• patients
  • Prophylaxis against opportunistic illnesses consisted of cotrimoxazole for patients with CD4 counts less than 200 cells/mm 3 and isoniazid/pyridoxine for all patients. (ucsf.edu)
  • When it happens, isoniazid-induced liver toxicity has been shown to occur in 50% of patients within the first 2 months of therapy. (wikipedia.org)
  • Liver toxicity occurs in up to 5% of patients and follows a pattern similar to isoniazid, usually arising in the first 1 to 3 months of therapy, but can occur even after more than 6 months of therapy. (wikipedia.org)
  • thought
  • Isoniazid is thought to induce a liver enzyme which causes a larger amount of acetaminophen to be metabolized to a toxic form. (wikipedia.org)
  • similar
  • While working in a similar manner to isoniazid, cross resistance is only seen in 13% of strains, since they are both prodrugs but activated by different pathways. (wikipedia.org)
  • further
  • Absorbed pyridoxamine is converted to PMP by pyridoxal kinase, which is further converted to PLP by pyridoxamine-phosphate transaminase or pyridoxine 5′-phosphate oxidase which also catalyzes the conversion of PNP to PLP. (wikipedia.org)