Exposure to polycyclic aromatic hydrocarbons (PAHs) in foundry workers has been evaluated by determination of benzo(a)pyrene-serum albumin adducts and urinary 1-hydroxypyrene. (bmj.com)
Dose-response relations between total PAH, pyrene, carcinogenic PAHs, and 1-hydroxypyrene for smokers, and polycyclic aromatic hydrocarbons adsorbed to dust for non-smokers are suggested. (bmj.com)
This Public Health Statement is the summary chapter from the Toxicological Profile for polycyclic aromatic hydrocarbons (PAHs) . (cdc.gov)
This statement was prepared to give you information about polycyclic aromatic hydrocarbons (PAHs) and to emphasize the human health effects that may result from exposure to them. (cdc.gov)
Information on benzo(a)pyrene (BaP), an indicator species for polycyclic aromatic hydrocarbons (PAHs), for use in responding to chemical incidents. (www.gov.uk)
Polycyclic aromatic hydrocarbons ( PAHs ) are a group of several hundred chemically-related environmentally persistent organic compounds. (www.gov.uk)
Urine was analyzed for metabolites of polycyclic aromatic hydrocarbons (PAHs) and breath was analyzed for volatile organic compounds (VOCs) including benzene. (cdc.gov)
Benzo[a]pyrene ( B[a]P ) is a surrogate for all polyaromatic hydrocarbons ( PAHs ). (ontario.ca)
Benzo(a)pyrene (BaP) is a compound in a group of chemicals called polycyclic aromatic hydrocarbons (PAHs). (chej.org)
Nine structurally different polycyclic aromatic hydrocarbons (PAHs) were tested for their ability to either agonize or antagonize the human androgen receptor (hAR) in a sensitive reporter gene assay based on CHO cells transiently cotransfected with a hAR vector and an MMTV-LUC vector. (dtu.dk)
Polycyclic aromatic hydrocarbons, PAHs make up a group of chemicals that are formed during incomplete combustion of organic materials. (swedishmatch.com)
Benzo(a)pyrene (B(a)P) is one of many identified PAHs. (swedishmatch.com)
In this dissertation, I present electronic spectra of a few polycyclic aromatic hydrocarbons (PAHs): tetracene, pentacene, pyrene, benzo[g,h,i]perylene and benzo[a]pyrene using resonantly enhanced multiphoton ionization (REMPI) and zero kinetic energy (ZEKE) photoelectron spectroscopy. (oregonstate.edu)
In low symmetry PAHs such as benzo[a]pyrene, the Franck-Condon allowed total symmetric modes are already IR active. (oregonstate.edu)
Many polycyclic aromatic hydrocarbons (PAHs) are found in these sealants. (cdc.gov)
This view is supported by research demonstrating that they contain toxic chemicals within their structure and also adsorb additional chemicals, including polychlorinated biphenyls (PCBs), pesticides, metals, and polycyclic aromatic hydrocarbons (PAHs), from the environment. (researchgate.net)
It is used in detecting contamination of PAHs and as a model polycyclic aromatic hydrocarbon for determination of the factors that affect bioavailability, rate of microbial degradation and biodegradation potential of PAHs in the environment [ 3 ]. (omicsonline.org)
Highly oxygenated organic molecules with high unsaturation (HU-HOMs) are formed by the multigenerational photo-oxidation of large polycyclic aromatic hydrocarbons (PAHs) on soot. (mpic.de)
Air pollution with increased concentrations of carcinogenic polycyclic aromatic hydrocarbons (c-PAHs, represented by benzo[a]pyrene, B[a]P) affect fetal development, reduce birth weights (LBW) of newborns, and increases intrauterine growth retardation (IUGR). (nel.edu)
Benzo(a)pyrene (BaP), the earliest and most significant carcinogen among polycyclic aromatic hydrocarbons (PAHs), has been found in foods, tobacco smoke, and automobiles exhaust, etc. (biomedcentral.com)
Food can be contaminated by PAHs because of the contamination of air, water or soil, and during industrial process, as heating, drying and Polycyclic aromatic hydrocarbons (PAHs) are a group of over 200 smoking process. (bvsalud.org)
PAHs were found in different foodstuffs, including different organic compounds with two or more fused aromatic rings vegetables, fruit, cereals, oils and fats, smoked fish and meat, coffee and ( Domingo & Nadal, 2015 ). (bvsalud.org)
Benzo31
Exposure of iron foundry workers to polycyclic aromatic hydrocarbons: benzo(a)pyrene-albumin adducts and 1-hydroxypyrene as biomarkers for exposure. (bmj.com)
Benzo(a)pyrene binding to albumin and 1-hydroxypyrene were quantitatively measured by enzyme linked immunosorbent assay (ELISA) and reverse phase high performance liquid chromatography (HPLC), respectively. (bmj.com)
Median benzo(a)pyrene-albumin adduct concentrations (10-90% percentiles) were similar in foundry workers (smokers 0.55 (0.27-1.00) and non-smokers 0.58 (0.17-1.15)) pmol/mg albumin and age matched controls (smokers 0.57 (0.16-1.45) and non-smokers 0.70 (0.19-1.55) pmol/mg albumin). (bmj.com)
There was no correlation between the concentrations of 1-hydroxypyrene and benzo(a)pyrene-albumin adducts. (bmj.com)
Smoking did not affect the concentrations of 1-hydroxypyrene or benzo(a)pyrene-albumin adducts. (bmj.com)
Benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide is an organic compound with molecular formula C20H14O3. (wikipedia.org)
It is a metabolite and derivative of benzo[a]pyrene (found in tobacco smoke) as a result of oxidation to include hydroxyl and epoxide functionalities. (wikipedia.org)
Benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide binds to the N2 atom of a guanine nucleobase in DNA, distorting the double helix structure by intercalation of the pyrene moiety between base pairs through π-stacking. (wikipedia.org)
Benzo[a]pyrene is a derivative in which a fifth benzene ring has been fused to the pyrene system, and is a component of tobacco smoke which is a procarcinogen partly responsible for the carcinogenic and mutagenic effects of smoking. (wikipedia.org)
Benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide is a metabolite of benzo[a]pyrene formed by the introduction of vicinal hydroxyl and epoxide functional groups to the fifth benzene ring. (wikipedia.org)
The metabolism of the tobacco smoke procarcinogen benzo[a]pyrene involves three distinct steps - the introduction of an epoxide group in the 7,8-position, its hydration to a vicinal diol and the introduction of an epoxide in the 9,10-position. (wikipedia.org)
In the first step, a cytochrome P450 1A1 (CYP1A1) catalysed oxidation produces several products including (+)-benzo[a]pyrene-7,8-epoxide. (wikipedia.org)
The enzyme epoxide hydrolase, then hydrates the epoxide ring to yield the vicinal diol (−)-benzo[a]pyrene-7,8-dihydrodiol, which is then oxidised by cytochrome P450 oxidase again forming the mutagen and carcinogen (+)-benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide. (wikipedia.org)
The anti stereoisomer (shown here) and its enantiomer are the ultimate carcinogens from benzo[a]pyrene, but the syn isomers are also produced. (wikipedia.org)
The anti-benzo[a]pyrene diol epoxides induce guanine to thymine transversions in related areas of p53, thereby inactivating its tumor suppression ability in certain cells, leading to genetic mutations and potentially to cancer. (wikipedia.org)
Induction of CYP1A1 by benzo[a]pyrene occurs via binding to the aryl hydrocarbon receptor in the cytosol, leading the transformed receptor to translocate to the nucleus where it dimerises with aryl hydrocarbon receptor nuclear translocator and then binds xenobiotic response elements in DNA located upstream of certain genes. (wikipedia.org)
Seemingly, CYP1A1 activity in the intestinal mucosa prevents major amounts of ingested benzo[a]pyrene to enter portal blood and systemic circulation. (wikipedia.org)
Moreover, benzo[a]pyrene has been found to activate a transposon, LINE1, in humans. (wikipedia.org)
Benzo[a]pyrene ( BaP ) acts as an indicator species for PAH contamination. (www.gov.uk)
2018. Pharmacokinetics of [C]-Benzo[a]pyrene (BaP) in humans: Impact of Co-Administration of smoked salmon and BaP dietary restriction. . (oregonstate.edu)
Researchers at Columbia University measured the amount of a car exhaust chemical known as benzo[a]pyrene in 233 African-American and Dominican women in New York City. (chem-tox.com)
It was possible to demonstrate, for example, that even low quantities of benzo[a]pyrene can have effects on the protein pattern and hence the metabolism and signal pathways in cells, even though the concentration is a hundred times below what is required to drive cells into apoptosis. (analytica-world.com)
The scientists undertook a detailed study of the effects of benzo[a]pyrene as a genotoxic model substance in cell cultures. (analytica-world.com)
Benzo[a]pyrene is long been known and one of the best studied carcinogenic substances. (analytica-world.com)
Benzo[a]pyrene is a polycyclic aromatic hydrocarbon which is generated during incomplete combustion of organic materials. (analytica-world.com)
Liver cells of mice were subjected for 24 hours to both a toxic and a benzo[a]pyrene concentration which was clearly below a threshold at which changes in the cell culture are typically observed. (analytica-world.com)
In this way, 190 proteins were identified - for a concentration that is toxic to the cell - which as a result of the treatment with benzo[a]pyrene underwent changes in their cellular quantity. (analytica-world.com)
Benzo[a]pyrene is one of 105 substances which are classified as carcinogen by the International Agency for Research on Cancer (IARC). (analytica-world.com)
Prenatal exposure to polycyclic aromatic hydrocarbons, benzo[a]pyrene-DNA adducts, and genomic DNA methylation in cord blood. (cdc.gov)
Important peak concentrations were identified and their average marker substance benzo[a]pyrene (BaP)) and bladder cancer devel- duration ranged between 12.5 and 22.1% of the work shift. (cdc.gov)
Furthermore, a known carcinogen (Benzo(a)pyrene) was detected in field-generated roofing fumes. (cdc.gov)
Fluoranthene is a polycyclic aromatic hydrocarbon (PAH). (wikipedia.org)
Carcinogenic2
Cyclopenta(c,d)pyrene (CPP) is a ubiquitous polycyclic aromatic hydrocarbon with potent mutagenic and carcinogenic activity. (epa.gov)
Car exhaust is a major source of the carcinogenic and neurotoxic chemicals polycyclic aromatic hydrocarbons (PAH). (chem-tox.com)
Benzene2
Pyrene is a polycyclic aromatic hydrocarbon consisting of four benzene rings fused together in a planar aromatic arrangement which approximates a rhombus in shape. (wikipedia.org)
Anthracene is a tricyclic poly aromatic hydrocarbon which is characterized by a three fused benzene ring. (omicsonline.org)
Phenanthrene3
This change was greatest for firefighters assigned to attack and search with 2.3, 5.6, 3.9, and 1.4-fold median increases in pyrene, phenanthrene, naphthalene, and fluorene metabolites. (cdc.gov)
Compared to interior attack, transitional attack resulted in 50% less uptake of pyrene (p = 0.09), 36% less uptake phenanthrene (p = 0.052), and 20% less uptake of fluorene (p (cdc.gov)
Only at the highest concentration tested (10 mu M), a slight inhibitory effect by pyrene: phenanthrene, and anthracene was observed. (dtu.dk)
Oxidation1
We show that particle-phase photochemical oxidation of polycyclic aromatic hydrocarbons on soot can produce a substantial amount of highly oxygenated OA, which changes soot from being hydrophobic to being hydrophilic and increases the ability of soot particles to serve as cloud condensation nuclei. (mpic.de)
Polyaromatic hydrocarbons1
The burned charcoal releases chemicals such as carbon monoxide (CO), polyaromatic hydrocarbons (PAH) and other combustion-related toxins that the smoker inhales. (who.int)
Chemicals1
When these are burned in the engine combustion process, they form new highly toxic chemicals including dioxin and a group of chemicals called polycyclic aromatic hydrocarbons (PAH for short). (chem-tox.com)
Ubiquitous1
Polycyclic aromatic hydrocarbons are ubiquitous in nature and persist in the environment as a result of their low solubility in water due to their hydrophobicity [ 1 ]. (omicsonline.org)
Five aromatic1
However, the Ah receptor agonists containing four or five aromatic rings (i.e. (dtu.dk)
Contamination1
This goal has been obtained by combining different inorganic and organic chemical proxies such as trace elements, polycyclic aromatic hydrocarbons, and lead isotope ratios and exploiting both principal component and factor analysis to associate chemical proxies to human-driven contamination processes. (springer.com)
Bacteria1
Jjemba PK, Kinkle BK, Shann JR. ( 2006 ) In-situ enumeration and probing of pyrene-degrading soilbacteria. (academictree.org)
Receptor1
Aryl hydrocarbon receptor (AHR) is a transcription factor [ 41 ], Gargaro, Manni et al. (biomedcentral.com)
20231
2023. Methods for Assessing the Bioaccumulation of Hydrocarbons and Related Substances in Terrestrial Organisms: A Critical Review . (sfu.ca)
Microbial1
2014 ) Characterization of the cell surface properties of drinking water pathogens by microbial adhesion to hydrocarbon and electrophoretic mobility measurements. (academictree.org)
Soils1
population structure and pyrene mineralization in polycyclic aromatic hydrocarbon-amended soils Soil Biology and Biochemistry . (academictree.org)
Together, these studies implicate UGT1A10 as an important detoxifier of polycyclic aromatic hydrocarbons in humans and that the UGT1A10 codon 139 polymorphism may be an important determinant in risk for tobacco-related cancers. (aspetjournals.org)
20021
a b Karl Griesbaum, Arno Behr, Dieter Biedenkapp, Heinz-Werner Voges, Dorothea Garbe, Christian Paetz, Gerd Collin, Dieter Mayer, Hartmut Höke "Hydrocarbons" in Ullmann's Encyclopedia of Industrial Chemistry 2002 Wiley-VCH, Weinheim. (wikipedia.org)
Naphthalene1
An integrated approach of bioassay and molecular docking to study the dihydroxylation mechanism of pyrene by naphthalene dioxygenase in Rhodococcus sp. (brenda-enzymes.org)
Indeno2
Indeno(1,2,3-cd)pyrene is a polycyclic aromatic hydrocarbon, or PAH, released from combustion of fossil fuels and waste incinerators. (ewg.org)
The purchasing utility is not required to test for or report Indeno[1,2,3-cd]pyrene, but it likely has the contaminant in its water supply. (ewg.org)
Kinetic1
Although a kinetic comparison using V max could not be performed against family 2B UGTs, UGT1A10 exhibited a 1.7- to 254-fold lower K m than active family 2B UGTs against 3-OH-BaP, 7-OH-BaP, and 1-OH-pyrene. (aspetjournals.org)
Median1
hydrocarbon found among all types of oils, with the highest median values. (bvsalud.org)
Effects1
To better assess the potential role of UGT1A10 in risk for tobacco-related cancers, the glucuronidation activity of UGT1A10 was compared with that of other known UGT enzymes against selected polycyclic aromatic hydrocarbons, and the effects of the codon 139 polymorphism on UGT1A10 function were examined in vitro. (aspetjournals.org)
Trans1
The trans isomer of 3,4-dihydro-3,4-dihydroxy-cyclopenta(c,d)pyrene has been shown to be the major metabolic product of CPP in rat, mouse, or human microsomal systems as well as in peroxyl radical-generating systems indicating the preferential formation of its obligatory precursor, CPP-3,4-epoxide. (epa.gov)
Rings1
Pyrene, the smallest two-dimensional mesh of aromatic rings, with various terminal thiol substitutions, has been considered as a potential molecular interconnect. (tcd.ie)
Reaction1
Reaction of Cyclopent(c,d)pyrene-3,4-epoxide with DNA and Deoxynucleotides. (epa.gov)
Introduction1
See the Introduction (Sheet 1 ( en ) or Sheet 2 ( fr )) for more information about the sources. (ontario.ca)
Water1
2020. Treatment of Polycyclic Aromatic Hydrocarbons in Oil Sands Process Affected Water with a Surface Flow Treatment Wetland . (sfu.ca)
Lead1
Three short sediment cores have been exploited to this aim and characterized in terms of major and trace elements, polycyclic aromatic hydrocarbons, and lead isotope ratios. (springer.com)
Activity1
UGT1A10 exhibited considerably more glucuronidation activity as determined by V max / K m against 3-hydroxy (OH)-BaP, 7-OH-BaP, 9-OH-BaP, and 1-OH-pyrene than any other UGT1A family member. (aspetjournals.org)