resistant HSV strains are usually susceptible to alternative agents, such as IV foscarnet and IV cidofovir, because of the different mechanisms of action of these agents. (jhoponline.com)
Acyclovir1
however, the breakpoints of half-maximal inhibitory concentration of ≥2 µg/mL for oral and IV acyclovir and of ≥100 µg/mL for IV foscarnet are widely accepted. (jhoponline.com)
Concentrations3
Cell culture: CMV and HSV isolates with reduced susceptibility to foscarnet have been selected in cell culture by passage of wild type virus in the presence of increasing concentrations of the drug. (nih.gov)
Foscarnet is a structural mimic of the anion pyrophosphate that selectively inhibits the pyrophosphate binding site on viral DNA polymerases at concentrations that do not affect human DNA polymerases. (wikipedia.org)
It is most likely a contact dermatitis due to high concentrations of foscarnet in urine. (wikipedia.org)
Acid1
All foscarnet resistant isolates are known to be generated through amino acid substitutions in the viral DNA polymerase pUL54 (CMV) or pUL30 (HSV) ( Table 3 ). (nih.gov)
Thymidine kinase1
Foscarnet does not require activation (phosphorylation) by thymidine kinase or other kinases. (nih.gov)
Response to therapy1
The quantitative relationship between the cell culture susceptibility of human cytomegalovirus (CMV) or herpes simplex virus 1 and 2 (HSV-1 and HSV-2) to foscarnet and clinical response to therapy has not been established and virus sensitivity testing has not been standardized. (nih.gov)